Abstract
Prostaglandin E compounds are potent vasodepressors in situ, decreasing blood pressure and vascular resistance. Von Euler (1936) showed that prostaglandin lowers blood pressure and induces vasodilatation in the perfused hindlimb of the cat, Lee et al (1965) concluded that the vasodepressor action of PGE(1) was attributable to a direct relaxation effect on peripheral arteriolar beds, Weiner and Kaley (1969) have shown that PGE(1) has a direct transient vasodilator effect on muscular microvessels and another independent effect whereby it antagonizes the vasoconstrictor action of angiotensin, vasopressin, epinephrine, and norepinephrine. Hedwall et al (1970) also demonstrated that the direct venodilator effect of PGE(1) could be dissociated from its inhibition of venoconstrictor responses to nerve stimulation, norepinephrine, and angiotensin,
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© 1972 Plenum Press, New York
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Strong, C.G., Chandler, J.T. (1972). Interactions of Prostaglandin E(1) and Catecholamines in Isolated Vascular Smooth Muscle. In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_19
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DOI: https://doi.org/10.1007/978-1-4684-2844-5_19
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