Formation of Prostaglandins in the Skin Following a Burn Injury

  • E. Anggard
  • C.-E. Jonsson
Part of the Alza Conference Series book series (AEMB, volume 195B)


Two phases are discerned in the vascular response to a burn injury, one immediate, lasting 5–10 min, and one delayed starting after about 30 min and lasting several hours to days. Histamine has been suggested as a mediator of the first phase of the inflammatory response, and vasoactive polypeptides have been implied in the delayed phase (Spector and Willoughby, 1968). In the following we shall describe results showing that prostaglandin E(2) is formed in the skin following a burn injury, and may thus be an additional mediator in the delayed phase of the tissue response to a burn injury.


Arachidonic Acid Sterol Ester Silicic Acid Chromatography Scaly Lesion Reverse Phase Partition Chromatography 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • E. Anggard
    • 1
    • 2
  • C.-E. Jonsson
    • 1
    • 2
  1. 1.Dept. of PharmacologyKarolinska Inst.StockholmSweden
  2. 2.The Burn Centre, Dept. of Plastic SurgeryUniversity HospitalUppsalaSweden

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