Contraction of Isolated Cutaneous Vascular Smooth Muscle and its Response to Prostaglandins

  • R. K. Winkelmann
  • W. M. SamsJr.
  • M. E. Goldyne
Part of the Alza Conference Series book series (AEMB, volume 195B)


The development of a technique for the preparation of continuous helical strips of smooth muscle from small arterioles showed that cutaneous vascular smooth muscles could be studied directly and that their responses to natural and pharmacological compounds are consistent (Bohr et al, 1961). The pharmacological responses are dependent on the species and organs selected for vessel study. The size of the vessel and even the region of the organ are important (Bohr, 1965). Such studies have provided the basis for a receptor theory of small coronary vessel response to catecholamine (Bohr, 1967). Similar studies of human cutaneous vessels have indicated the presence of alpha-receptors and are important in understanding the physiology and pathology of the skin (Winkelmann et al, 1970). Our purpose is to summarize the data obtained by this method and to show the effect of prostaglandins on isolated human cutaneous vascular strips.


Vascular Smooth Muscle Contractile Response Physiological Salt Solution Adenylate Cyclase System Skin Vessel 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • R. K. Winkelmann
    • 1
  • W. M. SamsJr.
    • 1
  • M. E. Goldyne
    • 1
  1. 1.Dept. of DermatologyMayo ClinicRochesterUSA

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