Interactions of Prostaglandin E(1) and Catecholamines in Isolated Vascular Smooth Muscle

  • C. G. Strong
  • J. T. Chandler
Part of the Alza Conference Series book series (AEMB, volume 195B)


Prostaglandin E compounds are potent vasodepressors in situ, decreasing blood pressure and vascular resistance. Von Euler (1936) showed that prostaglandin lowers blood pressure and induces vasodilatation in the perfused hindlimb of the cat, Lee et al (1965) concluded that the vasodepressor action of PGE(1) was attributable to a direct relaxation effect on peripheral arteriolar beds, Weiner and Kaley (1969) have shown that PGE(1) has a direct transient vasodilator effect on muscular microvessels and another independent effect whereby it antagonizes the vasoconstrictor action of angiotensin, vasopressin, epinephrine, and norepinephrine. Hedwall et al (1970) also demonstrated that the direct venodilator effect of PGE(1) could be dissociated from its inhibition of venoconstrictor responses to nerve stimulation, norepinephrine, and angiotensin,


Vascular Smooth Muscle Contractile Response Active Tension Physiological Salt Solution Aortic Strip 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bohr, D. F., 1964, Contraction of vascular smooth muscle, Can, Med. Assoc. J. 90:174.Google Scholar
  2. Bohr, D. F., 1967, Individuality in smooth muscle control, in “Ureteral Reflux in Children,” (J. F. Glenn, ed.), pp. 57–66, National Academy of Sciences — National Research Council, Washington, D. C.Google Scholar
  3. Bohr, D. F., and Johansson, B., 1966, Contraction of vascular smooth muscle in response to plasma: Comparison with response to known vasoactive agents, Circ. Res. 19:593.PubMedGoogle Scholar
  4. Carlson, L. A., and Oro, L., 1966, Effect of prostaglandin E(1) on blood pressure and heart rate in the dog: Prostaglandin and related factors 48, Acta Physiol. Scand 67:89.PubMedCrossRefGoogle Scholar
  5. Dixon, W. J., and Massey, F. J., Jr., 1969, “Introduction to Statistical Analysis,” 3rd edition, McGraw-Hill Book Company, Inc., New York.Google Scholar
  6. Ebashi, S., and Ebashi, F., 1964, A new protein component participating in the superprecipitation of myosin B, J. Biochem. (Tokyo) 55:604.Google Scholar
  7. Hartshorne, D. J., Theiner, M., and Mueller, H., 1969, Studies on troponin, Biochim. Biophys. Acta 175:320.PubMedGoogle Scholar
  8. Hedwall, P. R., Abdel-Sayed, W. A., Schmid, P. G., and Abboud, F. M., 1970, Inhibition of venoconstrictor responses by prostaglandin E(1), Proc. Soc. Exp. Biol. Med. 135:757.PubMedGoogle Scholar
  9. Khairallah, P. A., Page, I. H., and Turker, R. K., 1967, some properties of prostaglandin E(1) action on muscle, Arch. Int. Pharmacodyn. Ther. 169:328.PubMedGoogle Scholar
  10. Lee, J. B., Covino, B. G., Takman, B. H., and Smith, E. R., 1965, Renomedullary vasodepressor substance, medullin: Isolation, chemical characterization and physiological properties, Circ. Res. 17:57.PubMedGoogle Scholar
  11. Strong, C. G., and Bohr, D. F., 1967, Effects of prostaglandins E(1), E(2), A(1), and F(1-alpha) on isolated vascular smooth muscle. Amer. J. Physiol. 213:725.PubMedGoogle Scholar
  12. Von Euler, U. S., 1936, On the specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin), J. Physiol. (London) 88:213.Google Scholar
  13. Weeks, J. R., 1969, The prostaglandins: biologically active lipids with implications in circulatory physiology, Circ. Res. 24: (Suppl. 1):123.PubMedGoogle Scholar
  14. Weiner, R., and Kaley, G., 1969, Influence of prostaglandin E(1) on the terminal vascular bed. Amer. J. Physiol. 217:563.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • C. G. Strong
    • 1
  • J. T. Chandler
    • 1
  1. 1.Mayo Clinic and Mayo FoundationRochesterUSA

Personalised recommendations