Metabolism of Pesticides by Aquatic Animals

  • M. A. Q. Khan
  • F. Korte
  • J. F. Payne
Part of the Environmental Science Research book series (ESRH, volume 10)


Present state of knowledge of the metabolism of pesticidal chemicals by aquatic vertebrates and invertebrates has been reviewed. In vivo and in vitro metabolic pathways of organophosphates, organochlorines, carbamates and mercurials have been described. In vitro systems that metabolise cyclodienes and their epoxides namely, microsomal mixed-function oxidase, microsomal epoxide hydrase, and soluble glutathime-S-transferase(s) have been investigated in fresh water and marine animals.


Marine Fish Aquatic Animal Mosquito Larva Aquatic Invertebrate Largemouth Bass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. R. H. Adamson. 1974. in: Survival in Toxic Environments (M.A.Q. Khan and J.P. Bederka, Jr., eds.). Acad. Press 550 p.Google Scholar
  2. D. Allison, B. J. Kallman, O. B. Cope, and C. C. Van Valin. 1971. Science 143: 958–61.Google Scholar
  3. D. A. Armstrong and R. E. Milemaim. 1976. Marine Biol. 28: 11–16.CrossRefGoogle Scholar
  4. G. J. Atchison and H. E. Johnson. 1975. Trans. Amer. Fish. Soc. 104: 775–81.CrossRefGoogle Scholar
  5. C. A. Bache, W. H. Gutenmann, and D. J. Lisk. 1971. Science 172: 951–52.CrossRefPubMedGoogle Scholar
  6. R. T. Barber, A. Vijayakumar, and F. A. Cross. 1972. Science 178: 636–39.CrossRefPubMedGoogle Scholar
  7. G. M. Benke, K. L. Cheever, F. E. Mirer, and S. D. Murphy. 1974. Toxicol. Appl. Pharmacol. 28: 97109.CrossRefGoogle Scholar
  8. W. R. Bridges, B. J. Kallman, and A. K. Andrews. 1963. Trans. Amer. Fisher. Soc. 92: 421–27.CrossRefGoogle Scholar
  9. B. B. Brodie and R. P. Maickel. 1962. in: Proceed. First Internat. Pharmacol. Meeting. Vol. 6. 299–325.Google Scholar
  10. G. T. Brooks. 1974. Chlorinated Insecticides. Vol. II. CRC Press, Ohio 192 p.Google Scholar
  11. A. W. A. Brown. 1963. in: Handbook of Physiology, Vol. V. 773–93. Waverly Publishers, Baltimore, USA.Google Scholar
  12. A. R. Bryne, L. Kosta, and P. Stegnar. 1975. Environ. Letters 8: 147–55.CrossRefGoogle Scholar
  13. D. F. Buhler and M. E. Rasmusson. 1968. Compar. Biochem. Physiol. 25: 223–31.CrossRefGoogle Scholar
  14. K. A. Burns. 1976. Compar. Biochem. Physiol. 53: 44346.Google Scholar
  15. G. P. Carlson. 1973. Bull. Environ. Cont. Toxicol. 9: 295–300.Google Scholar
  16. G. P. Carlson. 1972. Compar. Biochem. Physiol. 43: 293–302.CrossRefGoogle Scholar
  17. G. P. Carlson. 1974. Bull. Environ. Contam. Toxicol.Google Scholar
  18. D. C. Darrow and R. F. Addison. 1973. Environ. Physiol. Biochem. 3: 196–203.Google Scholar
  19. W. D. Dettborn and F. C. G. Hoskin. 1975. Bull. Environ. Contam. Toxicol. 13: 133–40.CrossRefGoogle Scholar
  20. J. H. Dewaide. 1971. Metabolism of Xenobiotics. Comparative and Kinetic Studies as a Basis for Environmental Pharmacology. Drukerj Nijmegen, Netherlands, 164 p.Google Scholar
  21. J. H. Dewaide and P. T. Henderson. 1968. Biochem. Pharmacol. 17: 1901–07.CrossRefPubMedGoogle Scholar
  22. J. H. Dewaide and P. T. Henderson. 1970. Compar. Biochem. Physiol. 32: 489–97.CrossRefGoogle Scholar
  23. R. L. Dixon, R. H. Adamson, and D. P. Rail. 1967. in: Sharks, skates, and Rays. (W.P. Gilbert, R. F. Matheson, and D. P. Rall, eds.). John Hopkins Press. 547–552 pp.Google Scholar
  24. L. J. Dziuk and F. W. Plapp. Jr. 1973. Bull. Environ. Contam. Toxicol. 9: 15–19.CrossRefPubMedGoogle Scholar
  25. W. Ernst and H. Goerke. 1974. Marine Biol. 24: 287–304.CrossRefGoogle Scholar
  26. T. H. Elmamlouk and T. Gessner. 1976. Compar. Biochem. Physiol. 53: 19–24.CrossRefGoogle Scholar
  27. T. H. Elmamlouk and T. Gessner. 1976a. Compar. Biochem. Physiol. 53: 57–62.CrossRefGoogle Scholar
  28. T. H. Elmamlouk and T. Gessner. 1974. Compar. Biochem. Physiol. 48: 419–25.Google Scholar
  29. D. L. Fabacher and H. Chambers. 1972. Environ. Poll. 3: 139–41.CrossRefGoogle Scholar
  30. S. C. Fang. 1976. Archiv. Environ. Cont. Tox. 1: 18–26.CrossRefGoogle Scholar
  31. A. G. Farbwerke Hoechst. 1971. Thiodan and the Environ- ment. Technical Bulletin translated by Hoechst, U. K. 1971.Google Scholar
  32. J. Fukami, T. Mitsui, K. Fukunaga and T. Shishido. 1970. in: Biochemical Toxicology of Insecticides (R. D. O’Brien and I. Yamamoto, eds.). Acad. Press. 280 p.Google Scholar
  33. F. J. H. Freedeen, J. G. Saka and L. M. Royer. 197. J. Fish. Res. Board Can. 28: 105–9.Google Scholar
  34. J. H. Gackstatter. 1968. J. Fish Res. Bd. Can. 25: 1797–1801.CrossRefGoogle Scholar
  35. M. Garretto and M. A. Q. Khan. 1975. Gener. Pharmacol. 6: 91–96.CrossRefGoogle Scholar
  36. D. C. Gillespie and D. F. Scott. 1971. J. Fish. Res. Board Can. 28: 1807–08.CrossRefGoogle Scholar
  37. D. C. Gillespie and D. F. Scott. 1972. J. Fish. Res. Bd. Can. 29: 1035–41.CrossRefGoogle Scholar
  38. S. Gorbach, R. Haaring, W. Knauf, and W. J. Werner. 1971. Bull. Env. Cont. Toxicol. 6: 193–97.CrossRefGoogle Scholar
  39. S. Gorbach and W. Knauf. 1972. in: Environmental Quality and Safety. Vol. I. (F. Coulston and F. Korte, eds.). Acad. Press. 250 p.Google Scholar
  40. N. Graft and W. C. Lockhart. 1974. J. Assoc. Off. Anal. Chem. 57: 1282–1284.Google Scholar
  41. A. R. Grzenda, W. J. Taylor and D. F. Paris. 1972. Trans. Amer. Fish. Soc. 101: 686–90.CrossRefGoogle Scholar
  42. A. R. Grzenda, W. J. Taylor and D. F. Paris. 1971. Trans. Amer. Fish. Soc. 100: 215–221.CrossRefGoogle Scholar
  43. W. H. Gutenman and D. J. Lisk. 1965. New York Fish and Game J. 12: 108–11.Google Scholar
  44. M. Hitchcock and S. D. Murphy. 1971. Biochem. Pharmacol. 16: 1801–11.CrossRefGoogle Scholar
  45. J. W. Hogan and C. O. Knowles. 1972. Bull. Environ. Contam. Toxicol. 1: 61–64.CrossRefGoogle Scholar
  46. J. B. Hunn and J. L. Allen. 1975. J. Fish. Res. Bd. Canada 32: 1873–76.CrossRefGoogle Scholar
  47. N. Imura, S. K. Pan, and T. Ukita. 1972 Chemosphere 1: 197–201.CrossRefGoogle Scholar
  48. B. T. Johnson, C. R. Saunders and H. O. Saunders. 1971. Journ. Fish. Res. Board Canada. 28: 705–9.CrossRefGoogle Scholar
  49. F. W. Juengst, Jr. and M. Alexander. 1975. Marine Biol. 33: 1–6.CrossRefGoogle Scholar
  50. S. Jensen and A. Jarnellov. 1969. Nature 223: 145–354.CrossRefGoogle Scholar
  51. S. Jensen and A. Jarnellov. 1968. Nordforst Biocid Information. 14: 3–5.Google Scholar
  52. M. O. James, J. R. Bend and J. R. Fouts. 1973. Mt. Des. Isl. Biol. Bull. 2: 59–62.Google Scholar
  53. I. P. Kapoor, R. L. Metcalf, R. F. Nystrom and G. K. Sangha. 1970. J. Agr. Food Chem, 18: 1145–52.CrossRefGoogle Scholar
  54. J. A. Kawatski and J. C. Schmulbach. 1971. J. Econ. Entomol. 61: 316–17.Google Scholar
  55. H. M. Khan and M. A. Q. Khan. 1974. Archiv. Environ. Contam. Toxicol. 2: 289–301.CrossRefGoogle Scholar
  56. M. A. Q. Khan, J. R. Bend and J. R. Fouts. (Unpublished). Epoxidation and Epoxide Hydraction of Cyclodienes by Hepatic Subcell Fractions of Marine Animals.Google Scholar
  57. M. A. Q. Khan, W. Coello, A. A. Khan, and H. Pinto. 1972. Life Sci. 11: 405–15.CrossRefGoogle Scholar
  58. M. A. Q. Khan, A. Kamal, R. J. Wolin, and J. Runnels. Bull. Environ. Contam. Toxicol. 8: 219–28.Google Scholar
  59. M. A. Q. Khan, J. D. Rosen, and D. J. Sutherland. 1969. Science 164: 318–19.CrossRefPubMedGoogle Scholar
  60. M. A. Q. Khan, E. Toro, R. Moore, and G. Reddy. 1976. in: Pesticides in Aquatic Environments (M. A. Q. Khan, ed.) Plenum Press, 300 p.Google Scholar
  61. M. A. Q. Khan, R. H. Stanton, D. J. Sutherland, J. D. Rosen and N. Maitra. 1973. Archiv. Environ. Contam. Toxicol. 1: 159–69.CrossRefGoogle Scholar
  62. M. A. Q. Khan, R. H. Stanton, and G. Reddy. 1974. in: Survival in Toxic Environments (M. A. Q. Khan and J. P. Bederka, eds.). Acad. Press. 500 p.Google Scholar
  63. M. A. Q. Khan, M. L. Gassman and S. H. Ashrafi. 1975. in: Environmental Dynamics of Pesticides (R. Hague and V. H. Freed, Ed.). Plenum Press, 380 p.Google Scholar
  64. M. A. Q. Khan. 1977. Unpublished data: In vitro Metabolism of Cyclodiene Epoxides by Freshwater Fishes.Google Scholar
  65. T. Kimura and A. Q. A. Brown. 1964. J. Econ. Entomol. 57: 710–14.Google Scholar
  66. W. Klein, R. Kaul, Z. Parlar, M. Zimmer, and F. Korte. 1969. Beitrage zur Okologischen chemie XIX. Tetrahed Letters 37: 3197–99.CrossRefGoogle Scholar
  67. F. Korte, G. Ludwig and J. Vogel. 1962. Liebig Ann. Chem. 656: 135–40.CrossRefGoogle Scholar
  68. K. Kobayashi, H. Akitake and T. Tomiyama. 1969. Bull. Jap. Soc. Sci. Fish. 35: 1179–85.CrossRefGoogle Scholar
  69. K. Kobayashi, H. Akitake and T. Tomiyama. 1970. Bull. Jap. Soc. Sci. Fish. 36: 103–109.CrossRefGoogle Scholar
  70. R. I. Krieger and P. W. Lee. 1973. Archiv. Environ. Cont. Toxicol. 1: 112–16.CrossRefGoogle Scholar
  71. S. Korn. 1973. Trans. Amer. Fish. Soc. 102: 137–38.CrossRefGoogle Scholar
  72. J. J. Lech and C. N. Stathan. 1975. Toxicol. Appl. Pharmacol. 27: 300–305.Google Scholar
  73. S. Korn and N. V. Costrini. 1972. Compar. Gener. Pharmacol. 3: 160–66.CrossRefGoogle Scholar
  74. R. F. Lee, R. Sauerheber and G. H. Dobbs. 1972. Marine Biol. 17: 201–8.CrossRefGoogle Scholar
  75. J. G. Leesch and T. R. Fukuto. 1972. Pest. Biochem. Physiol. 2: 223–35.CrossRefGoogle Scholar
  76. W. L. Lockhart, D. A. Metner, and N. Grift. 1973. Mannitoba Entomol. 7: 26–36.Google Scholar
  77. W. L. Lockhart, R. Wagenmann, J. W. Clayborn, G. Graham, and D. Murray. 1975. Environ. Physiol. Biochem. 5: 361–69.PubMedGoogle Scholar
  78. J. L. Ludke, J. R. Gibson and C. I. Lusk. 1972. Toxicol. Appl. Pharmacol. 21: 89–97.CrossRefPubMedGoogle Scholar
  79. K. J. Macek, C. A. Rodgers, D. Stalling and S. Korn. 1969. Trans. Amer. Fish. Soc. 99: 689–95.CrossRefGoogle Scholar
  80. T. H. Maren, L. E. Broder and V. G. Stenger. 1968. Bull. Mt. Des. Isl. Biol. Lab. 8: 39–41.Google Scholar
  81. F. Matsumura. 1975. Toxicology of Insecticides. Plenum Press 600 p.Google Scholar
  82. F. Matsumura and A. Q. A. Brown. 1963. J. Econ. Entomol. 56: 381–88.Google Scholar
  83. C. M. Menzie. 1974. Metabolism of Pesticides: An update U.S. Dep. Interior, Fish and Wildlife Series, Special Scientific Report - Wildlife No. 184, Washington, D. C. 485 p.Google Scholar
  84. R. L. Metcalf, J. R. Sanborn, P. X. Lu, and D. Nye. 1975. Archiv. Environ. Contam. Toxicol. 3: 151–65.CrossRefGoogle Scholar
  85. S. D. Murphy. 1966.Google Scholar
  86. D. A. J. Murray. 1975. J. Fish. Res. Bd. Can. 32: 457–60.CrossRefGoogle Scholar
  87. G. A. Neville and M. Berlin. 1974. Environ. Res. 7: 75–82.CrossRefGoogle Scholar
  88. S. Neudorf and M. A. Q. Khan. 1975. Bull. Environ. Contam. Toxicol. 11: 493–50.Google Scholar
  89. R. D. O’Brien. 1967. Insecticides. Action and Metabolism Acad. Press. 328 p.Google Scholar
  90. N. Pasteur and G. Sinegre. 1975. Biochem. Gen. 13: 78994.CrossRefGoogle Scholar
  91. W. P. Penrose. 1975. J. Fish. Res. Bd. Can. 32: 2385–90.CrossRefGoogle Scholar
  92. M. K. K. Pillai and A. Q. A. Brown. 1965. J. Econ. Entomol. 58: 255–66.PubMedGoogle Scholar
  93. J. L. Potter, and R. D. O’Brien. 1954. Science 144: 55–56.CrossRefGoogle Scholar
  94. G. Reddy and M. A. Q. Khan. 1977. ( Unpublished data).Google Scholar
  95. R. E. Reinert, L. J. Stone and W. A. Willford. 1974. J. Fish. Res. Bd. Can. 31: 1649–52.CrossRefGoogle Scholar
  96. J. R. Sanborn, R. L. Metcalf, W. N. Bruce and P. Lu. 1976. Environ. Entomol. 5: 531–36.Google Scholar
  97. D. C. Schmidt and L. J. Weber. 1973. J. Fish. Res. Bd. Can. 30: 1301–09.CrossRefGoogle Scholar
  98. R. A. Schoettger. 1970. Toxicology of Thiodan in Several Fish and Aquatic Invertebrates. Investigation in Fish Control. 35. U.S. Dept. Interior, Bureau of Sport Fisheries and Wildlife. U.S. Govt. Print. Office., Washington, D. C.Google Scholar
  99. D. P. Schultz. 1973. J. Agr. Food Chem. 21: 186–92.CrossRefGoogle Scholar
  100. S. P. Shrivastava, G. P. Georghion, R. L. Metcalf and T. R. Fukuto. 1970. Bull. World Hlth. Orq. 42: 931–92.Google Scholar
  101. S. P. Shrivastava, G. P. Georghion, T. R. Fukuto. 1971. Ent. Exp. Appl. 14: 333–48.CrossRefGoogle Scholar
  102. J. N. Smith. 1968. Adv. Comp. Physiol. Biochem. 3: 173–232.PubMedGoogle Scholar
  103. J. B. Sprague, P. F. Elson and J. R. Duffy. 1970. Environ. Res. 1: 191–203.Google Scholar
  104. J. B. Sprague and J. R. Duffy. 1971. J. Fish. Res. Bd. Can. 28: 59–64.CrossRefGoogle Scholar
  105. C. N. Staltham and J. J. Lech. 1975. J. Fish. Res. Bd. Can. 32: 315–322.Google Scholar
  106. R. H. Stanton and M. A. Q. Khan. 1975. Gener. Pharmacol. 2: 121–27.Google Scholar
  107. R. H. Stanton and M. A. Q. Khan. 1973. Pest. Biochem. Physiol. 3: 351–57.CrossRefGoogle Scholar
  108. B. F. Stone. 1969. J. Econ. Entomol. 62: 977–81.PubMedGoogle Scholar
  109. B. F. Stone and A. Q. A. Brown. 1969. Bull. World Hlth. Orq. 40: 401–08.Google Scholar
  110. T. E. Tooby and F. J. Dubin. 1975. Environ. Bull. 8: 79–80.Google Scholar
  111. R. Wageman, B. Graham and W. L. Lockhart. 1975. Fish. Mar. Serv. Dev. Tech. Res. 486 (Environment Canada).Google Scholar
  112. C. H. Walker, G.A. El-Zegan, A.C. Crane and J.B.R. Kenny. 1974. in: Comparative Studies of Food and Environmental Contamination. Internat. Atom. Energy Agency (Vienna) SM-175/21: 529–40.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • M. A. Q. Khan
  • F. Korte
  • J. F. Payne

There are no affiliations available

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