Xenobiotic Metabolizing Enzymes in Marine Fish
In recent years, the interest of scientists from several disciplines has focused on the fate of the many xenobiotics, including pesticides, which are introduced into our environment. Many of these foreign chemicals eventually enter the oceans and can be ingested by marine species. Using in vivo and in vitro techniques, we have studied xenobiotic metabolism in a number of marine fish and crustacea. The pathways studied in vitro include oxidative metabolism by the cytochrome P-450-dependent mixed-function oxidases and metabolism of some products of oxidation, namely epoxides and arene oxides. A large number of pesticide molecules undergo metabolism by these reactions, which have been extensively studied in mammalian species. We also followed the uptake, distribution, and metabolism of a polychlorinated biphenyl, 2,4,5,2’,5’-pentachlorobiphenyl, and of the herbicides, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid, after administration to selected marine species.
KeywordsPhenylacetic Acid Styrene Oxide Spiny Lobster Cumene Hydroperoxide Sodium Periodate
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