Abstract
Prostaglandins have a significant and important inhibitory effect on two pertinent in vitro models, one of immediate and the other of delayed hypersensitivity. These inhibiting effects are best viewed in the context of the adenylate cyclase — cyclic AMP system and can be compared to the inhibition demonstrated by other agents which, like certain of the prostaglandins, stimulate adenylate cyclase. The similarities between the effects noted on two quite different immunologic responses are striking and suggest a general inhibitory role for the prostaglandins and other adenylate cyclase stimulators on leukocyte-lymphocyte responsiveness in general; this possibility will be dealt with by Dr. Henry Bourne. In this presentation we shall describe the activities of these inhibitors first on the immediate and then on the delayed system of hypersensitivity and conclude with some comments on the possible therapeutic implications of the effects noted.
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References
Assem, E. S. K. and Schild, H. O., 1969, Inhibition by sympathomimetic amines of histamine release induced by antigen in passively sensitized human lung, Nature (London), 244:1028.
Bourne, H. R., Lichtenstein, L. M., and Melmon, K. L., (submitted for publication), Pharmacologic control of allergic histamine release in vitro; Evidence for an inhibitory role of 3’,5’-adenosine monophosphate in human leukocytes.
Bourne, H. R., Melmon, K. L., and Lichtenstein, L. M., 1971, Histamine augments leukocyte cyclic AMP and blocks antigenic histamine release, Science, 173:743.
Brunner, K. T., Mauel, J., Cerottini, J. C., and Chapuis, B., 1968, Quantitative assay of the lytic action of immune lymphoid cells on 51Cr-labelled allogeneic target cells in vitro; inhibition by iso-antibody and by drugs, Immunology, 14:181.
Crunkhorn, P., and Willis, A. L., 1971, Cutaneous reactions to intradermal prostaglandins, Brit. J. Pharm. 41:49.
Henney, C. S., (in press). Quantitation of the cell-mediated immune response. I. The number of cytolytically active mouse lymphoid cells induced by immunization with allogenic mastocytoma cells, J. Immun.
Henney, C. S., and Lichtenstein, L. M., 1971, The role of cyclic AMP in the cytolytic activity of lymphocytes, J. Immun. 107:610.
Henney, C. S., and Mayer, M. M., (in press), Specific cytolytic activity of lymphocytes: Effect of antibodies against complement components C2, C3, and C51, J. Immunol.
Ishizaka, T., DeBernardo, R., Tomioka, H., Lichtenstein, L. M., and Ishizaka, K., (in press), Identification of basophil granulocytes as a site of allergic histamine release, J. Immun.
Ishizaka, T., Ishizaka, K., Orange, R. P., and Austen, K. F., 1971, The pharmacologic inhibition of the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung tissues mediated by human IgE, J. Immun. 106:1267.
Lichtenstein, L. M., 1968, Mechanism of allergic histamine release from human leukocytes. In: “International Symposium on the Biochemistry of Acute Allergic Reactions,” Edited by E. L. Becker and K. F. Austen, Blackwell Scientific Productions, London.
Lichtenstein, L. M., (in press). The immediate allergic response: in vitro separation of antigen activation, decay and histamine release, J. Immun.
Lichtenstein, L. M., and DeBernardo, R., (in press). The immediate allergic response: In vitro action of cyclic AMP active and other drugs on the two stages of histamine release, J. Immun.
Lichtenstein, L. M., Levy, D. A., and Ishizaka, K., 1970, In vitro reversed anaphylaxis: Characteristics of anti-IgE mediated histamine release. Immunology, 19:831.
Lichtenstein, L. M., and Margolis, S., 1968, Histamine release in vitro: Inhibition by catecholamines and methylxanthines, Science 161:902.
Lichtenstein, L. M., Norman, P. S., Osler, A. G., and Winkenwerder, W., L., 1966, In vitro studies of human ragweed allergy: Changes in cellular and humoral activity associated with specific desensitization, J. Clin. Invest. 45:1126.
Lichtenstein, L. M., and Osler, A. G., 1964, Studies on the mechanisms of hypersensitivity phenomena. IX. Histamine release from human leukocytes by ragweed pollen antigen, J. Exp. Med. 120:507.
Orange, R. P., Kaliner, M. A., and Austen, K. J., 1971, Enhancement of the immunologic release of histamine and SRS-A from human lung. Fed. Proc. 30:653.
Rehn, T. G., and Henney, C. S., (in press). The cytolytic activity of human lymphocytes. I. Cytolytic activity towards PPD coated target cells in tuberculin positive and negative individuals, Clin. Exp. Immun.
Robison, G. A., Butcher, R. W., and Sutherland, E. W., 1971, Cyclic AMP, Academic Press, N. Y.
Sadan, N., Rhyne, M. B., Mellits, D., Goldstein, E. O., Levy, D. A., and Lichtenstein, L. M., 1969, Immunotherapy of pollinosis in children: An investigation of the immunological basis of clinical improvement, N. Eng. J. Med. 280:623.
Smith, J. W., Steiner, A. L., Newberry, W. M., Jr., and Parker, C. W., 1971, Cyclic adenosine 3’,5’-monophosphate in human lymphocytes: Alterations after phytohemagglutinin stimulation, J. Clin. Invest. 50:432.
Sondergaard, J., and Greaves, M. W., 1971, Prostaglandin E(1): Effect on human cutaneous vasculature and skin histamine, Brit. J. Derm. 84:424.
Szentivanyi, A., 1968, The beta-adrenergic theory of the atopic abnormality in bronchial asthma, J. Allergy 42:203.
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Lichtenstein, L.M., Henney, C.S. (1972). Prostaglandin Inhibition of Immediate and Delayed Hypersensitivity in Vitro . In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_14
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DOI: https://doi.org/10.1007/978-1-4684-2844-5_14
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