Behavioral Toxicity of Anticholinesterase Agents: Methodological, Neurochemical, and Neuropsychological Aspects

  • G. Bignami
  • N. Rosić
  • H. Michałek
  • M. Milošević
  • G. L. Gatti
Part of the Environmental Science Research book series (ESRH, volume 5)


Anticholinesterases occupy a unique position in behavioral pharmacology and toxicology. In fact, the study of their effects and mechanisms of action has implications at widely differing levels. At one end, there is the problem of prevention and therapy of pesticide intoxication in man and animals, not to speak of the problems of production, storage, and disposal of chemical warfare agents. At the opposite end, investigators not directly concerned with these practical aspects have been using anticholinesterases as tools in the investigation of neurochemical and neuropsychological models, in order to elucidate the role of peripheral and central cholinergic systems.


Cholinesterase Activity Avoidance Performance Avoidance Acquisition Behavioral Tolerance Behavioral Toxicity 


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Copyright information

© University of Rochester 1975

Authors and Affiliations

  • G. Bignami
    • 1
  • N. Rosić
    • 2
  • H. Michałek
    • 1
  • M. Milošević
    • 2
  • G. L. Gatti
    • 1
  1. 1.Department of Therapeutical ChemistryIstituto Superiore di SanitaRomeItaly
  2. 2.Department of PharmacologyMedical SchoolBelgradeYugoslavia

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