Genetic Analysis of the Mammalian Nervous System Using Somatic Cell Culture Techniques

  • John D. Minna
Part of the Current Topics in Neurobiology book series (CTNB)


The success of genetic analysis of complex biochemical pathways, morphogenetic events, and their regulation in phage, bacteria, and yeast has suggested to many workers that such an analysis would be invaluable in the study of development and differentiation. The available information indicates that differentiation in higher organisms represents in part a mitotically inherited program of gene expression with commitment of different somatic cell lines to unique programs of gene expression (Gehring, 1969). Genetic analysis of developmental steps would seem to be both possible and necessary in order for us to understand differentiation.


Pituitary Adenoma Neuroblastoma Cell AChE Activity Hybrid Cell Clonal Line 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • John D. Minna
    • 1
  1. 1.Laboratory of Biochemical Genetics, National Heart and Lung InstituteNational Institutes of HealthBethesdaUSA

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