Motility of the Isolated Oviduct of Rats and Guinea Pigs

  • Martha F. Gimeno
  • Valeria Rettori
  • Alvaro L. Gimeno
  • E. M. Coutinho
Part of the Basic Life Sciences book series (BLSC, volume 4)


A large number of studies on tubal motility have been performed in vitro (Pauerstein et al., 1968; Boling, 1969; Brundin, 1969). Although the paramount importance of experiments in intact animals is well known, the different models used for in vitro studies have contributed significantly to our knowledge about the contractile functions of the oviduct. In experiments on different portions of isolated human Fallopian tubes, it was demonstrated that while added prosta­glandin E1 (PGE1) stimulated the tonus of the isthmus the spontaneous activity of all the other portions of the oviduct was depressed (Sandberg et al., 1962). These findings supported the development of an interesting working hypothesis regarding the role of prostaglandins in the process of fertilization (Sandberg et al, 1963). The well-known isthmoampuUary junction blockade, reported in rabbits, mice, hamsters, and guinea pigs (Greenwald, 1967), was also docu­mented in isolated human Fallopian tubes by means of intraluminal pressure measurements (Seitchik et al., 1968; Nakanishi and Wood, 1968).


Fallopian Tube Contractile Activity Phasic Contraction Adrenergic Agonist Tonic Contraction 
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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Martha F. Gimeno
    • 1
  • Valeria Rettori
    • 1
  • Alvaro L. Gimeno
    • 1
  • E. M. Coutinho
    • 2
  1. 1.Instituto de NeurobiologiaBuenos AiresArgentina
  2. 2.Maternidade Climerio de OliveiraUniversidade Federal da BahiaSalvadorBrasil

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