Progress Towards an Implantable Glucose Sensor and an Artificial Beta Cell

  • J. S. Soeldner
  • K. W. Chang
  • S. Aisenberg
  • John M. Hiebert
Part of the ALZA Conference Series book series (ALZA, volume 2)

Abstract

Diabetes mellitus is a relatively common disease which finds itself entering into the 1970’s with many perplexing problems. Fortunately for a great many diabetic patients, insulin has been available for clinical use for slightly over 50 years. Before the availability of this therapeutic hormone, the young juvenile onset diabetic patient could scarcely anticipate more than 2 years of life after onset of the disease. Prior to 1922, the somewhat older, less severe diabetic patient faced a great many problems with his diabetes but did tend to survive for a considerably longer period of time than the juvenile diabetic, but obviously the quality of life for that patient was far from optimal. The availability of insulin changed the total outlook towards this disease quite markedly.

Keywords

Blood Glucose Diabetic Patient Beta Cell Serum Insulin Insulin Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Marks H.H., and L.P. Krall. Onset, course, prognosis and mortality in Diabetes Mellitus. (Chapter 9). Joslin’s Diabetes Mellitus. Philadelphia. Lea and Febiger. 209, 1971.Google Scholar
  2. 2.
    Steinberg, A.G. The genetics of diabetes: a review. Ann. N.Y. Acad. Sci. 82: 197–207, 1959.CrossRefGoogle Scholar
  3. 3.
    Marble, A. Current concepts of diabetes. (Chapter 1). Joslin’s Diabetes Mellitus. Philadelphia. Lea and Febiger. 1, 1971.Google Scholar
  4. 4.
    Craighead, J.E., and J. Steinke. Diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus. Amer. J. Path. 63: 119–138, 1971.Google Scholar
  5. 5.
    Balodimos, M.C. Diabetic Nephropathy. (Chapter 17). Joslin’s Diabetes Mellitus. Philadelphia. Lea and Febiger. 526, 1971.Google Scholar
  6. 6.
    Spiro, R.G. Glycoproteins and Diabetic Microangiopathy. (Chapter 6). Joslin’s Diabetes Mellitus. Philadelphia. Lea and Febiger. 146, 1971.Google Scholar
  7. 7.
    Kilo, C., N. Vogler, and J.R. Williamson. Muscle capillary basement membrane changes related to aging and to diabetes mellitus. Diabetes 21: 881–905, 1972.Google Scholar
  8. 8.
    Gabbay, K.H. and J.B. O’Sullivan. The sorbitol pathway: enzyme localization and content in normal and diabetic nerve and cord. Diabetes 17: 239–243, 1968.Google Scholar
  9. 9.
    Bradley, R.F. Cardiovascular Disease. (Chapter 15). Joslin’s Diabetes Mellitus. Philadelphia. Lea and Febiger, 417, 1971.Google Scholar
  10. 10.
    Berson, S.A. and R.S. Yalow. Quantitative aspects of the reaction between insulin and insulin-binding antibody. J. Clin. Invest. 38: 1996–2016, 1959.CrossRefGoogle Scholar
  11. 11.
    Soeldner, J.S. and D. Slone. Critical variables in the radioimmunoassay of serum insulin using the double antibody technic. Diabetes 14:771–779, 1965.Google Scholar
  12. 12.
    Seltzer, H.S., E.W. Allen, A.L. Herron, Jr., and M.T. Brennan. Insulin secretion in response to glycemic stimulus. Relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J. Clin. Invest. 46:323–335, 1967.CrossRefGoogle Scholar
  13. 13.
    Soeldner, J.S., R.E. Gleason, R.F. Williams, MJ. Garcia, D.M. Beardwood, and A. Marble. Diminished serum insulin response to glucose in genetic prediabetic males with normal glucose tolerance. Diabetes 17:17–26, 1968.Google Scholar
  14. 14.
    Cerasi, E. and R. Luft. Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic control of insulin response? Acta Endocrin. 55:333–345, 1967.Google Scholar
  15. 15.
    Colwell, J.A., and A. Lein. Diminished insulin response to hyperglycemia in prediabetes and diabetes. Diabetes 16:560–565, 1967.Google Scholar
  16. 16.
    Perley, M., and D.M. Kipnis. Plasma insulin responses to glucose and tulbutamide of normal weight and obese diabetic and non-diabetic subjects. Diabetes 15:867–874, 1966.Google Scholar
  17. 17.
    Perley, M.J., and D.M. Kipnis. Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J. Clin. Invest. 46:1954–62, 1967.CrossRefGoogle Scholar
  18. 18.
    Hansen A., and K. Johansen. Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics. Diabetologia 6:27–33, 1970.CrossRefGoogle Scholar
  19. 19.
    Cahill, G.F., Jr., J.S. Soeldner, G.W. Harris, and R.O. Foster. Practical Developments in Diabetes Research. Diabetes 21 (Suppl. 2):703-712, 1972.Google Scholar
  20. 20.
    Kadish, A.H. Physiologic monitoring of blood glucose. Calif. Med. 98:325–327, 1963.Google Scholar
  21. 21.
    Molnar, G.D., E. Ackerman, J.W. Rosevear, L.C. Gatewood, K.E. Moxness. Continuous blood glucose analysis in ambulatory fed subjects. I. General methodology. Mayo Clin. Proc. 43:833–851, 1968.Google Scholar
  22. 22.
    Wolfson, S.K., Jr., and C.K. Strohl, Jr. Bioautofuel cell as a possible power source for cardiac pacemakers. Circulation 36(Suppl. 2):273–274, 1967.Google Scholar
  23. 23.
    Foster, R.O. The Dynamics of blood sugar regulation. Thesis, Massachusetts Inst. of Tech., 1970.Google Scholar
  24. 24.
    Grodsky, G.M. A Threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J. Clin. Invest. 51:2047–2059, 1972.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • J. S. Soeldner
    • 1
    • 2
    • 3
    • 4
  • K. W. Chang
    • 1
    • 2
    • 3
    • 4
  • S. Aisenberg
    • 1
    • 2
    • 3
    • 4
  • John M. Hiebert
    • 1
    • 2
    • 3
    • 4
  1. 1.E. P. Joslin Research Laboratory, Department of MedicinePeter Bent Brigham Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Space Sciences DivisionWhittaker CorporationWalthamUSA
  3. 3.The Joslin Diabetes Foundation, Inc.BostonUSA
  4. 4.Department of SurgeryBoston University Medical SchoolBostonUSA

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