Nutritional Deficiencies and Excesses

  • Lucille S. Hurley


Dietary derangement as an agent of teratogenesis has special significance in the history of teratology. The production of congenital anomalies by deficiences of vitamin A and riboflavin marked the beginning of the experimental stage of this science. Since then, these and other nutritional manipulations have served as valuable tools in the development of models, as well as providing information of intrinsic interest in relation to both basic and clinical questions.


Congenital Malformation Zinc Deficiency Iodine Deficiency Nutritional Deficiency Teratogenic Effect 
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  1. Aksu, O., Mackler, B., Shepard, T. H., and Lemire, R. J., 1968, Studies of the development of congenital anomalies in embryos of riboflavin-deficient, galactoflavin-fed rats. II. Role of the terminal electron transport system, Teratology 1: 93.Google Scholar
  2. Allan, J. D., and Brown, J. K., 1968, Maternal phenylketonuria and foetal brain damage, an attempt at prevention by dietary control, in: Some Recent Advances in Inborn Errors of Metabolism ( K. Holt and V. Coffey, eds.), pp. 14–39, E. and S. Livingstone Ltd., Edinburgh.Google Scholar
  3. Allen, L. H., and Zeman, F. J., 1971, Influence of increased postnatal food intake on body composition of progeny of protein-deficient rats, J. Nutr. 101: 1311.Google Scholar
  4. Allen, L. H., and Zeman, F. J., 1973a, Influence of increased postnatal nutrient intake on kidney cellular development in progeny of protein-deficient rats, J. Nutr. 103: 929.Google Scholar
  5. Allen, L. H., and Zeman, F. J., 19736, Kidney function in the progeny of protein-deficient rats, J. Nutr. 103: 1467.Google Scholar
  6. Ailing, C., Bruce, A., Karlsson, I., Sapia, O., and Svennerholm, L., 1972, Effect of maternal essential fatty acid supply on fatty acid composition of brain, liver, muscle and serum in 21-day-old rats, J. Nutr. 102: 773.Google Scholar
  7. Alt, H. L., 1938, Iron deficiency in pregnant rats, its effect on the young, Am. J. Dis. Child. 56: 975.Google Scholar
  8. Andersen, D. H., 1949, Effect of diet during pregnancy upon the incidence of congenital hereditary diaphragmatic hernia in the rat. Failure to produce cystic fibrosis of the pancreas by maternal vitamin A deficiency, Am. I. Pathol. 25: 163.Google Scholar
  9. Antonov, A. N., 1947, Children born during the seige of Leningrad in 1942,J Pediatr. 30: 250.Google Scholar
  10. Asling, C. W., 1961, Congenital defects of face and palate in rats following maternal deficiency of pteroylglutamic acid, in: Congenital Anomalies of the Face and Associated Structures ( S. Pruzansky, ed.), pp. 173–187, Charles C Thomas, Springfield, Illinois.Google Scholar
  11. Asling, C. W., and Hurley, L. S., 1963, The influence of trace elements on the skeleton. Clin. Orthopaed. 27: 213.Google Scholar
  12. Asling, C. W., Nelson, M. M., Wright, H. V., and Evans, H. M., 1955, Congenital skeletal abnormalities in fetal rats resulting from maternal pteroylglumatic acid deficiency during gestation, Anat. Rec. 121: 775.Google Scholar
  13. Asling, C. W., Hurley, L. S., and Wooten, E., 1960a, Abnormal development of the otic labyrinth in young rats following maternal dietary manganese deficiency, Anat. Rec. 136: 157.Google Scholar
  14. Asling, C. W., Nelson, M. M., Dougherty, H. D., Wright, H. V., and Evans, H. M., 1960b, The development of cleft palate resulting from maternal pteroylglutamic (folic) acid deficiency during the latter half of gestation in rats, Surg. Gynecol. Obstet. 111: 19.Google Scholar
  15. Baird, C. D. C., Nelson, M. M., Monie, I. W., and Evans, H. M., 1954, Congenital cardiovascular anomalies induced by pteroylglumatic acid deficiency during gestation in the rat, Circ. Res. 2: 544.Google Scholar
  16. Bannon, S. L., Higginbottom, R. M., McConnell, J. M., and Kaan, H. W., 1945, Development of galactose cataract in the albino rat embryo, Arch. Ophthalmol. 33: 224.Google Scholar
  17. Barnes, R. H., 1971, Nutrition and man’s intellect and behavior, Fed. Proc. 30: 1429.Google Scholar
  18. Bawden, J. W., and Osborne, J. W., 1962, Tracer study on the effect of dietary calcium deficiency during pregnancy in rats, J Dent. Res. 41: 1349.Google Scholar
  19. Bell, L. T., and Hurley, L. S., 1973, Ultrastructural effects of manganese deficiency in liver, heart, kidney and pancreas of mice. Lab. Invest. 29: 723.Google Scholar
  20. Bell, L. T., Branstrator, M., Roux, C., and Hurley, L. S., 1976, Chromosomal abnormalities in maternal and fetal tissues of magnesium or zinc deficient rats, Teratology 12: 221.Google Scholar
  21. Bennetts, H. W., 1932, Enzootic ataxia of lambs in Western Australia, Aust. Vet. J. 8: 137.Google Scholar
  22. Bennetts, H. W., and Chapman, F. E., 1937, Copper deficiency in sheep in Western Australia: A preliminary account of the aetiology of enzootic ataxia of lambs and an anaemia of ewes, Aust. Vet. J. 13: 138.Google Scholar
  23. Bennetts, H. W., and Beck, A. B., 1942, Enzootic ataxia and copper deficiency of sheep in Western Australia, Australian Council Sci. Ind. Res., Bull. No. 147.Google Scholar
  24. Berg, B. N., 1965, Dietary restriction and reproduction in the rat, J. Nutr. 87: 344.Google Scholar
  25. Berg, B. N., Sigg, E. B., and Greengard, P., 1967, Maintenance of pregnancy in protein-deficient rats by adrenocortical steroid or ACTH administration, Endocrinology 80: 829.Google Scholar
  26. Bergner, L., and Susser, M. W., 1970, Low birth weight and prenatal nutrition: An interpretative review, Pediatrics 46: 946.Google Scholar
  27. Bernhardt, I. B., and Dorsey, D. J., 1974, Hypervitaminosis A and congenital renal anomalies in a human infant, Obstet. Gynecol. 43: 750.Google Scholar
  28. Bessman, S. P., 1972, Genetic failure of fetal amino acid `justification“: A common basis for many forms of metabolic, nutritional, and ”nonspecific“ mental retardation, J. Pediatr. 81: 834.Google Scholar
  29. Blackwell, B. N., Blackwell, R. Q., Yu, T. T. S., Weng, Y. S., and Chow, B. F., 1969, Further studies on growth and feed utilization in progeny of underfed mother rats, J. Nutr. 97: 79.Google Scholar
  30. Bodansky, M., and Duff, V. B., 1941, Relation of parathyroid function and diet to the mineral composition of the bones in rats at the conclusion of pregnancy, J. Nutr. 21: 235.Google Scholar
  31. Boelter, M. D. D., and Greenberg, D. M., 1943, Effect of severe calcium deficiency on pregnancy and lactation in the rat, J. Nutr. 26: 105.Google Scholar
  32. Bologna, U., and Piccioni, V., 1956, Effetti dell’ipovitaminosi B2 sulla gravidanza e sui nati del ratto albino, Soc. Ital. Biol. Speriment. 26: 219.Google Scholar
  33. Brasel, J. A., and Winick, M., 1972, Maternal nutrition and prenatal growth. Experimental studies of effects of maternal undernutrition on fetal and placental growth, Arch. Dis. Child. 47: 479.Google Scholar
  34. Braun, K., Bromberg, Y. M., and Brzezinski, A., 1945, Riboflavin deficiency in pregnancy, J. Obstet. Gynecol. 52: 43.Google Scholar
  35. Brimblecombe, F. S. W., Ashford, J. R., and Fryer, J. G., 1968, Significance of low birth weight in perinatal mortality, Br. J. Prey. Soc. Med. 22: 27.Google Scholar
  36. Brown, M. L., and Snodgrass, C. H., 1965, Effect of dietary level of thiamine on reproduction in the rat, J. Nutr. 85: 102.Google Scholar
  37. Brzezinski, A., Bromberg, Y. M., and Braun, K., 1947, Riboflavin deficiency in pregnancy, its relationship to the course of pregnancy and to the condition of the foetus, J. Obstet. Gynecol. 54: 182.Google Scholar
  38. Burch, R. E., and Sullivan, J. F., 1976, Clinical and nutritional aspects of zinc deficiency and excess, in: Symposium on Trace Elements, (R. E. Burch and J. F. Sullivan, eds.) Med. Clin. N. Amer. 60: 675–685.Google Scholar
  39. Burke, B. S., and Stuart, H. C., 1948, Nutritional requirements during pregnancy and lactation, J. Am. Med. Assoc. 137: 119.Google Scholar
  40. Burke, B. S., Beal, V. A., Kirkwood, S. B., and Stuart, H. C., 1943, The influence of nutrition during pregnancy upon the condition of the infant at birth, J. Nutr. 26: 569.Google Scholar
  41. Burr, G. O., and Burr, M. M., 1930, On the nature and role of the fatty acids essential in nutrition, J. Biol. Chem. 86: 587.Google Scholar
  42. Butcher, R. E., Brunner, R. L., Roth, T., and Kimmel, C. A., 1972, A learning impairment associated with maternal hypervitaminosis-A in rats, Life Sci. I 11 (3): 141.Google Scholar
  43. Cancilla, P. A., and Barlow, R. M., 1966a, Structural changes of the central nervous system in swayback (enzootic ataxia) of lambs. II. Electron microscopy of the lower motor neuron, Acta Neuropathol. 6: 251.Google Scholar
  44. Cancilla, P. A., and Barlow, R. M., 1966b, Structural changes of central nervous system in swayback (enzootic ataxia) of lambs. III. Electron microscopy of the cerebral lesion, Acta Neuropathol. 6: 260.Google Scholar
  45. Carswell, F., Kerr, M. M., and Hutchison, J. H., 1970, Congenital goitre and hypothyroidism produced by maternal ingestion of iodides, Lancet 1: 1241.Google Scholar
  46. Chamberlain, J. G., 1966, Development of cleft palate induced by 6-aminonicotinamide late in rat gestation, Anat. Rec. 156: 31.Google Scholar
  47. Chamberlain, J. G., and Nelson, M. M., 1963a, Congenital abnormalities in the rat resulting from single injections of 6-aminonicotinamide during pregnancy, J. Exp. Zool. 153: 285.Google Scholar
  48. Chamberlain, J. G., and Nelson, M. M., 1963b, Multiple congenital abnormalities in the rat resulting from acute maternal niacin deficiency during pregnancy, Proc. Soc. Exp. Biol. Med. 112: 836.Google Scholar
  49. Chase, H. P., 1973, The effects of intrauterine and postnatal undernutrition on normal brain development, Ann. N.Y. Acad. Sci. 205: 231.Google Scholar
  50. Cheng, D. W., Chang, L. F., and Bairnson, T. A., 1957, Gross observations on developing abnormal embryos induced by maternal vitamin E deficiency, Anat. Rec. 129: 167.Google Scholar
  51. Cheng, D. W., Bairnson, T. A., Rao, A. N., and Subbammal, S., 1960, Effect of variations of rations on the incidence of teratogeny in vitamin E deficient rats, J. Nutr. 71: 54.Google Scholar
  52. Cheng, D. W:, Braun, K. G., Braun, B. J., and Udani, K. H., 1961, Tocopherol content of maternal and fetal rat tissues as related to vitamin E intake during gestation, J. Nutr. 74: 111.Google Scholar
  53. Chepenik, K. P., Johnson, E. M., and Kaplan, S., 1970, Effects of transitory maternal pteroylglutamic acid (PGA) deficiency on levels of adenosine phosphates in developing rat embryos. Teratology 3: 229.Google Scholar
  54. Chow, B. F., 1964, Growth of rats from normal dams restricted in diet in previous pregnancies, J. Nutr. 83: 289.Google Scholar
  55. Chow, B. F., and Lee, C. J., 1964, Effect of dietary restriction of pregnant rats on body weight gain of the offspring, J. Nutr. 82: 10.Google Scholar
  56. Christian, J. R., and Diamond, E. F., 1961, Galactosemia, a family study, Am. J. Dis. Child. 101: 75.Google Scholar
  57. Clark, G. M., Zamenhof, S., van Marthens, E., Grauel, L., and Kruger, L., 1973, The effect of prenatal malnutrition on dimensions of cerebral cortex, Brain Res. 54: 397.Google Scholar
  58. Clausen, J., 1969, The effect of vitamin A deficiency on myelination in the central nervous system of the rat, Eur. J. Biochem. 7: 575.Google Scholar
  59. Clements, F. W., 1960, Health significance of endemic goitre and related conditions. in: Endemic Goitre, pp. 245–260, World Health Organization, Geneva.Google Scholar
  60. Cohlan, S. Q., 1953, Excessive intake of vitamin A as a cause of congenital anomalies in the rat, Science 117: 535.Google Scholar
  61. Cohlan, S. Q., and Stone, S. M., 1961, Effects of dietary and intraperitoneal excess of L-lysine and L-leucine on rat pregnancy and offspring,J Nutr. 74: 93.Google Scholar
  62. Cohlan, S. Q., Jansen, V., Dancis, J., and Piomelli, S., 1970, Microcytic anemia with erythroblastosis in the offspring of magnesium deprived rats. Blood 36: 500.Google Scholar
  63. Comar, C. L., 1956, Radiocalcium studies in pregnancy, Ann. N.Y. Acad. Sci. 64: 281.Google Scholar
  64. Committee on Maternal Nutrition/Food and Nutrition Board, National Research Council, 1970, Maternal Nutrition and the Course of Pregnancy, National Academy of Sciences, Washington, D.C.Google Scholar
  65. Cox, W. M., Jr., and Imboden, M., 1936, The role of calcium and phosphorus in determining reproductive success, J. Nutr. 11: 147.Google Scholar
  66. Dakshinamurti, K., and Stephens, M. C., 1969, Pyridoxine deficiency in the neonatal rat, J. Neurochem. 16: 1515.Google Scholar
  67. Dancis, J., and Springer, D., 1970, Fetal homeostatsis in maternal malnutrition: Potassium and sodium deficiency in rats, Pediatr. Res. 4: 345.Google Scholar
  68. Dancis, J., Springer, D., and Cohlan, S. Q., 1971, Fetal homeostasis in maternal malnutrition. II. Magnesium deprivation. Pediatr. Res. 5: 131.Google Scholar
  69. Daniels, A. L., and Everson, G. J., 1935, The relation of manganese to congenital debility. J. Nutr. 9: 191.Google Scholar
  70. Danks, D. M., Campbell, P. E., Stevens, B. F., Mayne, V., and cartwright, E., 1972, Menkes’s kinky hair syndrome. An inherited defect in copper absorption with widespread effects. Pediatrics 50: 188.Google Scholar
  71. Davis, S. D., Nelson, T., and Shepard, T. H., 1970, Teratogenicity of vitamin BB deficiency: Omphalocele, skeletal and neural defects, and splenic hypoplasia, Science 169: 1329.Google Scholar
  72. DeLuca, H. F., 1974, Vitamin D: The vitamin and the hormone, Fed. Proc. 33: 2211.Google Scholar
  73. Deuel, H. J., Jr., Martin, C. R., and Alfin-Slater, R. B., 1954, The effect of fat level of the diet on general nutrition. XII. The requirement of essential fatty acids for pregnancy and lactation, J. Nutr. 54: 193.Google Scholar
  74. Diamond, I., and Hurley, L. S., 1970, Histopathology of zinc-deficient fetal rats. J. Nutr. 100: 325.Google Scholar
  75. Dickerson, J. W. T., and Hughes, P. C. R. 1972, Growth of the rat skeleton after severe nutritional intrauterine and post-natal retardation. Resuscitation 1: 163.Google Scholar
  76. Dingle, J. T., and Lucy, J. A., 1965, Vitamin A. carotenoids and cell formation, Biol. Rev. 40: (3): 422.Google Scholar
  77. DiSaia, P. J., 1966, Pregnancy and delivery of a patient with a Starr—Edwards mitral valve prosthesis, Obstet. Gynecol. 28: 469.Google Scholar
  78. Dobbing, J., 1972, Vulnerable periods of brain development. In: Lipids, Malnutrition and the Developing Brain ( A. Von Murait, ed.), p. 9, Assoc. Sci. Pub., Amsterdam.Google Scholar
  79. Dreosti, I. E., Tao, S., and Hurley, L. S., 1968, Plasma zinc and leukocyte changes in weanling and pregnant rats during zinc deficiency. Proc. Soc. Exp. Biol. Med. 127: 169.Google Scholar
  80. Dreosti, I. E., Grey, P. C., and Wilkens, D. J., 1972, Deoxyribonucleic acid synthesis, protein synthesis and teratogenesis in zinc-deficient rats. S. Afr. Med. J. 46: 1585.Google Scholar
  81. Dutt, B., and Mills, C. F., 1960, Reproductive failure in rats due to copper deficiency, J. Comp. Pathol. 70: 120.Google Scholar
  82. Eberle, E. D., and Eiduson, S., 1968, Effect of pyridoxine deficiency on aromatic r-amino acid decarboxylase in the developing rat liver and brain, J. Neurochem. 15: 1071.Google Scholar
  83. Emanuel, I., and Sever, L. E., 1973, Questions concerning the possible association of potatoes and neural-tube defects, and an alternative hypothesis relating to maternal growth and development. Teratology 8: 325.Google Scholar
  84. Ensminger, M. E., Bowland, J. P., and Cunha, T. J., 1947, Observations on the thiamine, riboflavin, and choline needs of sows for reproduction]. Anim. Sci. 6: 409.Google Scholar
  85. Ershoff, B. H., and Kruger, L., 1962, A neurological defect in the offspring of rats fed a pantothenic acid-deficient diet during pregnancy. Exp. Med. Surg. 20: 180.Google Scholar
  86. Erway, L. C., and Mitchell, S. E., 1973, Prevention of otolith defect in pastel mink by manganese supplementation. J. Hered. 64: 110.Google Scholar
  87. Erway, L., Hurley, L. S., and Fraser, A., 1966, Neurological defect: Manganese in phenocopy and prevention of a genetic abnormality of inner ear. Science 152: 1766.Google Scholar
  88. Erway, L., Hurley, L. S., and Fraser, A., 1970, Congenital ataxia and otolith defects due to manganese deficiency in mice. J. Nutr. 100: 643.Google Scholar
  89. Erway, L., Fraser, A., and Hurley, L. S., 1971, Prevention of congenital otolith defect in Pallid mutant mice by manganese supplementation. Genetics 67: 97.Google Scholar
  90. Evans, H. M., and Bishop, K. S., 1922, On the existence of a hitherto unrecognized dietary factor essential for reproduction, Science 56: 650.Google Scholar
  91. Evans, H. M., Lepkovsky, S., and Murphy, E. A., 1934a, Vital need of the body for certain unsaturated fatty acids. IV. Reproduction and lactation upon fat-free diet, J. Biol. Chem. 106: 431.Google Scholar
  92. Evans, H. M., Lepkovsky, S., and Murphy, E. A., 1934b, Vital need of the body for certain unsaturated fatty acids. V. Reproduction and lactation upon diets containing saturated fatty acids as their sole source of energy, J Biol. Chem. 106: 441.Google Scholar
  93. Everson, G., Northrop, L., Chung, N. Y., Getty, R., and Pudelkewicz, C., 1954, Effect of varying the intake of calcium pantothenate of rats during pregnancy. I. Chemical findings in the young at birth, J. Nutr. 53: 341.Google Scholar
  94. Everson, G. J., Hurley, L. S., and Geiger, J. F., 1959, Manganese deficiency in the guinea pig. J. Nutr. 68: 49.Google Scholar
  95. Everson, G. J., Tsai, H.-C. C., and Wang, T., 1967, Copper deficiency in the guinea pig, J. Nutr. 93: 533.Google Scholar
  96. Everson, G. J., Shrader, R. E., and Wang, T., 1968, Chemical and morphological changes in the brains of copper-deficient guinea pigs,J Nutr. 96: 115.Google Scholar
  97. Fairney, A., and Weir, A. A., 1970, The effect of abnormal maternal plasma calcium levels on the offspring of rats, J. Endocrinol. 48: 337.Google Scholar
  98. Falchuk, K. H., Fawcett, D. W., and Vallee, B. L., 1975, Role of zinc in cell division of Euglena Gracilis, J. Cell Sci. 17: 57.Google Scholar
  99. Felig, P., and Lynch, V., 1970, Starvation in human pregnancy: Hypoglycemia, hypoinsulinemia, and hyperketonemia, Science 170: 990.Google Scholar
  100. Fell, B. F., Williams, R. B., and Mills, C. F., 1961, Further studies of nervous-tissue degeneration resulting from “conditioned” copper deficiency in lambs. Proc. Nutr. Soc. 20:xxvii.Google Scholar
  101. Fell, B. F., Mills, C. F., and Boyne, R., 1965, Cytochrome oxidase deficiency in the motor neurones of copper-deficient lambs: A histochemical study, Res. Vet. Sci. 6: 170.Google Scholar
  102. Fellers, F. X., and Schwartz, R., 1958, Etiology of the severe form of idiopathic hypercalcemia of infancy, N. Engl. J. Med. 259: 1050.Google Scholar
  103. Ferm, V. H., 1972, The teratogenic effects of metals on mammalian embryos, Adv. Teratol. 5: 51.Google Scholar
  104. Ferm, V. H., 1967, Potentiation of the teratogenic effect of vitamin A with exposure to low environmental temperature, Life Sci. 6: 493.Google Scholar
  105. Fierro-Benitez, R., Ramirez, I., Garces, J., Jaramillo, C., Moncayo, F., and Stanbury, J. B., 1974, The clinical pattern of cretinism as seen in highland Ecuador, Am. J. Clin. Nutr. 27: 531.Google Scholar
  106. Fillmore, S. J., and McDevitt, E., 1970, Effects of coumarin compounds on the fetus, Ann. Intern. Med. 73: 731.Google Scholar
  107. Finnerty, J. J., and Mackay, B. R., 1962, Antepartum thrombophlebitis and pulmonary embolism, Obstet. Gynecol. 19: 405.Google Scholar
  108. Fisch, R. O., Doeden, D., Lansky, L. L., and Anderson, J. A., 1969, Maternal phenylketonuria, Am. J. Dis. Child. 118: 847.Google Scholar
  109. Forfar, J. O., Tompsett, S. L., and Forshall, W., 1959, Biochemical studies in idiopathic hypercalcaemia of infancy, Arch. Dis. Child. 34: 525.Google Scholar
  110. Fraser, J. L., and Watt, H. J., 1964, Megaloblastic anemia in pregnancy and the puerperium, Am. J. Obstet. Gynecol. 89: 532.Google Scholar
  111. Fratta, I. D., 1969, Nicotinamide deficiency and thalidomide: Potential teratogenic disturbances in Long—Evans rats, Lab. Anim. Care 19: 727.Google Scholar
  112. Fratta, I., Zak, S. B., Greengard, P., and Sigg, E. B., 1964, Fetal death from nicotinamide- deficient diet and its prevention by chlorpromazine and imipramine, Science 145: 1429.Google Scholar
  113. Friedman, W. F., and Mills, L. F., 1969, The relationship between vitamin D and the craniofacial and dental anomalies of the supravalvular aortic stenosis syndrome, Pediatrics 43: 12.Google Scholar
  114. Friedman, W. F., and Roberts, W. C., 1966, Vitamin D and the supravalvular aortic stenosis syndrome, the transplacental effects of vitamin D on the aorta of the rabbit, Circulation 34: 77.Google Scholar
  115. Gal, I., Sharman, I. M., and Pryse-Davies, J., 1972, Vitamin A in relation to human congenital malformations. Adv. Teratol. 5: 143.Google Scholar
  116. Giroud, A., and Boisselot, J., 1947, Répercussions de l’avitaminose B2 sur l’embryon du rat, Arch. Fr. Pediatr. 4: 319.Google Scholar
  117. Giroud, A. and Lefè6vres-Boisselot, J., 1951, Anomalies provoquées chez le foetus en l’absence d’acide folique, Arch. Fr. Pediatr. 8: 648.Google Scholar
  118. Giroud, A., and Martinet, M., 1954, Fentes du palais chez l’embryon de rat par hypervitaminose A. C.R. Soc. Biol. 148: 1742.Google Scholar
  119. Giroud, A., and Martinet, M., 1955a, Hypervitaminose A et anomalies chez le foetus de rat, Rev. Intern. Vitaminol. 26: 10.Google Scholar
  120. Giroud, A., and Martinet, M., 1955b, Production d’un excès de liquide amniotique dan l’anencéphalie, C.R. Soc. Biol. 149: 452.Google Scholar
  121. Giroud, A., and Martinet, M., 1955c, Malformations diverses du foetus de rat suivant les stades d’administration de vitamine A en excès, C.R. Soc. Biol. 149: 1088.Google Scholar
  122. Giroud, A., and Martinet, M., 1956a, Tératogenèse par hautes doses de vitamine A en fonction des stades du développement, Arch. Anat. Microsc. Morphol. Exp. 45: 7.Google Scholar
  123. Giroud, A., and Martinet, M., 1956b, Malformations de la face et hypervitaminose A, Rev. Stomatol. 57: 454.Google Scholar
  124. Giroud, A., and Martinet, M., 1956e, Hypervitaminose A et malformations congénitales, Ann. Pediatr. (Semaine des Hopitaux) 32: 1.Google Scholar
  125. Giroud, A., and Martinet, M., 1956d, Hypovitaminose et hypervitaminose A chez le jeune et chez l’embryon, Etud. Néo-Natales 5: 55.Google Scholar
  126. Giroud, A., and Martinet, M., 1959a, Tératogénèse par hypervitaminose A chez lè rat, la souris, le cobaye et le lapin, Arch. Fr. Pediatr. 16: 1.Google Scholar
  127. Giroud, A., and Martinet, M., 1959b, Anencéphalie chez la souris par hypervitaminose A, C.R. Assoc. Anat., XLVI Réunion, Montpellier, March 22–26, p. 288.Google Scholar
  128. Giroud, A., and Martinet, M., 1959c, Malformations oculaires avec fibrose du vitré chez des embryons de lapin soumis à l’hypervitaminose A, Bull. Soc. Ophtalmol. 1959 (3): 1.Google Scholar
  129. Giroud, A., and Martinet, M., 1962, Légèreté de la dose tératogène de la vitamine A, C.R. Soc. Biol. 156: 449.Google Scholar
  130. Giroud, A., Lévy, G., Lefè6vres, J., and Dupuis, R., 1952, Chute du taux de la riboflavine au stade ou se déterminent les malformations embryonnaires, Intern. Z. Vitamin’ 23: 490.Google Scholar
  131. Giroud, A., Lévy, G., and Lefèbvres, J., 1954, Recherches sur le taux de l’acide pantothénique chez les mères et les foetus normaux et chez les mères carencées, Rev. Intern. Vitaminol. 25: 148.Google Scholar
  132. Giroud, A., Lefèbvres, J., Prost, H., and Dupuis, R., 1955, Malformations des membres dues à des lésions vasculaires chez le foetus de rat déficient en acide pantothénique, J. Embryol. Exp. Morphol. 3: 1.Google Scholar
  133. Giroud, A., ‘Lefèbvres, J., and Dupuis, R., 1956, Action partiellement compensatrice de doses élevées d’acide ascorbique au cours de la gestation, chez des rattes déficientes en acide pantothénique, C.R. Soc. Biol. 150: 1735.Google Scholar
  134. Giroud, A., Delmas, A., Prost, H., and Lefèbvres, J., 1957, Malformations encéphaliques par carence en acide pantothénique et leur interprétation, Acta Anat.. 29: 17.Google Scholar
  135. Giroud, A., Martinet, M., and Roux, C., 1958a, Anencéphalie, encéphalocèles, ménigocèles par hypervitaminose A, Arch. Fr. Pediatr. 15: (6): 1.Google Scholar
  136. Giroud, A., Martinet, M., and Roux, C., 1958b, Urétéro-hydronéphrose expérimentale chez l’embryon par hypervitaminose A, Arch. Fr. Pediatr. 15: (4): 1.Google Scholar
  137. Giroud, A., Martinet, M., and Solère, M., 1958c, Encéphalocèles, méningocèles par hypervitaminose A et considérations cliniques, Rev. Neurol. 98: 13.Google Scholar
  138. Giroud, A., Delmas, A., and Martinet, M., 1959, Etude morphogénétique sur des embryons anencéphales, Arch. Anat. Histol. Embryol. Norm. Exper. 42: 203.Google Scholar
  139. Giroud, A., Boisselot-Lefèbvres, J., and Dupuis, R., 1961, Carence tératogène en acide pantothénique. Légèreté de la carence, Bull. Soc. Chim. Biol. 43: 859.Google Scholar
  140. Goodenday, L. S., and Gordan, G. S., 1971, No risk from vitamin D in pregnancy, Ann. Intern. Med. 75: 807.Google Scholar
  141. Gortner, R. A., Jr., and Ekwurtzel, J. B., 1965, Incidence of teratogeny induced by vitamin E deficiency in the rat, Proc. Soc. Exp. Biol. Med. 119: 1069.Google Scholar
  142. Grainger, R. B., O’Dell, B. L., and Hogan, A. G., 1954, Congenital malformations as related to deficiencies of riboflavin and vitamin B12, source of protein, calcium to phosphorus ratio and skeletal phosphorus metabolism, J. Nutr. 54: 33.Google Scholar
  143. Green, H. G., Gareis, F. J., Shepard, T. H., and Kelley, V. C., 1971, Cretinism associated with maternal sodium iodide I131 therapy during pregnancy, Am. J. Dis. Child. 122: 247.Google Scholar
  144. Greengard, P., Sigg, E. B., Fratta, I., and Zak, S. B., 1966, Prevention and remission by adrenocortical steroids of nicotinamide deficiency disorders and of 6-aminonicotinamide toxicity in rats and dogs, J. Pharmacol. Exp. Ther. 154: 624.Google Scholar
  145. Hale, F., 1933, Pigs born without eye balls, J. Hered. 24: 105.Google Scholar
  146. Hale, F., 1934, The relation of vitamin A to the eye development in the pig, Record of Proceedings, Annual Meeting, 1934, American Society of Animal Production, p. 126.Google Scholar
  147. Hale, F., 1935, The relation of vitamin A to anophthalmos in pigs, Am. J. Ophthalmol. 18: 1087.Google Scholar
  148. Hale, F., 1937, The relation of maternal vitamin A deficiency to microphthalmia in pigs, Tex. State J. Med. 33: 37.Google Scholar
  149. Hall, G. A., and Howell, J. McC., 1969, The effect of copper deficiency on reproduction in the female rat, Br. J. Nutr. 23: 41.Google Scholar
  150. Hall, M. H., 1972, Folic acid deficiency and congenital malformation, J. Obstet. Gynaecol. Br. 79: 159.Google Scholar
  151. Hall, S. M., and Zeman, F. J., 1968, Kidney function of the progeny of rats fed a low protein diet. J. Nutr. 95: 49.Google Scholar
  152. Hart, E. B., and Steenbock, H., 1918, Thyroid hyperplasia and the relation of iodine to the hairless pig malady, J. Biol. Chem. 33: 313.Google Scholar
  153. Hart, E. B., McCollum, E. V., Steenbock, H., and Humphrey, G. C., 1911, Physiological effect on growth and reproduction of rations balanced from restricted sources, Wis. Exp. Stn. Res. Bull. 17: 160.Google Scholar
  154. Hart, E. B., Steenbock, H., Humphrey, G. C., and Hulce, R. S., 1924, New observations and a reinterpretation of old observations on the nutritive value of the wheat plant, J. Biol. Chem. 62: 315.Google Scholar
  155. Haworth, J. C., Ford, J. D., and Younoszai, M. K., 1969, Effect of galactose toxicity on growth of the rat fetus and brain, Pediatr. Res. 3: 441.Google Scholar
  156. Hibbard, B. M., 1964, The role of folic acid in pregnancy, J. Obstet. Gynecol. 71: 529.Google Scholar
  157. Hibbard, B. M., and Hibbard, E. D., 1966, Recurrence of defective folate metabolism in successive pregnancies, J. Obstet. Gynaecol. 73: 428.Google Scholar
  158. Hibbard, E. D., and Smithells, R. W., 1965, Folic acid metabolism and human embryopathy, Lancet 1: 1254.Google Scholar
  159. Hirsh, J., Cade, J. F., and O’Sullivan, E. F., 1970, Clinical experience with anticoagulant therapy during pregnancy, Br. Med. J. 1: 270.Google Scholar
  160. Hogan, A. G., O’Dell, B. L., and Whitley, J. R., 1950, Maternal nutrition and hydrocephalus in newborn rats, Proc. Soc. Exp. Biol. Med. 74: 272.Google Scholar
  161. Hsueh, A. M., Blackwell, R. Q., and Chow, B. F., 1970, Effect of maternal diet in rats on feed consumption of the offspring, J. Nutr. 100: 1157.Google Scholar
  162. Hurley, L. S., 1968a, Approaches to the study of nutrition in mammalian development, Fed. Proc. 27: 193.Google Scholar
  163. Hurley, L. S., 1968b, The consequences of fetal impoverishment, Nutr. Today 3: 3.Google Scholar
  164. Hurley, L. S., 1969, Nutrients and genes: Interactions in development. Nutr. Rev. 27: 3.Google Scholar
  165. Hurley, L. S., 1971, Magnesium deficiency during pregnancy and its effect on the offspring. A comprehensive review. Proceedings of First International Symposium on Magnesium Deficiency in Human Pathology, pp. 481–492, May, Vittel, France, Imprimerie Amelot, 27 Brionne, France.Google Scholar
  166. Hurley, L. S., 1974a, Aspects of mineral metabolism in the perinatal period. in: Perinatal Pharmacology: Problems and Priorities, U. Dancis and J. C. Hwang, eds.), pp. 149–158, Raven Press, New York.Google Scholar
  167. Hurley, L. S., 1974b, Zinc deficiency, potatoes, and congenital malformations in man, Teratology 10: 205.Google Scholar
  168. Hurley, L. S., and Asling, C. W., 1963, Localized epiphyseal dysplasia in offspring of manganese-deficient rats, Anat. Rec. 145: 25.Google Scholar
  169. Hurley, L. S., and Bell, L. T., 1974a, Amelioration by copper supplementation of mutant gene crinkled in mice, Teratology 9: A22.Google Scholar
  170. Hurley, L. S., and Bell, L. T., 1974b, Genetic influence on response to dietary manganese deficiency, J. Nutr. 104: 133.Google Scholar
  171. Hurley, L. S., and Cosens, G., 1970, Teratogenic magnesium deficiency in pregnant rats, Teratology 3: 202.Google Scholar
  172. Hurley, L. S., and Cosens, G., 1971, Congenital malformations and fetal anemia resulting from magnesium deficiency in rats, Fed. Proc. 30: 516.Google Scholar
  173. Hurley, L. S., and Cosens, G., 1974, Reproduction and prenatal development in relation to dietary zinc level, in: Trace Element Metabolism in Animals, Vol. 2 ( W. G. Hoekstra, J. W. Suttie H. E. Ganther, and W. Mertz, eds.), pp. 516–518, University Park Press, Baltimore.Google Scholar
  174. Hurley, L. S., and Everson, G. J., 1959, Delayed development of righting reflexes in offspring of manganese-deficient rats, Proc. Soc. Exp. Biol. Med. 102: 360.Google Scholar
  175. Hurley, L. S., and Everson, G. J., 1963, Influence of timing of short-term supplementation during gestation on congenital abnormalities of manganese deficient rats, J. Nutr. 79: 23.Google Scholar
  176. Hurley, L. S., and Mutch, P. B., 1973, Prenatal and postnatal development after transitory gestational zinc deficiency in rats. J. Nutr. 103: 649.Google Scholar
  177. Hurley, L. S., and Shrader, R. E., 1972, Congenital malformations of the nervous system in zinc-deficient rats, in: Neurobiology of the Trace Metals Zinc and Copper, (C. C. Pfeiffer, ed.), pp. 7–51, International Review of Neurobiology, Suppl. 1, Academic Press, New York.Google Scholar
  178. Hurley, L. S. and Shrader, R. E., 1975, Abnormal development in preimplantation eggs after four days of maternal dietary zinc deficiency, Nature 254: 427.Google Scholar
  179. Hurley, L. S., and Swenerton, H., 1966, Congenital malformation resulting from zinc deficiency in rats. Proc. Soc. Exp. Biol. Med. 123: 692.Google Scholar
  180. Hurley, L. S., and Swenerton, H., 1971, Lack of mobilization of bone and liver zinc under teratogenic conditions of zinc deficiency in rats. J. Nutr. 101: 597.Google Scholar
  181. Hurley, L. S., and Tao, S., 1972, Alleviation of teratogenic effects of zinc deficiency by simultaneous lack of calcium. Am. J. Physiol. 222: 322.Google Scholar
  182. Hurley, L. S., and Volkert, N. E., 1965, Pantothenic acid and coenzyme A in the developing guinea pig liver, Biochim. Biophys. Acta. 104: 372.Google Scholar
  183. Hurley, L. S., Everson, G. J., and Geiger, J. F., 1958, Manganese deficiency in rats: Congenital nature of ataxia, J. Nutr. 66: 309.Google Scholar
  184. Hurley, L. S., Wooten, E., Everson, G. J., and Asling, C. W., 1960, Anomalous development of ossification in the inner ear of offspring of manganese deficient rats, J. Nutr. 71: 15.Google Scholar
  185. Hurley, L. S., Wooten, E., and Everson, G. J., 1961a, Disproportionate growth in offspring of manganese-deficient rats. II. Skull, brain, and cerebrospinal fluid pressure, J. Nutr. 74: 282.Google Scholar
  186. Hurley, L. S., Everson, G. J., Wooten, E., and Asling, C. W., 1961b, Disproportionate growth in offspring of manganese-deficient rats. I. The long bones, J. Nutr. 74: 274.Google Scholar
  187. Hurley, L. S., Volkert, N. E., and Eichner, J. T., 1965, Pantothenic acid deficiency in pregnant and non-pregnant guinea pigs, with special reference to effects on the fetus, J. Nutr. 86: 201.Google Scholar
  188. Hurley, L. S., Gowan, J., and Shrader, R., 1968a, Genetic–nutritional interaction in relation to manganese and calcification. in: Les tissues calcfiés, Symposium européen, Société d’enseignement supérieur, Paris, pp. 101–104.Google Scholar
  189. Hurley, L. S., Dreosti, I. E., and Swenerton, H., 1968b, Studies on zinc enzymes and nucleic acid synthesis in relation to congenital malformations in zinc deficient rats, Proc. West. Hemisphere Nutr. Congr. II, San Juan, Puerto Rico, p. 39.Google Scholar
  190. Hurley, L. S., Gowan, J., and Swenerton, H., 1971, Teratogenic effects of short-term and transitory zinc deficiency in rats, Teratology 4: 199.Google Scholar
  191. Hurley, L. S., Sucher, K., Story, D., and Cosens, G., 1973, Interaction of dietary protein and zinc in the pregnant rat, J. Nutr. 103:xxv.Google Scholar
  192. Hutchings, D. E., and Gaston, J., 1974, The effects of vitamin A excess administered during the mid-fetal period on learning and development in rat offspring, Deli. Psychobiol. 7: 225.Google Scholar
  193. Hutchings, D. E., Gibbon, J., and Kaufman, M. A., 1973, Maternal vitamin A excess during the early fetal period: Effects on learning and development in the offspring, Dev. Psychobiol. 6: 445.Google Scholar
  194. Hytten, F. E., and Leitch, I., 1971, The Physiology of Human Pregnancy, Blackwell Scientific Publications, Oxford, U.K.Google Scholar
  195. Innes, J. R. M., 1936, “Swayback”—a demyelinating disease of lambs with affinities to Schilder’s encephalitis in man, Vet. Rec. 48: 1539.Google Scholar
  196. Innes, J. R. M., and Shearer, G. D., 1940, “Swayback”; a demyelinating disease of lambs with affinities to Schilder’s encephalitis in man]. Comp. Pathol. Ther. 53:1.Google Scholar
  197. Isselbacher, K. J., 1959, Galactose metabolism and galatosemia, Am. J. Med. 26: 715.Google Scholar
  198. Itoh, H., Hansard, S. L., Glenn, J. C., Hoskins, F. H., and Thrasher, D. M., 1967, Placental transfer of calcium in pregnant sows on normal and limited-calcium rations, J. Anim. Sci. 26: 335.Google Scholar
  199. Jaffe, N. R., and Johnson, E. M., 1973, Alterations in the ontogeny and specific activity of phosphomonoesterases associated with abnormal chondrogenesis and osteogenesis in the limbs of fetuses from folic acid-deficient pregnant rats, Teratology 8: 33.Google Scholar
  200. Jeans, P. C., Smith, M. B., and Stearns, G., 1944, Incidence of prematurity in relation to maternal nutrition, J. Am. Dent. Assoc. 31: 576.Google Scholar
  201. Johnson, E. M., and Chepenik, K. P., 1966, Effects of folic acid deficiency on enzymatic differentiation in embryonic tissues and organs. Anat. Rec. 154: 362.Google Scholar
  202. Kalter, H., and Warkany, J., 1957, Congenital malformations in inbred strains of mice induced by riboflavin-deficient, galactoflavin-containing diets, J. Exp. Zool. 136: 531.Google Scholar
  203. Kelly, F. C., and Snedden, W. W., 1960, Prevalence and geographical distribution of endemic goitre, in: Endemic Goitre, pp. 27–233, World Health Organization, Geneva.Google Scholar
  204. Kenney, M. A., and Roderuck, C. E., 1963, Fatal syndrome associated with vitamin E status of pregnant rats, Proc. Soc. Exp. Biol. Med. 114: 257.Google Scholar
  205. Kerber, I. J., Warr, O. S., III, and Richardson, C., 1968, Pregnancy in a patient with a prosthetic mitral valve, J. Am. Med. Assoc. 203: 223.Google Scholar
  206. Kerr, G. R., Chamove, A. S., Harlow, H.-F., and Waisman, H. A., 1968, “Fetal PKU”: The effect of maternal hyperphenylalaninemia during pregnancy in the Rhesus monkey (Macaca mulatta), Pediatrics 42:27.Google Scholar
  207. Kinney, C. S., and Morse, L. M., 1964, Effect of a folic acid antagonist, aminopterin, on fetal development and nucleic acid metabolism in the rat, J. Nutr. 84: 288.Google Scholar
  208. Kirksey, A., and Pike, R. L., 1962, Some effects of high and low sodium intakes during pregnancy in the rat. 1. Food consumption, weight gain, reproductive performance, electrolyte balances, plasma total protein and protein fractions in normal pregnancy, J Nutr. 77: 33.Google Scholar
  209. Kirksey, A., Pike, R. L., and Callahan, J. A., 1962, Some effects of high and low sodium intakes during pregnancy in the rat. II. Electrolyte concentrations of maternal plasma, muscle, bone and brain and of placenta, amniotic fluid, fetal plasma and total fetus in normal pregnancy, J. Nutr. 77: 43.Google Scholar
  210. Kitay, D. Z., 1969, Folic acid deficiency in pregnancy, Am. J. Obstet. Gynecol. 104: 1067.Google Scholar
  211. Kochhar, D. M., 1967, Teratogenic activity of retinoic acid, Acta Pathol. Microbiol. Scand. 70: 398.Google Scholar
  212. Kochhar, D. M., 1968, Studies of vitamin A-induced teratogenesis: Effects on embryonic mesenchyme and epithelium, and on incorporation of H3-thymidine, Teratology 1: 299.Google Scholar
  213. Kochhar, D. M., 1973, Limb development in mouse embryos, I. Analysis of teratogenic effects of retinoic acid, Teratolgy 7: 289.Google Scholar
  214. Kochhar, D. M., and Johnson, E. M., 1965, Morphological and autoradiographic studies of cleft palate induced in rat embryos by maternal hypervitaminosis A, J. Embryol. Exp. Morphol. 14: 223.Google Scholar
  215. Körner, W. F., and Nowak, H., 1971, The influence of vitamin B6 deficiency during pregnancy on the fetal postnatal development of the rat, in: Malformations congénitales des Mammifères ( H. Tuchmann-Duplessis, ed.), pp. 243–253, Masson et Cie, Paris.Google Scholar
  216. Kratzing, C. C., and Perry, J. J., 1971, Hypertension in young rats following choline deficiency in maternal diets, J. Nutr. 101: 1657.Google Scholar
  217. Kraus, A. P., Perlow, S., and Singer, K., 1949, Danger of Dicurmarol treatment in pregnancy, J. Am. Med. Assoc. 139: 758.Google Scholar
  218. Lamming, G. E., Salisbury, G. W., Hays, R. L., and Kendall, K. A., 1954a, The effect of incipient vitamin A deficiency on reproduction in the rabbit. I. Decidua, ova and fertilization, J. Nutr. 52: 217.Google Scholar
  219. Lamming, G. E., Woollam, D. H. M., and Millen, J. W., 1954b, Hydrocephalus in young rabbits associated with maternal vitamin A deficiency, Br. J. Nutr. 8: 363.Google Scholar
  220. Langer, P., 1960, History of goitre, in: Endemic Goitre, pp. 9–25, World Health Organization, Geneva.Google Scholar
  221. Langman, J., and Welch, G. W., 1966, Effect of vitamin A on development of the central nervous system, J. Comp. Neurol. 128: 1.Google Scholar
  222. Languran, J., and Welch, G. W., 1967, Excess vitamin A and development of the cerebral cortex, J. Comp. Neurol. 131: 15.Google Scholar
  223. Latham, M. C., and Cobos, F., 1971, The effects of malnutrition on intellectual development and learning, Am. J. Public Health 61: 1307.Google Scholar
  224. Lee, Y. C. P., King, J. T., and Visscher, M. B., 1953, Strain difference in vitamin E and B12 and certain mineral trace-element requirements for reproduction in A and Z mice, Am. J. Physiol. 173: 456.Google Scholar
  225. Lefèbvres-Boisselot, J., 1951, Role tératogène de la déficience en acide pantothénique chez le rat, Ann. Med. 52: 225.Google Scholar
  226. Lefebvres-Boisselot, J., and Dupuis, R., 1956, Réduction de la croissance pondérale et trouble du métabolisme de l’eau, chez les foetus de rates déficientes en acide pantothénique, J. Physiol. 48: 598.Google Scholar
  227. Loh, K. R. W., Shrader, R. E., and Zeman, F. J., 1971, Effect of maternal protein deprivation on neonatal intestinal absorption in rats, J. Nutr. 101: 1663.Google Scholar
  228. Luse, S. A., Rhys, A., and Lessey, R., 1970, Effects of maternal phenylketonuria on the rat fetus, Am. J. Obstet. Gynecol. 108: 387.Google Scholar
  229. Lyon, M. F., 1953, Absence of otoliths in the mouse: An effect of the pallid mutant, J. Genet. 51: 638.Google Scholar
  230. Macomber, D., 1927, Effect of a diet low in calcium on fertility, pregnancy and lactation in the rat, J. Am. Med. Assoc. 88: 6.Google Scholar
  231. Marin-Padulla, M., and Ferm, V. H., 1965, Somite necrosis and developmental malformations induced by vitamin A in the golden hamster, J. Embryol. Exp. Morphol. 13 (1): 1.Google Scholar
  232. Martin, M. P., Bridgforth, E., McGanity, W. J., and Darby, W. J., 1957, The Vanderbilt cooperative study of maternal and infant nutrition. X. Ascorbic acid, J. Nutr. 62: 201.Google Scholar
  233. Masi, P. L., Frumento, F., and Parrini, C., 1966, Malformazioni congenite maxillo-dentali nella prole di topi trattati con ipervitaminosi A, Riv. Ist. Sieroter. Ital. 21: 1129.Google Scholar
  234. Maxwell, J. P., 1934, Osteomalacia and diet, Nutr. Abstr. Rev. 4: 1.Google Scholar
  235. McClure, T. J., 1961, Pathogenesis of early embryonic mortality caused by fasting pregnant rats and mice for short periods, J. Reprod. Fertil. 2: 381.Google Scholar
  236. McLaren, D. S., 1968, To eat to see, Nutr. Today 3: 2.Google Scholar
  237. Meader, R. D., 1965, Livers of choline-deficient pregnant and fetal rats. Anat. Rec. 153: 407.Google Scholar
  238. Mellanby, M., and Coumoulos, H., 1944, The improved dentition of 5-year-old London schoolchildren, a comparison between 1943 and 1929, Br. Med. J. 1: 837.Google Scholar
  239. Millen, J. W., and Woollam, D. H. M., 1956, The effect of the duration of vitamin A deficiency in female rabbits upon the incidence of hydrocephalus in their young, J. Neurol. Psychiatr. 19: 17.Google Scholar
  240. Millen, J. W., Woollam, D. H. M., and Lamming, G. E., 1953, Hydrocephalus associated with deficiency of vitamin A, Lancet 2: 1234.Google Scholar
  241. Millen, J. W., Woollam, D. H. M., and Lamming, G. E., 1954, Congenital hydrocephalus due to experimental hypovitaminosis A, Lancet 2: 679.Google Scholar
  242. Miller, J. R., 1962, Strain difference in response to the teratogenic effect of maternal fasting in the house mouse, Can. J. Genet. Cytol. 4: 69.Google Scholar
  243. Miller, Z., Poncet, I., and Takacs, E., 1962, Biochemical studies on experimental congenital malformations: flavin nucleotides and folic acid in fetuses and livers from normal and riboflavin-deficient rats, J. Biol. Chem. 237: 968.Google Scholar
  244. Mills, C. F., and Fell, B. F., 1960, Demyelination in lambs born of ewes maintained on high intakes of sulphate and molybdate, Nature 185: 20.Google Scholar
  245. Mills, C. F., Quarterman, J., Chesters, J. K., Williams, R. B., and Dalgarno, A. C., 1969, Metabolic role of zinc, Am. J. Clin. Nutr. 22: 1240.Google Scholar
  246. Mirone, L., 1954, Effect of choline-deficient diets on growth, reproduction and mortality of mice. Am. J. Physiol. 179: 49.Google Scholar
  247. Mjolnerod, O. K., Dommerud, S. A., Rasmussen, K., and Gjeruldsen, S. T., 1971, Congenital connective-tissue defect probably due to D-penicillamine treatment in pregnancy, Lancet 1: 673.Google Scholar
  248. Monie, I. W., Nelson, M. M., and Evans, H. M., 1954, Abnormalities of the urinary system of rat embryos resulting from maternal pteroylglutamic acid deficiency, Anat. Rec. 120: 119.Google Scholar
  249. Monie, I. W., Nelson, M. M., and Evans, H. M., 1957a, Persistent right umbilical vein as a result of vitamin deficiency during gestation, Circ. Res. 5: 187.Google Scholar
  250. Monie, I. W., Nelson, M. M., and Evans, H. M., 1957b, Abnormalities of the urinary system of rat embryos resulting from transitory deficiency of pteroylglutamic acid during gestation, Anat. Rec. 127: 711.Google Scholar
  251. Moon, W.-H. Y., and Kirksey, A., 1973, Cellular growth during prenatal and early postnatal periods in progeny of pyridoxine-deficient rats,J Nutr. 103: 123.Google Scholar
  252. Moore, R. A., Bittenger, I., Miller, M. L., and Hellman, L. M., 1942, Abortion in rabbits fed a vitamin K deficient diet, Am. J. Obstet. Gynecol. 43: 1007.Google Scholar
  253. Morriss, G. M., 1972, Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A, J. Anat. 113: 241.Google Scholar
  254. Mouriquand, G., and Edel, V., 1953, Sur l’hypervitaminose C, C.R. Soc. Biol. 147: 1432.Google Scholar
  255. Mouriquand, G., Gillet, R., and Coeur, A., 1935, La phase “d’avortement” et la phase de protection maternelle et foetale dans le scorbut experimental, C.R. Soc. Biol. 119: 1230.Google Scholar
  256. Naeye, R. L., 1965, Cardiovascular abnormalities in infants malnourished before birth, Biol. Neonate 8: 104.Google Scholar
  257. Naeye, R. L., Diener, M. M., and Dellinger, W. S., 1969, Urban poverty: Effects on prenatal nutrition, Science 166: 1026.Google Scholar
  258. Naeye, R. L., Diener, M. M., Harcke, H. T., Jr., and Blanc, W. A., 1971, Relation of poverty and race to birth weight and organ and cell structure in the newborn, Pediatr. Res. 5: 17.Google Scholar
  259. Nanda, R., 1971, Tritiated thymidine labelling of the palatal processes of rat embryos with cleft palate induced by hypervitaminosis A. Arch. Oral Biol. 16: 435.Google Scholar
  260. Nanda, R., 1974, Effect of vitamin A on the potentiality of rat palatal processes to fuse in vivo and in vitro, Cleft Palate J. 11: 123.Google Scholar
  261. Nelson, M. M., and Evans, H. M., 1946, Pantothenic acid deficiency and reproduction in the rat, J. Nutr. 31: 497.Google Scholar
  262. Nelson, M. M., and Evans, H. M., 1948, Effect of desoxypyridoxine on reproduction in the rat, Proc. Soc. Exp. Biol. Med. 68: 274.Google Scholar
  263. Nelson, M. M., and Evans, H. M., 1949, Pteroylglutamic acid and reproduction in the rat, J. Nutr. 38: 11.Google Scholar
  264. Nelson, M. M., and Evans, H. M., 1953, Relation of dietary protein levels to reproduction in the rat, J. Nutr. 51: 71.Google Scholar
  265. Nelson, M. M., and Evans, H. M., 1954, Maintenance of pregnancy in the absence of dietary protein with estrone and progesterone, Endocrinology 55: 543.Google Scholar
  266. Nelson, M. M., and Evans, H. M., 1955a, Relation of thiamine to reproduction in the rat, J. Nutr. 55: 151.Google Scholar
  267. Nelson, M. M., and Evans, H. M., 1955b, Maintenance of pregnancy in absence of dietary protein with progesterone, Proc. Soc. Exp. Biol. Med. 88: 444.Google Scholar
  268. Nelson, M. M., Lyons, W. R., and Evans, H. M., 1951, Maintenance of pregnancy in pyridoxine-deficient rats when injected with estrone and progesterone, Endocrinology 48: 726.Google Scholar
  269. Nelson, M. M., Asling, C. W., and Evans, H. M., 1952, Próduction of multiple congenital abnormalities in young by maternal pteroylglutamic acid deficiency during gestation, J. Nutr. 48: 61.Google Scholar
  270. Nelson, M. M., Lyons, W. R., and Evans, H. M., 1953, Comparison of ovarian and pituitary hormones for maintenance of pregnancy in pyridoxine-deficient rats, Endocrinology 52: 585.Google Scholar
  271. Nelson, M. M., Wright, H. V., Asling, C. W., and Evans, H. M., 1955, Multiple congenital abnormalities resulting from transitory deficiency of pteroylglutamic acid during gestation in the rat, J. Nutr. 56: 349.Google Scholar
  272. Nelson, M. M., Wright, H. V., Baird, C. D. C., and Evans, H. M., 1956a, Effect of 36-hour period of pteroylglutamic acid deficiency on fetal development in the rat, Proc. Soc. Exp. Biol. Med. 92: 554.Google Scholar
  273. Nelson, M. M., Baird, C. D. C., Wright, H. V., and Evans, H. M., 1956b, Multiple congenital abnormalities in the rat resulting from riboflavin deficiency induced by the antimetabolite galactoflavin, J. Nutr. 58: 125.Google Scholar
  274. Nelson, M. M., Wright, H. V., Baird, C. D. C., and Evans, H. M., 1957, Teratogenic effects of pantothenic acid deficiency in the rat, J. Nutr. 62: 395.Google Scholar
  275. Netzloff, M., Johnson, E., and Kaplan, S., 1968, Respiratory changes observed in abnormally developing rat embryos, Teratology 1: 375.Google Scholar
  276. Neuweiler, W., 1951, Die Hypervitaminose und ihre Beziehung zur Schwangerschaft, Intern Z. Vitaminforsch 22: 392.Google Scholar
  277. Newberne, P. M., and O’Dell, B. L., 1961, Vitamin B12 deficiency and hydrocephalus, in: Disorders of the Developing Nervous System ( W. S. Fields and M. M. Desmond, eds.), pp. 123–143, Charles C Thomas, Springfield, Illinois.Google Scholar
  278. Newberne, P. M., and Young, V.R., 1973, Marginal vitamin B12 intake during gestation in the rat has long term effects on the offspring, Nature 242: 263.Google Scholar
  279. Newberne, P. M., Ahlstrom, A., and Rogers, A. E., 1970, Effects of maternal dietary lipotropes on prenatal and neonatal rats, J. Nutr. 100: 1089.Google Scholar
  280. Niiyama, Y., Kishi, K., and Inoue, G., 1970, Effect of ovarian steroids on maintenance of pregnancy in rats fed diets devoid of one essential amino acid, J. Nutr. 100: 1461.Google Scholar
  281. Niiyama, Y., Kishi, K., Endo, S., and Inoue, G., 1973, Effect of diets devoid of one essential amino acid on pregnancy in rats maintained by ovarian steroids, J. Nutr. 103: 207.Google Scholar
  282. Nishikawa, M., 1963, Influence of maternal fasting for a short period upon the development of mouse embryos, Kaibogaku Zasshi 38: 181.Google Scholar
  283. Nishimura, H., and Miyamoto, S., 1969, Teratogenic effects of sodium chloride in mice, Acta Anat. 74: 121.Google Scholar
  284. O’Dell, B. L., 1968, Trace elements in embryonic development, in Symposium on Nutrition and Prenatal Development, Fed. Proc. 27: 199.Google Scholar
  285. O’Dell, B. L., Hardwick, B. C., and Reynolds, G., 1961, Mineral deficiencies of milk and congenital malformation in the rat, J. Nutr. 73: 151.Google Scholar
  286. Olwin, J. H., and Koppel, J. L., 1969. Anticoagulant therapy during pregnancy, Obstet. Gynecol. 34: 847.Google Scholar
  287. Orent, E. R., and McCollum, E. V., 1931, Effects of deprivation of manganese in the rat, J. Biol. Chem. 92: 651.Google Scholar
  288. Orent-Keiles, E., Robinson, A., and McCollum, E. V., 1937, The effects of sodium deprivation on the animal organism, Am. J. Physiol. 119: 651.Google Scholar
  289. Ornoy, A., Menczel, J., and Nebel, L., 1968, Alterations in the mineral composition and metabolism of rat fetuses and their placentas induced by maternal hypervitaminosis D2, Isr. J. Med. Sci. 4: 827.Google Scholar
  290. Ornoy, A., Nebel, L., and Menczel, Y., 1969, Impaired osteogenesis of fetal long bones induced by maternal hypervitaminosis D2, Arch. Pathol. 87: 563.Google Scholar
  291. Orony, A., Kaspi, T., and Nebel, L., 1972, Persistent defects of bone formation in young rats following maternal hypervitaminosis D2, Arch. J. Med. Sci. 7: 943.Google Scholar
  292. Palacios-Macedo, X., Diaz-Devis, C., and Escudero, J., 1969, Fetal risk with the use of coumarin anticoagulant agents in pregnant patients with intracardiac ball valve prosthesis, Am. J. Cardiol. 24: 853.Google Scholar
  293. Palludan, B., 1966a, A-Avitaminosis in Swine, Munksgaard, Copenhagen.Google Scholar
  294. Palludan, B., 1966b, Swine in teratological studies, in: Swine in Biomedical Research ( L. K. Bustad and R. O. McClella, eds.), pp. 51–78, Frayn Printing, Seattle, Washington.Google Scholar
  295. Palsson, P. A., and Grimsson, H., 1953, Demyelination in lambs from ewes which feed on sea-weeds, Proc. Soc. Exp. Biol. Med. 83: 518.Google Scholar
  296. Pang, R. L., and Kirksey, A., 1974, Early postnatal changes in brain composition in progeny of rats fed different levels of dietary pyridoxine, J. Nutr. 104: 111.Google Scholar
  297. Parmelee, A. H., Allen, E., Stein, I. F., and Buxbaum, H., 1940, Three cases of congenital goiter, Am. J. Obstet. Gynecol. 40: 145.Google Scholar
  298. Persaud, T. V. N., and Tiesj, D., 1969, Developmental abnormalities in rat induced by amino acid leucine, Naturwissenschaften 56: 37.Google Scholar
  299. Persaud, T. V. N., and Kaplan, S., 1970, The effects of hypoglycin-A, a leucine analogue, on the development of rat and chick embryos, Life Sci. (II) 9: 1305.Google Scholar
  300. Pharoah, P.O.D., Buttfield, I. H., and Hetzel, B. S., 1971, Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy, Lancet 1: 308.Google Scholar
  301. Phillips, G. D., and Sundaram, S. K., 1966, Sodium depletion of pregnant ewes and its effects on foetuses and foetal fluids, J. Physiol. 184: 889.Google Scholar
  302. Pike, R. L., 1951, Congenital cataract in albino rats fed different amounts of tryptophan and niacin, J. Nutr. 44: 191.Google Scholar
  303. Plumlee, M. P., Thrasher, D. M., Beeson, W. M., Andrews, F. N., and Parker, H. E., 1956, The effects of a manganese deficiency upon the growth, development, and reproduction of swine, J. Anim. Sci. 15: 352.Google Scholar
  304. Pond, W. G., Wagner, W. C., Dunn, J. A., and Walker, E. F., Jr., 1968, Reproduction and early postnatal growth of progeny in swine fed a protein-free diet during gestation, J. Nutr. 94: 309.Google Scholar
  305. Popjak, G., 1946, Maternal and foetal tissue-and plasma-lipids in normal and cholesterol-fed rabbits, J. Physiol. 105: 236.Google Scholar
  306. Potier de Courcy, G., 1966a, Caractères globaux des métabolismes nucléique et protéolique chez le foetus de rat carencé en acide pantothénique, Arch. Sci. Physiol. 20: 43.Google Scholar
  307. Potier de Courcy, G., 1966b, Conséquences de la carènce folique sur les caractères généraux des métabolismes nucléique et protéique chez le foetus de rat, Arch. Sci. Physiol. 20: 189.Google Scholar
  308. Potier de Courcy, G., and Desmettre-Miguet, S., 1970, Effects de la carence en riboflavine sur quelques éléments minéraux des tissus foeto-maternels du rat, Arch. Sci. Physiol. 24: 181.Google Scholar
  309. Potier de Courcy, G., and Terroine, T., 1966, Les désoxyribonucléases I et II dans la vie pré-et post-natale du rat normal et carencé en acide folique, Arch. Sci. Physiol. 20: 1.Google Scholar
  310. Potier de Courcy, G., and Terroine, T., 1968a, Influence de la carence en riboflavine sur la fonction phosphatasique alcaline des organes maternels et foetaux à différents stades de la gestation, Ann. Nutr. Aliment. 22: 95.Google Scholar
  311. Potier de Courcy, G., and Terroine, T., 1968b, Conséquences chez le rat de la carence en riboflavine sur la composition globale de certains tissus maternels et foetaux, Arch. Sci. Physiol. 22: 1.Google Scholar
  312. Potier de Courcy, G., Susbielle, H., and Terroine, T., 1970, Etude du zinc dans l’ariboflavinose tératogéne chez le rat, Arch. Sci. Physiol. 24: 409.Google Scholar
  313. Potvliege, P. R., 1972, Hypervitaminosis D2 in gravid rats, Arch. Pathol. 73: 29.Google Scholar
  314. Primrose, T., and Higgins, A., 1971, A study in human antepartum nutrition, J. Reprod. Med. 7: 257.Google Scholar
  315. Purvis, R. J., MacKay, G. S., Cockburn, F., Barrie, W. J. McK., Wilkinson, E. M., Belton, N. R., and Forfar, J. O., 1973, Enamel hypoplasia of the teeth associated with neonatal tetany: A manifestation of maternal vitamin-D deficiency, Lancet 2: 811.Google Scholar
  316. Quick, A. J., 1946, Experimentally induced changes in the prothrombin level of the blood. III. Prothrombin concentration of new-born pups of a mother given dicumarol before parturition, J Biol. Chem. 164: 371.Google Scholar
  317. Richardson, L. R., and Hogan, A. G., 1946, Diet of mother and hydrocephalus in infant rats, J. Nutr. 32: 459.Google Scholar
  318. Rivers, J. M., Krook, L., and Cormier, A., 1970, Biochemical and histological study of guinea pig fetal and uterine tissue in ascorbic acid deficiency, J. Nutr. 100: 217.Google Scholar
  319. Roberts, H. E., Williams, B. M., and Harvard, A., 1966a, Cerebral oedema in lambs associated with hypocuprosis, and its relationship to swayback. I. Field, clinical gross anatomical and biochemical observations, J. Comp. Pathol. 76: 279.Google Scholar
  320. Roberts, H. E., Williams, B. M., and Harvard, A., 1966b, Cerebral oedema in lambs associated with hypocuprosis, and its relationship to swayback. II. Histopathological findings, J. Comp. Pathol. 76: 285.Google Scholar
  321. Roderick, L. M., 1929, The pathology of sweet clover disease in cattle, J. Am. Vet. Med. Assoc. 75: 314.Google Scholar
  322. Roeder, L. M., and Chow, B. F., 1972, Maternal undernutrition and its long-term effects on the offspring, Am. J. Clin. Nutr. 25: 812.Google Scholar
  323. Rosa, F. W., and Turshen, M., 1970, Fetal Nutrition, Bull. W. H. O. 43: 785.Google Scholar
  324. Rosen, J. F., Roginsky, M., Nathenson, G., and Finberg, L., 1974, 25-hydroxyvitamin D, plasma levels in mothers and their premature infants with neonatal hypocalcemia, Am. J. Dis. Child. 127: 220.Google Scholar
  325. Ross, M. L., and Pike, R. L., 1956, The relationship of vitamin B6 to protein metabolism during pregnancy in the rat,J Nutr. 58: 251.Google Scholar
  326. Rothman, D., 1970, Folic acid in pregnancy, Am. J. Obstet. Gynecol. 108: 149.Google Scholar
  327. Roux, C., and Aubry, M., 1966, Teratogenic effect of an inhibition of cholesterol synthesis (AY9944) in the rat, C.R. Soc. Biol. 160: 1353.Google Scholar
  328. Roux, C., and Dupuis, R., 1961, Urohydronéphroses par carence pantothénique,Arch. Fr. Pediatr. 18: 1337.Google Scholar
  329. Roux, J. F., and Yoshioka, T., 1970, Lipid metabolism in the fetus during development, Clin. Obstet. Gynecol. 13: 595.Google Scholar
  330. Roux, C., Fournier, P., Dupuis, Y., and Dupuis, R., 1962a, Anomalies oculaires congénitales dans la carence en vitamine A, Bull. Soc. Ophthalmol. Fr. 1962: 1.Google Scholar
  331. Roux, C., Fournier, P., Dupuis, Y., and Dupuis, R., 1962b, About teratogenic vitamin A deficiency, Biol. Neonate 4: 371.Google Scholar
  332. Ruffo, A., and Vescia, A., 1941, Importanza dell’acido nicotinico per it ratto, Boll. Soc. Ital. Biol. Sper. 16: 185.Google Scholar
  333. Runner, M. N., and Miller, J. R., 1956, Congenital deformity in the mouse as a consequence of fasting, Anat. Rec. 124: 437.Google Scholar
  334. Russell, K. P., Rose, H., and Starr, P., 1957, The effects of radioactive iodine on maternal and fetal thyroid function during pregnancy, Surg. Gynecol. Obstet. 104: 560.Google Scholar
  335. Samborskaya, E. P., and Ferdman, T. D., 1966, The mechanism of termination of pregnancy by ascorbic acid, Bull. Exp. Biol. Med. 62: 934 (in Russian).Google Scholar
  336. Sarma, V., 1959, Maternal vitamin A deficiency and fetal microcephaly and anophthalmia, Obstet. Gynecol. 13: 299.Google Scholar
  337. Schofield, F. W., 1923–1924, Damaged sweet clover: The cause of a new disease in cattle simulating hemorrhagic septicemia and blackleg, J. Am. Vet. Med. Assoc. 64: 553.Google Scholar
  338. Schumacher, M. F., Williams, M. A., and Lyman, R. L., 1965, Effect of high intakes of thiamine, riboflavin and pyridoxine on reproduction in rats and vitamin requirements of the offspring, J. Nutr. 86: 343.Google Scholar
  339. Scott, K. E., and Usher, R., 1966, Fetal malnutrition: Its incidence, causes, and effects, Am. J. Obstet. Gynecol. 94: 951.Google Scholar
  340. Scott, D. E., Whalley, P. J., and Pritchard, J. A., 1970, Maternal folate deficiency and pregnancy wastage. II. Fetal malformation, Obstet. Gynecol. 36: 26.Google Scholar
  341. Scrimshaw, N. S. and Gordon, E., 1968, Malnutrition, Learning and Behavior, M. I. T. Press, Cambridge, Mass.Google Scholar
  342. Scriver, C. R., 1970, Vitamin D dependency, Pediatrics 45: 361.Google Scholar
  343. Scriver, C. R., 1974, Inborn errors of metabolism: A new frontier of nutrition, Nutr. Today 9: 4.Google Scholar
  344. Segal, S., and Bernstein, H., 1963, Observations on cataract formation in the newborn offspring of rats fed high-galactose diet, J. Pediatr. 62: 363.Google Scholar
  345. Sever, L. E., and Emanuel, I., 1973, Is there a connection between maternal zinc deficiency and congenital malformations of the central nervous system in man? Teratology 7: 117.Google Scholar
  346. Shepard, T. H., and Bass, G. L., 1970, Organ culture of limb buds from riboflavin-deficient and normal rat embryos in normal and riboflavin deficient media, Teratology 3: 163.Google Scholar
  347. Shepard, T. H., Lemire, R. J., Aksu, O., and Mackler, B., 1968, Studies of the development of congenital anomalies in embryos of riboflavin deficient, galactoflavin fed rats. I. Growth and embryologic pathology, Teratology 1: 75.Google Scholar
  348. Shils, M. E., and McCollum, E. V., 1943, Further studies on the symptoms of manganese deficiency in the rat and mouse, J. Nutr. 26: 1.Google Scholar
  349. Shrader, R. E., and Everson, G. J., 1967, Anomalous development of otoliths associated with postural defects in manganese-deficient guinea pigs, J. Nutr. 91: 453.Google Scholar
  350. Shrader, R. E., and Zeman, F. J., 1969, Effect of maternal protein deprivation on morphological and enzymatic development of neonatal rat tissue, J. Nutr. 99: 401.Google Scholar
  351. Shrader, R. E., and Zeman, F. J., 1973a, Skeletal development in rats as affected by maternal protein deprivation and postnatal food supply, J. Nutr. 103: 792.Google Scholar
  352. Shrader, R. E., and Zeman, F. J., 1973b, In vitro synthesis of anterior pituitary growth hormone as affected by maternal protein deprivation and postnatal food supply, J. Nutr. 103:1012.Google Scholar
  353. Shrader, R. E., Erway, L., and Hurley, L. S., 1973, Mucopolysaccharide synthesis in the developing inner ear of manganese-deficient and pallid mutant mice, Teratology 8: 257.Google Scholar
  354. Sima, A., and Sourander, P., 1973, The effect of perinatal undernutrition on perineurial diffusion barrier to exogenous protein, Acta Neuropathol. (Berlin) 24: 263.Google Scholar
  355. Sisson, T. R. C., and Lund, C. J., 1958, The influence of maternal iron deficiency on the newborn, Am. J. Clin. Nutr. 6: 376.Google Scholar
  356. Smith, C. A., 1947a, Effects of maternal undernutrition upon the newborn infant in Holland (1944–1945), J. Pediatr. 30: 229.Google Scholar
  357. Smith, C. A., 19476, The effect of wartime starvation in Holland upon pregnancy and its product, Am. J. Obstet. Gynecol. 53: 599.Google Scholar
  358. Smith, C. A., Oberhelman, H. A., Jr., Storer, E. H., Woodward, E. R., and Dragstedt, L. R., 1951, Production of experimental cretinism in dogs by the administration of radioactive iodine, Arch. Surg. 63: 807.Google Scholar
  359. Solursh, M., and Meier, S., 1973, ‘The selective inhibition of mucopolysaccharide synthesis by vitamin A treatment of cultured chick embryo chondrocytes, Calcif. Tissue Res. 13: 131.Google Scholar
  360. Sontag, L. W., Munson, P., and Huff, E., 1936, Effects on the fetus of hypervitaminosis D and calcium and phosphorus deficiency during pregnancy, Am. J. Dis. Child. 51: 304.Google Scholar
  361. Stanbury, J. B., and Querido, A., 1956, Genetic and environmental factors in cretinism: A classification, J. Clin. Endocrinol. Metab. 16: 1522.Google Scholar
  362. Stanbury, J. B., and Querido, A., 1957, On the nature of endemic cretinism, J. Clin. Endocrinol. Metab. 17: 801.Google Scholar
  363. Stein, Z., Susser, M., Saenger, G., and Marolla, F., 1972, Nutrition and mental performance, Science 178: 708.Google Scholar
  364. Stone, M. L., 1968, Effects on the fetus of folic acid deficiency in pregnancy, Clin. Obstet. Gynecol. 11: 1143.Google Scholar
  365. Suomalainen, P., 1950, Effect of E-avitaminosis on the histiotrophic nutrition of the mouse embryo, Nature 165: 364.Google Scholar
  366. Suttle, N. F., and Field, A. C., 1968, Effect of intake of copper, molybdenum and sulphate on copper metabolism in sheep. II. Copper status of the newborn lamb, J. Comp. Pathol. 78: 363.Google Scholar
  367. Swanson, W. W., and lob, V., 1939, The growth of fetus and infant as related to mineral intake during pregnancy, Am. J. Obstet. Gynecol. 38: 382.Google Scholar
  368. Swenerton, H., and Hurley, L. S., 1968, Severe zinc deficiency in male and female rats,J Nutr. 95: 8.Google Scholar
  369. Swenerton, H., Shrader, R., and Hurley, L. S., 1969, Zinc-deficient embryos: Reduced thymidine incorporation, Science 166: 1014.Google Scholar
  370. Swenerton, H., Shrader, R., and Hurley, L. S., 1972. Lactic and malic dehydrogenases in testes of zinc-deficient rats, Proc. Soc. Exp. Biol. Med. 141: 283.Google Scholar
  371. Takekoshi, S., 1964, The mechanism of vitamin A induced teratogenesis, J. Embryol. Exp. Morphol. 12: 263.Google Scholar
  372. Tao, S. H., and Hurley, L. S., 1975, Effect of dietary calcium deficiency during pregnancy on zinc mobilization in intact and parathyroidectomized rats, J. Nutr. 105: 220.Google Scholar
  373. Terada, M., 1970, Effect of intermittent fasting before pregnancy upon maternal fasting as a teratogen in mice, J. Nutr. 100: 767.Google Scholar
  374. Toverud, K. U., and Toverud, G., 1931, Studies on the mineral metabolism during pregnancy and lactation and its bearing on the disposition to rickets and dental caries, Acta Paediatr. Suppl. 2 12: 1.Google Scholar
  375. Tuchmann-Duplessis, H., and Mercier-Parot, L., 1964, Avortements et malformations sous l’effet d’un agent provoquant une hyperlipémie et une hypercholestérolémie, Bull. Acad. Natl. Med. (Paris) 148: 392.Google Scholar
  376. Tuchmann-Duplessis, H., Lefébvres-Boisselot, J., and Mercier-Parot, L., 1959, L’action tératogène de l’acide x-methyl-folique sur diverses espéces animales, Arch. Fr. Pediatr. 15 (4): 1.Google Scholar
  377. Tuncer, M., 1970, Bone development, incidence of hypoglycemia and effect of maternal and fetal factors in low birth weight infants, Turk. J. Pediatr. 12: 59.Google Scholar
  378. Turbow, M. M., and Chamberlain, J. G., 1968, Direct effects of 6-aminonicotinamide on the developing rat embryo in vitro and in in vivo, Teratology 1: 103.Google Scholar
  379. Ullrey, D. E., Becker, D. E., Terrill, S. W., and Notzold, R. A., 1955, Dietary levels of pantothenic acid and reproductive performance of female swine, J. Nutr. 57: 401.Google Scholar
  380. van den Berg, B. J., and Yerushalmy, J., 1966, The relationship of the rate of intrauterine growth of infants of low birth weight to mortality, morbidity, and congenital anomalies, J. Pediatr. 69: 531.Google Scholar
  381. van Gelder, D. W., and Darby, F. U., 1944, Congenital and infantile beriberi, J. Pediatr. 25: 226.Google Scholar
  382. Wallis, G. C., 1938, Some effects of vitamin D deficiency on mature dairy cows, J. Dairy Sci. 21: 315.Google Scholar
  383. Warkany, J., 1943, Effect of maternal rachitogenic diet on skeletal development of young rat, Am. J. Dis. Child. 66: 511.Google Scholar
  384. Warkany, J., and Deuschle, F. M., 1955, Congenital malformations induced in rats by maternal riboflavin deficiency: Dentofacial changes, J. Am. Dent. Assoc. 51: 139.Google Scholar
  385. Warkany, J., and Petering, H. G., 1972, Congenital malformations of the central nervous system in rats produced by maternal zinc deficiency,Teratology 5: 319.Google Scholar
  386. Warkany, J., and Petering, H. G., 1973, Congenital malformations of the brain produced by short zinc deficiencies in rats, Am. J. Ment. Defic. 77: 645.Google Scholar
  387. Warkany, J., and Roth, C. B., 1948, Congenital malformations induced in rats by maternal vitamin A deficiency. II. Effect of varying the preparatory diet upon the yield of abnormal young, J. Nutr. 35: 1.Google Scholar
  388. Warkany, J., and Schraffenberger, E., 1943, Congenital malformations induced in rats by maternal nutritional deficiency. V. Effects of purified diet lacking riboflavin, Proc. Soc. Exp. Biol. Med. 54: 92.Google Scholar
  389. Warkany, J., and Schraffenberger, E., 1944, Congenital malformations of the eyes induced in rats by maternal vitamin A deficiency, Proc. Soc. Exp. Biol. Med. 57: 49.Google Scholar
  390. Warkany, J., and Schraffenberger, E., 1946, Congenital malformation induced in rats by maternal vitamin A deficiency, Arch. Ophthalmol. 35: 150.Google Scholar
  391. Wilson, J. G., and Warkany, J., 1947, Epithelial keratinization as evidence of fetal vitamin A deficiency, Proc. Soc. Exp. Biol. Med. 64: 419.Google Scholar
  392. Wilson, J. G., and Warkany, J., 1948, Malformations in the genito-urinary tract induced by maternal vitamin A deficiency in the rat, Am. J. Anat. 83: 357.Google Scholar
  393. Wilson, J. G., and Warkany, J., 1950, Cardiac and aortic arch anomalies in the offspring of vitamin A deficient rats correlated with similar human anomalies, Pediatrics 5: 708.Google Scholar
  394. Wilson, J. G., Roth, C. B., and Warkany, J., 1953, An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation, Am. J. Anat. 92: 189.Google Scholar
  395. Wilson, M. G., Meyers, H. I., and Peters, A. H., 1967, Postnatal bone growth of infants with fetal growth retardation, Pediatrics 40: 213.Google Scholar
  396. Winick, M., 1969, Malnutrition and brain development, J. Pediatr. 74: 667.Google Scholar
  397. Winick, M., and Noble, A., 1966, Cellular response in rats during malnutrition at various ages, J. Nutr. 89: 300.Google Scholar
  398. Winick, M., Brasel, J. A., and Velasco, E. G., 1973, Effects of prenatal nutrition upon pregnancy risk, Clin. Obstet. Gynecol. 16: 184.Google Scholar
  399. Woodard, J. C., and Newberne, P. M., 1967, The pathogenesis of hydrocephalus in newborn rats deficient in vitamin 1312, J. Embryol. Exp. Morphol. 17: 177.Google Scholar
  400. Wooley, D. W., and van der Hoven, T., 1964, Serotonin deficiency in infancy as one cause of a mental defect in phenylketonuria, Science 144: 883.Google Scholar
  401. Yasuda, M., Nanjo, H., and Suzuki, M., 1966, The effect of fasting upon the development of embryos in elderly pregnant mice, Kaibogaku Zasshi 41: 43.Google Scholar
  402. Zamenhof, S., and van Marthens, E., 1974, Study of factors influencing prenatal brain development, Mol. Cell. Biochem. 4: 157.Google Scholar
  403. Zamenhof, S., Hall, S. M., Grauel, L., van Marthens, E., and Donahue, M. J., 1974, Deprivation of amino acids and prenatal brain development in rats, J. Nutr. 104: 1002.Google Scholar
  404. Zeman, F. J., 1967, Effect on the young rat of maternal protein restriction, J. Nutr. 93: 167.Google Scholar
  405. Zeman, F. J., 1968, Effects of maternal protein restriction on the kidney of the newborn young of rats, J. Nutr. 94: 111.Google Scholar
  406. Zeman, F. J., 1970, Effect of protein deficiency during gestation on postnatal cellular development in the young rat,J Nutr. 100: 530.Google Scholar
  407. Zeman, F. J., and Stanbrough, E. C., 1969, Effect of maternal protein deficiency on cellular development in the fetal rat, J. Nutr. 99: 274.Google Scholar
  408. Zeman, F. J., Shrader, R. E., and Allen, L. H., 1973, Persistent effects on maternal protein deficiency in postnatal rats, Nutr. Rep. Int. 7: 421.Google Scholar
  409. Zilversmit, D. B., Remington, M., and Hughes, L. B., 1972, Fetal growth and placental permeability in rabbits fed cholesterol, J. Nutr. 102: 1681.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Lucille S. Hurley
    • 1
  1. 1.Department of NutritionUniversity of CaliforniaDavisUSA

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