The Role of Prostaglandins in Microcirculatory Regulation and Inflammation

  • G. Kaley
  • E. J. Messina
  • R. Weiner
Part of the Alza Conference Series book series (AEMB, volume 195B)


The mediation of inflammatory changes during tissue injury reactions has been ascribed to a wide variety of biologically active agents, yet the complete description of these factors still awaits definition. Inf lamination, irrespective of its cause, sets into motion a series of typical, interwoven events which in its early phases is characterized by vasodilation, adhesion of platelets, increased vascular permeability and emigration of leukocytes into the affected area. Since the recent suggestion that prostaglandins may play an important role in the pathogenesis of inflammation (Kaley and Weiner, 1968) evidence has accrued to indicate that these ubiquitous compounds are not only able to mimic the diverse features of the acute inflammatory reaction (Crunkhorn and Willis, 1971a; Kaley and Weiner, 1971a), but also that they are generated and released from many tissues under conditions when there is a disturbance of normal cell function (Piper and Vane, 1971) and that they are found in inflammatory exudates of different origin (Willis, 1969; Greaves et al, 1971).


Vascular Permeability Gracilis Muscle Inflammatory Exudate Normal Cell Function Arteriolar Diameter 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • G. Kaley
    • 1
  • E. J. Messina
    • 1
  • R. Weiner
    • 1
  1. 1.Department of PhysiologyNew York Medical CollegeUSA

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