Hormone Patterns in Early Human Gestation

  • Daniel R. MishellJr.
  • Ian H. Thorneycroft
  • Yukihiro Nagata
  • Takaaki Murata
  • Robert M. Nakamura
Part of the Basic Life Sciences book series (BLSC, volume 4)


Accurate measurement of the low concentration of gonadotropins and steroid hormones present in human serum has been made possible by the development of sensitive radioimmunoassay (RIA) techniques; With the use of RIA FSH and LH, progesterone and 170H-progesterone have been previously measured in early normal pregnancy (Jaffe et al., 1969; Parlow et al., 1970; Wide, 1969). In order to determine the daily pattern of hormone levels in early normal pregnancy, gonadotropins as well as steroid hormone levels were measured in serum samples obtained daily from three women from the time of the last menstrual period prior to conception throughout the first few months of gestation.


Early Pregnancy Corpus Luteum Normal Pregnancy Progesterone Level Early Gestation 
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  1. Brown, J. B. (1956), Urinary excretion of estrogens during pregnancy, lactation and there establishment of menstruation, Lancet 1:104.Google Scholar
  2. Brown, W. E., and Bradbury, J. T. (1947), A study of physiological action of human chorionic hormone, Am. J. Obstet. Gynecol. 53:749.PubMedGoogle Scholar
  3. Crosignani, P. G., Nakamura, R. M., Hovland, D. N., and Mishell, D. R., Jr. (1970), A method of solid phase radioimmunoassay utilizing polypropylene discs, J. Clin. Endocrinol. 30:153.CrossRefGoogle Scholar
  4. Czygan, P. J., Lehmann, F., Breckwoldt, M., and Betterndorf, G. (1972), Continuous monitoring of plasma FSH, LH, HCG and placenta lactogen during HMG-induced ovulatory cycles and subsequent pregnancies, Acta Endocrinol. 70:417.PubMedGoogle Scholar
  5. Faiman, C, Ryan, R. B., Zwirek, S. J., and Rubin, M. E. (1968), Serum FSH and HCG during human pregnancy and Puerperium, J. Clin. Endocrinol. 28:1323.CrossRefGoogle Scholar
  6. Fotherby, K. (1971), Hormone production during early human pregnancy, Bibl. Reprod. 17:589.Google Scholar
  7. Freid, P. H., and Rakoff, A. E. (1951), The effects of chiorionic gonadotropin and prolactin on the maintenance of corpus luteum function, J. Clin. Endocrinol. 12:321.CrossRefGoogle Scholar
  8. Froewis, J. (1963), Wann erfolgt die ausreichende Umschaltung der schwangerschaftserhalt enden Hormonproduktion des Corpus Luteum Graviditateis auf die Plazenta? Ein klinischer Beitrag, Wien, Klin. Wschr. 75:368.Google Scholar
  9. Hanson, F. W., Powell, J. E., and Stevens, V. C. (1970), Follicle-stimulating hormone levels during pregnancy, Obstet. Gynecol. 36:667.PubMedGoogle Scholar
  10. Holmdahl, T. H., and Johansson, E. D. B. (1972), Peripheral plasma levels of 17a-hydroxy progesterone during human pregnancy, Acta Endocrinol. 71:165.Google Scholar
  11. Holmdahl, T. H., Johansson, E. D. B., and Wide, L. (1971), The site of progesterone production in early pregnancy, Acta Endocrinol. 67:353.PubMedGoogle Scholar
  12. Jaffe, R. B., Lee, P. A., and Midgley, A. R., Jr. (1969), Serum gonadotropins before, at the inception of, and following human pregnancy, J. Clin. Endocrinol. 29:1281.CrossRefGoogle Scholar
  13. Johansson, E. D. B. (1969), Plasma levels of progesterone in pregnancy measured by a rapid competitive protein binding technique, Acta Endocrinol. 61:607.PubMedGoogle Scholar
  14. Macnaughton, M. C, Coutts, J. R. T., and Browning, M. C. K. (1970), Steroid excretion in molar pregnancy and early hormone-induced pregnancy, Proc. Roy. Soc. Med. 63:1087.PubMedCentralPubMedGoogle Scholar
  15. Mishell, D. R., Jr., Nakamura, R. M., Crosignani, P. G., Stone, S., Kharma, K., Nagata, Y., and Thorneycroft, I. H. (1971), Serum gonadotrophin and steroid patterns during the normal menstrual cycle, Am. J. Obstet. Gynecol 111:60.PubMedGoogle Scholar
  16. Mishell, D. R., Jr., Thorneycroft, I. H., Nagata, Y., and Nakamura, R. M. (1974a), in: Gonadotrophin Therapy in Female Infertility (E. Rosemberg, ed.), Excerpta Medica Foundation, in press.Google Scholar
  17. Mishell, D. R., Jr., Nakamura, R. M., Barberia, J., and Thorneycroft, I. H. (1974b), Initial detection of HCG in serum in normal human gestation, Am. J. Obstet. Gynecol. 118:990.PubMedGoogle Scholar
  18. Parlow, A. F., Daane, T. A., and Dignam, W. J. (1970), On the concentration of radio immunoassayable FSH circulating in blood throughout human pregnancy, J. Clin. Endocrinol. 31:213.CrossRefGoogle Scholar
  19. Short, R. V.: in: Foetal Autonomy (G. E. W. Wolstenholme and M. O’Connor, eds.), Churchill, London.Google Scholar
  20. Thorneycroft, I. H., and Stone, S. C. (1972), Radioimmunoassay of serum progesterone in women receiving oral contraceptive steroids, Contraception 5:129.PubMedCrossRefGoogle Scholar
  21. Thorneycroft, I. H., Mishell, D. R., Jr., Stone, S. C, Kharma, K. M., and Nakamura, R. M. (1971), The relation of serum 17-hydroxyprogesterone and estradiol-1 17ß levels during the human menstrual cycle, Am. J. Obstet. Gynecol. 111:947.PubMedGoogle Scholar
  22. Tulsky, A. S., and Koff, A. K. (1957), Some observations on the role of the corpus luteum in early human pregnancy, Fer til. Steril. 8:118.Google Scholar
  23. Vaitukaitis, J. L., Braunstein, G. D., and Ross, G. T. (1972), A radioimmunoassay whichspecifically measures human chorionic gonadotropin in the presence of human luteinizing hormone, Am. J. Obstet. Gynecol. 113:751.PubMedGoogle Scholar
  24. Wide, L. (1969), Early diagnosis of pregnancy, Lancet 2:863.PubMedCrossRefGoogle Scholar
  25. Yoshimi, T., Stroot, C. A., Marshall, J. R., and Lipsett, M. B. (1969), Corpus luteum function in early pregnancy, J. Clin. Endocrinol. 29:225.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Daniel R. MishellJr.
  • Ian H. Thorneycroft
    • 1
  • Yukihiro Nagata
    • 1
  • Takaaki Murata
    • 1
  • Robert M. Nakamura
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of Southern California School of MedicineLos AngelesUSA

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