Induction of Tumor-Immune Responses and Their Interaction with the Developing Tumor

  • Robert William Baldwin
  • Richard Adrian Robins


The central thesis of tumor immunology is that host responses to tumor-associated antigens exert a degree of immunological control over a developing tumor. This concept has developed principally from studies on experimental animal tumors induced by chemical carcinogens or oncogenic viruses, and to a lesser extent with naturally occurring tumors, in which it has been established that immunological rejection of tumors can sometimes be induced in suitably presensitized syngeneic recipients (Sjögren, 1965; Baldwin, 1973). Furthermore, immune rejection responses can be demonstrated in the tumor-bearing host, so that while the primary tumor implant is beyond host control, a concomitant challenge with the same tumor may be rejected, provided it is not too large (Gershon et al., 1967; Vaage, 1971). This has led to a further postulate, which proposes that the failure of immunocompetent hosts to reject a nascent tumor results from specific immune defects induced by tumor-associated products influencing primarily the cell-mediated arm of the tumor-immune response (I. Hellström and K.E. Hellström, 1969; K.E. Hellström and I. Hellström, 1974; Baldwin and Robins, 1975).


Spleen Cell Lymphoid Cell Tumor Antigen Suppressor Cell Tumor Immunity 
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  1. Asherson, G.L., and Zembala, M., 1975, Curr. Top. Microbiol. Immunol. 72:55.PubMedCrossRefGoogle Scholar
  2. Baldwin, R.W., 1973, Adv. Cancer Res. 18:1.PubMedCrossRefGoogle Scholar
  3. Baldwin, R.W., 1976, Transplant. Rev. 28:62.PubMedGoogle Scholar
  4. Baldwin, R.W., and Barker, C.R., 1967, Int. J. Cancer 2:355.PubMedCrossRefGoogle Scholar
  5. Baldwin, R.W., and Embleton, M.J., 1971, Int. J. Cancer 7:17.PubMedCrossRefGoogle Scholar
  6. Baldwin, R.W., and Embleton, M.J., 1974, Int. J. Cancer 13:433.PubMedCrossRefGoogle Scholar
  7. Baldwin, R.W., and Embleton, M.J., 1976, Int. Rev. Exp. Pathol., in press.Google Scholar
  8. Baldwin, R.W., and Pimm, M.V., 1973, Br. J. Cancer 28:281.PubMedCrossRefGoogle Scholar
  9. Baldwin, R.W., and Price, M.R., 1975, Cancer: A Comprehensive Treatise (F.F. Becker, ed.), Vol. 1, Plenum Press, New York, p. 353.CrossRefGoogle Scholar
  10. Baldwin, R.W., and Robins, R.A., 1975, Curr. Top. Microbiol. Immunol. 72:21.PubMedCrossRefGoogle Scholar
  11. Baldwin, R.W., Price, M.R., and Robins, R.A., 1972, Nature (London) New Biol. 238:185.CrossRefGoogle Scholar
  12. Baldwin, R.W., Bowen, J.G., and Price, M.R., 1973a, Br. J. Cancer 28:16.PubMedCrossRefGoogle Scholar
  13. Baldwin, R.W., Embleton, M.J., and Moore, M., 1973b, Br. J. Cancer 28:389.PubMedCrossRefGoogle Scholar
  14. Baldwin, R.W., Embleton, M.J., and Robins, R.A., 1973c, Int. J. Cancer 11:1.PubMedCrossRefGoogle Scholar
  15. Baldwin, R.W., Price, M.R., and Robins, R.A., 1973d, Int. J. Cancer 11:527.PubMedCrossRefGoogle Scholar
  16. Baldwin, R.W., Cook, A.J., Hopper, D.G., and Pimm, M.V., 1974a, Int. J. Cancer 13:743.PubMedCrossRefGoogle Scholar
  17. Baldwin, R.W., Embleton, M.J., Price, M.R., and Vose, B.M., 1974b, Transplant. Rev. 20:77.PubMedGoogle Scholar
  18. Baldwin, R.W., Hopper, D.G., and Pimm, M.V., 1976, Ann. N. Y. Acad. Sci., in press.Google Scholar
  19. Bansal, S.C., and Sjögren, H.O., 1972, Int. J. Cancer 9:490.PubMedCrossRefGoogle Scholar
  20. Barski, G., and Youn, J.K., 1969, J. Nat. Cancer Inst. 43:111.PubMedGoogle Scholar
  21. Basham, C., and Currie, G.A., 1974, Br. J. Cancer 29:189.PubMedCrossRefGoogle Scholar
  22. Belehradek, J., Barski, G., and Thonier, M., 1972, Int. J. Cancer 9:461.PubMedCrossRefGoogle Scholar
  23. Bennett, B., Old, L.J., and Boyse, E.A., 1964, Transplantation 2:183.PubMedCrossRefGoogle Scholar
  24. Berczi, I., and Sehon, A.H., 1975, Int. J. Cancer 16:665.PubMedCrossRefGoogle Scholar
  25. Blair, P.B., and Lane, M.A., 1974, J. Immunol. 112:439.PubMedGoogle Scholar
  26. Blair, P.B., Lane, M.A., and Yagi, M.J., 1975, J. Immunol. 115:190.PubMedGoogle Scholar
  27. Blasecki, J.W., and Tevethia, S.S., 1975, Int. J. Cancer 16:275.PubMedCrossRefGoogle Scholar
  28. Bowen, J.G., and Baldwin, R.W., 1976, Int. J. Cancer 17:254.PubMedCrossRefGoogle Scholar
  29. Bowen, J.G., Robins, R.A., and Baldwin, R.W., 1975, Int. J. Cancer 15:640.PubMedCrossRefGoogle Scholar
  30. Bray, A.E., Holt, P.G., Roberts, L.M., and Keast, D., 1975, Int. J. Cancer 16:607.PubMedCrossRefGoogle Scholar
  31. Bruce, J., Mitchison, N.A., and Shellam, G.R., 1976, Int. J. Cancer 17:342.PubMedCrossRefGoogle Scholar
  32. Cantor, H., and Boyse, E.A., 1975, J.Exp. Med. 141:1376.PubMedCrossRefGoogle Scholar
  33. Cantor, H., and Simpson, E., 1975, Eur. J. Immunol. 5:330.PubMedCrossRefGoogle Scholar
  34. Cerottini, J.-C., and Brunner, K.T., 1971, In Vitro Methods in Cell-Mediated Immunity (B.R. Bloom and P. Glade, eds.), Academic Press, New York, p. 369.Google Scholar
  35. Cerottini, J.-C., Engers, H.D., MacDonald, M.R., and Brunner, K.T., 1974a, J.Exp. Med. 140:703.PubMedCrossRefGoogle Scholar
  36. Cerottini, J.-C., MacDonald, H.R., Engers, H.D., and Brunner, K.T., 1974b, Progress in Immunology II (L. Brent and J. Holborow, eds.), Vol. 3, North-Holland Publishing Company, Amsterdam, p. 153.Google Scholar
  37. Cleveland, P.H., McKhann, C.F., Johnson, K., and Nelson, S., 1974, Int. J. Cancer 14:417.PubMedCrossRefGoogle Scholar
  38. Cohen, L., and Howe, M.L., 1973,Proc. Nat. Acad. Sci. U.S.A. 70:2707.CrossRefGoogle Scholar
  39. Cohn, M., 1976, Molecular Approaches to Immunology, Miami Winter Symposium (E.E. Smith and D.W. Ribbons, eds.), Vol. 9.Google Scholar
  40. Currie, G.A., and Basham, C., 1972, Br. J. Cancer 26:427.PubMedCrossRefGoogle Scholar
  41. Eccles, S.A., and Alexander, P., 1974, Nature (London) 250:667.CrossRefGoogle Scholar
  42. Eggers, A.E., and Wunderlich, J.R., 1975, J.Immunol. 114:1554.PubMedGoogle Scholar
  43. Embleton, M.J., 1973, Br. J. Cancer 28, Suppl. I,142.Google Scholar
  44. Embleton, M.J., 1976a, Int. J. Cancer (abstract), in press.Google Scholar
  45. Embleton, M.J., 1976b, Br. J. Cancer, 33:584.PubMedCrossRefGoogle Scholar
  46. Embleton, M.J., and Price, M.R., 1975, Behring Inst. Mitt. 56:157.Google Scholar
  47. Evans, R., 1972, Transplantation 14:468.PubMedCrossRefGoogle Scholar
  48. Evans, R., 1973, Br. J. Cancer 28, Suppl. I,19.Google Scholar
  49. Evans, R., and Alexander, P., 1970, Nature (London) 228:620.CrossRefGoogle Scholar
  50. Evans, R., and Alexander, P., 1972a, Nature (London) 236:168.CrossRefGoogle Scholar
  51. Evans, R., and Alexander, P., 1972b, Immunology 23:627.PubMedGoogle Scholar
  52. Fujimoto, S., Greene, M.I., and Sehon, A.H., 1976a, J. Immunol. 116:791.PubMedGoogle Scholar
  53. Fujimoto, S., Greene, M.I., and Sehon, A.H., 1976b, J.Immunol. 116:800.PubMedGoogle Scholar
  54. Gershon, R.K., 1975, Transplant. Rev. 26:170.PubMedGoogle Scholar
  55. Gershon, R.K., Carter, R.L., and Kondo, K., 1967, Nature (London) 213:674.CrossRefGoogle Scholar
  56. Gillette, R.W., and Fox, A., 1975, Cell Immunol. 19:328.PubMedCrossRefGoogle Scholar
  57. Glaser, M., and Herberman, R.B., 1974, J. Nat. Cancer Inst. 53:1767.PubMedGoogle Scholar
  58. Glaser, M., Kirchner, H., and Herberman, R.B., 1975, Int. J. Cancer 16:384.PubMedCrossRefGoogle Scholar
  59. Glasgow, A.H., Nimberg, R.B., Menzoian, J.O., Saproschetz, I., Cooperband, S.R., Schmid, K., and Mannick, J.A., 1974, N. Engl. J. Med. 291:1263.PubMedCrossRefGoogle Scholar
  60. Gorczynski, R.M., 1974a, J. Immunol. 112:533.PubMedGoogle Scholar
  61. Gorczynski, R.M., 1974b, J. Immunol. 112:1826.PubMedGoogle Scholar
  62. Granger, G.A., and Weiser, R.S., 1966, Science 151:97.PubMedCrossRefGoogle Scholar
  63. Greenberg, A.H., Shen, L., and Roitt, I.M., 1973, Gin. Exp. Immunol. 15:251Google Scholar
  64. Harder, F.H., and McKhann, CF., 1968, J Nat. Cancer Inst. 40:231PubMedGoogle Scholar
  65. Haskill, J.S., Proctor, J.W., and Yamamura, Y., 1975a, J Nat. Cancer Inst. 54:387.PubMedGoogle Scholar
  66. Haskill, J.S., Yamamura, Y., and Radov, L., 1975b, Int. J. Cancer 16:798.PubMedCrossRefGoogle Scholar
  67. Hayami, M., Hellström, I., Hellström, K.E., and Yamanouchi, K., 1972, Int.J Cancer Google Scholar
  68. Hayami, M., Hellström, I., Hellström, K.E., and Lannin, D.R., 1974, Int. J. Cancer 13:43.PubMedCrossRefGoogle Scholar
  69. Häyry, P., and Anderson, L.C., 1974, Eur. J. Immunol. 4:145.PubMedCrossRefGoogle Scholar
  70. Hellström, I., and Hellström, K.E., 1969, Int. J. Cancer 4:587.PubMedCrossRefGoogle Scholar
  71. Hellström, I., Sjögren, H.O., Warner, G.A., and Hellström, K.E., 1971,Int. J. Cancer 7:226.PubMedCrossRefGoogle Scholar
  72. Hellström, K.E., and Hellström, I., 1969, Adv. Cancer Res. 12:167.PubMedCrossRefGoogle Scholar
  73. Hellström, K.E., and Hellström, I., 1970, Annu. Rev. Microbiol. 24:373.PubMedCrossRefGoogle Scholar
  74. Hellström, K.E., and Hellström, I., 1974, Adv. Immunol. 18:209.PubMedCrossRefGoogle Scholar
  75. Hellström, K.E., and Hellström, I., 1976, Ann. N. Y. Acad. Sei. 276:176.CrossRefGoogle Scholar
  76. Hersey, P., 1973, Nature (London) New Biol. 244:22.CrossRefGoogle Scholar
  77. Howell, S.B., Dean, J.D., Esber, E.C., and Law L.W., 1974, Int. J. Cancer 14:662.PubMedCrossRefGoogle Scholar
  78. Isa, A.M., and Sanders, B.R., 1975, Transplantation 20:296.PubMedCrossRefGoogle Scholar
  79. Ishidate, M., 1967’,Nature (London) 215:184.Google Scholar
  80. Kall, M.A., and Hellström, I., 1975, J Immunol. 114:1083.PubMedGoogle Scholar
  81. Kassel, R.L., Old, L.J., Carswell, E.A., Fiore, N.C., and Hardy, W.D., 1973, J Exp. Med. Google Scholar
  82. Kearney, R., Basten, A., and Nelson, D.S., 1975, Int. J. Cancer 15:438.PubMedCrossRefGoogle Scholar
  83. Kirchner, H., Chused, T.M., Herberman, R.B., Holden, H.T., and Lavrin, D.H., 1974a,Google Scholar
  84. J. Exp. Med. 139:1473.Google Scholar
  85. Kirchner, H., Herberman, R.B., Glaser, M., and Lavrin, D.H., 1974b, Cell. Immunol. 13:32.PubMedCrossRefGoogle Scholar
  86. Kirchner, H., Muchmore, A.V., Chused, T.M., Holden, H.T., and Herberman, R.B., 1975,Google Scholar
  87. J. Immunol. 114:206.Google Scholar
  88. Kisielow, P., Hirst, J.A., Shiku, H., Beverley, P.C.L., Hoffman, M.K., Boyse, E.A., and Oettgen, H.F., 1975, Nature (London) 253:219.CrossRefGoogle Scholar
  89. Lamon, E.W., 1974, Biochim. Biophys. Acta 355:149.PubMedGoogle Scholar
  90. Laux, D., and Lausch, R.N., 1974, J Immunol. 112:1900.PubMedGoogle Scholar
  91. Le François, D., Youn, J.K., Belehradek, J., and Barski, G., 1971, J.Nat. Cancer Inst. Google Scholar
  92. Levy, M.H., and Wheelock, E.F., 1974, Adv. Cancer Res. 20:131.PubMedCrossRefGoogle Scholar
  93. Mackaness, G.B., and Lagrange, P.H., 1974, J.Exp. Med. 140:865.PubMedCrossRefGoogle Scholar
  94. MacLennan, I.C.M., 1972, Transplant. Rev. 13:67.PubMedGoogle Scholar
  95. Meltzer, M.S., Oppenheim, J.J., Littman, B.H., Leonard, E.J., and Rapp, H J., 1972, J Nat. Google Scholar
  96. Cancer Inst. 49:727.Google Scholar
  97. Milgrom, F., Humphrey, L.J., Tender, O., Yasuda, J., and Witebakey, E., 1968, Int. Arch. Google Scholar
  98. Allergy 33:478.Google Scholar
  99. Möller, E., 1965, Science 147:873.CrossRefGoogle Scholar
  100. Möller, G., Lemke, H., and Opitz, H.-G., 1916,Scand. J. Immunol 5:269.CrossRefGoogle Scholar
  101. Myburgh, J.A., and Mitchison, N.A., 1976, Transplantation 22:236.PubMedCrossRefGoogle Scholar
  102. Nathan, C F., and Terry, W. D., 1975, J Exp. Med. 142:887.PubMedCrossRefGoogle Scholar
  103. Nelson, K., Pollack, S. B., and Hellström, K. E., 1975a, Int. J. Cancer 15:806.PubMedCrossRefGoogle Scholar
  104. Nelson, K., Pollack, S. B., and Hellström, K. E., 1975b, Int. J. Cancer 16:539.PubMedCrossRefGoogle Scholar
  105. Nelson, K., Pollack, S. B., and Hellström, K. E., 1975c, Int. J. Cancer 16:932.PubMedCrossRefGoogle Scholar
  106. Nicolson, G.L., 1976, Biochim. Biophys. Acta 458:1.PubMedGoogle Scholar
  107. Nind, A. P. P., Matthews, N., Pihl, E. A. V., Rolland, J. M., and Nairn, R. C., 1975, Br. J. Cancer 31:620.PubMedCrossRefGoogle Scholar
  108. Nordlund, J. J., and Gershon, R. K., 1975, J Immunol. 114:1486.PubMedGoogle Scholar
  109. Oettgen, H.F., Old, L.J., McLean, E.P., and Carswell, E.A., 1968, Nature (London) 220:295.CrossRefGoogle Scholar
  110. Ortiz de Landazuri, M., Kedar, E., and Fahey, J.L., 1974, J Nat. Cancer Inst. 52:147.Google Scholar
  111. Pellis, N.R., and Kahan, B.D., 1975, JImmunol. 115:1717.Google Scholar
  112. Perlmann, P., and Holm, G., 1969, Adv. Immunol. 11:117.PubMedCrossRefGoogle Scholar
  113. Perlmann, P., Wigzell, H., Goldstein, P., Lamon, E.W., Larsson, A., O’Toole, C, Perlmann, H., and Svedmyr, E.A.J., 1973, Adv. Biosci. Mill. Google Scholar
  114. Plata, F., and Levy, J.P., 1974, Nature (London) 249:271.CrossRefGoogle Scholar
  115. Poupon, M.-F., Lespinats, G., and Kolb, J.-P., 1974, J Nat. Cancer Inst. 52:1127.PubMedGoogle Scholar
  116. Prather, S.O., and Lausch, R.N., 1976, Int. J. Cancer 17:380.PubMedCrossRefGoogle Scholar
  117. Price, M.R., and Baldwin, R.W., 1976, Cell SurfaceReviews (G. Poste and G.L. Nicolson, eds.), Vol. Ill, North-Holland Publishing Co., Amsterdam, in press.Google Scholar
  118. Rees, R.C., Bray, J., Robins, R.A., and Baldwin, R.W., 1975a, Int.Cancer 15:762.CrossRefGoogle Scholar
  119. Rees, R.C., Price, M.R., Shah, L.P., and Baldwin, R.W., 1975b, Transplantation 19:424.PubMedCrossRefGoogle Scholar
  120. Robins, R.A., 1975, Br. J. Cancer 32:21.PubMedCrossRefGoogle Scholar
  121. Robins, R.A., and Baldwin, R.W., 191 A, Int. J. Cancer 14:589.CrossRefGoogle Scholar
  122. Rotter, V., and Trainin, N., 1975, Transplantation 20:68.PubMedCrossRefGoogle Scholar
  123. Rouse, B.T., Rollinghoff, M., and Warner, N.L., 1912, Nature (London) New Biol. 238:116.Google Scholar
  124. Sample, W.F., Gertner, H.R., and Chretien, P.B., 1971, J Nat. Cancer Inst. 46:1291.PubMedGoogle Scholar
  125. Shellam, G.R., 1974, Int. J. Cancer 14:65.PubMedCrossRefGoogle Scholar
  126. Shellam, G.R., and Knight, R.A., 1974, Nature (London) 252:330.CrossRefGoogle Scholar
  127. Shellam, G.R., Knight, R.A., Mitchison, N.A., Gorczynski, R.M., and Maoz, A., 1976, Transplant. Rev. 29:249.PubMedGoogle Scholar
  128. Simes, R.J., Kearney, R., and Nelson, D.S., 1915, Immunology 29:343.Google Scholar
  129. Sjögren, H.O., 1965, Prog. Exp. Tumor Res. 6:289.PubMedGoogle Scholar
  130. Sjögren, H.O., Hellström, L, Bansal, S.C., and Hellström, K.E., 1971, Proc. Nat. Acad. Sei. Google Scholar
  131. U.S.A. 68:1372.Google Scholar
  132. Small, M., and Trainin, N., 1975 Jnt. J. Cancer 15:962.Google Scholar
  133. Smith, H.G., and Leonard, E.J., 1974, J Nat. Cancer Inst. 53:187.PubMedGoogle Scholar
  134. Steele, G., Sjögren, H.O., and Price, M.R., 1975 Jnt. J. Cancer 16:33.Google Scholar
  135. Tamerius, J.D., and Hellström, I., 1974, J.Immunol 112:1987.PubMedGoogle Scholar
  136. Tamerius, J., Nepom, J., Hellström, I., and Hellström, K.E., 1976,J.Immunol. 116:724.PubMedGoogle Scholar
  137. Taranger, L.A., Chapman, W.H., Hellström, I., and Hellström, K.E., 1972, Science 176:1337.PubMedCrossRefGoogle Scholar
  138. Tevethia, S.S., Blasecki, J.W., Waneck, G., and Goldstein, A., 1974,J.Immunol. 113:1417.PubMedGoogle Scholar
  139. Thomson, D.M.P., 1975,Int. J. Cancer 15:1016.PubMedCrossRefGoogle Scholar
  140. Thomson, D.M.P., Eccles, S., and Alexander, P., 1973, Br. J. Cancer 28:6.PubMedCrossRefGoogle Scholar
  141. Treves, A.J., Schechter, B., Cohen, I.R., and Feldman, M., 1976,J.Immunol 116:1059.PubMedGoogle Scholar
  142. Umiel, T., and Trainin, N., 1974, Transplantation 18:244.PubMedCrossRefGoogle Scholar
  143. Unanue, E.R., and Calderon, J., 1975, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 34:1737.Google Scholar
  144. Vaage, J., 1971, Cancer Res. 31:1655.PubMedGoogle Scholar
  145. van Loveren, N., and den Otter, W., 1974, J.Nat. Cancer Inst. 53:1057.Google Scholar
  146. Veit, B.C., and Feldman, J.D., 1975,Int. J. Cancer 15:367.PubMedCrossRefGoogle Scholar
  147. Wahl, D.V., Chapman, W.H., Hellström, I., and Hellström, K.E., 1974, J.J.Cancer 14:114.Google Scholar
  148. Whitney, R.B., and Levy, J.G., 1975,J.Nat. Cancer Inst. 54:733.PubMedGoogle Scholar
  149. Wood, G.W., and Gillespie, G.Y., 1975, Int. J. Cancer 16:1022.PubMedCrossRefGoogle Scholar
  150. Youn, J.K., Le François, D., Hue, G., Santillana, M., and Barski, G., 1975, Int. J. Cancer 16:629.PubMedCrossRefGoogle Scholar
  151. Zöller, M., Price, M.R., and Baldwin, R.W., 1975, Int. J. Cancer 16:593.PubMedCrossRefGoogle Scholar
  152. Zöller, M., Price, M.R., and Baldwin, R.W., 1976, Int. J. Cancer 17:129.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Robert William Baldwin
    • 1
  • Richard Adrian Robins
    • 1
  1. 1.Cancer Research Campaign LaboratoriesUniversity of NottinghanNottinghamEngland

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