Prostaglandin Inhibition of Immediate and Delayed Hypersensitivity in Vitro
Prostaglandins have a significant and important inhibitory effect on two pertinent in vitro models, one of immediate and the other of delayed hypersensitivity. These inhibiting effects are best viewed in the context of the adenylate cyclase — cyclic AMP system and can be compared to the inhibition demonstrated by other agents which, like certain of the prostaglandins, stimulate adenylate cyclase. The similarities between the effects noted on two quite different immunologic responses are striking and suggest a general inhibitory role for the prostaglandins and other adenylate cyclase stimulators on leukocyte-lymphocyte responsiveness in general; this possibility will be dealt with by Dr. Henry Bourne. In this presentation we shall describe the activities of these inhibitors first on the immediate and then on the delayed system of hypersensitivity and conclude with some comments on the possible therapeutic implications of the effects noted.
KeywordsAdenylate Cyclase Histamine Release Prostaglandin Inhibition Adenylate Cyclase Stimulator Mastocytoma Cell
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