The Role of Prostaglandins in the Regulation of Growth and Morphology of Transformed Fibroblasts
The use of N6,O2’-dibutyryl 3’,5’-adenosine monophosphate (dbc-AMP) has demonstrated that cyclic AMP regulates several functions of fibroblasts (Table I) (Johnson et al, 1971a and 1971b; Sheppard, 1971; Hsie and Puck, 1971), Since these functions are frequently altered by transformation, the regulation of cyclic AMP metabolism is of obvious inportance to cancer research.
KeywordsAdenylate Cyclase Adenylate Cyclase Activity Mouse Embryo Fibroblast Stimulate Adenylate Cyclase Activity Dibutyryl Adenosine
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