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Neuropoisons pp 303-323 | Cite as

The Neuroparalytic and Hemagglutinating Activities of Botulinum Toxin

  • Lance L. Simpson

Abstract

Were any investigator of botulinum toxin asked to describe the poison’s taste, he would indeed be faced with a challenging question. It is unlikely there are surviving witnesses who could testify concerning the taste of toxin. Because the agent is so exceptionally lethal, a quantity sufficient to stimulate the palate would surely be fatal to an unprotected individual or animal. If the approximation of 0.5–5.0 μg toxin per human oral lethal dose is correct (Lamanna and Carr, 1967; Zacks et al., 1968), then a 5-ml volume of ingested fluid need contain only 10-9 m toxin. A molarity of 10-9 is several orders of magnitude beneath that needed to stimulate even the most sensitive of taste receptors.

Keywords

Botulinum Toxin Botulinum Toxin Type Central Nervous System Effect Botulinum Neurotoxin Clostridium Botulinum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Lance L. Simpson
    • 1
    • 2
  1. 1.Laboratory of Chemical BiodynamicsUniversity of CaliforniaBerkeleyUSA
  2. 2.Division of NeuroscienceNew York State Psychiatric InstituteNew YorkUSA

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