Interconversion of Plasma Lipoproteins

  • Alex V. Nichols
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 15)

Abstract

Interconversion of a lipoprotein molecule to a lipoprotein molecule of different physical and chemical properties perhaps can be best considered in terms of our current understanding of lipoprotein structure. Thus, normal lipoproteins are generally described as spherical structures with a core of triglycerides and cholesteryl esters stabilized by a surface of specific apoproteins, phospholipids and cholesterol (1, 2). On the surface, the phospholipids and cholesterol form a monolayer in which apoproteins exhibiting amphipathic helical regions are embedded. This overview will consider interconversions which result from significant alterations in molecular size and/or shape due to enzymatically or physico-chemically-induced changes in core and/or surface domains of a lipoprotein molecule. Analytic approaches to the investigation of interconversions include: preparative and analytic ultracentrifugation, electron microscopy, gel chromatography and electrophoresis, and chemical analysis.

Keywords

Cholesterol Hydrolysis Hydrated Lipase Amide 

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Alex V. Nichols
    • 1
  1. 1.Donner Laboratory, Lawrence Berkeley LaboratoryUniversity of CaliforniaBerkeleyUSA

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