Advertisement

Heredity and Alcoholism

  • Donald W. Goodwin
  • Samuel B. Guze

Abstract

Alcoholism is a familial disorder. Studies have repeatedly shown a high prevAlcnce of alcoholism among the relatives of alcoholics. “Familial” however, is not synonymous with “hereditary.” Speaking French may also be familial but presumably not because of genes.

Keywords

Blood Group Biological Parent Drinking Problem Dizygotic Twin Foster Child 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Achte, K., 1958. Korreloituvatko ABO-variryhmat ja alkoholismi (Correlation of ABO blood groups with alcoholism), Duodecim. 74: 20.PubMedGoogle Scholar
  2. Amark, C., 1951. A study in alcoholism: Clinical, social-psychiatric and genetic investigations, Acta Psychiat. Neurol. Scand. Suppl. 70.Google Scholar
  3. Bleuler, M., 1932. Psychotische Belastung von körperlich Kranken, Z. Gesamte Neurol. Psychiat. 142: 780.CrossRefGoogle Scholar
  4. Boss, M., 1929. Zur Frage der erbbiologischen Bedeutung des Alkohols, Mschr. Psychiat. Neurol. 72: 264.CrossRefGoogle Scholar
  5. Brugger, C., 1934. Familienuntersuchungen bei Alkoholdeliranten, Z. Ges Neurol. Psychiat. 151: 740.CrossRefGoogle Scholar
  6. Camps, F. E. and Dodd, B. E., 1967. Increase in the incidence of nonsecretors of ABH blood group substances among alcoholic patients, Brit. J. Med. 1: 30.CrossRefGoogle Scholar
  7. Cruz-Coke, R. and Varela, A., 1966. Inheritance of alcoholism. Lancet, 2: 1282.PubMedCrossRefGoogle Scholar
  8. Dahlberg, G. and Stenberg, S., 1934. Alkoholismen som Sämhallsprohlem, Oskar Eklunds, Stockholm.Google Scholar
  9. Dittrich, H. and Neubauer, O., 1967. Störungen des Farbsehens bei Leberkrankeiten, München Med. Wschr. 109: 2690.Google Scholar
  10. Eimer, E. O. and Senter, R. J., 1968. Alcohol consumption in domestic and wild rats, Psychosom. Sci. 10: 319.Google Scholar
  11. Eriksson, K., 1968. Genetic selection for voluntary alcohol consumption in the albino rats, Science, 159: 739.PubMedCrossRefGoogle Scholar
  12. Failkow, P. J., Thuline, M. C., and Fenster, R. F., 1966. Lack of association between cirrhosis of the liver and the common types of color blindness, N. Engl. J. Med. 275: 584.CrossRefGoogle Scholar
  13. Forsander, O. and Salaspuro, M., 1962. Voluntary ethanol consumption as related to ketone bodies metabolism in rats. Life Sci. 1: 467.PubMedCrossRefGoogle Scholar
  14. Fremming, K. H., 1947. Sygdomsrisikoen for Sindslideher og andre sjaeledige Ahnormtil- stande i den danske Gennemsnitshefolkning, Ejnar Munksgaard, Copenhagen.Google Scholar
  15. Fuller, J. L., 1964. Measurement of alcohol preference in genetic experiments, J. Comp. Physiol, Psychol 57: 85.PubMedCrossRefGoogle Scholar
  16. Goodwin, D. W., 1971. Is alcoholism hereditary? Arch. Gen. Psychiat. 25: 545.PubMedCrossRefGoogle Scholar
  17. Goodwin, D. W., Schulsinger, F., Hermansen, L., Guze, S. B., and Winokur, G., 1973. Alcohol problems in adoptees raised apart from alcoholic biological parents, Arch. Gen. Psychiat. 28: 238–243.PubMedCrossRefGoogle Scholar
  18. Gregory, I., 1960. Family data concerning the hypothesis of hereditary predisposition toward alcholism, J. Ment. Sci. 106: 1068.PubMedGoogle Scholar
  19. Guze, S., Wolfgram, E., and McKinney, J., 1967. Psychiatric illness in the families of convicted criminals: A study of 519 first degree relatives, Dis. Nerv. Syst. 28: 651.PubMedGoogle Scholar
  20. Hebb, D. O., 1958. “A Textbook of Psychology,” W. B. Saunders Co., Philadephia.Google Scholar
  21. Jara, N., Segovia-Riquelme, N., and Mardones, J., 1970. Fructose metabolism in drinker and nondrinker rats. Arch. Biol. Med. Exp. 7: 47.PubMedGoogle Scholar
  22. Kaij, L., 1960. Studies on the Etiology and Sequels of Abuse of Alcohol, Department of Psychiatry, University of Lund, Lund.Google Scholar
  23. Kroon, H. M., 1924. Die Erblichkeit der Trunksucht in der Familie X, Genetica, 6: 391.CrossRefGoogle Scholar
  24. Lester, D. and Freed, E. X., 1972. A rat model of alcoholism?, in: Nature and Nurture in Alcoholism (F. A. Seixas, G. S. Omenn, E. D. Burk, and S. Eggleston, eds.) The New York Academy of Sciences, New York.Google Scholar
  25. Lester, D. and Greenberg, L. A., 1952. Nutrition and the etiology of alcoholism: The effect of sucrose, fat and saccharine on the self-selection of alcohol by rats. Quart. J. Stud. Alc. 13: 553.Google Scholar
  26. Leohlin, J. C., 1972. An analysis of alcohol-related questionnaire items from the National Merit twin study, in press.Google Scholar
  27. Luxenburger, H., 1928. Demographische und psychiatrische Untersuchungen in der engeren biologischen Families von Paralytikerehegatten, Z. Gesamte Neurol. Psychiat. 112: 331.CrossRefGoogle Scholar
  28. Mardones, J., Hederra, A., and Segovia, N. 1949. Fluctuaciones individuals del consumo de alcohol en ratas carenciadas, Bol. Soc. Biol. (Santiago) 7: 1.Google Scholar
  29. McClearn, G. E., 1962. Genetic differences in the effect of alcohol upon behavior of mice, Proc. Third Int. Conf. Alc. Road Traffic 153.Google Scholar
  30. McClearn, G. E. and Rodgers, D. A. 1959. Differences in alcohol preference among inbred strains of mice, Quart. J. Studi. Alc. 20: 691.Google Scholar
  31. McClearn, G. E. and Rodgers, D. A. 1961. Genetic factors in alcohol preference of laboratory mice, J. Compl Physiol. Psychol. 54: 116.CrossRefGoogle Scholar
  32. Myers, R. D., 1962. Alcohol choice in Wistar and G-4 rats as a function of environmental temperature and alcohol concentration, J. Comp. Physiol. Psychol. 45: 606.CrossRefGoogle Scholar
  33. Nichols, J. R. and Hisao, S. 1967. Addiction liability of albino rats breeding for quantitative difference in morphine drinking, Science, 157: 561.PubMedCrossRefGoogle Scholar
  34. Nordmo, S. H., 1959. Blood groups in schizophrenia, alcoholism and mental deficiency, Amer. J. Psychiat. 116: 460.PubMedGoogle Scholar
  35. Partanen, J., Bruun, K., and Markkanen, T., 1966. Inheritance of Drinking Behavior, Rutgers University Center of Alcohol Studies, New Brunswick, New Jersey.Google Scholar
  36. Peeples, E. E., 1962. “Taste Sensitivity to Penylthiocarbamide in Alcoholics,” master’s thesis, Stetson University, Deland, Florida.Google Scholar
  37. Pohlisch, K., 1933. Soziale und persönliche Bedingungen des chronischen Alcoholismus, in: Sammlung psychiatrischer und neurologischer Einzeldarstellungen, G. Thieme Verlag, Leipzig, Germany.Google Scholar
  38. Popham, R. E., deLint, J. E. E., and Schmidt, W., 1967. Inheritance of Drinking Behavior, Alkoholpolitik, No. 3.Google Scholar
  39. Reed, J. G., 1951. A study of the alcoholic consumption and amino acid excretion patterns of rats of different inbred strains, Tex, Univ. Puhl, 109: 144.Google Scholar
  40. Reid, N., Brunt, P., Bias, W., Maddrey, W., Alonso, B., and Iber, F., 1968. Genetic characteristics and cirrhosis: A controlled study of 200 patients, Brit. Med. J. 2: 463.PubMedCrossRefGoogle Scholar
  41. Richter, C. P., 1926. A study of the effect of moderate doses of alcohol on the growth and behavior of the rat, J. Exp. Zool. 44: 397.CrossRefGoogle Scholar
  42. Rimmer, J. and Chambers, D. S., 1969. Alcoholism: Methodological considerations in the study of family illness, Amer. J. Orthopsychiat. 39: 760.PubMedCrossRefGoogle Scholar
  43. Rodgers, D. A., 1966. Factors underlying differences in alcohol preference among inbred strains of mice, Psychosom. Med. 28: 498.Google Scholar
  44. Rodgers, D. A. and McClearn, G. E., 1962. Alcohol preference of mice, in: Roots of Behavior (E. L. Bliss, ed.) Harper & Row, New York.Google Scholar
  45. Rodgers, D. A., McClearn, G. E., Bennett, E. L., and Herbert, M., 1963. Alcohol preference as a function of its caloric utility in mice, J. Comp. Physiol, Psychol. 56: 666.PubMedCrossRefGoogle Scholar
  46. Roe, A. and Burks, B., 1945. Adult adjustment of foster children of alcoholic and psychotic parentage and the influence of the foster home. Memoirs of the Section on Alcohol Studies, YAlc University No. 3, Quart. J. Stud. Alc. New Haven. Google Scholar
  47. Schlesinger, K., Kakihana, R., and Bennett, E. 1967. Effect of genotype and prior consumption of alcohol on rats of ethanol 1-14C metabolism in mice. Quart. J. Studies Alc. 28: 231.Google Scholar
  48. Schuckit, M. A., Goodwin, D. W., and Winokur, G., 1972. A half-sibling study of alcoholism, Amer. J. Psychiat., in press.Google Scholar
  49. Segovia-Riquelme, N., Campos, I., Solodkowska, W., Figuerola-Camps, I., and Mardones, J., 1964. Glucose and gluconate metabolism in “drinker” and “nondrinker” rats, Med. Exp. 11: 185.PubMedGoogle Scholar
  50. Segovia-Riquelme, N., Hederra, A., Anex, M., Barnier, O., Figuerola-Camps, I., Campos- Hoppe, I., Jara, N., and Mardones, J., 1970. Nutritional and genetic factors in the appetite for alcohol, in: Alcohol and Alcoholism (R. Popham, ed.) University of Toronto Press, Toronto.Google Scholar
  51. Segovia-Riquelme, N., Varela, A., and Mardones, J., 1971. Appetite for alcohol in: Biological Basis of Alcoholism (Y. Israel and J. Mardones, eds.) John Wiley & Sons, Toronto, Canada.Google Scholar
  52. Sheppard, J. R., Albersheim, P., and McClear, G. E., 1968. Aldehydedehydrogenase and ethanol preference in mice, Proc. XXVIII Int. Conge. Alcohol Alcoholism (Wash.), 1: 110.Google Scholar
  53. Sjögren, T., 1958. Genetic-statistical and psychiatric investigations of a west Swedish population. Acta Psychiat. Neurol. Suppl. 52.Google Scholar
  54. Slater, E., 1935. The incidence of mental disorder, Ann. Eugenics. 6: 172.CrossRefGoogle Scholar
  55. Smith, J. W. and Brinton, G. A., 1971. Color-vision defects in alcoholism. Quart. J. Stud. Alc. 32: 41.Google Scholar
  56. Swinson, R. P. and Madden, J. S., 1972. ABO blood groups and ABH substance secretion in alcoholism, in press.Google Scholar
  57. Thomas, K., 1969. Selection and avoidance of alcohol solutions by two strains of inbred mice and derived generations. Quart. J. Stud. Alc. 30: 849.Google Scholar
  58. Thuline, M. C., 1967. Colour blindness and alcoholism. Lancet, 1: 274.Google Scholar
  59. Varela, A., Rivera, L., Mardones, J., and Cruz-Coke, R., 1969. Color vision defects in non-alcoholic relatives of alcoholic patients, Brit. J. Addict. 64: 67.CrossRefGoogle Scholar
  60. Williams, R. J., Berry, L. J., and Beerstecher, Jr., E., 1949. Biochemical individuality: III. Genotrophic factors in the etiology of alcoholism, Arch. Biochem. N. F., 23: 275.Google Scholar
  61. Winokur, G., 1967. X-borne recessive genes in alcoholism. Letters to the editor. Lancet, 2: 466.CrossRefGoogle Scholar
  62. Winokur, G. and Clayton, P. J., 1968. Family history studies: IV. Comparison of mAlc and femAlc alcoholics. Quart. J. Stud. Alc. 29: 885.Google Scholar
  63. Winokur, G., Reich, T., Rimmer, J., and Pitts, F., 1970. Alcoholism: III. Diagnosis and familial psychiatric illness in 259 alcoholic probands. Arch. Gen. Psychiat. 23: 104.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Donald W. Goodwin
    • 1
  • Samuel B. Guze
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. LouisUSA

Personalised recommendations