Analysis of Temperature-Sensitive recB and recC Mutations

  • Sidney R. Kushner
Part of the Basic Life Sciences book series


The in vivo pleiotropic effects associated with the temperature-sensitive recB270 and recC271 mutations have been correlated with the in vitro behavior of the recBC nucleases coded for by these alleles. The ATP-dependent breakdown of double-stranded DNA is essential for cell viability, radiation repair, and genetic recombination. Temperature sensitivity can be suppressed in vitro and in vivo.


Temperature Sensitivity Mutant Enzyme Genetic Recombination United States Public Health polA Mutation 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Sidney R. Kushner
    • 1
  1. 1.Department of BiochemistryStanford University School of MedicineStanfordUSA

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