Extremes of Temperature

  • Marshall J. Edwards
  • Raoul A. Wanner


For many years excess heat has been recognized as a powerful inhibitor of normal cellular proliferation in such widely differing systems as the testes and cell cultures. Also it has been recognized as an agent which can cause heavy mortality in preimplantation embryos. It is surprising that until recently it has not been examined in any detail as an agent capable of causing disturbances of prenatal development. The effects of hypothermia have attracted even less attention. Both hyperthermia and hypothermia have produced severe developmental defects, particularly of the central nervous system, as well as of the skeleton and soft tissue. Although this review will concentrate on extremes of temperature and prenatal malformations, some reference will be made to the embryonic wastage associated with changes of temperature during development.


Rectal Temperature Brain Weight Brain Growth Renal Agenesis White Mouse 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Marshall J. Edwards
    • 1
  • Raoul A. Wanner
    • 1
  1. 1.Department of Veterinary MedicineThe University of SydneySydneyAustralia

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