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Influence of Repair on the Specificity of Ultraviolet-Induced Reversion of an Ochre Allele of the Structural Gene for Iso-1- cytochrome c

  • Christopher W. Lawrence
  • John W. Stewart
  • Fred Sherman
  • Roshan Christensen
Part of the Basic Life Sciences book series

Abstract

The specific action of UV on the reversion of the ochre allele cyc1-9, in which 21 out of 23 revertants have been shown to arise from A•T-to-G•C transitions at position one in the UAA codon, was found to depend on the function of the RAD6 gene, since cyc1-9 reversion occurred by a variety of single-base-pair substitutions in a strain carrying the rad6-1 allele.

Keywords

Amino Acid Replacement RAD6 Gene Public Health Service Research Double Mutant Strain Rochester School 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Lawrence, C. W., Stewart, J. W., Sherman, F. and Christensen, R. (1974). J. Mol. Biol. 85, 137–162.PubMedCrossRefGoogle Scholar
  2. Lemontt, J. F. (1971). Genetics 68, 21–33.PubMedGoogle Scholar
  3. Sherman, F. and Stewart, J. W. (1974). Genetics 78, 97–113.PubMedGoogle Scholar
  4. Stewart, J. W., Sherman, F., Jackson, M., Thomas, F. L. X. and Shipman, N. (1972). J. Mol. Biol. 68, 83–96.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Christopher W. Lawrence
    • 1
  • John W. Stewart
    • 1
  • Fred Sherman
    • 1
  • Roshan Christensen
    • 1
  1. 1.Department of Radiation Biology and BiophysicsUniversity of Rochester School of Medicine and DensitryRochesterUSA

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