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Behavioral Assessment of Ototoxicity in Nonhuman Primates

  • William C. Stebbins
  • Sheryl Coombs
Part of the Environmental Science Research book series (ESRH, volume 5)

Abstract

Impaired sensory function as a consequence of the administration of toxic substances is the subject of this chapter. We are specifically concerned with changes in the monkey’s hearing after the administration of certain ototoxic drugs and exposure to intense sound. We will describe the procedures we have used and the findings obtained both in the study of normal hearing and of the temporary and permanent hearing loss which occurs subsequent to noise and drug treatment. Examples of the related tissue changes in the inner ear will also be presented. The primary objective, however, is a description of the behavioral procedures and findings; samples of related cochlear histopathology are given because they are an integral part of our research and because they underscore the importance of the close relation between behavioral function and anatomical structure to be examined in any investigation of toxicity.

Keywords

Hearing Loss Hair Cell Nonhuman Primate Pure Tone Noise Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Elder, J. H. 1935. The upper limit of hearing in chimpanzee. American Journal of Physiology, 112:109–115.Google Scholar
  2. Farrer, D. N. and M. M. Prim. 1965. A preliminary report on auditory frequency threshold comparisons of humans and pre-adolescent chimpanzees. U.S. Air Force 6571 Aeromedical Research Laboratory Technical Report No. 65–6.Google Scholar
  3. Hawkins, J. E. Jr. 1967. Iatrogenic toxic deafness in children. In: McConnell, F. and P. H. Ward, eds..Deafness in Childhood, pp. 156–168. Nashville, Tennessee, Vanderbilt University Press.Google Scholar
  4. Hawkins, J. E. Jr. 1971. The role of vasoconstriction in noise-induced hearing loss. Annals of Otology, Rhinology and Laryngology, 80:903–913.Google Scholar
  5. Hawkins, J. E. Jr., and L.-G. Johnsson. 1972. Personal communication.Google Scholar
  6. Heffner, H., R. Ravizza, and B. Masterton. 1969a. Hearing in primitive mammals, III: Tree shrew (Tupaia glis). fournal of Auditory Research, 9:12–18.Google Scholar
  7. Heffner, H., R. Ravizza, and B. Masterton. 1969b. Hearing in primitive mammals, IV: Bush- baby (Galago senegalensis). Journal of Auditory Research, 9:19–23.Google Scholar
  8. Johnsson, L.-G., and J. E. Hawkins Jr. 1967. A direct approach to cochlear anatomy and pathology in man. Archives of Otology, 85:599–613.CrossRefGoogle Scholar
  9. Moody, D. B. 1970. Reaction-time as an index of sensory function. In: Stebbins, W. C., ed.. Animal Psychophysics, pp. 277–302. New York, Appleton-Century-Crofts.Google Scholar
  10. Moody, D. B. 1973. Behavioral studies of noise-induced hearing loss in primates: loudness recruitment. In: Hawkins, J. E., M. Lawrence, and W. P. Work, eds.. Advances in Oto- Rhino-Laryngology, Vol. 20, Otophysiology, pp. 82–101. Basel, S. Karger.Google Scholar
  11. Moody, D. B., W. C. Stebbins, and J. M. Miller. 1970. A primate restraint and handling system for auditory research. Behavioral Research Methods and Instrumentation, 2(4): 180–182.CrossRefGoogle Scholar
  12. Rosenberger, P. B. 1970. Response-adjusting stimulus intensity. In: Stebbins, W. C., ed.. Animal Psychophysics, pp. 161–184. New York, Appleton-Century-Crofts.Google Scholar
  13. Sivian, L. G. and S. D. White. 1933. On minimum audible sound fields. Journal of the Acoustical Society of America, 4:288–321.CrossRefGoogle Scholar
  14. Skinner, B. F. 1938. Behavior of Organisms. New York, Appleton-Century-Crofts.Google Scholar
  15. Stebbins, W. C. 1966. Auditory reaction time and the derivation of equal loudness contours for the monkey. Journal of the Experimental Analysis of Behavior, 9:135–142.CrossRefGoogle Scholar
  16. Stebbins, W. C., ed. 1970a. Animal Psychophysics: The Design and Conduct of Sensory Experiments. New York, Appleton-Century-Crofts.Google Scholar
  17. Stebbins, W. C. 1970b. Studies of hearing and hearing loss in the monkey. In: Stebbins, W. C., ed., Animal Psychophysics, pp. 41–66. New York, Appleton-Century-Crofts.Google Scholar
  18. Stebbins, W. C., S. Green, and F. L. Miller. 1966. Auditory sensitivity of the monkey. Science, 153:1646–1647.CrossRefGoogle Scholar
  19. Stebbins, W. C., J. M. Miller, L.-G. Johnsson, and J. E. Hawkins Jr. 1969. Ototoxic hearing loss and cochlear pathology in the monkey. Annals of Otology, Rhinology, and Laryngology, 78(5):1007–1025.Google Scholar
  20. Stebbins, W. C., W. W. Clark, R. D. Pearson, and N. G. Weiland. 1973. Noise- and drug-induced hearing loss in monkeys. In: Hawkins, J. E., M. Lawrence, and W. P. Work, eds., Advances in Oto-Rhino-Laryngology, Vol. 20, Otophysiology, pp. 42–63. Basel, S. Karger.Google Scholar
  21. Taylor, H. M. 1947. Deafness from drugs and chemical poisons. In: Fowler, E. P., ed., Loose- Leaf Medicine of the Ear, pp. 339–348. New York, Thomas Nelson and Sons.Google Scholar

Copyright information

© University of Rochester 1975

Authors and Affiliations

  • William C. Stebbins
    • 1
  • Sheryl Coombs
    • 1
  1. 1.The Kresge Hearing Research Institute and Departments of Otorhinolaryngology and PsychologyUniversity of MichiganAnn ArborUSA

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