Distribution of Pyrimidine Dimers During Postreplication Repair in UV-Irradiated Excision-Deficient Cells of Escherichia coli K12

  • Ann Ganesan
Part of the Basic Life Sciences book series


During postreplication repair in excision-deficient mutants of Escherichia coli K-12, pyrimidine dimers are gradually lost from UV-irradiated DNA. Our data indicate that dimers are transferred, by a process which may involve genetic exchange, into daughter strands made after irradiation. Dimer transfer appears to continue through several rounds of replication, resulting in the gradual dilution of dimers into successive generations of DNA molecules.


Successive Generation Genetic Exchange Pyrimidine Dimer Require Amino Acid Daughter Strand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ganesan, A. K. (1973). Proc. Nat. Acad. Sci. USA. 70, 2753–2756.PubMedCrossRefGoogle Scholar
  2. Ganesan, A. K. (1974). J. Mol. Biol. 87, 103–119.PubMedCrossRefGoogle Scholar
  3. Howard-Flanders, P., Rupp, W. D., Wilkins, B. M. and Cole, R. S. (1968). Cold Spring Harbor Symp. Quant. Biol. 33, 195–205.PubMedCrossRefGoogle Scholar
  4. Rupp, W. D., Wilde, C. E., III, Reno, D. L. and Howard-Flanders, P. (1971). J. Mol. Biol. 61, 25–44.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Ann Ganesan
    • 1
  1. 1.Department of Biological SciencesStanford UniversityStanfordUSA

Personalised recommendations