Neuropoisons pp 187-212 | Cite as

Tetrodotoxin and Saxitoxin as Pharmacological Tools

  • Peter W. Gage


Interest in the poisons tetrodotoxin and saxitoxin was initially aroused because of deaths which occurred following careless or innocent consumption of puffer-fish or shellfish. From ancient times it was well known to the Japanese and Chinese that it was hazardous to eat the ovaries and eggs of the puffer-fish (tetrodons, also known as fugu or swellfish), but rather than forsake the fish which is apparently prized by oriental gourmets, chefs were specially trained and licensed to prepare nontoxic fugu. Restaurants which were fortunate enough to have the services of such a cook could include the item in their menu (see Chap. 6). Natural predators were no doubt aware of puffer toxicity, and this must have been very useful in the struggle for survival of the species. One of the earliest pharmacological uses of tetrodotoxin would have been as a poison in suicide, and perhaps homicide, attempts (Kao, 1964).


Transmitter Release Presynaptic Terminal Potassium Conductance Pharmacological Tool Presynaptic Membrane 
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  1. Adrian, R. H., L. L. Constantin, and L. D. Peachey (1969), J. Physiol., 204:231.PubMedGoogle Scholar
  2. Albuquerque, E. X. and W. Gramp (1968), J. Physiol., 195:141.PubMedGoogle Scholar
  3. Armstrong, C. M. and L. Binstock (1965), J. Gen. Physiol., 48:859.PubMedCrossRefGoogle Scholar
  4. Baumann, F. (1968), J. Gen. Physiol., 52:855.PubMedCrossRefGoogle Scholar
  5. Bell, C. (1968), Brit. J. Pharm. Chemother, 32:96.Google Scholar
  6. Benolken, R. M. and C. J. Russell (1967), Science, 155:1576.PubMedCrossRefGoogle Scholar
  7. Blankenship, J. E. (1968), J. Neurophysiol., 31:186.PubMedGoogle Scholar
  8. Blankenship, J. E. and M. Kuno (1968), J. Neurophysiol., 31:195.PubMedGoogle Scholar
  9. Bloedel, J., P. W. Gage, R. Llinás, and D. M. J. Quastel (1966a), Nature, 212:49.PubMedCrossRefGoogle Scholar
  10. Bloedel, J. R., P. W. Gage, R. Llinás, and D. M. J. Quastel (1966b), J. Physiol., 188:52.Google Scholar
  11. Bülbring, E. and T. Tomita (1967), J. Physiol., 189:299.PubMedGoogle Scholar
  12. Chamberlain, S. G. and G. S. Kerkut (1967), Nature, 216:89.PubMedCrossRefGoogle Scholar
  13. Chan, S. L. and J. H. Quastel (1967), Science, 156:1752.PubMedCrossRefGoogle Scholar
  14. Colomo, F. and S. D. Erulkar (1968), J. Physiol., 199:205.PubMedGoogle Scholar
  15. Crawford, M. L. J. and S. Shibata (1968), Brit. J. Pharm. Chemother., 32:25.Google Scholar
  16. Dudel, J., K. Peper, R. Rudel, and W. Trautwein (1967), Nature, 213:296.PubMedCrossRefGoogle Scholar
  17. Elmqvist, D. and D. S. Feldman (1965), Acta Physiol. Scand., 64:475.PubMedCrossRefGoogle Scholar
  18. Frank, G. B. and C. Pinsky (1966), Brit. J. Pharmacol., 26:435.PubMedGoogle Scholar
  19. Gage, P. W. (1967), Fed. Proc., 26:1627.PubMedGoogle Scholar
  20. Gage, P. W. and R. S. Eisenberg (1969), J. Gen. Physiol., 53:265.PubMedCrossRefGoogle Scholar
  21. Hafemann, D. R., A. Costin, and T. J. Tarby (1969), Brain Research, 12:363.PubMedCrossRefGoogle Scholar
  22. Hagiwara, S. and S. Nakajima (1966), J. Gen. Physiol., 49:793.PubMedCrossRefGoogle Scholar
  23. Hagiwara, S. and I. Tasaki (1958), J. Physiol., 143:114.PubMedGoogle Scholar
  24. Hashimoto, Y., M. E. Holman, and A. J. McLean (1967), Nature, 215:430.PubMedCrossRefGoogle Scholar
  25. Hille, B. (1968), J. Gen. Physiol., 51:199.PubMedCrossRefGoogle Scholar
  26. Hodgkin, A. L. (1964), “The conduction of the nervous impulse,” Liverpool University Press, England.Google Scholar
  27. Hodgkin, A. L. and A. F. Huxley (1952a), J. Physiol., 116:449.PubMedGoogle Scholar
  28. Hodgkin, A. L. and A. F. Huxley (1952b), J. Physiol., 116:473.PubMedGoogle Scholar
  29. Hodgkin, A. L. and A. F. Huxley (1952c), J. Physiol., 116:497.PubMedGoogle Scholar
  30. Hodgkin, A. L. and A. F. Huxley (1952d), J. Physiol., 117:500.PubMedGoogle Scholar
  31. Hubbard, J. I., D. Stenhouse, and R. M. Eccles (1967), Science, 157:330.PubMedCrossRefGoogle Scholar
  32. Kao, C. Y. (1964), Pharmacol. Rev., 18:997.Google Scholar
  33. Katsuki, Y., K. Yanagisawa, and J. Kanzaki (1966), Science, 151:1544.PubMedCrossRefGoogle Scholar
  34. Katz, B. and R. Miledi (1967a), Proc. Roy. Soc. B., 167:8.CrossRefGoogle Scholar
  35. Katz, B. and R. Miledi (1967b), J. Physiol., 192:407.PubMedGoogle Scholar
  36. Katz, B. and R. Miledi (1969), J. Physiol., 203:459.PubMedGoogle Scholar
  37. Koizumi, K., D. G. Levine, and C. McC. Brooks (1967), Neurology, 17:395.PubMedGoogle Scholar
  38. Koketsu, K. and S. Nishi (1969), J. Gen. Physiol., 53:608.PubMedCrossRefGoogle Scholar
  39. Kuriyama, H., T. Osa, and N. Toida (1966), Br. J. Pharmac. Chemother., 27:366.Google Scholar
  40. Kusano, K., D. R. Livengood, and R. Werman (1967), J. Gen. Physiol., 50:2579.PubMedCrossRefGoogle Scholar
  41. Liley, A. W. (1956), J. Physiol., 134:427.PubMedGoogle Scholar
  42. Lipsius, M. R., M. J. Siegman, and C. Y. Kao (1968), J. Pharm. Exp. Ther., 164:60.Google Scholar
  43. Lowenstein, W. R., C. A. Terzuolo, and Y. Washizu (1963), Science, 10:1180.CrossRefGoogle Scholar
  44. Mcllwain, H. (1967), J. Physiol., 190:39P.Google Scholar
  45. Marumo, F., T. Yamada, Y. Asano, T. Sasaoka, A. Yoshida, and H. Endou (1968), Pflugers Arch., 303:49.PubMedCrossRefGoogle Scholar
  46. Miledi, R. and C. R. Slater (1966), J. Physiol., 184:473.PubMedGoogle Scholar
  47. Millecchia, R. and A. Mauro (1969), J. Gen. Physiol., 54:310.PubMedCrossRefGoogle Scholar
  48. Moore, J. W., M. P. Blaustein, N. C. Anderson, and T. Narahashi (1967), J. Gen. Physiol., 50:1401.PubMedCrossRefGoogle Scholar
  49. Moore, J. W., T. Narahashi, and T. I. Shaw (1967), J. Physiol., 188:99.PubMedGoogle Scholar
  50. Nakajima, S. and K. Onodera (1969a), J. Physiol., 200:161.PubMedGoogle Scholar
  51. Nakajima, S. and K. Onodera (1969b), J. Physiol., 200:187.PubMedGoogle Scholar
  52. Narahashi, T., T. Deguchi, N. Urakawa, and U. Ohkubo (1960), Amer. J. Physiol., 198:934.PubMedGoogle Scholar
  53. Narahashi, T., J. W. Moore, and W. Scott (1964), J. Gen. Physiol., 47:965.PubMedCrossRefGoogle Scholar
  54. Narahashi, T., N. C. Anderson, and J. W. Moore (1966), Science, 153:765.PubMedCrossRefGoogle Scholar
  55. Narahashi, T., J. W. Moore, and R. N. Poston (1966), Science, 154:425.Google Scholar
  56. Narahashi, T., N. C. Anderson, and J. W. Moore (1967), J. Gen. Physiol., 50:1413.PubMedCrossRefGoogle Scholar
  57. Narahashi, T., J. W. Moore, and R. N. Poston (1967), Science, 156:976.PubMedCrossRefGoogle Scholar
  58. Nishi, K. and M. Sato (1966), J. Physiol., 184:376.PubMedGoogle Scholar
  59. Nonomura, Y., Y. Hotta, and H. Ohashi (1966), Science, 152:97.PubMedCrossRefGoogle Scholar
  60. Orkand, R. K. and R. Niedergerke (1964), Science, 146:1176.PubMedCrossRefGoogle Scholar
  61. Ozeki, M. and M. Sato (1965), J. Physiol., 180:186.PubMedGoogle Scholar
  62. Ozeki, M., A. R. Freeman, and H. Grundfest (1966), J. Gen. Physiol., 49:1319.PubMedCrossRefGoogle Scholar
  63. Pullman, T. N., A. R. Lavender, and I. Aho (1968), Proc. Nat. Acad. Sci., 60:822.PubMedCrossRefGoogle Scholar
  64. Shanes, A. M., W. H. Freygang, H. Grundfest, and E. Amatniek (1959), J. Gen. Physiol., 42:793.PubMedCrossRefGoogle Scholar
  65. Takata, M., J. W. Moore, C. Y. Kao, and F. A. Fuhrman (1966), J. Gen. Physiol., 49:977.PubMedCrossRefGoogle Scholar
  66. Takeuchi, A. and N. Takeuchi (1962), J. Gen. Physiol., 45:1181.PubMedCrossRefGoogle Scholar
  67. Tasaki, I. and I. Singer (1966), Ann. N. Y. Acad. Sci., 137:792.PubMedCrossRefGoogle Scholar
  68. Taylor, R. E. (1959), Amer. J. Physiol., 196:1071.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Peter W. Gage
    • 1
  1. 1.School of PhysiologyUniversity of New South WalesKensingtonAustralia

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