Abstract
In recent years there has been a great increase of interest in the mechanisms by which nerves transfer information to other nerves and to nonneural end organs. New chemical, pharmacological and physiological techniques have been developed to study the variety of neurotransmitter agents and mechanisms which exist in nature. Nevertheless, our knowledge of the sequence of events from synthesis of a transmitter through its ultimate effect at the innervated end-organ is incomplete for any given agent or synapse.
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Supported by NIH Grant HD 04817–01.
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References
Ambache, N. (1949), J. Physiol., 108:127.
Ambache, N. (1951), J. Physiol., 113:1.
Ambache, N. and A. W. Lessin (1955), J. Physiol., 127:449.
Andersson-Cedergren, E. (1959), J. Ultrast. Res. Suppl., 1:5.
Bishop, G. H. and J. J. Bronfenbrenner (1936), Amer. J. Physiol., 117:393.
Brooks, V. B. (1956), J. Physiol., 134:264.
Bueker, E. D. (1943), J. Exp. Zool., 93:99.
Buller, A. J., J. C. Eccles, and R. M. Eccles (1960), J. Physiol., 150:417.
Burgen, A. S. V., F. Dickens, and L. J. Zatman (1949), J. Physiol. (London), 109:10.
Burn, H. and M. J. Rand (1965), Ann. Rev. Pharmac., 5:163.
Cardella, M. A. (1964), Botulinum toxoids, in “Botulism, Proceedings of a Symposium,” U.S. Public Health Service, Cincinnati.
Carpenter, F. G. (1967), J. Physiol., 188:1.
Dawson, D. and F. C. A. Romanul (1964), Arch. Neurol., 13:263.
Del Castillo, J. and B. Katz (1954), J. Physiol. (London), 124:560.
Del Castillo, J. and B. Katz (1955), J. Physiol., 128:396.
Denny-Brown, D. (1929), Proc. Roy. Soc. B, 104:371.
Denny-Brown, D. and C. Bolnner (1944), Arch. Neurol Psychiat., 51:1.
de Robertis, E. and H. S. Bennett (1954), Fed. Proc., 13:35.
Dickson, E. C. and R. Shevky (1923), J. Exp. Med., 37:711.
Drachman, D. B. (1964), Science, 145:719.
Drachman, D. B. (1967), Arch. Neurol., 17:206.
Drachman, D. B. (1968), The role of acetylcholine as a trophic neuromuscular transmitter, in “Ciba Foundation Symposium on Growth of the Nervous System” (G. E. W. Wolstenholme and M. O’Connor, eds.), J. & A. Churchill Ltd., London, p. 251.
Drachman, D. B. and A. J. Coulombre (1962a), Science, 138:144.
Drachman, D. B. and A. J. Coulombre (1962b), Lancet, II:523.
Drachman, D. B. and J. Houk (1969), Amer. J. Physiol., 216:1453.
Drachman, D. B. and P. D. F. Murray (1969), J. Embryol. Exp. Morphol, 22 No. 3:349.
Drachman, D. B. and F. C. A. Romanul, Arch. Neurol., in press.
Drachman, D. B. and L. Sokiloff (1966), Developmental Biol., 14:401.
Duchen, L. W. and S. J. Strich (1968), Quart. J. Physiol., 53:84.
Eccles, J. C. (1964), “The Physiology of Synapses,” Springer-Verlag, Berlin.
Eccles, J. C., R. M. Eccles, and W. Kozak (1962), J. Physiol., 163:324.
Edds, M. V. (1953), Rev. Biol., 28:260.
Elmqvist, D. and D. S. Feldman (1965), J. Physiol., 181:487.
Emmelin, N. (1961), J. Physiol., 156:121.
Fatt, P. and B. Katz (1950), Nature (London), 166:597.
Fatt, P. and B. Katz (1952), J. Phvsiol. (London), 117:109.
Fell, H. and R. B. Canti (1934), Proc. Royal Soc. Bull., 116:316.
Fex, S., B. Sonesson, S. Thesleff, and J. Zelena (1966), J. Physiol., 184:872.
Gage, P. W. and D. M. J. Quastel (1966), J. Physiol., 185:95.
Guth, L. (1968), Ann. Rev. Physiol., 48:645.
Guth, L. (1969a), Neurosci. Res. Prog. Bull., 7:1.
Guth, L. (1969b), Exp. Neurol., 24:508.
Guth, L., R. W. Albers, and W. C. Brown (1964), Exp. Neurol., 10:236.
Gutmann, E. and R. Zak (1961), Physiol. Bohemoslov. 10:493.
Hamburger, V. and M. Waugh (1940), Physiol. Zoo., 13:367.
Hebb, C. (1963), Formation, storage and liberation of acetylcholine, in “Handbuch der Experimentellen Pharmakologie” (G.B. Koelle, ed.), Chap. 3, Springer-Verlag, Berlin.
Hilton, S. M. and G. P. Lewis (1955), J. Physiol., 128:235.
Hogan, E. L., D. M. Dawson, and F. C. A. Romanul (1965), Arch. Neurol., 13:274.
Hubbard, J. I. and S. Kwanbunbumpen (1968), J. Physiol., 194:407.
Hubbard, J. I., S. F. Jones, and E. M. Landau (1968), J. Physiol., 194:355.
Jirmanova, I., M. Sobotkova, S. Thesleff, and J. Zelena (1964), Physiol. Bohemoslov., 13:467.
Josefsson, J. O. and S. Thesleff (1961), Acta Physiol. Scand., 51:163.
Katz, B. (1966), “Nerve, Muscle and Synapse,” McGraw-Hill, New York.
Katz, B. and R. Miledi (1965), Proc. Royal Soc., 161:496.
Koelle, G. B. (1963), Cytologic distribution and physiologic functions of cholinesterases, in “Handbuch der Experimentellen Pharmakologie,” Chap. 6, Springer-Verlag, Berlin.
Kupfer, C. (1958), Proc. Soc. Exp. Biol. Med., 99:474.
Lewis, D. M. (1962), J. Physiol., 161:24P.
Marchbanks, R. M. (1968), Biochem. J., 110:533.
Michaelson, I. A. (1967), Ann. N.Y. Acad. Sci., 144:387.
Murray, P. D. F. (1926), Proc. Linnaean Soc., 51:187.
Nastuk, W. (1966), Ann. N.Y. Acad. Sci., 135:110.
Rand, M. J. and B. C. Whalter (1965), Nature, 206:588.
Romanes, G. J. (1946), J. Anat., 80:117.
Romanul, F. C. A. (1964), Arch. Neurol., 11:355.
Romanul, F. C. A. and E. L. Hogan (1964), Arch. Neurol., 13:263.
Romanul, F. C. A. and J. P. Van Der Meulen (1966), Nature, 212(5068):1369.
Rose, S. and P. H. Glow (1967), Exp. Neurol., 18:267.
Salmons, S. and G. Vrbova (1969), J. Physiol., 201:535.
Simpson, L. L. (1968), J. Neurochem., 15:359.
Simpson, L. L. and H. Morimoto (1969), J. Bact., 97:571.
Solandt, D. Y., R. C. Parridge, and J. Hunter (1943), J. Neurophysiol., 6:17.
Sonesson, B. and A. Thesleff (1968), Life Sciences, 7:411.
Stevenson, J. W. and G. T. Girvin (1953), Atti VI Congr. Int. Microbiol., 4:133.
Stewart, D. M. and A. W. Martin (1966), Exp. Neurol., 16:299.
Stromblad, B. C. R. (1960), Experientia, 26:458.
Takeuchi, A. and N. Takeuchi (1960), J. Physiol. (London), 144:52.
Thesleff, S. (1960), J. Physiol. (London), 151:598.
Tower, S. (1931a), Bull. Johns Hopkins Hosp., 48:115.
Tower, S. (1931b), Brain, 54:99.
Tower, S. (1935), Amer. J. Anat., 56:1.
Tower, S. (1937), J. Comp. Neurol., 17:241.
Vincenzi, F. F. (1967), Nature, 213:394.
Watson, W. E. (1969), J. Physiol., 202:611.
Westwood, D. A. and B. C. Whaler (1968), Brit. J. Pharmac. Chemother., 33:21.
Whittaker, V. P. (1965), The application of subcellular fractionation techniques to the study of brain function, Chap. 2, in “Progress in Biophysics and Molecular Biology,” vol. 15, Pergamon Press, New York.
Whittaker, V. P. (1968), Neurosciences Research Program Bulletin, MIT, 6:27.
Zacks, S. I., M. V. Rhoades, and M. E. Sheff (1968), Exp. and Mol. Pathol., 9:77.
Zacks, S. I., J. F. Metzger, C. W. Smith, and J. M. Blumberg (1962), J. Neuropath. Exp. Neurol., 21:610.
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Drachman, D.B. (1971). Botulinum Toxin as a Tool for Research on the Nervous System. In: Simpson, L.L. (eds) Neuropoisons. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2940-4_15
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