Alkali-Labile Lesions in DNA from Cells Treated with Methylating Agents, 4-Nitroquinoline-N-oxide, or Ultraviolet Light

  • I. G. Walker
  • R. Sridhar
Part of the Basic Life Sciences book series


Methylating agents, 4-nitroquinoline-N-oxide, and ultraviolet radiation produce alkali-labile structures in the DNA of mammalian cells. The number of these structures does not diminish during a 5-hr posttreatment incubation.


Sucrose Sedimentation 


  1. Walker, I. G. and Ewart, D. F. (1973a). Mutat. Res. 19, 331–341.PubMedCrossRefGoogle Scholar
  2. Walker, I. G. and Ewart, D. F. (1973b). Can. J. Biochem. 51, 148–157.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • I. G. Walker
    • 1
  • R. Sridhar
    • 1
  1. 1.Department of BiochemistryUniversity of Western OntarioLondonCanada

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