Complement Receptors

  • Celso Bianco
  • Victor Nussenzweig


In the beginning of this century, it was noted by many investigators that in the presence of immune serum, protozoa, bacteria, and other particles adhered to leukocytes and platelets, both in vivo and in vitro (reviewed by D.S. Nelson, 1963). This attachment of parasites promoted their clearance from the blood and was part of the mechanism of defense against infection. Progress in the understanding of these observations was very slow and controversial, however, probably because several different phenomena were involved, in which antibody and complement participated in varying degrees.


Immune Complex Lymphoid Organ Complement Component Complement Receptor Mouse Peritoneal Macrophage 

Abbreviations in this chapter


antibody-mediated cell cytotoxicity


complement components 1–4

(factors P, B, and D)

complement components of the alternative pathway

(CRI and II)

complement receptors I and II


complement-receptor lymphocytes


sheep erythrocytes


sheep erythrocytes coated with rabbit antibodies of undetermined class


sheep erythrocytes coated with antibody and complement

(EIgG, EIgM)

sheep erythrocytes coated with IgG or IgM


complement mediated complex-release activity


cobra venom factor




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  1. Arnaiz-Villena, A., and Festenstein, H., 1976, Nature (London) 258:732.CrossRefGoogle Scholar
  2. Arnaiz-Villena, A., and Hay, F.C., 1975, Immunology 28:719.PubMedGoogle Scholar
  3. Arnaiz-Villena, A., Halloran, P., David, C.S., and Festenstein, H., 1975, J. Immunogenet. 2:415.CrossRefGoogle Scholar
  4. Bianco, C., 1976, in: Biological Amplification Systems in Immunity (N. Day and R. Good, eds.), Plenum Press, New York, in press.Google Scholar
  5. Bianco, C., and Nussenzweig, V., 1971, Science 173:154.PubMedCrossRefGoogle Scholar
  6. Bianco, C., Patrick, R., and Nussenzweig, V., 1970,J.Exp. Med. 132:702.PubMedCrossRefGoogle Scholar
  7. Bianco, C., Griffin, F.M., and Silverstein, S.C., 1975,J.Exp. Med. 141:1278.PubMedCrossRefGoogle Scholar
  8. Bloom, B., and David, J., 1976, In Vitro Methods of Cell-Mediated Immunity, 2nd Ed, Academic Press, New York, in press.Google Scholar
  9. Bokisch, V.A., and Sobel, A.T., 1974,J.Exp. Med. 140:1336.PubMedCrossRefGoogle Scholar
  10. Bokisch, V.A., Dierich, M.P., and Müller-Eberhard, H.J., 1915, Proc. Nat. Acad. Sci. U.S.A. 72:1989.CrossRefGoogle Scholar
  11. Calkins, C.E., Carboni, J.M., and Waksman, B.H., 1975,J.Immunol. 115:1339.PubMedGoogle Scholar
  12. Cooper, N.R., 1969, Science 165:396.PubMedCrossRefGoogle Scholar
  13. Cooper, N.R., 1975,J.Exp. Med. 141:890.PubMedGoogle Scholar
  14. Coutinho, A., 1975, Transplant. Rev. 23:49.PubMedGoogle Scholar
  15. Czop, J., and Nussenzweig, V., 1976, J.Exp. Med. 143:615.PubMedCrossRefGoogle Scholar
  16. Diamantstein, T., and Blitstein-Willinger, E., 1975, Immunology 29:1087.PubMedGoogle Scholar
  17. Dickler, H.B., and Sachs, D.H., 1974,J.Exp. Med. 140:779.PubMedCrossRefGoogle Scholar
  18. Dierich, M. P. and Reisfeld, R. A., 1975,J.Immunol. 114:1676.PubMedGoogle Scholar
  19. Dukor, P., and Hartmann, K.H., 1973, Cell Immunol. 7:349.PubMedCrossRefGoogle Scholar
  20. Dukor, P., Bianco, C., and Nussenzweig, V., 1970, Proc. Nat. Acad. Sci. U.S.A. 67:991.CrossRefGoogle Scholar
  21. Dukor, P., Bianco, C., and Nussenzweig, V., 1971, Eur. J. Immunol. 1:491.PubMedCrossRefGoogle Scholar
  22. Dukor, P., Dietrich, F.M., Gisler, R.H., Schumann, G., Bitter-Suermann, D., 1974, in: Progress in Immunology, II, vol. 3 (L. Brent and J. Holborow, eds.), North-Holland Publishing Co., Amsterdam, p. 99.Google Scholar
  23. Eden, A., Bianco, C., and Nussenzweig, V., 1971, Cell. Immunol. 2:658.PubMedCrossRefGoogle Scholar
  24. Eden, A., Bianco, C., and Nussenzweig, V., 1973a, Cell. Immunol. 7:459.PubMedCrossRefGoogle Scholar
  25. Eden, A., Bianco, C., Nussenzweig, V., and Mayer, M.M., 1973b, J.Immunol. 110:1452.PubMedGoogle Scholar
  26. Eden, A., Miller, G.W., and Nussenzweig, V., 1973c,J.Clin. Invest. 52:3239.PubMedCrossRefGoogle Scholar
  27. Ehlenberger, A.G., and Nussenzweig, V., 1975, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 34:854.Google Scholar
  28. Ehlenberger, A.G., and Nussenzweig, V., 1977, J. Exp. Med., in press.Google Scholar
  29. Ehlenberger, A.G., McWilliams, M., Phillips-Quagliata, J.M., Lamm, M.E., and Nussenzweig, V., 1976,J.Clin. Invest. 57:53.PubMedCrossRefGoogle Scholar
  30. Elin, R.J., Sandberg, A.L., and Rosenstreich, D.L., 1976, J. Immunol., 117:1238.PubMedGoogle Scholar
  31. Feldmann, M., and Pepys, M.B., 1974, Nature (London) 249:159.CrossRefGoogle Scholar
  32. Ferreira, A., and Nussenzweig, V., 1975,J.Exp. Med. 141:513.PubMedCrossRefGoogle Scholar
  33. Ferreira, A., and Nussenzweig, V., 1976, J. Immunol., 117:771.PubMedGoogle Scholar
  34. Ferreira, A., Fotino, M., and Nussenzweig, V., 1911, Eur. J. Immunol., in press.Google Scholar
  35. Gelfand, J.A., Fauci, A.S., Green, I., and Frank, M.M., 1976,J.Immunol. 116:595.PubMedGoogle Scholar
  36. Gelfand, M.C., Elfenbein, G.J., Frank, M.M., and Paul, W.E., 1974a,J.Exp. Med. 139:1125.PubMedCrossRefGoogle Scholar
  37. Gelfand, M.C., Sachs, P.H., Lieberman, R., and Paul, W.E., 1974b,J.Exp. Med. 139:1142.PubMedCrossRefGoogle Scholar
  38. Gelfand, M.C., Frank, M.M., and Green, I., 1975,J.Exp. Med. 142:1025.CrossRefGoogle Scholar
  39. Gigli, I., and Nelson, R.A., 1968, Exp. Cell Res. 51:45.PubMedCrossRefGoogle Scholar
  40. Gitlin, J.D., Rosen, F.S., and Lachmann, P.J., 1975,J.Exp. Med. 141:1221.PubMedCrossRefGoogle Scholar
  41. Goldstein, I., Kaplan, H.B., Radin, A., and Frosch, M., 1976, J. Immunol., 117:1282.PubMedGoogle Scholar
  42. Gordon, S., Unkeless, J.C., and Cohn, Z.A., 1975, in: Immune Recognition, Proceedings of the Ninth Leukocyte Culture Conference (A.S. Rosenthal, ed.), Academic Press, New York, p. 589.Google Scholar
  43. Gormus, B.J., Crandall, R.B., and Shands, J.W., Jr., 1974,J.Immunol. 112:770.PubMedGoogle Scholar
  44. Greaves, F.M., Brown, G., and Rickinson, A.B., 1975, Clin. Immunol. Immunopathol. 3:514.PubMedCrossRefGoogle Scholar
  45. Griffin, F.M., Bianco, C., and Silverstein, S.C., 1975,J.Exp. Med. 141:1269.PubMedCrossRefGoogle Scholar
  46. Gupta, S., Pahwa, R., Reilly, R., Good, R.A., and Siegal, F.P., 1976a, Proc. Nat. Acad. Sci. U.S.A. 73:919.CrossRefGoogle Scholar
  47. Gupta, S., Ross, G.D., Good, R.A., and Siegal, F.P., 1976b, J.Allergy Gin. Immunol. 57:189.CrossRefGoogle Scholar
  48. Hallberg, T., 1975, Acta Pathol. Microbiol. Scand. Sect. C., Suppl., No. 250.Google Scholar
  49. Hartmann, K.U., and Bokisch, V.A., 1975,J.Exp. Med. 142:600.PubMedCrossRefGoogle Scholar
  50. Henson, P.M., 1972, in: Biological Activities of Complement (D.G. Ingram, ed.), Karger, Basel, p. 173.Google Scholar
  51. Henson, P.M., and Neshyba, J., 1976, J. Immunol., 116:1736.Google Scholar
  52. Huber, C., and Wigzell, H., 1915, Eur. J. Immunol. 5:432.CrossRefGoogle Scholar
  53. Huber, H., Polley, M.J., Linscott, W.D., Fudenberg, H.H., and Müller-Eberhard, H.J., 1968, Science 162:1281.PubMedCrossRefGoogle Scholar
  54. Janossy, G., Humphrey, J.H., Pepys, M.B., and Greaves, M.F., 1973, Nature (London) New Biol. 246:108.Google Scholar
  55. Jondal, M., and Klein, G., 1973,J.Exp. Med. 138:1365.PubMedCrossRefGoogle Scholar
  56. Jondal, M., Wigzell, H., and Aiuti, F., 1973, Transplant. Rev. 16:163.PubMedGoogle Scholar
  57. Julius, M.H., Simpson, E., and Herzenberg, L.A., 1973, Eur. J. Immunol. 3:645.PubMedCrossRefGoogle Scholar
  58. Klein, G., 1976, N. Engl. J. Med. 293:26.Google Scholar
  59. Lachmann, P.J., and Müller-Eberhard, H.J., 1968,J.Immunol. 100:691.PubMedGoogle Scholar
  60. Lachmann, P.J., Elias, D.E., and Moffet, A., 1972, in: Biological Activities of Complement (D.H. Ingram, ed.), S. Karger, Basel, p. 202.Google Scholar
  61. Lay, W.H., and Nussenzweig, V., 1968, J.Exp. Med. 128:991.PubMedCrossRefGoogle Scholar
  62. Lay, W. H. and Nussenzweig, V., 1969, J. Immunol. 102:1172.PubMedGoogle Scholar
  63. Lin, P.S., and Hsu, C.C.S., 1976, Clin. Exp. Immunol. 23:209.Google Scholar
  64. Lobo, P.I., Westervelt, F.B., and Horwitz, D.A., 1975,J.Immunol. 114:116.PubMedGoogle Scholar
  65. Lotem, J., and Sachs, L., 1974, Proc. Nat. Acad. Sci. U.S.A. 71:3507.CrossRefGoogle Scholar
  66. Lustig, H., and Bianco, C., 1976,J.Immunol. 116:253.PubMedGoogle Scholar
  67. Mackler, B.F., Altman, L.C., Rosenstreich, D.L., and Oppenheim, J.J., 1974, Nature(London) 249:834.CrossRefGoogle Scholar
  68. MacLennan, I.C.M., Howard, A., Gotch, F.M., and Quie, P.G., 1973, Immunology 25:459.PubMedGoogle Scholar
  69. Mantovani, B., Rabinovitch, M., and Nussenzweig, V., 1972,J.Exp. Med. 135:780.PubMedCrossRefGoogle Scholar
  70. Mason, D.W., 1976a, J. Exp. Med. 143:1122.PubMedCrossRefGoogle Scholar
  71. Mason, D.W., 1976b,J.Exp. Med. 143:1111.PubMedCrossRefGoogle Scholar
  72. McWilliams, M., Phillips-Quagliata, J.M., and Lamm, M.E., 1975,J.Immunol. 115:54.PubMedGoogle Scholar
  73. Mendes, N.F., Mike, S.S., and Peixinho, Z.F., 1974,J.Immunol. 113:531.PubMedGoogle Scholar
  74. Miller, G.W., and Nussenzweig, V., 1975, Proc. Nat. Acad. Sci. U.S.A. 72:418.CrossRefGoogle Scholar
  75. Miller, G.W., Saluk, P.H., and Nussenzweig, V., 1973,J.Exp. Med. 138:495.PubMedCrossRefGoogle Scholar
  76. Möller, G., and Coutinho, A., 1975,J.Exp. Med. 141:647.PubMedCrossRefGoogle Scholar
  77. Müller-Eberhard, HJ., 1975, Annu. Rev. Biochem. 44:697.PubMedCrossRefGoogle Scholar
  78. Munthe-Kaas, A.C., Berg, T., Seglen, P.O., and Seljelid, R., 1975,J.Exp. Med. 141:1.PubMedCrossRefGoogle Scholar
  79. Nelson, D.S., 1963, Adv. Immunol. 3:131.CrossRefGoogle Scholar
  80. Nelson, R.A., 1953, Science 118:733.PubMedCrossRefGoogle Scholar
  81. Nogueira, N., and Cohn, Z.A., 1976, J. Exp. Med., 143:1402.PubMedCrossRefGoogle Scholar
  82. Nossal, G.J.V., Abbot, A., Mitchell, J., and Lummers, Z., 1968,J.Exp. Med. 127:277.PubMedCrossRefGoogle Scholar
  83. Nussenzweig, V., 1974, Adv. Immunol. 19:217.PubMedCrossRefGoogle Scholar
  84. Nussenzweig, V., Bianco, C., and Eden, A., 1973, in: 3rd International Convocation onImmunology, Specific Receptors of Antibodies, Antigens and Cells (D. Pressman, ed.), S. Karger, Basel, p. 317.Google Scholar
  85. Okada, H., and Nishioka, K., 1973,J.Immunol. 111:1444.PubMedGoogle Scholar
  86. Osler, A.G., and Siraganian, R.P., 1972, Prog. Allergy 16:450.PubMedGoogle Scholar
  87. Papamichail, M., Gutierrez, C., Embling, P., Johnson, E., Holborow, E.J., and Pepys, M.B., 1975,Scand. J. Immunol. 4:343.PubMedCrossRefGoogle Scholar
  88. Paperhausen, P., Papageorgiou, P., and Hirschhorn, K., 1975, J.Immunol. 114:519.Google Scholar
  89. Pepys, M.B., 1972, Nature (London) 237:157.CrossRefGoogle Scholar
  90. Pepys, M.B., 1974,J.Exp. Med. 140:126.PubMedCrossRefGoogle Scholar
  91. Pepys, M.B., Wansbrough-Jones, M.H., and Mirjah, D.D., 1976a, Clin. Exp. Med. 23:378.Google Scholar
  92. Pepys, M.B., Wansbrough-Jones, M.H., Mirjah, D.D., and Dash, A.C., 1976b,J.Immunol., 116:1746.Google Scholar
  93. Perlmann, P., and Holm, G., 1969, Adv. Immunol. 11:117.PubMedCrossRefGoogle Scholar
  94. Perlmann, P., Perlmann, H., and Müller-Eberhard, H.J., 1975,J.Exp. Med. 141:287.PubMedCrossRefGoogle Scholar
  95. Pryjma, J., and Humphrey, J.H., 1975, Immunology 28:569.PubMedGoogle Scholar
  96. Rabellino, E., and Metcalf, D., 1975,J.Immunol. 115:688.PubMedGoogle Scholar
  97. Rabinovitch, M., 1967, Exp. Cell Res. 46:19.PubMedCrossRefGoogle Scholar
  98. Rabinovitch, M., 1970, in: Mononuclear Phagocytes (R. van Fürth, ed.), Blackwell Scientific Publications, Oxford, p. 299.Google Scholar
  99. Rabinovitch, M., and DeStefano, M.J., 1973,J.Immunol. 110:695.PubMedGoogle Scholar
  100. Ramasamy, R., and Williams, H., 1975.Immunology 28:577.PubMedGoogle Scholar
  101. Reynolds, H.Y., Atkinson, J.P., Newhall, H.H., and Frank, M.M., 1975, J.Immunol. 114:1813.PubMedGoogle Scholar
  102. Rosen, F.S., 1975, in: Immunogenetics and Immunodeficiency (B. Benacerraf, ed.), University Park Press, Baltimore, p. 229.CrossRefGoogle Scholar
  103. Ross, G.D., 1976, in: Clinical Evaluation of Immune Function in Man (G. Siskind and S. Litwin, eds.), Grune and Stratton, New York, in press.Google Scholar
  104. Ross, G.D., and Polley, M.J., 1975,J.Exp. Med. 141:1163.PubMedCrossRefGoogle Scholar
  105. Ross, G.D, Polley, M.J., Rabellino, E.M., and Grey, H.M., 1973,J.Exp. Med. 138:798.PubMedCrossRefGoogle Scholar
  106. Ross, G.D., Rabellino, E.M., and Polley, M.J., 1976, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:254.Google Scholar
  107. Ruddy, S., and Austen, K.F., 1969,J.Immunol. 102:533.PubMedGoogle Scholar
  108. Sandberg, A.L., Wahl, S.M., and Mergenhagen, S.E., 1975,J.Immunol. 115:139.PubMedGoogle Scholar
  109. Scheid, M.P., Goldstein, G., Hammerling, U., and Boyse, E.A., 1975, in: Membrane Receptors of Lymphocytes (M. Seligmann, J.L. Preud’Homme, and F.M. Kourilsky,eds.), North-Holland Publishing Co., Amsterdam, p. 353.Google Scholar
  110. Schlesinger, M., and Chaouat, M., 1975, Eur. J. Immunol. 5:27.PubMedCrossRefGoogle Scholar
  111. Schreiber, A.D., and Frank, M.M., 1972,J.Clin. Invest. 51:583.PubMedCrossRefGoogle Scholar
  112. Scornik, J.C., 1976, Science 192:563.PubMedCrossRefGoogle Scholar
  113. Shevach, E.M., Herberman, R., Frank, M.M., and Green, I., 1972,J.Clin. Invest. 51:1933.PubMedCrossRefGoogle Scholar
  114. Shevach, E.M., Jaffe, E.S., and Green, I., 1973, Transplant. Rev. 16:3.PubMedGoogle Scholar
  115. Shevach, E.M., Edelson, R., Frank, M., Lutzner, M., and Green, I., 1974, Proc. Nat. Acad. Sci. U.S.A. 71:863CrossRefGoogle Scholar
  116. Schorlemmer, H.U., Davies, P., and Allison, A.C., 1976, Nature (London) 261:48.CrossRefGoogle Scholar
  117. Stossel, T.P., 1975, Semin. Hematol. 12:83.PubMedGoogle Scholar
  118. Stossel, T.P., Field, R. J., Gitlin, J. D., Alper, C. A., and Rosen, F. S., 1975, J.Exp. Med. 141:1329.PubMedCrossRefGoogle Scholar
  119. Takahashi, M., Czop, J., Ferreira, A., and Nussenzweig, V., 1976, Transplant. Rev. 32:121.PubMedGoogle Scholar
  120. Tamura, N., and Nelson, R.A., 1967,J.Immunol. 99:582.PubMedGoogle Scholar
  121. Theophilopoulos, A.N., Bokisch, V.A., and Dixon, F.J., 1974a, J.Exp. Med. 139:696.CrossRefGoogle Scholar
  122. Theophilopoulos, A.N., Dixon, F.J., and Bokisch, V.A., 1974b,J.Exp. Med. 140:877.CrossRefGoogle Scholar
  123. Thorbecke, G.J., Romano, T.J., and Lerman, S.P., 1974, :Progress in Immunology II, Vol. 3 (L. Brent and J. Holborow, eds.), North-Holland Publishing Co., Amsterdam, p. 25.Google Scholar
  124. Tigelaar, R.E., Vaz, N.M., and Ovary, Z., 1971,J.Immunol. 106:661.PubMedGoogle Scholar
  125. Ueki, A., Itagashi, Y., Hyodoh, F., and Kimoto, T., 1974, Virchows Arch. B. 18:101.Google Scholar
  126. Unanue, E.R., 1972, Adv. Immunol. 15:95.PubMedCrossRefGoogle Scholar
  127. Wahl, S.M., Iverson, G.M., and Oppenheim, J.J., 1974,J.Exp. Med. 140:1631.PubMedCrossRefGoogle Scholar
  128. Waldman, H., and Lachmann, P.J., 1975, Eur. J. Immunol. 5:185.CrossRefGoogle Scholar
  129. Wellek, B., Helmut, H.H., and Wolfgang, O., 1975,J.Immunol. 114:1643.PubMedGoogle Scholar
  130. Winchester, R.J., Fu, S.M., Hoffman, T., and Kunkel, H.G., 1975,J.Immunol. 114:1210.PubMedGoogle Scholar
  131. Yata, Y., Tsukimoto, I., and Tachibana, T., 1973, Clin. Exp. Immunol. 14:319.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Celso Bianco
    • 1
  • Victor Nussenzweig
    • 2
  1. 1.The Rockefeller UniversityNew YorkUSA
  2. 2.Department of PathologyNew York University School of MedicineNew YorkUSA

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