The Role of Prostaglandins in the Immune Response

  • C. W. Parker
Part of the Alza Conference Series book series (AEMB, volume 195B)


Prostaglandins could exert an important influence on the immune response at at least six levels: (1) As a part of the control mechanism which is altered when lymphocytes dedifferentiate and replicate in response to antigen. (2) As short or long range messengers in cell-cell interactions between lymphoid cells. Thus prostaglandins might be involved in the interactions between thymic (T) and bone marrow (B) cells that are required for the full development of cellular and humoral immunity (Hartman, 1971). Or they might participate in the phenomenon of antigenic competition where an ongoing immune response interferes nonspecifically with the effectiveness of an unrelated antigen (Moller, 1971). (3) As regional hormones which might influence the level of differentiation of lymphoid cells in their local environment. Thus, local differences in prostaglandin levels in the thymus and peripheral lymphoid tissues might be involved in thymic cell differentiation in the periphery (Owen & Raff, 1970).


Adenylate Cyclase Lymphocyte Transformation Adenylate Cyclase System Bronchodilator Activity Intact Lymphocyte 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • C. W. Parker
    • 1
  1. 1.Department of Internal MedicineWashington University Schol of MedicineUSA

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