Prostaglandins and the Microvascular System: Physiological and Histochemical Correlations

  • G. R. Siggins
Part of the Alza Conference Series book series (AEMB, volume 195B)


It is well known that the prostaglandins markedly alter cardiovascular activity. However, the nature of the vascular response to exogenously administered prostaglandins depends not only upon the type and dose of prostaglandin studied but also upon the test system used. In general, a myriad of reports have shown that prostaglandins E(1), E(2), A(1), A(2), F(1-alpha) and F(2-alpha) are potent vasodilator substances. All of these prostaglandins, and especially PGF(2-alpha), have also been reported to produce vasoconstriction in some vascular preparations (DuCharme and Weeks, 1967; Jackson and Stovall, 1968; Nakano, 1968; Strong and Bohr, 1967; Sunahara and Kadar, 1968; Davies and Withrington, 1969; Mark et al, 1971). At least a few of the discrepancies in effect reported for the prostaglandins may result from the general employment of indirect methods, such as estimations of systemic blood pressure, flow and vascular resistance, to estimate changes in vessel diameter.


Cheek Pouch Hamster Cheek Pouch Arteriolar Wall Perivascular Nerve Chemical Sympathectomy 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • G. R. Siggins
    • 1
  1. 1.Laboratory of Neuropharmacology, Division of Special Mental Health Research, NIMHSaint Elizabeth’s HospitalUSA

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