Effect of Prostaglandins upon Enzyme Release from Lysosomes and Experimental Arthritis

  • R. B. Zurier
  • G. Weissmann
Part of the Alza Conference Series book series (AEMB, volume 195B)


Cells engaged in the uptake of particles become the center of acute inflammatory reactions (Metchnikoff, 1905). This phenomenon has been attributed, in part, to the release from phagocytic cells of enzymes previously sequestered within lysosomes (Weissmann, 1967). Exposure of joints to lysosomal extracts results in inflammation and cartilage degradation (Weissmann et al, 1969). Therefore, inhibition of enzyme release from cells which participate in the inflammatory response may modify the inflammation and subsequent tissue injury.


Corticosterone Level Adjuvant Arthritis Purify Protein Derivative Enzyme Release Experimental Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson, A. J., Brocklehurst, W. E., and Willis, A. L., 1971, Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin induced inflammation in the rat, Pharmacol. Res. Commun. 3:13.CrossRefGoogle Scholar
  2. Aspinall, R. L., and Cammarata, P. S., 1969, Effect of Prostaglandin E(2) on adjuvant arthritis, Nature, 224:1320.PubMedCrossRefGoogle Scholar
  3. Berney, S., Bishko, F., and Quagliata, F., 1971, Distribution of normal and sensitized lymphoid cells with adjuvant induced arthritis, Arth. & Rheum., 14:370.Google Scholar
  4. Bourne, H. R., Lehrer, R. I., Cline, M. J., Melmon, R. J., 1971, Cyclic 3′,5′-adenosine monophosphate in the human leukocyte: Synthesis, degradation and effects on neutrophil candidacidal activity, J. Clin. Invest., 50:920.PubMedCrossRefGoogle Scholar
  5. Couch, T. L., and Benton, A. W., 1971, The effect of the venom of the honey bee Apis Mellifera L., on the adrenocortical response of the adult male rat, Toxicon, 9:000.Google Scholar
  6. deDuve, C., and Wattiaux, R., 1966, Functions of lysosomes, Ann. Rev. Physiol., 28:435.Google Scholar
  7. deWied, D., Witter, A., Versteeg, D. H. G., and Mulder, A. H., 1969; Release of ACTH by substances of central nervous system origin, Endocrinol., 85:561.CrossRefGoogle Scholar
  8. Dingle, J. T., 1968, Vacuoles, vesicles and lysosomes, Brit. Med. Bull., 24:141.Google Scholar
  9. Eliasson, R., 1959, Acta Physiol. Scand., 46, Suppl. 158:1.Google Scholar
  10. Flack, J. D., Jessup, R., and Ramwell, P. W., 1969, Prostaglandin stimulation of rat corticosteroidogenesis, Science, 163:691.PubMedCrossRefGoogle Scholar
  11. Freed, J. J., and Lebowitz, M. M., 1970, The association of a class of saltatory movements with microtubules in cultured cells, J. Cell Biol. 45:334.PubMedCrossRefGoogle Scholar
  12. Goodman, D. B. P., Rasmussen, H., DiBella, F., and Guthrow, C., 1970, Cyclic adenosine 3′,5′-monophosphate-stimulated phosphorylation of isolated neurotubule subunits, Proc. Nat. Acad. Sci., 67:652.PubMedCrossRefGoogle Scholar
  13. Henney, C. S., and Lichtenstein, L. M., 1971, The role of cyclic AMP in the cytolytic activity of lymphocytes, J. Immunol., 107:610.PubMedGoogle Scholar
  14. Hirschhorn, R., Grossman, J., and Weissmann, G., 1970, Effect of cyclic 3′,5′-adenosine monophosphate and theophylline on lymphocyte transformation, Proc. Soc. Exp. Biol. & Med., 133:1361.Google Scholar
  15. Karnovsky, M. L., Baehner, R. L., Githens, S., Simmons, S., and Glass, E. A., June 1970, Correlations of metabolism and function in various phagocytes, Excerpta Medica International Congress, Series, No. 229, In Immunopathology of Inflammation, p. 121.Google Scholar
  16. Koopman, W. J., Orange, R. P., and Austen, K. F., 1971, Prostaglandin inhibition of the immunologic release of slow reacting substance of anaphylaxis in the rat, Proc. Soc. Exp. Biol. & Med. 137:64.Google Scholar
  17. Metchnikoff, E., 1905 (1968 reprint), Immunity in infective diseases, Johnson Reprint Corp., New York.Google Scholar
  18. Pearson, C. M., and Wood, F. D., 1959, Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. I. General clinical and pathological characteristics and some modifying factors, Arth. S Rheum. 2:440.CrossRefGoogle Scholar
  19. Ramwell, P. W., and Shaw, J., 1970, Biological significance of the prostaglandins. Recent Progress Horm. Res., Vol, 26, Academic Press, N. Y.Google Scholar
  20. Rosenau, W., 1963, In Cell-Bound Antibodies, Ed. by B. Amos and H. Koprowski, p. 75, Wistar Inst. Press, Philadelphia.Google Scholar
  21. Scott, R. E., 1970, Effects of prostaglandins, epinephrine and NaF on human leukocyte, platelet and liver adenylate cyclase, Blood, 35:514.PubMedGoogle Scholar
  22. Sessa, G., Freer, J. H., Colacicco, G., and Weissmann, G., 1969, Interaction of a lytic polypeptide, melittin, with lipid membrane systems, J. Biol. Chem. 244:3575.PubMedGoogle Scholar
  23. Smith, J. W., Steiner, A. L., Parker, C. W., 1971, Human lymphocyte metabolism: Effects of cyclic and ncncyclic nucleotides on stimulation by phytohemagglutinin, J. Clin. Invest. 50:442.PubMedCrossRefGoogle Scholar
  24. Vane, J. R., 1971, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs, Nature New Biol., 231:232.PubMedGoogle Scholar
  25. Vogt, W., Meyer, J., Kunze, H., Lufft, E., and Babilli, S., 1969, Enststehung von SRS-C in der durchstromten Meerschweinchenlunge durch phospholipase A. Identifizierung mit prostaglandin., Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak. 262:124.CrossRefGoogle Scholar
  26. Weissmann, G., 1967, The role of lysosomes in inflammation and disease, Ann. Rev. Med. 18:97.PubMedCrossRefGoogle Scholar
  27. Weissmann, G., Dukor, P., and Zurier, R. B., 1971a, Effect of cyclic AMP on release of lysosomal enzymes from phagocytes. Nature New Biol., 231:131.PubMedGoogle Scholar
  28. Weissmann, G., and Dukor, P., 1970, The role of lysosomes in the immune response, Adv. Immunol. 12:283.PubMedCrossRefGoogle Scholar
  29. Weissmann, G., Reiser, H., and Bernheimer, A. W., 1963, Studies on lysosomes. III. The effects of streptolysins o and S on the release of acid hydrolases from a granular fraction of rabbit liver, J. Exp. Med. 118:205.PubMedCrossRefGoogle Scholar
  30. Weissmann, G., 1964, Labilization and stabilization of lysosomes, Fed. Proc. 23:1038.PubMedGoogle Scholar
  31. Weissmann, G., Dukor, P., and Sessa, G., June 1970, Studies on lysosomes: Mechanisms of enzyœe release from endocytic cells and a model for latency invitro, Excerpta Medica International Congress Series No. 229, Immunopathology of Inflammation, p. 107.Google Scholar
  32. Weissmann, G., Spilberg, I., and Krakauer, K., 1969, Arthritis induced in rabbits by lysates of granulocyte lysosomes, Arth. 6 Rheum., 12:103.CrossRefGoogle Scholar
  33. Weissmann, G., Zurier, R. B., Spieler, P., and Goldstein, I., 1971b, Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles, J. Exp. Med., 134: 149s.PubMedGoogle Scholar
  34. Zaitzev, G. P., and Poriadin, V. T., 1964, Use of the agriculture products in man, in Honeybee and the Health of Man, Ministry of Agriculture USSR, p. 52, Moscow.Google Scholar
  35. Zucker-Franklin, D., and Hirsch, J. G., 1964, Electron microscope studies on the degranulation of rabbit peritoneal leukocytes during phagocytosis, J. Exp. Med. 120:569.PubMedCrossRefGoogle Scholar
  36. Zurier, R. B., and Quagliata, F., (in press), Effect of prostaglandin E(1) on adjuvant arthritis, Nature.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • R. B. Zurier
    • 1
  • G. Weissmann
    • 1
  1. 1.Departments of Medicine, Cell Biology and GeneticsNew York University School of MedicineUSA

Personalised recommendations