Radiations and Other Physical Agents

  • Robert L. Brent


The purpose of this chapter is to describe the effects of exposing mammalian embryos to various forms of ionizing and nonionizing radiation. Although some clinical applications will be alluded to, the primary purpose will be to present the quantitative information derived from animal experiments. A detailed consideration of the clinical implications and clinical interpretation of the hazards of ionizing and nonionizing radiation are discussed in other monographs (Brent and Gorson, 1972; Brent and Harris, 1976).


Microwave Radiation Physical Agent Atomic Bomb Tritiated Water Audiogenic Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Ionizing Radiation

  1. Ader, R., and Deitchman, R., 1972, Prenatal materai X-irradiation: Maternal and offspring effects, J. Comp. Physiol. Psychol. 78: 202–207.Google Scholar
  2. Ager, E., Schuman, L., Wallace, H., Rosenfield, A., and Gullen, W., 1965, An epidemiological study of childhood leukemia, J. Chron. Dis 18: 113–132.Google Scholar
  3. Albright, E. C., and Allday, R. W., 1967, Thyroid carcinoma after radiation therapy for adolescent acne vulgaris, J. Am. Med. Assoc. 199: 280–281.Google Scholar
  4. Altman, J., Anderson, W., and Wright, K., 1968a, Gross morphological consequences of irradiation of the cerebellum in infant rats with repeated doses of low-level X-ray, Exp. Neurol. 21: 69.Google Scholar
  5. Altman, J., Anderson, W., and Wright, K., 1968b, Reconstitution of the external granular layer of the cerebellar cortex in infant rats after low-level X-irradiation, Anat. Rec. 163: 453–471.Google Scholar
  6. Baker, T. G., and Beaumont, H. M., 1967, Radiosensitivity of oogonia and oocytes in the foetal and neonatal monkey, Nature 214: 981.Google Scholar
  7. Baker, T. G., 1970, Comparative aspects of the effects of radiation during oogenesis, Mutat. Res. 11: 9–22.Google Scholar
  8. Beaumont, H., 1962, Effect of irradiation during foetal life on the subsequent structure and secretory activity of the gonads. J. Endocrinol. 24: 325–339.Google Scholar
  9. Berke, R. A., Hoops, E. C., Kereiakes, J. C., and Saenger, E. L., 1973, Radiation dose to breast-feeding child after mother has 99m-MAA lung scan, J. Nucl. Med. 14: 51–52.Google Scholar
  10. Berry, M., and Eayrs, J. T., 1970, Evoked cortical potentials in prenatally irradiated rats. Exp. Neurol. 28: 411–426.Google Scholar
  11. Billings, M., Yamazaki, J., Bennett, L., and Lamson, B., 1966, Late effects of low dose whole body X-irradiation of four-day-old rats, Pediatrics 38: 1047–1056.Google Scholar
  12. Bloom, A. D., Neriishi, S., and Archer, P. G., 1968, Cytogenetics of the in utero exposed of Hiroshima and Nagasaki. Lancet 2: 10.Google Scholar
  13. Blot, W. J., and Miller, R. W., 1973, Mental retardation in utero exposure to the atomic bombs of Hiroshima and Nagasaki, Radiology 106: 617–619.Google Scholar
  14. Blot, W. J., and Sawada, H., 1972, Fertility among female survivors of the atomic bombs of Hiroshima and Nagasaki. Am. J. Hum. Genet. 24: 613–622.Google Scholar
  15. Bonavita, V., Amore, G., Avellone, S., and Guarneri, R., 1965, Lactate dehydrogenase isoenzymes in the nervous tissue. V. The effect of X-rays on the enzyme of the developing and adult rat brain, J. Neurochem. 12: 37–43.Google Scholar
  16. Brent, R. L., 1960a, The effect of irradiation on the mammalian fetus, Clin. Obstet. Gynecol. 3: 928–950.Google Scholar
  17. Brent, R. L., 1960b, The indirect effect of irradiation on embryonic development. II. Irradiation on the placenta, Am. J. Dis. Child. 100: 103–108.Google Scholar
  18. Brent, R. L., 1963, The modification of the teratogenic and lethal effects of irradiation to the mammalian fetus, in: Effects of Ionizing Radiation on the Reproductive System ( W. D. Carlson and F. X. Gassner, eds.), pp. 451–462, Pergamon Press, New York.Google Scholar
  19. Brent, R. L., 1967, Medicolegal aspects of teratology, J. Pediatr. 71: 288–298.Google Scholar
  20. Brent, R. L., 1968, The long term effects of embryonic and fetal irradiation, Pediatr. Res. 2: 291Google Scholar
  21. Brent, R. L., 1970, Effects of radiation on the foetus, newborn and child, in: Late Effects of Radiation ( R. M. Fry, D. Grahn, M. L. Griem, and J. H. Rust, eds.), pp. 23–60, Taylor & Francis, London.Google Scholar
  22. Brent, R. L., 1971, The response of the 9%2-day-old-rat embryo to variations in dose rate of 150 R X-irradiation, Radiat. Res. 45: 127–136.Google Scholar
  23. Brent, R. L., 1972a, Irradiation in pregnancy, in: Davis’ Gynecology and Obstetrics, Vol. 2 (J. J. Sciarra, ed.), pp. 1–32, Harper Sc Row, New York.Google Scholar
  24. Brent, R. L., 1972b, Protecting the public from teratogenic and mutagenic hazards, J. Clin. Pharmacol. 12: 61–70.Google Scholar
  25. Brent, R. L., 1973a, Radiation exposure during first trimester: When is abortion indicated?, Questions and Answers, J. Am. Med. Assoc. 224: 536.Google Scholar
  26. Brent, R. L., 1973b, Radiation and teratogenesis in pregnancy, in: Pathobiology of Development, pp. 76–96, Wilkins & Wilkins, Baltimore.Google Scholar
  27. Brent, R. L., and Bolden, B. T., 1961, The long term effects of low dosage embryonic irradiation, Radiat. Res. 14: 453–454.Google Scholar
  28. Brent, R. L., and Bolden, B. T., 1967a, The indirect effect of irradiation on embryonic development. III. The contribution of ovarian irradiation, uterine irradiation, oviduct irradiation and zygote irradiation to fetal mortality and growth retardation in the rat, Radiat. Res. 30: 759–773.Google Scholar
  29. Brent, R. L., and Bolden, B. T., 1967b, The indirect effect of irradiation on embryonic development. IV. The lethal effects of maternal irradiation on the first day of gestation in the rate, Proc. Soc. Exp. Biol. Med. 125: 709–712.Google Scholar
  30. Brent, R. L., and Bolden, B. T., 1968, Indirect effect of X-irradiation on embryonic development. V. Utilizaton of high doses of maternal irradiation on the first day of gestation. Radiat. Res. 36: 563–570.Google Scholar
  31. Brent, R. L., and Gorson, R. O., 1972, Radiation exposure in pregnancy, in: Current Problems in Radiology ( R. D. Moseley, Jr., D. H. Baker, R. O. Gorson, A. Lalli, H. B. Latourette, and J. Quinn, III, eds.), Vol. 2, pp. 1–48, Medical Publishers, Chicago, Illinois.Google Scholar
  32. Brent, R. L., and Harris, M., 1976, The Prevention of Embryonic, Fetal, and Perinatal Disease, U.S. Government Publication (1976).Google Scholar
  33. Brent, R. L., and McLaughlin, M. M., 1960, The indirect effect of irradiation on embryonic development. I. Irradiation of the mother while shielding the embryonic site, Am. J. Dis. Child. 100: 94–102.Google Scholar
  34. Brizzee, K. R., and Brannon, R. B., 1972, Cell recovery in foetal brain after ionizing radiation, Int. J. Radiat. Biol. 21: 375.Google Scholar
  35. Brizzee, K. R., Jacobs, L., and Kharetchko, X., 1961a, Effects of total body X-irradiation in utero on early postnatal changes in neuron volumetric relationships and packing density in cerebral cortex, Radiat. Res. 14: 96–103.Google Scholar
  36. Brizzee, K. R., Jacobs, L., Kharetchko, X., and Sharp, J., 1961b, Quantitative histologic and behavioral studies on effects of fetal X-irradiation in developing cerebral cortex of white rats, in: Response of the Nervous System to Ionizing Radiation (T. J. Haley and R. S. Snider, eds.), Academic Press, New York.Google Scholar
  37. Brizzee, K. R., Jacobs, L. A., and Bench, C. J., 1967, Histologic effect of total body X-irradiation in various dose fractionation patterns on fetal cerebral hemisphere, Radiat. Res. 31: 415–429.Google Scholar
  38. Brown, S., 1964, Effects of continuous low intensity radiation on successive generations of the albino rat, Genetics 50: 1101–1113.Google Scholar
  39. Burke, G., Levinson, M. J., and Zitman, I. H., 1967, Thyroid carcinoma ten years after sodium iodine I131 treatment, J. Am. Med. Assoc. 199: 247–251.Google Scholar
  40. Burrow, G., Hamilton, H., Hrubec, Z., Amamoto, K., Matsunaga, F., and Brill, A., 1964, Study of adolescents exposed in utero to the atomic bomb, Nagasaki, Japan. I. General aspects: Clinical laboratory data, Yale J. Biol. Med. 36: 430–444.Google Scholar
  41. Burrow, G., Hamilton, H., and Hrubec, Z., 1965, Study of adolescents exposed in utero to the atomic bomb, Nagasaki, Japan, J. Am. Med. Assoc. 192: 357–364.Google Scholar
  42. Cloutier, R. J., Smith, S. A., and Watson, E. E., 1973, Dose to the fetus from radionuclides in the bladder, Health Phys. 25: 147–161.Google Scholar
  43. Cohen, Y., Tatcher, M., and Robinson, E., 1973, Radiotherapy in pregnancy. Radiol. Clin. Biol. 42: 34–39.Google Scholar
  44. Conard, R., and Hicking, A., 1965, Medical findings in Marshallese people exposed to fallout radiation, J. Am. Med. Assoc. 192: 457–459.Google Scholar
  45. Cooke, J., Brown, S., and Krise, G., 1964, Prenatal chronic gamma irradiation and audiogenic seizures in rats, Exp. Neurol. 9: 243–248.Google Scholar
  46. Coppenger, C. J., and Brown, S. O., 1965, Postnatal manifestations in albino rats continuously irradiated during prenatal development, Texas Rep. Biol. Med. 23: 45–55.Google Scholar
  47. Coppenger, C. J., and Brown, S. O., 1967, The gross manifestations of continuous gamma irradiation on the prenatal rat, Radiat. Res. 31: 230–242.Google Scholar
  48. Cowen, D., and Geller, L. M., 1960, Long term pathological effects of prenatal X-irradiation on the central nervous system of the rat. J. Neuropathol. Exp. Neurol. 19: 488–527.Google Scholar
  49. D’Amato, C. J., and Hicks, S. P., 1965, Effects of low levels of ionizing radiation on the developing cerebral cortex of the rat. Neurology 15: 1104–1116.Google Scholar
  50. Dekaban, A., 1968, Abnormalities in children exposed to X-radiation injury to the human fetus, Part 1., J. Nucl. Med. 9: 471–477.Google Scholar
  51. Dekaban, A., 1969, Effects of X-radiation on mouse fetus during gestation: Emphasis on distribution of cerebral lesions, Part 2, J. Nucl. Med. 10: 67–77.Google Scholar
  52. DeVellis, J., Schjeide, A., and Clemente, C., 1967, Protein synthesis and enzymic patterns in the developing brain following X-irradiation of newborn rats. J. Neurochem. 14: 499–511.Google Scholar
  53. Diamond, E. L., Schmerler, H., and Lilienfeld, A. M., 1973, The relationship of intra-uterine radiation to subsequent mortality and development of leukemia in children, Am. J. Epidemiol. 97: 283–313.Google Scholar
  54. Driscoll, S., Hick, S., Copenhaver, E., and Easterday, C., 1963, Acute radiation injury in two human fetuses. Arch. Pathol. 76: 113–119.Google Scholar
  55. Duffy, B. J., Jr., and Fitzgerald, P. J., 1950, Thyroid cancer in childhood and adolescence: Report 28 cases, Cancer, N.Y. 3: 1018.Google Scholar
  56. Einhorn, J., Hulten, M., Lindsten, J., Wicklund, H., and Zetterqvist, P., 1972, Clinical and cytogenetic investigation in children of parents treated with radioiodine, Acta Radiol. 2: 193–208.Google Scholar
  57. Erickson, B., Murphree, R., and Andrews, J., 1963, Effects of prenatal gamma irradiation on the germ cells of the male pig, Radiat. Res. 20: 640–648.Google Scholar
  58. Erickson, B. H., and Martin, P. G., 1973, Influence of age on the response of rat stem spermatogonia to X-radiation, Biol. Reprod. 8: 607–612.Google Scholar
  59. Ershoff, B., and Brat, V., 1960, Comparative effects of prenatal gamma radiation and X-irradiation on the reproductive system of the rat, Am. J. Physiol. 198: 1119–1122.Google Scholar
  60. Ershoff, B., Steers, C., and Kruger, L., 1962, Effects of radioprotective agents on foot deformities and gait defects in the prenatally X-irradiated rat, Proc. Soc. Exp. Biol. Med. 111: 391–394, 1962.Google Scholar
  61. Fasal, E., Jackson, E. W., and Klauber, M. R., 1971, Birth characteristics and leukemia in childhood, J. Natl. Cancer Inst. 47: 501.Google Scholar
  62. Ford, C. E., Searle, A. G., Evans, E. P., and West, B. J., 1969, Differential transmission of translocations induced in spermatogonia of mice by irradiation, Cytogenetics 8: 447–470.Google Scholar
  63. Ford, D., and Patterson, T., 1959, Fetal exposure to diagnostic X-rays and leukemia and other malignant diseases in childhood, J. Natl. Cancer Inst. 22: 1093–1104.Google Scholar
  64. Fraumeni, J. F., and Miller, R. W., 1967, Epidemiology of human leukemia: Recent observations, J. Natl. Cancer Inst. 38: 593–605.Google Scholar
  65. Freedman, L., and Keehn, R., 1966, Urinary findings of children who were in utero during the atomic bombings of Hiroshima and Nagasaki, Yale J. Biol. Med. 39: 196–206.Google Scholar
  66. Frolen, H., 1970, Genetic effects of 90Sr on various stages of spermatogenesis in mice, Acta Radiol. 9: 596–608.Google Scholar
  67. Furchtgott, E., 1963, Behavioral effects of ionizing radiations, Psychol. Bull. 60: 157–200.Google Scholar
  68. Furchtgott, E., and Kimbrell, G. McA, 1967, Olfactory discrimination in prenatally X-irradiated rats. Radiat. Res. 30: 217–220.Google Scholar
  69. Furchtgott, E., Tacker, R., and Draper, D., 1968, Open-field behavior and heart rate in prenatally X-irradiated rats, Teratology 1: 201–206.Google Scholar
  70. Geets, W., 1967, Influence des radiations ionisantes sur le development du systeme nerveux, Acta Genet. Med. Gemell. 16: 275–309.Google Scholar
  71. Geller, L. M., 1970, Audiogenic seizure susceptibility of rats X/irradiated in utero during first one-third of pregnancy, Exp. Neurol. 29: 268–280.Google Scholar
  72. Geller, L. M., 1973, Audiogenic seizure susceptibility of rats X-irradiated in utero late in pregnancy, Exp. Neurol. 38: 135–143.Google Scholar
  73. Gibbons, A. F. E., and Chang, M. C., 1973, The effects of x-irradiation of the rat ovary on implantation and embryonic development, Biol. Reprod. 9: 343–349.Google Scholar
  74. Gillanders, L. A., 1973, Radiography of potentially pregnant females, Br. Med. J. 1: 291–292.Google Scholar
  75. Glass, S. J., 1944, Dwarfism associated with microcephalic idiocy and renal rickets, J. Clin. Endocrinol. Metab. 4: 47.Google Scholar
  76. Graham, S., Levin, M. L., Lilienfield, A. M., Schuman, L. M., Gibson, R., Dowd, J. E., and Hempleman, L., 1966, Preconception, intrauterine and postnatal irradiation as related to leukemia, Natl. Cancer Inst. Monogr. 19: 347–371.Google Scholar
  77. Greim, M. D., Meier, P., and Dobben, G. D., 1967, Analysis of the morbidity and mortality of children irradiated in fetal life, Radiology 88: 347–349.Google Scholar
  78. Greulick, W. W., Crismon, C. S., Turner, M. A., Greulich, M. A., and Okumoto, Y., 1953, The physical growth and development of children who survived the atomic bombing of Hiroshima and Nagasaki, J. Pediatr. 43: 121.Google Scholar
  79. Haas, R. J., Schreml, W., Fliedner, T. M., and Calvo, W., 1973, The effect of triatiated water on the development of the rat oocyte after maternal infusion during pregnancy, Int. J. Radial. Biol. 23: 603–609.Google Scholar
  80. Hagler, S., Rosenblum, P., and Rosenblum, A., 1966, Carcinoma of the thyroid in children and young adults. Iatrogenic relation to previous irradiation, Pediatr. 38: 77–81.Google Scholar
  81. Hahn, E. W., and Feingold, S. M., 1973, Abscopal delay of embryonic development after pre-fertilization X-irradiation. Radiat. Res. 53: 267–272.Google Scholar
  82. Harvey, E. B., and Chang, M. C., 1962, Effects of radiocobalt irradiation of pregnant hamsters on the development of embryos. J. Cell. Comp. Physiol. 59: 293–305.Google Scholar
  83. Havlena, J. M., Werboff, J., and Sikov, M. R., 1964, X-irradiation of the 36-hour rat embryo: Neonatal mortality and postnatal activity, earning and seizure susceptibility, Radiat. Res. 22: 193.Google Scholar
  84. Hicks, S. P., 1953, Effects of ionizing radiation on the adult and embryonic nervous system, in: Metabolic and Toxic Diseases of the Nervous System, Proceedings of the Association for Research in Nervous and Mental Disease, Vol. 32 ( H. H. Merritt and C. C. Hare, eds.), pp. 439–462, Williams and Wilkins, Baltimore.Google Scholar
  85. Hicks, S. P., 1958, Radiation as an experimental tool in mammalian developmental neurology, Physiol. Rev. 38: 337–356.Google Scholar
  86. Hicks, S. P., and D’Amato, C. J., 1963, Low dose radiation of developing brain, Science 141: 903–905.Google Scholar
  87. Hicks, S. P., and D’Amato, C. J., 1966, Effects of ionizing radiation on mammalian development, in: Advances in Teratology ( D. H. M. Woollam, ed.), pp. 196–243, Logos Press, London.Google Scholar
  88. Hicks, S. P., D’Amato, C. J., and Lowe, M. L., 1959, The development of the mammalian nervous system. I. Malformations of the brain, especially the cerebral cortex, induced in rats by radiation, J. Comp. Neurol. 113: 435–469.Google Scholar
  89. Hoshino, T., Itoga, T., and Kato, H., 1965, Leukemia in the offspring of parents exposed to the atomic bomb at Hiroshima and Nagasaki, presented at Japanese Association of Hematology, March 28–30.Google Scholar
  90. Hupp, E., Pace, H., Furchtgott, E., and Murphree, R., 1960, Effect of fetal irradiation on mating activity in male rate. Psychol. Rep. 7: 289–294.Google Scholar
  91. Jablon, S., 1973, Comments, Health Phys. 24: 257–258.Google Scholar
  92. Jacobsen, L., 1965, A retrospective study of the possible teratogenic effects of diagnostic pelvic X-irradiation. Proc. Xlth Int. Congr. Radiol., Excerpta Medica International Congress, Series No. 105, pp. 1372–1375.Google Scholar
  93. Jacobsen, L., and Mellemgaard, L., 1968, Anomalies of the eyes in descendants of women irradiated with small X-ray doses during age of fertility, Acta Ophthal. 46: 352–354.Google Scholar
  94. Kameyama, Y., and Hoshino, K., 1972, Postnatal manifestation of hydrocephalus in mice caused by prenatal X-irradiation, Congenital Anomolies 12: 1–9.Google Scholar
  95. Kameyama, Y., Hayashi, Y., and Hoshino, K., 1972, Abnornal vascularity in the brain mantle with X-ray induced microcephaly in mice, Congenital Anomolies 12: 147–156.Google Scholar
  96. Kato, H., 1971, Mortality in children exposed to the A-Bombs while in utero. Am. J. Epidemiol. 93: 435.Google Scholar
  97. Kinlen, L. J., and Acheson, E. D., 1968, Diagnostic irradiation, congenital malformations and spontaneous abortion, Br. J. Radial. 41: 648–654.Google Scholar
  98. Kitabatake, T., 1966a, Retrospective survey on medical irradiation and leukemogenesis in Japan, Tokoku J. Exp. Med. 90: 25–34.Google Scholar
  99. Kitabatake, T., 1966b, Relationship between medical irradiation and development of malignant lymphoma: A retrospective survey. Nippon Acta Radiol. 26: 891–893.Google Scholar
  100. Kucerova, M., 1970, Long-term cytogenetic and clinical control of a child following intrauterine irradiation, Acta Radiol. 9: 353–361.Google Scholar
  101. Langendorff, H. U. M., and Neumann, G. K., 1972, Die wirkung einer fraktionierten rontgen-bestrahlung auf die fertilitat von in utero bestrahlten mausen. Strahlentherapie 144: 324–337.Google Scholar
  102. Laskey, J. W., Parrish, J. L., and Cahill, D. F., 1973, Some effects of lifetime parental exposure to low levels of tritium on the F2 generation, Radiat. Res. 56: 171–179.Google Scholar
  103. Leonard, A., and Deknudt, Gh., 1969, Dose-response relationship for translocations induced by X-irradiation in spermatogonia of mice, Radiat. Res. 40: 276–284.Google Scholar
  104. Leonard, A., Imbaud, F., and Maisin, J., 1964, Testicular injury in rats irradiated during infancy, Br. J. Radiol. 37: 764–768.Google Scholar
  105. Levinson, B., 1952, Effects of neonatal irradiation on learning, J. Comp. Physiol. Psychol. 45: 140–145.Google Scholar
  106. Levinson, B., 1959, Effects of neonatal irradiation on learning in rats, J. Comp. Physiol. Psychol. 52: 53–55.Google Scholar
  107. Levinson, B., 1962, Comment on Meier’s “Prenatal anoxia and irradiation: Maternal-fetal relations,” Psychol. Rep. 10: 173–174.Google Scholar
  108. Levy, B., Rugh, R., Lunin, L., Chilton, N., and Moss, M., 1953, The effect of a single subacute X-ray exposure to the fetus on skeletal growth: A quantitative study, J. Morphol. 93: 561–571Google Scholar
  109. Lewis, E. B., 1957, Leukemia and ionizing radiation, Science 125: 865–972.Google Scholar
  110. Lilienfeld, A. M., 1966, Epidemiological studies of the leukemogenic effects of radiation, Yale J. Biol. Med. 39: 143–164.Google Scholar
  111. Lipton, M., 1966, Locomotor behavior and neuromorphologic anomalies in prenatally and postnatally irradiated rats, Radiat. Res. 28: 822–829.Google Scholar
  112. Lyon, M. F., Morris, T., Glenister, P., and O’Grady, E., 1970, Induction of translocations in mouse spermatogonia by X-ray doses divided into many small fractions, Mutat. Res. 9: 219–223.Google Scholar
  113. Maclntyre, M., Stenchever, M., Wolf, B., and Hempel, J., 1965, Effect of maternal antepartum exposure to X-rays on leukocyte chromosomes of newborn infants, Obstet. Gyneco. 25: 650–656.Google Scholar
  114. McMahon, B., and Hutchinson, G. B., 1964, Prenatal X-ray and childhood: A review, Acta Unio Int. Contra Cancrum 20: 1172–1174.Google Scholar
  115. Meier, G. W., and Foshee, D. P., 1962, Indirect foetal irradiation effects in the development of behavior, in: Effects of Ionizing Radiation on the Nervous System, Proceedings of the Symposium of the International Atomic Energy Agency, pp. 245–259, Vienna.Google Scholar
  116. Meyer, M., Diamond, E., and Merz, T., 1968, Sex ratio of children born to mothers who had been exposed to X-rays in utero, Johns Hopkins Med. J. 123: 123–127.Google Scholar
  117. Miller, R. W., 1956, Delayed effects occurring within the first decade after exposure of young individuals to the Hiroshima atomic bomb, Pediatrics 18: 1–18.Google Scholar
  118. Miller, R. W., 1968, Effects of ionizing radiation from the atomic bomb on Japanese children, Pediatrics (Suppl.) 41: 257–264.Google Scholar
  119. Miller, R. W., 1970, Epidemiological conclusions from radiation toxicity studies, in: Late Effects of Radiation ( R. J. M. Fry, D. Grahn, M. L. Griem, and J. H. Rust, eds.), Taylor & Francis, London.Google Scholar
  120. Miller, R. W., 1971, Transplacental chemical carcinogenesis in man, J. Natl. Cancer Inst. 47: 1169.Google Scholar
  121. Mondorf, L., and Faber, M., 1968, The influence of radiation on human fertility, J. Reprod. Fertil. 15: 165–169.Google Scholar
  122. Muramatsu, S., Nakamura, W., and Eto, H., 1973, Relative biological effectiveness of x-rays and fast neutrons in inducing translocations in mouse spermatogonia, Mutat. Res. 19: 343–347.Google Scholar
  123. Murphree, R., and Pace, H., 1960, The effects of prenatal radiation on postnatal development in rats. Radiat. Res. 12: 495–504.Google Scholar
  124. Murphy, D. P., 1929, The outcome of 625 pregnancies in women subjected to pelvic radium or roentgen irradiation. Am. J. Obstet. Gynecol. 18: 179–187.Google Scholar
  125. Murphy, W. T., and Berens, D. L., 1952, Late sequelae following cancericidal radiation in children, a report of 3 cases. Radiology 58: 35–42.Google Scholar
  126. NCRP press conference, January 26, 1971, Washington, D. C. (news release).Google Scholar
  127. Nair, V., 1969, An ontogenetic study of the effects of exposure to X-irradiation on the pharmacology of barbiturates, Chicago Med. Sch. Q. 28: 9–25.Google Scholar
  128. Natarajan, N., and Bross, I. D. J., 1973, Preconception radiation and leukemia, J. Med. 4: 276–281.Google Scholar
  129. Neifakh, A. A., 1957, Role of the maternal organism in the irradiation illness of fetal mice, Dokl. Akad. Nauk. Biol. Sci. Sect. 116: 821–824.Google Scholar
  130. Neutel, C. I., and Buck, C., 1971, Effect of smoking during pregnancy on the risk of cancer in children, J. Natl. Cancer Inst. 47: 59.Google Scholar
  131. Nichols, C., Lindsay, S., Sheline, G., and Chaikoff, I., 1965, Induction of neoplasms in rat thyroid glands by X-irradiation of a single lobe, Arch. Pathol. 80: 177–183.Google Scholar
  132. O’Brien, C. A., Hupp, E. W., Sorensen, A. M., and Brown, S. O., 1966, Effects of prenatal gamma radiation on the reproductive physiology of the Spanish, Am. J. Vet. Res. 27: 711–721.Google Scholar
  133. O’Brien, J. P., 1956, Vertebrate radiobiology: Embryology, Annu. Rev. Nucl. Sci. 6: 423–453.Google Scholar
  134. Peters, H., 1961, Radiation sensitivity of oocytes at different stages of development in the immature mouse, Radiat. Res. 15: 582–593.Google Scholar
  135. Peters, H., and Levy, E., 1964, Effect of irradiation in infancy on the mouse ovary. A quantitative study of oocyte sensitivity. J. Reprod. Fertil. 7: 37–45.Google Scholar
  136. Petrosyan, S., and Pereslegin, I., 1962, Acute radiation sickness of newborn rats and its remote consequences, Med. Radiol. 5: 38–45 (in Russian).Google Scholar
  137. Piontkovskii, I. A., 1958, Certain properties of the higher nervous activity in adult animals irradiated prenatally by ionizing radiations; the problem of the effect of ionizing irradiation on offspring. Byull. Eksp. Biol. Med. 46: 77–80. (in Russian).Google Scholar
  138. Piontkovskii, I. A., 1961, Some peculiarities of higher nervous activity in adult animals subjected to radiation in utero. Part III, Byull. Eksp. Biol. Med. 51: 27–31 (in Russian).Google Scholar
  139. Plummer, G., 1952, Anomalies occurring in children exposed in utero to the atomic bomb in Hiroshima, Pediatrics 10: 687–692.Google Scholar
  140. Pobisch, R., 1960, Die Einwirkung der Röntgenstrahlen auf den Kaninchenembryo mit beson-derer Berücksichtigung der postnatalen Entwicklung, Radiol. Austriaca 11: 19–82.Google Scholar
  141. Polhemus, D., and Koch, R., 1969, Leukemia and medical irradiation, Pediatrics 23: 453–461.Google Scholar
  142. Reisman, L. E., Jacobson, A., Davis, L., Kasahara, S., and Kelly, S., 1967, Effects of diagnostic X-rays on chromosomes in infants. A preliminary report, Radiology 89: 75–80.Google Scholar
  143. Reynold, E. L., 1954, Growth and development of Hiroshima children exposed to the atomic bomb. Three-year study (1951–1953). Atomic Bomb Casualty Commission, Technical Report 20–59, Hiroshima.Google Scholar
  144. Rice, J. M., 1973, An overview of transplacental chemical carcinogenesis, Teratology 8: 113–196.Google Scholar
  145. Roizin, L., Rugh, R., and Kaufman, M. A., 1962, Neuropathologic investigations of the X-irradiated embryo rat brain, J. Neuropathol. Exp. Neurol. 21: 219–243.Google Scholar
  146. Ronderos, A., 1961, Fetal tolerance to radiation. Radiology 76: 454–456.Google Scholar
  147. Ross, M. H., and Bras, G., 1965, Tumor incidence patterns and nutrition in the rat, J. Nutr. 87: 245–260.Google Scholar
  148. Rugh, R., 1953, Vertebrate radiobiology: Embryology, Annu. Rev. Nucl. Sci. 3: 271–302.Google Scholar
  149. Rugh, R., 1959, Vertebrate radiobiology: Embryology, Annu. Rev. Nucl. Sci. 9: 493–522.Google Scholar
  150. Rugh, R., 1962, Neurological sequelae to low level X-irradiation of the developing embryo, in: Effects of Ionizing Radiation on the Nervous System ( T. J. Haley and R. S. Snider, eds.), pp. 202–224, International Atomic Energy Agency, Vienna.Google Scholar
  151. Rugh, R., 1963, Ionizing radiations and the mammalian embryo, Acta Radiol. 1: 101–113.Google Scholar
  152. Rugh, R., 1965, Effect of ionizing radiations, including radioisotopes, on the placenta and embryo, Birth Defects, Orig. Art. Ser. 1: 64–73.Google Scholar
  153. Rugh, R., 1969, Normal incidence of brain hernia in the mouse, Science 163: 407.Google Scholar
  154. Rugh, R., and Grupp, E., 1959, The radiosensitivity of the embryonic nervous system, Bull. Sloane Hosp. Women 5: 49–52.Google Scholar
  155. Rugh, R., and Grupp, E., 1960, Fractionated X-irradiation of the mammalian embryo and congenital anomalies, Am. J. Roentgenol. 84: 125–144.Google Scholar
  156. Rugh, R., and Grupp, E., 1961, Neuropathological effects of low level X-irradiation of the mammalian embryo, Mil. Med. 126: 647–664.Google Scholar
  157. Rugh, R., and Jackson, S., 1958, Effect of fetal X-irradiation upon the subsequent fertility of the offspring, J. Exp. Zool. 138: 209–221.Google Scholar
  158. Rugh, R., and Skaredoff, L., 1969, X-rays and the monkey fetal retina, Invest. Ophthalmol. 8: 31–40.Google Scholar
  159. Rugh, R., and Skaredoff, L., 1971, The immediate and delayed effects of 1000 R X-rays on the rodent testes, Fertil. Steril. 22: 73.Google Scholar
  160. Rugh, R., and Wohlfromm, M., 1964a, X-irradiation sterilization of the premature female mouse, Atompraxis 10: 511–518.Google Scholar
  161. Rugh, R., and Wohlfromm, M., 1964b, Can X-irradiation prior to sexual maturity affect the fetility of the male mammal (mouse)? Atompraxis 10: 33–42.Google Scholar
  162. Rugh, R., and Wohlfromm, M., 1965, Prenatal X-irradiation and postnatal mortality, Radiat. Res. 26: 493–506.Google Scholar
  163. Rugh, R., and Wohlfromm, M., 1966, Resistance of the prenatal female mouse to X-ray sterilization, Fertil. Steril. 17: 396–410.Google Scholar
  164. Rugh, R., Duhamel, L., Chandler, A., and Varma, A., 1964a, Cataract development after embryonic and fetal X-irradiation, Radiat. Res. 22: 519–534.Google Scholar
  165. Rugh, R., Duhamel, L., Osborne, A. W., and Varma, A., 1964b, Persistent stunting following X-irradiation of the fetus, Am. J. Anat. 115: 185–197.Google Scholar
  166. Rugh, R., Duhamel, L., and Skaredoff, L., 1966, Relation of embryonic and fetal X-irradiation to life time average weights and tumor incidence in mice, Proc. Soc. Biol. Med. 121: 714–718.Google Scholar
  167. Rugh, R., Wohlfromm, M., and Varma, A., 1969, Low dose X-ray effects on the preclevage mammalian zygote. Radiat. Res. 37: 401–414.Google Scholar
  168. Russell, L. B., 1954, The effects of radiation on mammalian prenatal development, in: Radiation Biology, Part II ( A. Hollaender, ed.), McGraw-Hill, New York.Google Scholar
  169. Russell, L. B., 1957, Effects of low doses of X-rays on embryonic development in the mouse. Proc. Soc. Exp. Biol. Med. 95: 174–178.Google Scholar
  170. Russell, L. B., 1965, in: Ciba Foundation Symposium on Preimplanted Stages of Pregnancy (G. E. W. Wolstenholme, ed.), p. 217, J. & A. Churchill, London.Google Scholar
  171. Russell, L. B. and Montgomery C. S., 1966, Radiation-sensitivity differences within cell division cycles during mouse cleavage, Int. J. Radiat. Biol. 10: 151–164.Google Scholar
  172. Russell, W. L., and Oakberg, E. F., 1963, The cellular basis and aetiology of the late effects of irradiation on fertility in female mice, in: Cellular Basis and Aetiology of Late Somatic, Effects of Ionizing Radiation ( R. J. C. Harris, ed.), pp. 224–232, Academic Press, New York.Google Scholar
  173. Russell, L. B., and Russell, W. L., 1954, An analysis of the changing radiation response of the developing mouse embryo, J. Cell. Comp. Physiol. 43: 103–149.Google Scholar
  174. Russell, L. B., and Saylors, C. L., 1963, The relative sensitivity of various germ-cell stages of the mouse to radiation-induced non-dysjunction, chromosome losses and deficiencies, in: Sobels: Repair from Genetic Radiation, pp 313–342, Pergamon Press, New York.Google Scholar
  175. Russell, L. B., Badgett, S. K., and Saylors, C. L., 1959, Comparison of the effects of acute, continuous and fractionated irradiation during embryonic development, in: A Special Supplement to International Journal of Radiation Biology ( A. A. Buzzati-Traverso, ed.), pp. 343–359, Immediate and Low Level Effects of Ionizing Radiation Conference held in Venice, Taylor & Francis, London.Google Scholar
  176. Sato, H., 1966, Chromosomes of irradiated embryos, Lancet 1: 551.Google Scholar
  177. Scharer, K., Muhlethaler, J., Stettler, M., and Bosch, H., 1968, Chronic radiation nephritis after exposure in utero, Hely. Paediatr. Acta 23: 489–508.Google Scholar
  178. Schroder, J. H., and Hug, O., 1971, Dominante lethal Mutationen in der Nachkommenschaft bestrahlter mannlicher Mause. I. Untersuchung der Dosiswirkungsbeziehung und des Unterschiedes zwischen ganz und Teilkorperbestrahlung bei meiotischen und postmeiotischen Keimzellenstadien, Mutat. Res. 11: 215–245.Google Scholar
  179. Searle, A. G., and Phillips, R. J. S., 1971, The mutagenic effectiveness of fast neutrons in male and female mice, Mutat. Res. 11: 97–105.Google Scholar
  180. Searle, A. G., Evans, E. P., and Beechey, C. V., 1971, Evidence against a cytogenetically radioresistant spermatogonial population in male mice, Mutat. Res. 12: 219–220.Google Scholar
  181. Segall, A., MacMahon, B., and Hannigan, M., 1964, Congenital malformations and background radiation in northern New England, J. Chron. Dis. 17: 915–932.Google Scholar
  182. Selby, P. B., 1973a, X-ray-induced specific-locus mutation rate in newborn male mice, Mutat. Res. 18: 63–75.Google Scholar
  183. Selby, P. B., 1973b, X-ray-induced specific-locus mutation rates in young male mice, Mutat. Res. 18: 77–88.Google Scholar
  184. Senyszyn, J. J., and Rugh, R., 1969, Hydrocephaly following fetal X-irradiation, Radiology 93: 626–634.Google Scholar
  185. Sharp, J., 1965, The effects of prenatal X-irradiation on acquisition, retention, and extinction of a conditioned emotional response, Radiat. Res. 24: 154–157.Google Scholar
  186. Sharp, J., 1968, Critical flicker frequency in albino rats following prenatal X-irradiation, Radiat. Res. 33: 22–29.Google Scholar
  187. Sikov, M. R., and Noonan, T. R., 1958, Anomalous development induced in the embryonic rat by the maternal administration of radiophosphorus, Am. J. Anat. 103: 137–162.Google Scholar
  188. Sikov, M., Meyer, J., Resta, C., and Lofstrom, J., 1960, Neurological disorders produced by prenatal X-irradiation of the rat. Radiat. Res. 12:472 (abstract 151 ).Google Scholar
  189. Sikov, M. R., Mahlum, D. D., and Howard, E. B., 1972, Effect of age on the morphologic response of the rat thyroid to irradiation by iodine 131I, Radiat. Res. 49: 233–244.Google Scholar
  190. Silverman, F. N., 1966, Thyroid carcinoma and X-irradiation, Thereapeutic radiation versus diagnostic roentgenology, Pediatrics 38: 943–945.Google Scholar
  191. Simpson, C. L., Hemplemann, L., and Fuller, L., 1955, Neoplasia in children treated with X-ray in infancy for thymic enlargement, Radiology 64: 840–845.Google Scholar
  192. Skreb, N., Bijelic, N., and Lukovic, G., 1963, Weight of rat embryos after X-ray irradiation, Experientia 19: 1–4.Google Scholar
  193. Spalding, J. F., and Brooks, M. R., 1972, Comparative litter and reproduction characteristics of mouse populations with X-ray exposure, including 45 generations of male progenitors, Proc. Soc. Exp. Biol. Med. 141: 445–447.Google Scholar
  194. Stadler, J., and Gowen, J. W., 1964, Observations on the effects of continuous irradiation over 10 generations on reproductivities of different strains of mice, in: Proceedings of an International Symposium on the Effects of Ionizing Radiation on Reproductive Systems ( W. D. Carlson and F. X. Gassner, eds.), Pergamon Press, New York.Google Scholar
  195. Stahl, W., 1963, Recent Soviet work on antenatal effects of radiation and a discussion of future implications of general work in this field, in: Proceedings of the Symposium on Prenatal Behavior, Washington, D. C., October 5–7, Division of Biology and Medicine, U. S. Atomic Energy Commission, Conference Report 631008, p. 37.Google Scholar
  196. Sternberg, J., 1970, Irradiation and radiocontamination during pregnancy, Am. J. Obstet. Gynecol. 108: 490–514.Google Scholar
  197. Stettner, E., 1921, Ein weiterer Fall einer Schadingung einer menschlichen Frucht durch Röntgen Bestrahlung, Jahrb. Kinderheikd. Phys. Erzieh. 95: 43–51.Google Scholar
  198. Stewart, A., 1973, The carcinogenic effects of low level radiation. A re-appraisal of epidemiologists methods and observations, Health Phys. 24: 223.Google Scholar
  199. Stewart, A. M., 1972, Mycloid leukaemia and cot deaths, Br. Med. J. 187: 423.Google Scholar
  200. Stewart, A., and Kneale, G. W., 1970, Radiation dose effects in relation to obstetric X-rays and childhood cancers, Lancet 1: 1185–1188.Google Scholar
  201. Stewart, A., Webb, D., Giles, D., and Hewitt, D., 1956, Malignant disease in childhood and diagnostic irradiation in utero, Lancet 2: 447.Google Scholar
  202. Stewart, A., Webb, D., and Hewitt, D., 1958, A survey of childhood malignancies, Br. Med. J. 1: 1495–1508.Google Scholar
  203. Strange, J. R., and Murphree, R. L., 1972, Exposure-rate response in the prenatally irradiated rat: Effects of 100 R on day 11 of gestation to the developing eye, Radiat. Res. 51: 674–684.Google Scholar
  204. Sutow, W., Conrad, R., and Griffith, K., 1965, Growth status of children exposed to fallout radiation on Marshall Islands, Pediatrics 36: 721–731.Google Scholar
  205. Svigris, A., 1958, Sensitivity of hemopoietic organs of pregnant animals and their fetuses to ionizing radiations, Akush. Ginek. 34: 11–17 (in Russian).Google Scholar
  206. Swasdikul, D., and Block, M., 1972, Effect of radiation upon the “embryonic” thymus, Radiat. Res. 50: 73–84.Google Scholar
  207. Tabuchi, A., 1964, Fetal disorders due to ionizing radiation, Hiroshima J. Med. Sci. 13: 125–173.Google Scholar
  208. Tabuchi, A., Nakagawa, S., Hirai, T., Sato, H., Hori, I., Matsuda, M., Yano, K., Shimada, K., and Nakao, Y., 1967, Fetal hazards due to X-ray diagnosis during pregnancy, Hiroshima J. Med. Sci. 16: 49–66.Google Scholar
  209. Tacker, R., and Furchtgott, E., 1963, Adjustment to food deprivation cycles as a function of age and prenantal X-irradiation, J. Genet. Psychol. 102: 257–260.Google Scholar
  210. Toth, B., 1968, A critical review of experiments in chemical carcinogenesis using newborn animals, Cancer Res. 28: 727–738.Google Scholar
  211. Toyooka, E. T., Pifer, J. W., and Hempelmann, L. H., 1963a, Neoplasms in children treated with X-rays for thymic enlargement. III. Clinical description of cases., J. Natl. Cancer Inst. 31: 1379–1405.Google Scholar
  212. Toyooka, E. T., Pifer, J. W., Crump, S. L., Dutton, A. M., and Hempelmann, L. H., 1963b, Neoplasms in children treated with X-rays for thymic enlargement. II. Tumor incidence as a function of radiation factors, J. Natl. Cancer Inst. 31: 1357–1377.Google Scholar
  213. Vernadakis, A., Curry, J. H., Maletta, G. J., Irvine, G., and Timiras, P. A., 1966, Convulsive responses in prenatally irradiated rats, Exp. Neurol. 16: 57–64.Google Scholar
  214. Vorisek, P., 1965, Einfluss der kontinuierlichen intrauterinen Bestrahlung auf die perinatale Mortalität der Frucht, Strahlentherapie 127: 112–120.Google Scholar
  215. Walker, S., and Furchtgott, E., 1970, Effects of prenatal X-irradiation on the acquisition, extinction and discrimination of a classically conditioned response, Radiat. Res. 42: 120–128.Google Scholar
  216. Wechkin, S., Elder, R., Jr., and Furchtgott, E., 1961, Motor performance in the rat as a function of age and prenatal X-irradiation. J. Comp. Physiol. Psychol. 54: 658–659.Google Scholar
  217. Werboff, J., Broeder, J., Havlena, J., and Sikov, M., 1961, Effects of prenatal X-ray irradiation on audiogenic seizures in the rat, Exp. Neurol 4: 189–196.Google Scholar
  218. Wilson, J. G., 1954, Differentiation and reaction of rat embryos to radiation, J. Cell. Comp. Physiol. 43: 11–37.Google Scholar
  219. Wilson, J. G., Brent, R. L., and Jordan, H. C., 1953a, Differentiation as a determinant of the reaction of rat embryos to X-irradiation, Proc. Soc. Exp. Biol. Med. 82:67–70; also U. S. A. E. C. D. U. R.-243.Google Scholar
  220. Wilson, J. G., Jordan, H. C., and Brent, R. L., 1953b, Effects of irradiation on embryonic de- velopment. II. X-rays on the ninth day of gestation in the rat*, Am. J. Anat. 92: 153–188.Google Scholar
  221. Wood, J. W., Johnson, K. G., and Omori, Y., 1967a, In utero exposure to the Hiroshima atomic bomb. An evaluation of head size and mental retardation: Twenty years later, Pediatrics 39: 385–392.Google Scholar
  222. Wood, J., Johnson, K., Omori, Y., Kawamoto, S. and Keehn, R., 1967b, Mental retardation in children exposed in utero to the atomic bombs in Hiroshima and Nagasaki, Am. J. Public Health 57: 1381–1390.Google Scholar
  223. Wood, J., Keehn, R., Kawamoto, S. and Johnson, K., 1967c, The growth and development of children exposed in utero to the atomic bombs in Hiroshima and Nagasaki, Am. J. Public Health 57: 1374–1380.Google Scholar
  224. Wright, F. W., 1973, Diagnostic radiology and the fetus, Br. Med. J. 3: 693–694.Google Scholar
  225. Wyburn, J. R., 1972, Human breast milk excretion on radionuclides following administration of radiopharmaceuticals, J. Nucl. Med. 14: 115–117.Google Scholar
  226. Yamazaki, J. N., 1966, A review of the literature on the radiation dosage required to cause manifest central nervous system disturbances from in utero and postnatal exposure, Pediatrics 37: 877–903.Google Scholar
  227. Yamazaki, J., Wright, S., and Wright, P., 1954, Outcome of pregnancy in women exposed to the atomic bomb in Nagasaki, Am. J. Dis. Child. 87: 448–463.Google Scholar

Microwave Radiation

  1. Alliston, C. W., Howarth, B., Jr., and Ulberg, L. C., 1965, Embryonic mortality following culture in vitro of one and two-cell rabbit eggs at elevated temperatures,/ Reprod. Fertil. 9: 337–341.Google Scholar
  2. Boak, R. A., Carpenter, C. M., and Warren, S. L., 1932, Studies on the physiological effects of fever temperatures. II. The effect of repeated shortwave (30 meter) fever on growth and fertility of rabbits, J. Exp. Med. 56: 725–739.Google Scholar
  3. Brent, R. L., 1972, Irradiation in pregnancy, Davis’ Gynecology and Obstetrics, Vol. 2 (J. J. Sciarra, ed.), pp. 1–32, Harper & Row, New York.Google Scholar
  4. Brent, R. L., and Franklin, J. B., 1960, Uterine vascular clamping new procedure for the study of congenital malformations, Science 132: 89–91.Google Scholar
  5. Brent, R. L., and Wallace, J. D., 1972, The utilization of microwave radiation in developmental biology research, Pediatr. Res. 6: 431.Google Scholar
  6. Brent, R. L., Franklin, J. B., and Wallace, J. D., 1971, The interruption of pregnancy using microwave radiation, Teratology 4: 484.Google Scholar
  7. Brent, R. L., and Gorson, R. O., 1972, Radiation exposure in pregnancy, in: Current Problems in Radiology ( Robert D. Moseley, Jr., David H. Baker, Robert O. Gorson, Anthony Lalli, Howard B. Latourette, and James L. Quinn, III, eds.), Vol. 2, pp. 1–48, Year Book Medical Publishers, Chicago, Illinois.Google Scholar
  8. Burfening, P. J., Alliston, C. W., and Ulberg, L. C., 1969, Gross morphology and predictability for survival of 4-day rabbit embryos following heat-stress during the first cleavage division, J. Exp. Zool. 170: 55–60.Google Scholar
  9. Carpenter, R. L., 1962, An experimental study of the biological effects of microwave radiation to the eye, Rome Air Development Center Rep. TDR. 62–131.Google Scholar
  10. Chang, M. C., 1957, Effect of pyrogen on embryonic degeneration in the rabbit, Fed. Proc. 16: 21.Google Scholar
  11. Chizzolini, M., 1957, Liverprotection effect of trigonelline on fatty liver from carbon tetrachloride: experimental research, Attuai. Ostet. Ginecol. 3: 1221–1229.Google Scholar
  12. Dietzel, F., and Kern, W., 1970, Fehlgeburt nach Kurzwellenbehandlung—tierexperimentelle Untersuchungen, Arch. Gynaekol. 209: 237–255.Google Scholar
  13. Elliot, D. S., Burfening, P. J., and Ulberg, L. C., 1968, Subsequent development during incubation of fertilized mouse ova stressed by high ambient temperatures, J. Exp. Zool. 169: 481–486.Google Scholar
  14. Fernandez-Cano, L., 1958, Effect of increase or decrease of body temperature and hypoxia on pregnancy in the rat, Fertil Steril. 9: 455–459.Google Scholar
  15. Gellhorn, G., 1928, Diathermy in gynecology, J. Am. Med. Assoc. 90: 1005–1008.Google Scholar
  16. George, E. F., Franklin, J. B., and Brent, R. L., 1967, Altered embryonic effects of uterine vascular clamping in the pregnant rat by uterine temperature control, Proc. Soc. Exp. Biol. Med. 124: 257–260.Google Scholar
  17. Harmsen, H., 1954, Uber die biologische Wirksamkeit von ultrakurz Wellen niederer Feldstarke auf Ratten, Arch. Hyg. 738: 278–297.Google Scholar
  18. Hart, F. N., and Faber, J. J., 1965, Fetal and maternal temperatures in rabbits, J. App. Physiol. 20: 734–741.Google Scholar
  19. Hofmann, D., and Dietzel, F., 1966, Aborte and Missbildungen nach Kurzwellendurehflutung in der Schwangerschaft, Geburtschilfe Frauenheilkd. 26: 378–390.Google Scholar
  20. Howarth, B., Jr., 1969, Embryonic survival in adrenalectomized rabbits following exposure to elevated ambient temperature and constant humidity, J. Anim. Sci. 28: 80–83.Google Scholar
  21. Labhsetwar, A. P., 1972, New antifertility agent—an orally active prostaglandin-ICI 74, 205, Nature, 238: 400–401.Google Scholar
  22. Ludwig, F., and Ries-Bern, J. V., 1942, Die Beeinflussung der embryonalen Entwicklung durch Kurzwellen, Arch. Gynaekol. 173: 323–324.Google Scholar
  23. Mali, J. W. H., 1969, Some physiological aspects of the temperature of the body surface, Bibl. Radiol. 5: 8–21.Google Scholar
  24. McRee, D. I., 1971, Threshold for lenticular damage in the rabbit eye due to single exposure to CW microwave radiation: An analysis of the experimental information at a frequency of 2.45 GHz, Health Phys.. 21: 763–769.Google Scholar
  25. Michaelson, S. L., 1969, Biological effects of microwave exposure, in: Biological Effects in Health Implication of Microwave Radiation, Symposium Proceedings, Richmond, Virginia, Sept. 17–19 ( S. F. Cleary, ed.), pp. 35–58, U. S. Public Health Service, Rockville, Maryland.Google Scholar
  26. Michaelson, S. M., 1971a, Biomedical aspects of microwave exposure, Am. Ind. Hyg. Assoc. J. 32: 338–345.Google Scholar
  27. Michaelson, S. M., 197lb, Soviet views on the biological effect of microwaves—an analysis, Health Phys. 21: 108–111.Google Scholar
  28. Milroy, W. C., and Michaelson, S. M., 1971, Biological effects of microwave radiation, Health Phys. 20: 567–575.Google Scholar
  29. Pincus, G., 1966, Control of conception by hormonal steroids, Science 153: 493–500.Google Scholar
  30. Pobzhitkov, V. A., Tyagin, N. V., and Grebeschechnikova, A. M., 1961, The influence of a super-high frequency pulsed electromagnetic field on conception and the course of pregnancy in white mice, Byull. Eksp. Biol. Med. 51: 615–618.Google Scholar
  31. Rubin, A., and Erdman, W. J., II, 1959, Microwave exposure of the human female pelvis during early pregnancy and prior to conception, Case Rep. Am. J. Phys. Med. 38: 219–220.Google Scholar
  32. Schumacher, P. H., 1936, Technik and Erfolg des Ureterenkatheterismus bei einfacher Harnstauung and bei Nierenbeckenentzundung in der Schwangerschaft, Zentralblatt. Gynaekol. 60: 435–441.Google Scholar
  33. Shah, M. K., 1956, Reciprocal egg transplantation to study embryo-uterine relationship in heat-induced failure of pregnancy in rabbits, Nature 117: 1134–1135.Google Scholar
  34. Shelton, M., and Huston, J. E., 1968, Effects of high temperature stress during gestation on certain aspects of reproduction in the ewe, J. Anim. Sci. 27: 153–158.Google Scholar
  35. Sher, L. D., 1970, Symposium on Biological Effects and Health Implications of Microwave Radiation, Richmond, Virginia, Sept. 17–19, 1969, Med. Res. Eng. 9: 12–13.Google Scholar
  36. Thwaites, C. J., 1970, Embryo mortality in the heat of the corpus luteum, thyroid and adrenal glands, J. Reprod. Fertil. 21: 95–107.Google Scholar
  37. Ulberg, U. L., and Burfening, P. J., 1967, Embryo death resulting from adverse environment on spermatozoa or ova, J. Anim. Sci. 26: 571–577.Google Scholar
  38. Weber, J., Zak, K., Malee, I., and Hontela, S., 1969, Einfluss der Kurzwellen—Diathermie auf die intrauterine Temperatur, Zentralblatt Gynaekol., 60: 1923–1924.Google Scholar

Ultrasonic Radiation

  1. Abdulla, U., Talbert, D., Lucas, M., and Mullarkey, M., 1972, Effect on ultrasound on chromosomes of lymphocyte, Br. Med. J. 3: 797–799.Google Scholar
  2. Basauri, L., and Lele, P. P., 1962, A simple method for production of trackless focal lesions with focused ultrasound: Statistical evaluation of the effects of irradiation on the central nervous system of the cat, J. Physiof 160: 513–534.Google Scholar
  3. Bobrow, M., Bleaney, B., Blackwell, N., and Unrau, A. E., 1971, Absence of any observed effect of ultrasonic irradiation on human chromosomes, J. Obstet. Gynaecol. Br. Commonw. 78: 730–736.Google Scholar
  4. Boyd, E., Abdulla, U., Donald, I., Fleming, J. E. E., Hall, A. J., and Ferguson-Smith, M. A., 1971, Chromosome breakage and ultrasound, Br. Med. J. 2: 501–502.Google Scholar
  5. Brent, R. L., 1971, unpublished results.Google Scholar
  6. Buckton, K. E., and Baker, N. V., 1972, An investigation into possible chromosome damaging effects of ultrasound on human blood cells, Br. J. Radio. 45: 340–342.Google Scholar
  7. Campbell, S., 1969, The prediction of fetal maturity by ultrasonic measurement of the biparietal diameter, J. Obstet. Gynaecol. Br. Commonw. 76: 603–609.Google Scholar
  8. Coakley, W. T., 1971, Acoustic detection of single cavitation events in focused fields in water at 1 MHz, J. Acoust. Soc. Am. 49: 792–801.Google Scholar
  9. Coakley, W. T., Hughes, D. E., Slade, J. S., and Laurence, K. M., 1971, Chromosome aberrations after exposure to ultrasound, Br. Med. J. 1: 109–110.Google Scholar
  10. urzen, P., 1972, The safety of diagnostic ultrasound, Practitioner, 209: 822.Google Scholar
  11. Dewhurst, C. J., Beazley, J. M., and Campbell, S., 1972, Assessment of fetal maturity and dysmaturity, Am. J. Obstet. Gynecol. 113: 141.Google Scholar
  12. Doust, B. D., 1973, Role of ultrasound in obstetrics and gynecology, Hasp. Pract. 8: 143–152.Google Scholar
  13. Eller, A., and Flynn, H. G., 1969, Generation of subharmonics of order one-half by bubbles in a sound field,/ Acoust. Soc. Am. 46: 722–727.Google Scholar
  14. Garrett, W., and Robinson, D., 1971, Assessment of fetal size and growth rate by ultrasonic echoscopy, Obstet. Gynecol. 38: 525.Google Scholar
  15. Gottesfield, K., 1970, The ultrasonic diagnosis of intrauterine fetal death, Am. J. Obstet. Gynecol. 108: 623.Google Scholar
  16. Gottesfield, K., Thompson, H., Holmes, J., et al., 1966, Ultrasonic placentography—a new method for placental localization, Am. J. Obstet. Gynecol. 96: 538.Google Scholar
  17. Gottesfield, K., Taylor, E., Thompson, H., et al., 1967, Diagnosis of hydatiform mole by ultrasound, Obstet. Gynecol. 30: 163.Google Scholar
  18. Harvey, E. N., 1930, Biological aspects of ultrasonic waves, a general survey, Biol. Bull. 59: 306–325.Google Scholar
  19. Hellman, L. M., Kobayashi, M., and Cromb, E., 1973, Ultrasonic diagnosis of embryonic malformations, Am. J. Obstet. Gynecol. 115 (5): 615–623.Google Scholar
  20. Ikeuchi, T., Sasaki, M., Oshimura, M., Azumi, T., Tsuji, K., and Shimizu, T., 1973, Ultrasound and embryonic chromosomes, Br. Med. J. 1: 112.Google Scholar
  21. Janssens, D., Vrijens, M., Thiery, M., and Van Kets, H., 1973, Ultrasonic detection, localization and identification of intrauterine contraceptive devices, Contraception 8 (5): 485–495.Google Scholar
  22. King, D., 1973, Placental ultrasonography, J. Clin. Ultrasound 1: 21.Google Scholar
  23. Kirsten, E. V., Zinsser, H. H., and Reid, J. M., 1963, The effect of one Mc ultrasound on the genetics of mice, IEEE Trans. Ultrasonics Engineering UE-10, p. 112.Google Scholar
  24. Kobayashi, M., Hellman, L., and Fillisti, L., 1970, Placental localization by ultrasound, Am. J. Obstet. Gynecol. 106: 279.Google Scholar
  25. Kohorn, E., Seeker-Walker, R., Morrison, J., et al., 1969, Placental localization, Am. J. Obstet. Gynecol. 103: 868.Google Scholar
  26. Lele, P. P., 1963, Effects of focused ultrasonic radiation on peripheral nerve, with observations on local heating, Exp. Neurol. 8: 47–83.Google Scholar
  27. Lele, P. P., and Pierce, A. D., 1972, The thermal hypothesis of the Mechanism of ultrasonic focal destruction in organized tissues, in: Interactions of Ultrasound and Biological Tissues—Workshop Proceedings (J. M. Reid and R. R. Sikov, eds.), U.S. D. H. E. W. Publications (FDA) 73–8008 BRH/DBE, 73–1, Washington, D.C.Google Scholar
  28. Leopold, G. R., 1971, Diagnostic ultrasound in the detection of molar pregnancy, Radiology 98: 171.Google Scholar
  29. Leopold, G. R., and Asher, W. M., 1974, Ultrasound in obstetrics and gynecology, Radiol. Clin. North Am. 12 (1): 127.Google Scholar
  30. Lucas, M., Mullarkey, M., and Abdulla, U., 1972, Study of chromosomes in the newborn after ultrasonic fetal heart monitoring in labour, Br. Med. J. 3: 795–796.Google Scholar
  31. Mannor, S. N., Serr, D. M., Tamari, I., Meshorer, A., and Frei, E. H., 1972, The safety of ultrasound in fetal monitoring, Amer. J. Obstet. Gynecol. 113: 653–661.Google Scholar
  32. Michell, R. C., and Bradley-Watson, P. J., 1973, The detection of fetal meningocoele by ultrasound B scan, J. Obstet. Gynaecol. Br. Commonw. 80: 1100–1101.Google Scholar
  33. Nemes, G., and Kerenyi, T. D., 1971, Ultrasonic localization of the IUCD, J. Obstet. Gynecol. 109: 1219–1220.Google Scholar
  34. Neppiras, E. A., 1969, Subharmonic and other low-frequency emissions from bubbles in sound-irradiated liquids, J. Acoust. Soc. Am. 49: 792–801.Google Scholar
  35. Nyborg, W. L., 1968, Mechanisms for non-thermal effects of sound, J. Acoust. Soc. Am. 44: 1302–1309.Google Scholar
  36. O’Shea, J. M., and Bradbury, J. H., 1972, The effect of ultrasonic irradiation on proteins, Aust. J. Biol. Sci. 26: 583–590.Google Scholar
  37. Robinson, A., 1973, Thymoxamine ineffective against spasticity, Lancet 2 (7844): 1504.Google Scholar
  38. Robinson, H. P., 1973, Fetal heart rates as determined by sonar in early pregnancy, J. Obstet. Gynaecol. Brit. Commonw., 80: 805–809.Google Scholar
  39. Robinson, T. C., and Lele, P. P., 1972, An analysis of lesion development in the brain and in plastics by high-intensity focused ultrasound at low-megahertz frequencies, J. Acoust. Soc. Am. 51: 1333–1351.Google Scholar
  40. Rooney, J. A., 1972, Shear as a mechanism for sonically induced biological effects, J. Acoust. Soc. Am. 52: 1718–1724.Google Scholar
  41. Rott, H. D., and Soldner, P., 1973, The effect of ultrasound on human chromosomes in vitro, Humangenetik 20: 103–112.Google Scholar
  42. Sabbagha, R. E., and Turner, H. J., 1972, Methodology of B-scan sonar cephalometry with electronic calipers and correlation with fetal birth weight. Obstet. Gynecol. 40: 74–81.Google Scholar
  43. Sabbagha, R. E., Turner, H. J., Rockette, H., Mazer, J., and Orgill, J., 1974, Sonar BPD and fetal age: Definition of the relationship, Obstet. Gynecol. 43 (1): 7–14.Google Scholar
  44. Shoji, R., Murakami, U., and Shimizu, T., 1975, Influence of low-intensity ultrasonic irradiation on prenatal development of two inbred mouse strains, Teratology 12: 227–231.Google Scholar
  45. Sikov, M. R., 1973, Ultrasound: Its potential use for the termination of pregnancy, Contraception 8 (5): 429–438.Google Scholar
  46. Smyth, M. G., 1966, Animal toxicity studies with ultrasound at diagnostic power levels, in: Diagnostic Ultrasound ( C C. Grossman, H. J. Holmes, C. Joyner, and E. W. Purnel, eds.), pp. 296–299, Plenum Press, New York.Google Scholar
  47. Thompson, H., and Makowski, E., 1971, Estimation of birth weight and gestational age, Obstet. Gynecol. 37: 44.Google Scholar
  48. Warwick, R. R., Pond, J. B., Woodward, B., and Connolly, C. C., 1970, Hazards of diagnostic ultrasonography—A study with mice, IEEE Trans. Sonia Ultrasonics SU-17, pp. 158–164.Google Scholar
  49. Watts, P. L., and Stewart, C. R., 1972, The effect of fetal heart monitoring by ultrasound on maternal and fetal chromosomes, J. Obstet. Gynaecol. Brit. Commonw. 79: 715–716.Google Scholar
  50. Watts, P. L., Hall, A., and Fleming J., 1972, Ultrasound and chromosome damage, Br. J. Radial. 45: 335.Google Scholar
  51. Winsberg, F., 1973a, Echocardiography of the fetal and newborn heart, Invest. Radiol. 7: 52.Google Scholar
  52. Winsberg, F., 1973b, Echographic changes with placental ageing, J. Clin. Ultrasound 1: 52.Google Scholar
  53. Winters, H. S., 1966, Ultrasound detection of intrauterine contraceptive devices, Am. J. Obstet. Gynecol. 95: 880–882.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Robert L. Brent
    • 1
  1. 1.Jefferson Medical CollegeThomas Jefferson UniversityPhiladelphiaUSA

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