Prostaglandin E(1) and E(2): Qualitative Difference in Platelet Aggregation

  • H. Shio
  • P. W. Ramwell
Part of the Alza Conference Series book series (AEMB, volume 195B)


Blood platelets exhibit a number of characteristic reactions, i.e. aggregation, adhesion, clot retraction, shape change, etc. Since these reactions are greatly modified by drugs, and since platelets are obtained relatively easily as a single cell preparation, platelets are now considered as a good model system of pharmacological analysis (Shio and Ramwell, 1972a). The aggregation of the cells can be analyzed by means of optical density (OD) change of platelet-rich plasma (PRP) (Born, 1962), and shape change, e.g. by adenosine diphosphate (ADP), is also quantitatively determined with OD recording (Born 1970, Shio et al, 1970).


Platelet Aggregation Platelet Rich Plasma Human Platelet Adenylate Cyclase Stimulation Aspirin Ingestion 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • H. Shio
    • 1
    • 2
  • P. W. Ramwell
    • 1
    • 2
  1. 1.Institute of Biological SciencesAlza Corp.Palo AltoUSA
  2. 2.Worcester Foundation for Experimental BiologyShrewsburyUSA

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