Testosterone Polydimethylsiloxane Implants and Contraception in Male Rabbits

  • L. L. Ewing
  • C. Desjardins
  • L. G. Stratton
Part of the ALZA Conference Series book series (ALZA, volume 2)


Numerous experiments (1–4) have shown that low doses (5 mg/kg/day) of testosterone inhibit spermatogenesis in intact rats whereas high closes (10 mg/kg/ day) qualitatively maintain spermatogenesis in adult hypophysectomized rats. The capacity of testosterone to exert differential effects on spermatogenesis has been attributed to the fact that low doses of testosterone effectively inhibit the secretion of pituitary gonadotrophic hormones, but are insufficient to achieve direct stimulation of the seminiferous epithelium (5). In view of these findings it is not surprising that appropriate androgen therapy (6, 7) results in azoospermia in man that can be reversed upon withdrawal of the hormonal steroid.


Seminal Plasma Plasma Testosterone Seminiferous Epithelium Tritium Concentration Male Rabbit 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • L. L. Ewing
    • 1
  • C. Desjardins
    • 1
  • L. G. Stratton
    • 1
  1. 1.Division of Reproductive Biology, Department of Population DynamicsJohns Hopkins University School of Hygiene and Public HealthUSA

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