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Mode of Action of Cobra Venom and Its Purified Toxins

  • C. Y. Lee

Abstract

The cobra is a common snake throughout Asia and Africa. There are at least twelve cobra species in six genera; most of them are found in Africa, and only two species, Naja naja and Ophiophagus hannah, are present in Asia. However, many subspecies of Naja naja have been recognized in different parts of Asia, except Japan, Korea, and northern China (see Table I).

Keywords

Snake Venom Crude Venom Cobra Venom Squid Axon Cortical Electrical Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albuquerque, E. X. and S. Thesleff (1967), J. Physiol. (London), 190:123.Google Scholar
  2. Albuquerque, E. X. and S. Thesleff (1968), Acta Physiol. Scand., 72:248.PubMedGoogle Scholar
  3. Aloof-Hirsch, S., A. De Vries, and A. Berger (1968), Biochim. Biophys. Acta, 154:53.PubMedGoogle Scholar
  4. Amuchastegui, S. R. (1940), C. R. Soc. Biol. (Paris), 133:318.Google Scholar
  5. Angelakos, E. T. and P. M. Glassman (1965), Arch. Int. Pharmacodyn., 154:82.PubMedGoogle Scholar
  6. Aravindakshan, I. and B. M. Braganca (1959), Biochim. Biophys. Acta, 31:463.PubMedGoogle Scholar
  7. Aravindakshan, I. and B. M. Braganca (1961a), Biochem. J., 79:80.PubMedGoogle Scholar
  8. Aravindakshan, I. and B. M. Braganca (1961b), Biochem. J., 79:84.PubMedGoogle Scholar
  9. Arthus, M. (1910), Arch. Int. Physiol., 10:161.Google Scholar
  10. Augustinsson, K. B. (1951), Acta Chem. Scand., 5:699, 712.Google Scholar
  11. Babilli, S. and W. Vogt (1965), J. Physiol. (London), 177:31P.Google Scholar
  12. Barnes, J. M. and J. Trueta (1941), Lancet, 1:623.Google Scholar
  13. Beerens, J. and H. Cuypers (1935), Brux. Méd., 15:757.Google Scholar
  14. Bergström, S., L. A. Carlson, and G. R. Weeks (1968), Pharmacol. Reviews, 20:1.Google Scholar
  15. Bertrand, G. and R. Vladesco (1940a), Ann. Inst. Pasteur, 64:344.Google Scholar
  16. Bertrand, G. and R. Vladesco (1940b), Ann. Inst. Pasteur, 65:5.Google Scholar
  17. Bhanganada, K. and J. F. Perry (1963), J. Amer. Med. Assn., 183:257.Google Scholar
  18. Bicher, H. I. (1966), Mem. Inst. Butantan, Simp. Int., 33(2):523.Google Scholar
  19. Bicher, H. I., C. Klibansky, J. Shiloah, S. Gitter, and A. De Vries (1965), Biochem. Pharmacol., 14:1779.PubMedGoogle Scholar
  20. Bjork, W. (1961), Biochim. Biophys. Acta, 49:195.Google Scholar
  21. Bjork, W. (1964), Biochim. Biophys. Acta, 89:483.Google Scholar
  22. Bjork, W. and H. G. Boman (1959), Biochim. Biophys. Acta, 34:503.PubMedGoogle Scholar
  23. Boquet, P. (1964), Toxicon, 2:5.Google Scholar
  24. Boquet, P. (1966), Toxicon, 3:243.PubMedGoogle Scholar
  25. Boquet, P., Y. Izard, M. Jouannet, and J. Meaume (1966a), Ann. Inst. Pasteur, 111:719.Google Scholar
  26. Boquet, P., Y. Izard, M. Jouannet, and J. Meaume (1966b), C. R. Acad. Sci. (Paris), 262:1134.Google Scholar
  27. Boquet, P., Y. Izard, M. Jouannet, and J. Meaume (1967a), Studies on some antigenic proteins and polypeptides from Naja nigricollis venom, in “Animal Toxins” (F. E. Russell and P. R. Saunders, eds.), Pergamon Press, Oxford and New York, pp. 293–298.Google Scholar
  28. Boquet, P., Y. Izard, J. Meaume, and M. Jouannet (1967b), Ann. Inst. Pasteur, 112:213.Google Scholar
  29. Botes, D. P. (1970), Purification and amino acid sequence of three neurotoxins from the cape cobra (Naja nivea). 2nd Int. Symp. Animal and Plant Toxins, Israel, Abstracts, p. 33.Google Scholar
  30. Botes, D.P. and D. J. Strydom (1969), J. Biol. Chem., 244:4147.PubMedGoogle Scholar
  31. Bovet-Nitti, F. (1947), Experientia, 3:283.PubMedGoogle Scholar
  32. Braganca, B. M. and V. G. Khandeparkar (1966), Life Sci., 5:1911.PubMedGoogle Scholar
  33. Braganca, B. M. and N. T. Patel (1965), Canad. J. Biochem., 43:915.Google Scholar
  34. Braganca, B. M. and J. H. Quastel (1953), Biochem. J., 53:88.PubMedGoogle Scholar
  35. Braganca, B. M. and Y. M. Sambray (1967), Nature (London), 216:1210.Google Scholar
  36. Braganca, B. M., P. G. Badrinath, and E. J. Ambrose (1965), Nature (London), 207:534.Google Scholar
  37. Braganca, B. M., N. T. Patel, and P. G. Badrinath (1967), Biochim. Biophys. Acta, 136:508.PubMedGoogle Scholar
  38. Brazil, V. and J. Vellard (1928), Ann. Inst. Pasteur, 42:403.Google Scholar
  39. Brisbois, L., N. Rabinovitch-Mahler, P. Delori, and L. Gillo (1968), J. Chromatography, 37:463.Google Scholar
  40. Brunton, T. L. and J. Fayrer (1873), Proc. Roy. Soc, 21:358.Google Scholar
  41. Brunton, T. L. and J. Fayrer (1874), Proc. Roy. Soc, 22:68.Google Scholar
  42. Brunton, T. L. and J. Fayrer (1875), Proc. Roy. Soc, 23:261.Google Scholar
  43. Buglia, G. and G. Barbieri (1923), Arch. Ital. Biol., 72:116.Google Scholar
  44. Calmette, A. (1907), “Les venins, les animaux venimeux et la sérothérapie antivenimeuse,” Masson, Paris, pp. 1–396.Google Scholar
  45. Césari, E. and P. Boquet (1936), Ann. Inst. Pasteur, 56:511.Google Scholar
  46. Césari, E. and P. Boquet (1937), Ann. Inst. Pasteur, 58:6.Google Scholar
  47. Chain, E. (1937), Quart. J. Exp. Physiol., 26:299.Google Scholar
  48. Chain, E. (1938), Quart. J. Exp. Physiol., 27:49.Google Scholar
  49. Chain, E. (1939), Biochem. J., 33:407.PubMedGoogle Scholar
  50. Chang, C. C. and C. Y. Lee (1955), J. Formosan Med. Assn., 54:103.Google Scholar
  51. Chang, C. C. and C. Y. Lee (1963), Arch. Int. Pharmacodyn., 144:241.PubMedGoogle Scholar
  52. Chang, C. C. and C. Y. Lee (1966), Brit. J. Pharmacol., 28:172.PubMedGoogle Scholar
  53. Chaudhuri, D. K. (1949), Ann. Biochem. Exp. Med., 9:67, 73, 79, 85.PubMedGoogle Scholar
  54. Chatterjee, A. K. (1949), Indian J. Med. Ret., 37:241.Google Scholar
  55. Chen, Y. H. and T. B. Lo (1968), J. Chinese Chem. Soc. Ser. II, 15:84.Google Scholar
  56. Cheymol, J., F. Bourillet, and M. Roch (1966), Mem. Inst. Butantan, Simp. Int., 33(2):541.Google Scholar
  57. Cheymol, J., F. Bourillet, and M. Roch-Arveiller (1967), Arch. Int. Pharmacodyn., 170:193.PubMedGoogle Scholar
  58. Chiang, T. S., K. J. Ho, and C. Y. Lee (1964), J. Formosan Med. Assn., 63:127.Google Scholar
  59. Chiu, P. J. S. (1966), Action of cardiotoxin on the isolated guinea-pig ileum. M. S. thesis, National Taiwan University.Google Scholar
  60. Chiu, T. H., C. Y. Lee, and S. Y. Lee (1968), J. Formosan Med. Assn., 67:557.Google Scholar
  61. Chopra, R. N. and V. Iswariah (1931), Indian J. Med. Res., 18:1113.Google Scholar
  62. Chou, T. C. and C. Y. Lee (1970), Europ. J. Pharmacol., 8:326.Google Scholar
  63. Christensen, P. A. (1955), South African snake venoms and antivenoms, The South African Institute for Medical Research, Johannesburg, pp. 1–129.Google Scholar
  64. Christensen, P. A. (1966), Mem. Inst. Butantan, Simp. Int. 33(1):305.Google Scholar
  65. Cicardo, V. H. (1935), C. R. Soc. Biol. (Paris), 120:732.Google Scholar
  66. Cohen, M. and G. B. Sumyk (1966), Toxicon, 3:291.PubMedGoogle Scholar
  67. Condrea, E. and A. De Vries (1965), Toxicon, 2:261.Google Scholar
  68. Condrea, E. and P. Rosenberg (1968), Biochim. Biophys. Acta, 150:271.PubMedGoogle Scholar
  69. Condrea, E., A. De Vries, and J. Mager (1964a), Biochim. Biophys. Acta, 84:60.PubMedGoogle Scholar
  70. Condrea, E., B. Mammon, S. Aloof, and A. De Vries (1964b), Biochim. Biophys. Acta, 84:365.PubMedGoogle Scholar
  71. Condrea, E., Y. Avi-Dor, and J. Mager (1965), Biochim. Biophys. Acta, 110:337.PubMedGoogle Scholar
  72. Condrea, E., P. Rosenberg, and W. D. Dettbarn (1967), Biochim. Biophys. Acta, 135:669.PubMedGoogle Scholar
  73. Currie, B. T., D. E. Oakley, and C. A. Broomfield (1968), Nature (London), 220:371.Google Scholar
  74. Cushny, A. R. and S. Yagi (1918), Trans. Roy. Soc. (London), Ser. B 208:1.Google Scholar
  75. Dakhil, T. and W. Vogt (1962), Arch. Exp. Pathol Pharmak., 243:174.Google Scholar
  76. D’Amour, F. E. and D. L. Smith (1941), J. Pharmacol., 72:74.Google Scholar
  77. Dawson, R. M. C. (1963), Biochem. J., 88:414.PubMedGoogle Scholar
  78. De, S. S. (1944), J. Indian. Chem. Soc., 21:292.Google Scholar
  79. Delezenne, C. (1919), Ann. Inst. Pasteur, 33:68.Google Scholar
  80. Delezenne, C. and S. Ledebt (1911a), C. R. Soc. Biol. (Paris), 71:121.Google Scholar
  81. Delezenne, C. and S. Ledebt (1911b), C. R. Acad. Sci. (Paris), 152:790.Google Scholar
  82. Delezenne, C. and S. Ledebt (1911c), C. R. Acad. Sci. (Paris), 153:81.Google Scholar
  83. Delezenne, C. and S. Ledebt (1912), C. R. Acad. Sci. (Paris), 155:1101.Google Scholar
  84. De Nicola, P. and G. A. Cappelletti (1959), Edizioni Haematologica (Pavia), 17:173.Google Scholar
  85. Detrait, J. and P. Boquet (1958), C. R. Acad. Sci. (Paris), 246:1107.Google Scholar
  86. Detrait, J., Y. Izard, and P. Boquet (1959), C. R. Soc. Biol. (Paris), 153:1722.Google Scholar
  87. Devi, A. and N. K. Sarkar (1966), Mem. Inst. Butantan, Simp. Int., 33(2):573.Google Scholar
  88. De Vries, A., C. Kirschmann, C. Klibansky, E. Condrea, and S. Gitter (1962), Toxicon, 1:19.Google Scholar
  89. Doery, H. M. and J. E. Pearson (1964), Biochem. J., 92:599.PubMedGoogle Scholar
  90. Eaker, D. L. and J. Porath (1967), The amino acid sequence of a neurotoxin from Naja nigricollis venom. 7th Int. Congr. Biochem. Tokyo, Col. VIII-3, Abstracts Suppl. I, p. 1087.Google Scholar
  91. Edlinger, E. and B. Dietel (1959), Naturwissenschaften, 46:516.Google Scholar
  92. Edwards, S. W. and E. G. Ball (1954), J. Biol. Chem., 209:619.PubMedGoogle Scholar
  93. Elliot, R. H. (1905), Phil Trans. Roy. Soc, 197:361.Google Scholar
  94. Elliott, W. B., J. M. Augustyn, and C. Gans (1966), Mem. Inst. Butantan, Simp. Int., 33(2):411.Google Scholar
  95. Epstein, D. (1930), Quart. J. Exp. Physiol., 20:7.Google Scholar
  96. Feldberg, W. (1940), J. Physiol. (London), 99:104.Google Scholar
  97. Feldberg, W. and C. H. Kellaway (1937a), Aust. J. Exp. Biol. Med. Sci., 15:159.Google Scholar
  98. Feldberg, W. and C. H. Kellaway (1937b), Austral. J. Exp. Biol. Med. Sci., 15:441.Google Scholar
  99. Feldberg, W. and C. H. Kellaway (1938), J. Physiol. (London), 94:187.Google Scholar
  100. Feldberg, W., H. F. Holden, and C. H. Kellaway (1938), J. Physiol. (London), 94:232.Google Scholar
  101. Felix, F., J. L. Potter, and M. Laskowski (1960), J. Biol. Chem., 235:1150.PubMedGoogle Scholar
  102. Feng, T. P. and T. H. Li (1941), Chinese. J. Physiol., 16:37.Google Scholar
  103. Fischer, G. A. and J. J. Kabara (1967), Low molecular weight toxins isolated from Elapidae venoms, in “Animal Toxins” (F. E. Russell and P. R. Saunders eds.), Pergamon Press, Oxford and New York, pp. 283–292.Google Scholar
  104. Fleckenstein, A. and O. Fettig (1952), Arch. Exp. Pathol Pharmak., 216:415.Google Scholar
  105. Fleckenstein, A. and H. Gerhardt (1952), Arch. Exp. Pathol Pharmak., 214:135.Google Scholar
  106. Fleckenstein, A. and W. Jaeger (1952), Arch. Exp. Pathol. Pharmak., 215:163.Google Scholar
  107. Fleckenstein, A., G. Berg, J. Gayer, and S. Schönig (1951), Arch. Exp. Pathol. Pharmak., 213:265.Google Scholar
  108. Fontana, F. (1787), Treatise on the venom of the viper, on the American poisons, and on the cherry laurel, and some other vegetable poisons, vols. I and II, J. Murray, London, pp. 1–409; 1–395.Google Scholar
  109. Fraser, T. R. (1897a), Brit. Med. J., 2:595.PubMedGoogle Scholar
  110. Fraser, T. R. (1897b), Indian Med. Rec, 13:147.Google Scholar
  111. Fraser, T. R. and J. A. Gunn (1909), Phil. Trans. Roy. Soc. (London), B200:241.Google Scholar
  112. Gaertner, C., N. Goldblum, S. Gitter, and A. De Vries (1962), J. Immunol., 88:526.Google Scholar
  113. Ganguly, S. N. and M. Malkana (1936), Indian J. Med. Res., 24:281.Google Scholar
  114. Gautrelet, J. and N. Halpern (1933), C. R. Soc. Biol. (Paris), 113:1486.Google Scholar
  115. Gautrelet, J. and N. Halpern (1934), C. R. Soc. Biol. (Paris), 115:942.Google Scholar
  116. Gautrelet, J., N. Halpern, and E. Corteggiani (1934), Arch. Int. Physiol., 38:293.Google Scholar
  117. Ghosh, B. N. and A. K. Chatterjee (1948), J. Indian Chem. Soc, 25:359.Google Scholar
  118. Ghosh, B. N., P. K. Dutt, and D. K. Chowdhury (1939), J. Indian Chem. Soc., 16:75.Google Scholar
  119. Gitter, S., S. Amiel, G. Gilat, T. Sonnino, and Y. Welwart (1963), Nature (London), 197:383.Google Scholar
  120. Gottdenker, F. and M. Wachstein (1940), J. Pharmacol., 69:117.Google Scholar
  121. Grasset, E. and P. A. Christensen (1947), Trans. Roy. Soc. Trop. Med. Hyg., 41:207.PubMedGoogle Scholar
  122. Grasset, E. and L. Goldstein (1947), Trans. Roy. Soc. Trop. Med. Hyg., 40:771.PubMedGoogle Scholar
  123. Grasset, E., A. Zoutendyk, and A. Schaafsma (1935), Trans. Roy. Soc. Trop. Med. Hyg., 28:601.Google Scholar
  124. Grassmann, W. and K. Hannig (1954), Hoppe-Seylers Z. Physiol. Chem., 296:30.PubMedGoogle Scholar
  125. Green, D. E. and S. Fleischer (1963), Biochim. Biophys. Acta, 70:554.PubMedGoogle Scholar
  126. Green, H. N. and H. B. Stoner (1950), Biological actions of the adenine nucleotides, H. K. Lewis & Co., Ltd., London, pp. 1–221.Google Scholar
  127. Gulland, J. M. and E. M. Jackson (1938a), Biochem. J., 32:590.PubMedGoogle Scholar
  128. Gulland, J. M. and E. M. Jackson (1938b), Biochem. J., 32:597.PubMedGoogle Scholar
  129. Guyot, P. and P. Boquet (1960), C. R. Acad. Sci. (Paris), 251:1822.Google Scholar
  130. Habermann, E. (1954), Naturwissenschaften, 41:429.Google Scholar
  131. Habermann, E. (1957), Arch. Exp. Pathol. Pharmak., 230:538.Google Scholar
  132. Habermann, E. (1960), Arch. Exp. Pathol. Pharmak., 238:502.Google Scholar
  133. Habermann, E. and J. Jentsch (1967), Hoppe-Seyler’s Z. Physiol. Chem., 348:37.PubMedGoogle Scholar
  134. Habermann, E. and B. Krusche (1962), Biochem. Pharmacol., 11:400.PubMedGoogle Scholar
  135. Habermann, E. and W. P. Neumann (1954), Arch. Exp. Pathol. Pharmak., 223:388.Google Scholar
  136. Habermann, E. and K. G. Reiz (1965), Biochem. Z., 343:192.PubMedGoogle Scholar
  137. Hirschfeld, L. and R. Klinger (1915), Biochem. Z., 70:398.Google Scholar
  138. Hoff, E. C., R. G. Grenell, and J. F. Fulton (1945), Medicine, 24:161.Google Scholar
  139. Honjo, I. and K. Ozawa (1968), Biochim. Biophys. Acta, 162:624.PubMedGoogle Scholar
  140. Houssay, B. A. (1930), C. R. Soc. Biol. (Paris), 105:308.Google Scholar
  141. Houssay, B. A. and P. Mazzocco (1925), C. R. Soc. Biol. (Paris), 93:1120.Google Scholar
  142. Houssay, B. A. and S. Pavé (1922), C. R. Soc. Biol. (Paris), 87:821.Google Scholar
  143. Houssay, B. A., N. J. Otero, J. Negrete, and P. Mazzocco (1921), Rev. Assn. Méd. Argent., 34:299.Google Scholar
  144. Houssay, B. A., J. Negrete, and P. Mazzocco (1922), C. R. Soc. Biol. (Paris), 87:823.Google Scholar
  145. Huang, P. C. (1954a), J. Formosan Med. Assn., 53:128.Google Scholar
  146. Huang, P. C. (1954b), J. Formosan Med. Assn., 53:353.Google Scholar
  147. Hughes, A. (1935), Biochem. J., 29:430.PubMedGoogle Scholar
  148. Hunter, W. K. (1909), Proc. Roy. Soc. Med., 3(ii):105.Google Scholar
  149. Ibrahim, S. A., H. Sanders, and R. H. S. Thompson (1964), Biochem. J., 93:588.PubMedGoogle Scholar
  150. Ishii, T. (1929), Jap. J. Microbiol. Pathol., 23:1093, 1127.Google Scholar
  151. Iwase, Y. (1933), J. Formosan. Med. Assn., 32:624.Google Scholar
  152. Iyergar, N. K., K. B. Sehra, B. Mukerji, and R. N. Chopra (1938), Current Sci. Indian Inst. Sci., 7:51.Google Scholar
  153. Izard, Y., M. Boquet, A. M. Rousseray, and P. Boquet (1969a), C. R. Acad. Sci. (Paris), 269:96.Google Scholar
  154. Izard, Y., P. Boquet, E. Golémi, and D. Goupil (1969b), C. R. Acad. Sci. (Paris), 269:666.Google Scholar
  155. Jiménez-Porras, J. M. (1968), Ann. Rev. Pharmacol., 8:299.PubMedGoogle Scholar
  156. Johnson, M., M. A. G. Kaye, R. Hems, and H. A. Krebs (1953), Biochem. J., 54:625.PubMedGoogle Scholar
  157. Kaiser, E. and H. Michl (1958), Die Biochemie der tierischen Gifte, Franz Deuticke, Vienna, pp. 1–258.Google Scholar
  158. Karczmar, A. G. (1967), Ann. Rev. Pharmacol., 7:241.PubMedGoogle Scholar
  159. Karlsson, E., D. L. Eaker, and J. Porath (1966). Biochim. Biophys. Acta, 127:505.PubMedGoogle Scholar
  160. Kaye, M. A. G. (1955), Biochim. Biophys. Acta, 18:456.PubMedGoogle Scholar
  161. Kaye, M. A. G. (1960), Biochim. Biophys. Acta, 38:34.PubMedGoogle Scholar
  162. Kellaway, C. H. (1929), Brit. J. Exp. Pathol, 10:281.Google Scholar
  163. Kellaway, C. H. (1932), Austral. J. Exp. Biol. Med. Sci., 10:195.Google Scholar
  164. Kellaway, C. H. (1937), Bull. Johns Hopkins Hosp., 60:20.Google Scholar
  165. Kellaway, C. H. and F. Holden (1932), Austral. J. Exp. Biol. Med. Sci., 10:167.Google Scholar
  166. Kellaway, C. H. and E. R. Trethewie (1940), Austral. J. Exp. Biol. Med. Sci., 18:63.Google Scholar
  167. Kellaway, C. H., R. O. Cherry, and F. E. Williams (1932), Austral. J. Exp. Biol. Med. Sci., 10:181.Google Scholar
  168. Klibansky, C. and A. De Vries (1964), Toxicon, 2:181.Google Scholar
  169. Klibansky, C., E. Condrea, and A. De Vries (1962), Amer. J. Physiol., 203:114.Google Scholar
  170. Klibansky, C., J. Shiloah, and A. De Vries (1964), Biochem. Pharmacol., 13:1107.PubMedGoogle Scholar
  171. Klibansky, C., E. Ozcan, H. Joshua, M. Djaldetti, H. Bessler, and A. De Vries (1966), Toxicon, 3:213.PubMedGoogle Scholar
  172. Krupnick, J., H. I. Bicher, and S. Gitter (1968), Toxicon, 6:11.PubMedGoogle Scholar
  173. Kruse, I. and H. Dam (1950), Biochem. Biophys. Acta, 5:268.PubMedGoogle Scholar
  174. Lamb, G. and W. K. Hunter (1904a), Lancet, 1:20.Google Scholar
  175. Lamb, G. and W. K. Hunter (1904b), Lancet, 1:518.Google Scholar
  176. Larsen, P. R. and J. Wolff (1967a), Science, 155:335.PubMedGoogle Scholar
  177. Larsen, P. R. and J. Wolff (1967b), Biochem. Pharmacol., 16:2003.PubMedGoogle Scholar
  178. Larsen, P. R. and J. Wolff (1968a), Biochem. Pharmacol., 17:503.PubMedGoogle Scholar
  179. Larsen, P. R. and J. Wolff (1968b), J. Biol. Chem., 243:1283.PubMedGoogle Scholar
  180. Lee, C. Y. (1963), J. Showa Med. Assn., 23:221.Google Scholar
  181. Lee, C. Y. and C. C. Chang (1966), Mem. Inst. Butantan, Simp. Int., 33(2):555.Google Scholar
  182. Lee, C. Y. and C. Ouyang (1958), Proc. 7th Int. Congr. Int. Soc. Haematol Rome, 2, 1.Google Scholar
  183. Lee, C. Y. and M. T. Peng (1961), Arch. Int. Pharmacodyn., 13:180.Google Scholar
  184. Lee, C. Y. and L. F. Tseng (1966), Toxicon, 3:281.PubMedGoogle Scholar
  185. Lee, C. Y. and L. F. Tseng (1969), Toxicon, 7:89.PubMedGoogle Scholar
  186. Lee, C. Y., C. C. Chang, and K. Kamijo (1956), Biochem. J., 62:582.PubMedGoogle Scholar
  187. Lee, C. Y., C. C. Chang, and C. Su (1960), J. Formosan Med. Assn., 59:1065.Google Scholar
  188. Lee, C. Y., C. C. Chang, C. Su, and Y. W. Chen (1962), J. Formosan Med. Ass., 61:239.Google Scholar
  189. Lee, C. Y., C. C. Chang, T. H. Chiu, P. J. S. Chiu, T. C. Tseng, and S. Y. Lee (1968), Arch. Exp. Pathol. Pharmak., 259:360.Google Scholar
  190. Lee, C. Y., J. S. Lin, and J. W. Wei (1970), Identification of cardiotoxin with cobramine B, DLF and cobra venom cytotoxin. 2nd Int. Symp. Animal and Plant Toxins, Israel, Abstracts, p. 59.Google Scholar
  191. Levaditi, C. and S. Mutermilch (1913), C. R. Soc. Biol. (Paris), 74:1305.Google Scholar
  192. Lin, Y. C. and L. T. Chang (1957), J. Formosan Med. Assn., 56:336.Google Scholar
  193. Lin, Y. C., T. C. Su, and K. H. Ling (1957), J. Formosan Med. Assn., 56:176.Google Scholar
  194. Link, T. (1935), Z. Immun-Forsch., 85:504.Google Scholar
  195. Lo, T. B. and Y. H. Chen (1966), J. Chinese Chem. Soc, Ser. II, 13:195.Google Scholar
  196. Lo, T. B., Y. H. Chen, and C. Y. Lee (1966), J. Chinese Chem. Soc, Ser. II, 13:25.Google Scholar
  197. Macht, D. I. (1935), Amer. J. Physiol., 113:90.Google Scholar
  198. Macht, D. I. (1936), Proc. Soc. Exp. Biol. Med., 35:316.Google Scholar
  199. Macht, D. I. (1943), Proc. Soc Exp. Biol. Med., 53:225.Google Scholar
  200. Macht, D. I. and D. B. Kehoe (1943), Fed. Proc., 2:31.Google Scholar
  201. Marcacci, M. and L. Bruzzese (1959), Edizioni Haematologica, (Pavia), 17:231.Google Scholar
  202. Markwardt, F., W. Barthel, E. Glusa, and A. Hoffmann (1966), Arch. Exp. Pathol Pharmak., 252:297.Google Scholar
  203. Master, R. W. P. and S. S. Rao (1961), J. Biol. Chem., 236:1986.PubMedGoogle Scholar
  204. Meaume, J. (1966), Toxicon, 4:25.PubMedGoogle Scholar
  205. Meaume, J., Y. Izard, and P. Boquet (1966), C. R. Acad. Sci. (Paris), 262:1650.Google Scholar
  206. Mebs, D. (1968), Europ. J. Pharmacol., 2:403.Google Scholar
  207. Meldrum, B. S. (1965a), Pharmacol. Reviews, 17:393.Google Scholar
  208. Meldrum, B. S. (1965b), Brit. J. Pharmacol., 25:197.PubMedGoogle Scholar
  209. Mellanby, E. (1934–1936), Ann. Rep. Brit. Empire Cancer Campaign, 11:81,Google Scholar
  210. Mellanby, E. (1934–1936), Ann. Rep. Brit. Empire Cancer Campaign, 12:99,Google Scholar
  211. Mellanby, E. (1934–1936), Ann. Rep. Brit. Empire Cancer Campaign, 13:99.Google Scholar
  212. Mellanby, J. (1909), J. Physiol. (London), 38:441.Google Scholar
  213. Meurling, S. (1935), C. R. Soc. Biol. (Paris), 120:1119.Google Scholar
  214. Meyer, A. (1963), Anoxias, intoxication and metabolic isorders, in “Neuropathology” (W. Blackwood, W. H. McMenemey, A. Meyer, R. M. Norman, and D. S. Russell, eds.), Edward Arnold, London, pp. 235–287.Google Scholar
  215. Mitel’man, L. S. (1966), Byul. Eksp. Biol. Med., 62:69.Google Scholar
  216. Morales, F., K. Bhanganada, and J. F. Perry (1963), Effect of several agents on the lethal action of two common venoms, in “Venomous and Poisonous Animals and Noxious Plants of the Pacific Region” (H. L. Keegan and W. V. Macfarlane, eds.), Pergamon Press, New York, pp. 385–398.Google Scholar
  217. Moran, N. C., B. Uvnös, and B. Westerholm (1962), Acta Physiol. Scand., 56:26.Google Scholar
  218. Morawitz, P. (1905), Ergebn. Physiol., 4:307.Google Scholar
  219. Mounter, L. A. (1951), Biochem. J., 50:122.PubMedGoogle Scholar
  220. Nakamura, T. (1933), J. Formosan Med. Assn., 32:33.Google Scholar
  221. Narahashi, T. and J. M. Tobias (1964), Amer. J. Physiol., 207:1441.PubMedGoogle Scholar
  222. Narita, K. and C. Y. Lee (1970), The amino acid sequence of cardiotoxin from Naja naja atra venom, Biochem. Biophys. Res. Comm. (in press).Google Scholar
  223. Neelin, J. M. (1963), Canad. J. Biochem. Physiol., 41:1073.PubMedGoogle Scholar
  224. Nelson, P. G. (1958), J. Cell. Comp. Physiol., 52:127.Google Scholar
  225. Nygaard, A. P. (1953), J. Biol. Chem., 204:655.PubMedGoogle Scholar
  226. Nygaard, A. P. and J. B. Sumner (1953), J. Biol. Chem., 200:723.PubMedGoogle Scholar
  227. Nygaard, A. P., M. U. Dianzani, and G. F. Bahr (1954), Exp. Cell Res., 6:453.PubMedGoogle Scholar
  228. O’Brien, J. R. (1956a), Brit. J. Haemat., 2:430.PubMedGoogle Scholar
  229. O’Brien, J. R. (1956b), J. Clin. Pathol, 9:47.PubMedGoogle Scholar
  230. Oh, Y. (1942), J. Formosan Med. Assn., 41:1185.Google Scholar
  231. Ouyang, C. (1957), J. Formosan Med. Assn., 56:435.Google Scholar
  232. Pacella, G. (1923), C. R. Soc. Biol. (Paris), 88:366.Google Scholar
  233. Parnas, I. and. F. E. Russell (1967), Effects of venoms on nerve, muscle and neuromuscular junction, in “Animal Toxins” (F. E. Russell and P. R. Saunders, eds.), Pergamon Press, Oxford and New York, pp.401–415.Google Scholar
  234. Patel, T. N., B. M. Braganca, and R. A. Bellare (1969), Exp. Cell Res., 57:289.PubMedGoogle Scholar
  235. Patzer, P. and W. Vogt (1967), Arch. Exp. Pathol. Pharmak., 257:320.Google Scholar
  236. Peng, M. T. (1951), Mem. Fac. Med. Nat’l. Taiwan Univ., 1:200.Google Scholar
  237. Peng, M. T. (1952), Mem. Fac. Med. Nat’l Taiwan Univ., 2:170.Google Scholar
  238. Peng, M. T. (1960), J. Formosan Med. Assn., 59:1073.Google Scholar
  239. Peron, F. G. (1964), Biochim. Biophys. Acta, 82:125.Google Scholar
  240. Petrushka, E., J. H. Quastel, and P. G. Scholefield (1959a), Canad. J. Biochem. Physiol., 37:975.PubMedGoogle Scholar
  241. Petrushka, E., J. H. Quastel, and P. G. Scholefield (1959b), Canad. J. Biochem. Physiol., 37:989.PubMedGoogle Scholar
  242. Porath, J. (1966), Mem. Inst. Butantan, Simp. Int., 33:(2)379.Google Scholar
  243. Radomski, J. L. and W. B. Deichmann (1958), Biochem. J., 70:293.PubMedGoogle Scholar
  244. Ragotzi, V. (1890), Virchows Arch. Pathol. Anat. Physiol., 122:201.Google Scholar
  245. Raudonat, H. W. and R. Holler (1958), Arch. Exp. Pathol. Pharmak., 233:431.Google Scholar
  246. Ray, P. (1940), J. Indian Chem. Soc., 17:681.Google Scholar
  247. Razzell, W. E. and H. G. Khorana (1959a), J. Biol. Chem., 234:2105.PubMedGoogle Scholar
  248. Razzell, W. E. and H. G. Khorana (1959b), J. Biol. Chem., 234:2114.PubMedGoogle Scholar
  249. Reid, H. A. (1964), Brit. Med. J., 2:540.PubMedGoogle Scholar
  250. Ri, T. (1939), Folia Pharmacol. Japonica, 27:13.Google Scholar
  251. Richards, G. M., G. Du Vair, and M. Laskowski (1965), Biochemistry, 4:501.PubMedGoogle Scholar
  252. Riker, W. F., G. Werner, J. Roberts, and A. Kuperman (1959), Ann. N.Y. Acad. Sci., 81:328.Google Scholar
  253. Rimon, A. and B. Schapiro (1959), Biochem. J., 71:620.PubMedGoogle Scholar
  254. Rocha e Silva, M. and W. T. Beraldo (1948), J. Pharmacol., 93:457.Google Scholar
  255. Rogers, L. (1905), Phil. Trans. Roy. Soc., B197:123.Google Scholar
  256. Rosenberg, P. (1965), Toxicon, 3:125.PubMedGoogle Scholar
  257. Rosenberg, P. (1966), Mem. Inst. Butantan, Simp. Int., 33(2):477.Google Scholar
  258. Rosenberg, P. and E. Condrea (1968), Biochem. Pharmacol., 17:2033.PubMedGoogle Scholar
  259. Rosenberg, P. and T. R. Podleski (1962), J. Pharmacol., 137:249.Google Scholar
  260. Rosenberg, P. and T. R. Podleski (1963), Biochim. Biophys. Acta, 75:104.PubMedGoogle Scholar
  261. Ruch, J. V. and O. Gabriel-Robez-Kremer (1962), C. R. Soc. Biol. (Paris), 156:1508.Google Scholar
  262. Ruch, J. V. and O. Gabriel-Robez-Kremer (1963), C. R. Soc. Biol. (Paris), 157:2291.Google Scholar
  263. Ruch, J. V., M. Zahnd, O. Gabriel-Robez-Kremer, Y. Rumpler, and P. Gerlinger (1965), Arch. Biol. (Liège), 76:25.Google Scholar
  264. Russell, F. E. (1967), Federation Proc., 26:1206.Google Scholar
  265. Sanders, M., B. A. Arin, and M. G. Soret (1954), Acta Neuroveg., 8:362.Google Scholar
  266. Sarkar, B. B., S. R. Maitra, and B. N. Ghosh (1942), Indian J. Med. Res., 30:453.Google Scholar
  267. Sarkar, N. K. (1947a), J. Indian Chem. Soc., 24:227.Google Scholar
  268. Sarkar, N. K. (1947b), J. Indian Chem. Soc., 24:61.Google Scholar
  269. Sarkar, N. K. (1951), Proc. Soc. Exp. Biol. Med., 78:469.PubMedGoogle Scholar
  270. Sarkar, N. K. and S. R. Maitra (1950), Amer. J. Physiol., 163:209.PubMedGoogle Scholar
  271. Sasaki, T. (1957a), J. Pharmaceut. Soc Japan, 77:845.Google Scholar
  272. Sasaki, T. (1957b), J. Pharmaceut. Soc. Japan, 77:848.Google Scholar
  273. Sato, I., K. W. Ryan, and S. Mitsuhashi (1964), Jap. J. Exp. Med., 34:119.PubMedGoogle Scholar
  274. Sato, S. and N. Tamiya (1968), The primary structure of erabutoxin. 19th Seminar on Protein Structure, Tokyo, Proc., p. 13.Google Scholar
  275. Shü, I. C., K. H. Ling, and C. C. Yang (1968), Toxicon, 5:295.PubMedGoogle Scholar
  276. Slotta, K. H. (1955), Fortschr. Chem. Org. Naturst., 12:406.Google Scholar
  277. Slotta, K. H. and H. L. Fraenkel-Conrat (1938), Ber. Deutsch. Chem. Gesellsch., 71A:264.Google Scholar
  278. Slotta, K. H., J. D. Gonzalez, and S. C. Roth (1967), The direct and indirect hemolytic factors from animal venoms, in “Animal Toxins” (F. E. Russell and P. R. Saunders, eds.), Pergamon Press, Oxford and New York, pp. 369–377.Google Scholar
  279. Slotta, K. H. and J. A. Vick (1969), Toxicon, 6:167.PubMedGoogle Scholar
  280. Su, C. (1960), J. Formosan Med. Ass., 59:1083.Google Scholar
  281. Su, C., C. C. Chang, and C. Y. Lee (1967), Pharmacological properties of the neurotoxin of cobra venom, in “Animal Toxins” (F. E. Russell and P. R. Saunders, eds.), Pergamon Press, Oxford and New York, pp. 259–267.Google Scholar
  282. Sulkowski, E., W. Bjork, and M. Laskowski (1963), J. Biol. Chem., 238:2477.PubMedGoogle Scholar
  283. Sumyk, G., H. Lal, and E. J. Hawrylewicz (1963), Federation Proc., 22:668.Google Scholar
  284. Suzuki, T. (1966), Mem. Inst. Butantan, Simp. Int., 33(2):389.Google Scholar
  285. Suzuki, T. and S. Iwanaga (1958), J. Pharmaceut. Soc. Japan, 78:354.Google Scholar
  286. Takeuchi, T. and N. Takeuchi (1964), J. Physiol. (London), 170:296.Google Scholar
  287. Tamiya, N. and H. Arai (1966), Biochem. J., 99:624.PubMedGoogle Scholar
  288. Tamiya, N. and S. Sato (1967), 1th Int. Congr. Biochem., Tokyo, Col. VIII-2, Abstracts III, p. 497.Google Scholar
  289. Taub, A. M. and W. B. Elliott (1964), Toxicon, 2:87.Google Scholar
  290. Taylor, J., S. M. K. Mallick, and M. L. Ahuja (1935), Indian J. Med. Res. 23:131.Google Scholar
  291. Tobias, J. M. (1955), J. Cell. Comp. Physiol., 46:183.Google Scholar
  292. Tobias, J. M. (1960), J. Gen. Physiol., 43:57.PubMedGoogle Scholar
  293. Tseng, L. F., T. H. Chiu, and C. Y. Lee (1968), Toxicol. Appl. Pharmacol., 12:526.Google Scholar
  294. Tseng, T. C. (1964), A study on cardiotoxin isolated from Formosan cobra venom, M. S. thesis, National Taiwan University.Google Scholar
  295. Tu, A. T., G. P. James, and A. Chua (1965), Toxicon, 3:5.PubMedGoogle Scholar
  296. Ueda, E., T. Sasaki, and M. T. Peng (1951), A chemical study on Formosan cobra venom, Mem. Fac. Med. National Taiwan Univ., 1:194.Google Scholar
  297. Vazquez-Colon, L., F. D. Ziegler, and W. B. Elliott (1966), Biochemistry, 5:1134.PubMedGoogle Scholar
  298. Ventakachalam, K. and A. M. Ratnagiriswaran (1934), Indian J. Med. Res., 22:289.Google Scholar
  299. Vick, J. A., H. P. Ciuchta, and E. H. Polley (1964), Nature (London), 203:1387.Google Scholar
  300. Vick, J. A., H. P. Ciuchta, and E. H. Polley (1965), Arch. Int. Pharmacodyn., 153:424.PubMedGoogle Scholar
  301. Vick, J. A., H. P. Ciuchta, and J. H. Manthei (1967), Pathophysiological studies of ten snake venoms, in “Animal Toxins” (F. E. Russell and P. R. Saunders, eds.), Pergamon Press, Oxford and New York, pp. 269–282.Google Scholar
  302. Vogt, W. (1957), J. Physiol. (London), 136:131.Google Scholar
  303. Vogt, W., T. Suzuki, and S. Babilli (1966), Mem. Soc. Endocrinol, 14:137.Google Scholar
  304. Vogt, W., U. Meyer, H. Kunze, E. Lufft, and S. Babilli (1969), Arch. Exp. Pathol. Pharmak., 262:124.Google Scholar
  305. Vollmer, E. (1893), Arch. Exp. Pathol Pharmak., 31:1.Google Scholar
  306. Wakui, K. and S. Kawachi (1961), J. Pharmaceut. Soc. Japan, 81:1394.Google Scholar
  307. Waser, P. G. and U. Lüthi (1957), Arch. Inst. Pharmacodyn., 112:272.Google Scholar
  308. Westermann, E. and W. Klapper (1960), Arch. Exp. Pathol. Pharmak., 239:68.Google Scholar
  309. Wille, G. and W. Vogt (1965), Arch. Exp. Pathol Pharmak., 251:193.Google Scholar
  310. Williams, E. J., S. C. Sung, and M. Laskowski (1960), J. Biol. Chem., 236:1130.Google Scholar
  311. Witter, R. F. and M. A. Cottone (1956), Biochim. Biophys. Acta, 22:364.PubMedGoogle Scholar
  312. Witter, R. F., A. Morrison, and G. R. Shepardson (1957), Biochim. Biophys. Acta, 26:120.PubMedGoogle Scholar
  313. Wolff, J., H. Salabé, M. Ambrose, and P. R. Larsen (1968), J. Biol. Chem., 243:1290.PubMedGoogle Scholar
  314. Yamaguti, K. (1923), Z. Hyg. Infektionskrank., 100:182.Google Scholar
  315. Yang, C. C. (1965), J. Biol. Chem., 240:1616.PubMedGoogle Scholar
  316. Yang, C. C. (1967), Biochim. Biophys. Acta, 133:346.PubMedGoogle Scholar
  317. Yang, C. C. and L. T. Chang (1954), J. Formosan Med. Assn., 53:609.Google Scholar
  318. Yang, C. C. and T. C. Tung (1953), J. Formosan Med. Assn., 52:83.Google Scholar
  319. Yang, C. C. and T. C. Tung (1954), J. Formosan Med. Assn., 53:123.Google Scholar
  320. Yang, C. C., L. C. Huang, and T. C. Tung (1954), J. Formosan Med. Assn., 53:1.Google Scholar
  321. Yang, C. C., C. J. Chen, and C. C. Su (1959), J. Biochem. (Tokyo), 46:1201.Google Scholar
  322. Yang, C. C., C. C. Chang, K. Hayashi, and T. Suzuki (1969a), Toxicon, 7:43.PubMedGoogle Scholar
  323. Yang, C. C., H. J. Yang, and J. S. Huang (1969b), Biochim. Biophys. Acta, 188:65.PubMedGoogle Scholar
  324. Zaimis, E. J. (1957), Factors influencing the action of neuromuscular blocking substances, in “Lectures on the Scientific Basis of Medicine,” John de Graif, Inc., New York, p. 208.Google Scholar
  325. Zaki, O. A., A. Khogali, D. Petkovic, and S. A. Ibrahim (1967), Toxicon, 5:91.PubMedGoogle Scholar
  326. Zeller, E. A. (1947), Experientia, 3:375.Google Scholar
  327. Zeller, E. A. (1948), Advan. Enzymol., 8:459.Google Scholar
  328. Zeller, E. A. (1950), Arch. Biochem., 28:138.PubMedGoogle Scholar
  329. Zeller, E. A. (1951), Enzymes as essential components of bacterial and animal toxins, in “The Enzymes” (J. B. Summer and K. Myrback, eds.) Vol. 1, Pt. 2, Academic Press, New York, pp. 986–1013.Google Scholar
  330. Ziegler, F. D., L. Vázquez-Colón, W. B. Elliott, C. Gans, and A. Taub (1967), Production by snake venoms of uncoupling activity and reverse acceptor control in rat liver mitochondrial preparations. Part II. Studies on energy metabolism following treatment of mitochondria with several snake venoms. In “Animal Toxins” (F. E. Russell and P. R. Saunders, eds.), Pergamon Press, Oxford and New York, pp. 236–243.Google Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • C. Y. Lee
    • 1
  1. 1.Pharmacological Institute, College of MedicineNational Taiwan UniversityTaipeiTaiwan, China

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