Chromosome Abnormalities and Abortion

  • A. Boué
  • J. Boué
Part of the Basic Life Sciences book series (BLSC, volume 4)


Although spontaneous abortions represent one of the most frequent pathological entities, their causes have remained relatively obscure until the last decade. However, the work carried out at the Carnegie Institution at the beginning of the century and published in 1921 by Mall and Meyer had demonstrated the importance of abnormalities in the development of the zygote. In 1943, Hertig and Sheldow reported the results of anatomical and pathological examinations of 1000 abortuses. In 617 cases, they found obvious abnormalities of which 489 cases represented either the total absence of an embryo or an important disorder of embryogenesis. In 1957, Javert examined 892 abortuses. In 173 of these, the development was arrested before day 21 after conception, and 99% were morphologically abnormal.


Spontaneous Abortion Developmental Arrest Barr Body Autosomal Trisomy Quinacrine Mustard 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • A. Boué
    • 1
  • J. Boué
    • 1
  1. 1.International Children’s Centre, Groupe I.N.S.E.R.M. U.73Château de LongchampParisFrance

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