Alkali-Labile Lesions in DNA from Cells Treated with Methylating Agents, 4-Nitroquinoline-N-oxide, or Ultraviolet Light

  • I. G. Walker
  • R. Sridhar
Part of the Basic Life Sciences book series


Methylating agents, 4-nitroquinoline-N-oxide, and ultraviolet radiation produce alkali-labile structures in the DNA of mammalian cells. The number of these structures does not diminish during a 5-hr posttreatment incubation.


Mammalian Cell HeLa Cell Untreated Cell Medical Research Council Ultraviolet Radiation 
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  1. Walker, I. G. and Ewart, D. F. (1973a). Mutat. Res. 19, 331–341.PubMedCrossRefGoogle Scholar
  2. Walker, I. G. and Ewart, D. F. (1973b). Can. J. Biochem. 51, 148–157.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • I. G. Walker
    • 1
  • R. Sridhar
    • 1
  1. 1.Department of BiochemistryUniversity of Western OntarioLondonCanada

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