Biochemistry of Plasmalipoproteins in Liver Diseases

  • D. Seidel
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 15)


The liver is the major site of synthesis of plasmalipoproteins and has central functions in lipoprotein catabolism. Since abnormal serum lipid concentrations are often associated with abnormal liver function it is reasonable to anticipate that liver disease will result in alterations of plasmalipoproteins, the protein lipid particle in which form all serum lipids circulate. Undoubtedly, the example best known to clinicians is the hypercholesterolemia and hyperphospholipidemia accompanying biliary obstruction or cholestasis, a phenomenon recorded more than a century ago by FLINT (1). The increased serum cholesterol in such patients is in form unesterified cholesterol, thus, the percentage of serum cholesterol present in esterified form is decreased, although in absolute amounts esterified cholesterol concentrations usually remain normal as long as liver function otherwise remained undisturbed, or as long as the plasma activity or the lecithin:cholesterol:acyltransferase (LCAT enzyme) is normal (2).


Liver Disease Obstructive Jaundice Cholesterol Acyltransferase Cholestatic Liver Disease Liver Diseased Patient 
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  1. 1.
    FLINT, A. jr.: Experimental researches into a new excretory function of the liver, consisting in the removal of cholesterine from the blood, and its discharge from the body in the form of stercorine. Amer. J. med. Sci. 44 305 (1962).Google Scholar
  2. 2.
    SEIDEL, D.: Hyperlipoproteinaemia bei Erkrankungen der Leber. Schweiz. med. Wschr. 105, 857 (1975).Google Scholar
  3. 3.
    RUSS, E.M., RAYMUNT, J. and D.P.BARR: Lipoproteins in primary biliary cirrhosis. J. Clin. Invest. 35 133 (1956).PubMedCrossRefGoogle Scholar
  4. 4.
    SWITZER, S.: Plasma lipoproteins in liver disease. I. Immunologically distinct low-density lipoproteins in patients with biliary obstruction. J. Clin. Invest. 46 1855 (1967).Google Scholar
  5. 5.
    SEIDEL, D. ALAUPOVIC, P. and R.H. FURMAN: A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects. J. Clin. Invest. 48 1211 (1969).Google Scholar
  6. 6.
    SEIDEL, D. ALAUPOVIC, P., R.H. FURMAN and W. J. McCONATHY: A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins. J. Clin. Invest. 49 2396 (1970).Google Scholar
  7. 7.
    PICARD, J. and D. VEISSIERE: Séparation des lipoprotéines sériques anormales dans la cholestase. C.R. Acad. Sci. (Paris) Ser. D. 270 1845 (1970).Google Scholar
  8. 8.
    MILLS, G.L., SEIDEL, D. and P.ALAUPOVIC: Ultracentrifugal characterization of a lipoprotein occuring in obstructive jaundice. Clin. Chim. Acta 26, 239 (1969).PubMedCrossRefGoogle Scholar
  9. 9.
    HAMILTON, R.L., HAVEL, R.J. KANE, J.P., BLAUROCK, E.A. and T.SATA: Cholestasis: lamellar structure of the abnormal human serum lipoprotein. Science (Wash. D.C.) 172, 475 (1971).CrossRefGoogle Scholar
  10. 10.
    SEIDEL, D., AGOSTINI, B. and P.MUELLER: Structure of an abnormal plasma lipoprotein (LP-X) characterizing obstructive jaundice. Biochim. Biophys. Acta 260, 146 (1972).PubMedGoogle Scholar
  11. 11.
    NANZATO, E., FELLIN, R., BAGGIO, G., WALCH, S., NEUBECK, W. and D. SEIDEL: Formation of lipoprotein-X. Its relationship to bile compounds. J. Clin. Invest. 57, 1248 (1976).CrossRefGoogle Scholar
  12. 12.
    NEUBECK, W. and D. SEIDEL: Direct method for measuring lipoprotein-X in serum. Clin. Chem. 21, 853 (1975).PubMedGoogle Scholar
  13. 13.
    SEIDEL, D., SCHMITT, E.A. and P. ALAUPDVIC: Ein abnormes Low-density-Lipoprotein bei Cholestase. II. Bedeutung in der Differentialdiagnose des Ikterus. Dtsch. Med. Wochenschr. 95, 1805 (1970).PubMedCrossRefGoogle Scholar
  14. 14.
    POLEY, J.R., ALAUPOVIC, P., MCCONATHY, W.J., SEIDEL, D., ROY, C.C. and A. WEBER: Diagnosis of extrahepatic biliary obstruction in infants by immunochemical detection of LP-X and modified 133 I-Rose Bengal excretion. J. Lab. Clin. Med. 81, 325 (1973).PubMedGoogle Scholar
  15. 15.
    SEIDEL, D., GRETZ, H. and C. RUPPERT: Significance of the LP-X test in differential diagnosis of jaundice. Clin. Chem. 19, 86 (1973).PubMedGoogle Scholar
  16. 16.
    PREXL, H-J, and W. PETEK: Die Bedeutung des Lipoprotein-X und der Serumcholestase in der präoperativen Diagnostik des Verschlussikterus. Chirurg. 44, 310 (1973).PubMedGoogle Scholar
  17. 17.
    RITLAND, S., BLOMHOFF, J.P., ELGJO, K. and E. CJONE: Lipoprotein-X (LP-X) in liver disease.Google Scholar
  18. 18.
    VERGANI, C., PIETROGRANDE, M., GRONDONA, M.C. and M. PIZZOLATO: Study of the abnormal lipoprotein-X in obstructive and non-obstructive jaundice. Clin. Chim. Acta 48, 243 (1973).PubMedCrossRefGoogle Scholar
  19. 19.
    ROSTI, D. and C.G. DE GASPARI: Valoré diagnostico della LP-X negli itteri neonatali. Minerva Pediatr. 26, 582 (1974).Google Scholar
  20. 20.
    MAYER, K.: Der Wert der LP-X-Bestimmung zur Erfassung einer Cholestase. In: Jahrestagung der Deutschen, Osterreichischen und Schweizerichen Gesellschaft für Klinische Chemie, Freiburg, West Germany, März 16–13 (Abstr.) 1975 ).Google Scholar
  21. 21.
    FISCHER, M., FALKENSAMMER, C., BARONACH, G., WAKETUCH, S., KRONBERGER, O. and H. Schnack: Zur Diagnose der Cholestase: Lipoprotein-X (LP-X). Wien. Klin. Wochenschrift 87, 524 (1975).Google Scholar
  22. 22.
    LIERSCH, M., HEUCK, C.C., BAGGIO, G. and D. SEIDEL: Regulation of Cholesterol Biosynthesis in Rat Liver by Two Different Plasma Lipoproteins. Atherosclerosis 26, 505 (1977).PubMedCrossRefGoogle Scholar
  23. 23.
    MCINTYRE, N., HARRY, D.S. and A.I.G. PEARSON: The Hypercholesterolaemia of Obstructive Jaundice. Gut 16, 379 (1975).PubMedCrossRefGoogle Scholar
  24. 24.
    RITLAND, S., BLOMHOFF, J.P. and E. GJONE: Lecithin:Cholesterol Acyltransferase and Lipoprotein-X in Liver Disease. Clin. Chim. Acta 49, 251 (1973).PubMedCrossRefGoogle Scholar
  25. 25.
    MAGNANI, H.N.: The influence of LP-X and other lipoproteins associated with hepatic dysfunction on the activity of lecithin: cholesterol acyltransferase. Biochem. Biophys. Acta 450 390 (1976).PubMedGoogle Scholar
  26. 26.
    BARAONA, E. and LIEBER, L.S.: Effects of chronic ethanol feeding on serum lipoprotein metabolism in the rat. J. Clin. Invest. 49, 769 (1970).PubMedCrossRefGoogle Scholar
  27. 27.
    KLÖR, U., DITSCHUNEIT, H.H., RABOW, D. and H.DITSCHNUNEIT: Further characterization of dyslipoproteinemia in hepatic disease. Abstr. Eur. J. Clin. Invest. 2, 291 (1972).Google Scholar
  28. 28.
    ALCINDOR, L.G., INFANTE, R. and J.CARDLI: Plasma VLDL catabolism in cholestasis. Abstr. 5th meeting of the int. Ass. for the study of the liver. Versailles, July 1972.Google Scholar
  29. 29.
    PEARSON, A.J.G.: Triglycerides in obstructive liver disease Abstr. 5th meeting of the int. Ass. for the study of the liver. Versailles, July 1972.Google Scholar
  30. 30.
    FELLIN, R. and D. SEIDEL: Behaviour of serum lipoproteins in cholestasis. 1. Int. Symp. on cholestasis, Florence, June 1973. Proc. of the Symposium.Google Scholar
  31. 31.
    MÜLLER, P., FELLIN, R., LAMBRECHT, J., AGOSTINI, B., WIELAND, H., ROST, W. and D. SEIDEL: Hypertriglyceridemia Secondary to Liver Disease. Europ. J. Clin. Invest. 4, 419 (1974).PubMedGoogle Scholar
  32. 32.
    SEIDEL, D. GRETEN, H., GEISEN, H.P., WENGELER, H. and H.WIELAND: Further aspects in the characterization of high and very low density lipoproteins in patients with liver disease. Europ. J. Clin. Invest. 2, 359 (1972).Google Scholar
  33. 33.
    GOFMAN, J.: The serum lipoprotein transport system in health, metabolic disorders, atherosclerosis and coronary artery diseases. Plasma 2, 484 (1954).Google Scholar
  34. 34.
    SEIDEL, D. et al.: unpublished observations.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • D. Seidel
    • 1
  1. 1.Medizinische UniversitätsklinikHeidelbergWest Germany

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