Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs

  • A. L. Willis
  • P. Davison
  • P. W. Ramwell
  • W. E. Brocklehurst
  • B. Smith
Part of the Alza Conference Series book series (AEMB, volume 195B)


When studying the pharmacological mediation of an inflammatory reaction, several difficulties are encountered. These lie in the multiplicity of factors involved and the complexity of their interactions. However, there are rigid criteria which ought to be satisfied before a substance can be definitely classified as a mediator of inflammation; these are listed below:
  1. (1)

    The putative mediator of inflammation should induce some or all of the signs of inflammation.

  2. (2)

    During the inflammatory reaction, the putative mediator should be released in amounts whose local concentrations in the tissue are capable of inducing these signs; ideally its appearance should correlate with development of the inflammatory reaction.

  3. (3)

    Release or actions of the putative mediator should be reduced by known anti-inflammatory drugs and, as a corollary, drugs which reduce the release or actions of the mediator should possess anti-inflammatory properties.



Lysosomal Enzyme Sodium Salicylate Prostaglandin Production Rheumatoid arthritiS Prostaglandin Synthetase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • A. L. Willis
    • 1
  • P. Davison
    • 1
  • P. W. Ramwell
    • 1
  • W. E. Brocklehurst
    • 1
  • B. Smith
    • 1
  1. 1.Department of Physiology, Medical SchoolStanford UniversityUSA

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