The Prognosis for Quantitative Lipoprotein Electrophoresis

  • Frank T. Lindgren
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 15)

Abstract

Surely any system for classifying lipid and lipoprotein disorders will have limitations, and this is certainly true for the Fredrickson, Levy and Lees “typing” system (1). Although during the past decade this “typing” system has allowed classification of most lipoprotein disorders into six types, there has been some dissatisfaction and disenchantment in its usage. Sometime ago, two editorials (2, 3) have advocated discontinuance of “routine electrophoresis” in clinical testing. Unfortunately, this would potentially have the effect of removing a cornerstone of the typing system, namely, the direct estimation or quantification of the major lipoprotein classes.

Keywords

Cholesterol Agarose Electrophoresis Triglyceride Choles 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Beaumont, J. L., Carlson, L. A., Cooper, G. R., Fejbar, Z., Fredrickson, D. S. and Strassen, T. Bull. Wld. Hlth. Org. 43: 891, 1970.Google Scholar
  2. 2.
    Immarino, R. M. Human Path. 5: 626, 1974.CrossRefGoogle Scholar
  3. 3.
    Fredrickson, D. S. Circulation 51: 209, 1975.Google Scholar
  4. 4.
    Dyerberg, J. and Hjorne, H. Acta Med. Scand. 191: 413, 1972.PubMedGoogle Scholar
  5. 5.
    Hatch, F. T., Lindgren, F. T., Adamson, G. L., Jensen, L. C., Wong, A. W. and Levy, R. I. J. Lab. Clin. Med. 81: 946, 1973.PubMedGoogle Scholar
  6. 6.
    Miller, G. J. and Miller, N. E. Lancet 1: 16, 1975.CrossRefGoogle Scholar
  7. 7.
    Castelli, W. P., Doyle, J. T., Gordon, T., Hames, C., Hulley, S. B., Kagan, A., McGee, D., Vicic, W. J. and Zukel, W. J. Circulation 52 Suppl. II: II - 378, 1975.Google Scholar
  8. 8.
    Wood, P. D., Stern, M. P., Silvers, A., Reaven, G. M. and von der Groeben, J. Circulation 45: 114, 1972.PubMedGoogle Scholar
  9. 9.
    Fredrickson, D. S., Morganroth, J. and Levy, R. I. Ann. Intern. Med. 14: 815, 1975.Google Scholar
  10. 10.
    Fredrickson, D. S., Levy, R. I., Bonnell, M. and Ernst, N. DHEW Publication No (NIH) 73–110, 1973.Google Scholar
  11. 11.
    Lindgren, F. T., Adamson, G. L., Jensen, L. C. and Wood, P. D. Lipids 10: 750, 1975.CrossRefGoogle Scholar
  12. 12.
    Wong, R. A., Banchero, P. G., Jensen, L. C., Pan, S. S., Adamson, G. L. and Lindgren, F. T. J. Lab. Clin. Med., in press.Google Scholar
  13. 13.
    Lindgren, F. T. In: Analysis of Lipids and Lipoproteins, E. G. Perkins, ed., J. Amer. Oil Chem. Soc., Champaign, IL., 1972, pp. 187–274.Google Scholar
  14. 14.
    Manual of Laboratory Operations, Lipid Research Clinics Program, Vol. 1, Lipid and Lipoprotein Analysis DHEW Publication No (NIH) 75–628, 1975.Google Scholar
  15. 15.
    Friedewald, W. T., Levy, R. I. and Fredrickson, D. S. Clin. Chem. 18: 499, 1972.PubMedGoogle Scholar
  16. 16.
    Lindgren, F. T., Silvers, A., Jutagir, R., Layshot, L. and Bradley, D. D. Lipids 12: 278, 1977.CrossRefGoogle Scholar
  17. 17.
    Lindgren, F. T., Jensen, L. C. and Hatch, F. T. In: Blood Lipids and Lipoproteins, G. J. Nelson, ed., John Wiley-Interscience, N.Y., 1972, pp. 181–274.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Frank T. Lindgren
    • 1
  1. 1.Donner Laboratory, Lawrence Berkeley LaboratoryUniversity of CaliforniaBerkeleyUSA

Personalised recommendations