Interconversion of Plasma Lipoproteins

  • Alex V. Nichols
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 15)


Interconversion of a lipoprotein molecule to a lipoprotein molecule of different physical and chemical properties perhaps can be best considered in terms of our current understanding of lipoprotein structure. Thus, normal lipoproteins are generally described as spherical structures with a core of triglycerides and cholesteryl esters stabilized by a surface of specific apoproteins, phospholipids and cholesterol (1, 2). On the surface, the phospholipids and cholesterol form a monolayer in which apoproteins exhibiting amphipathic helical regions are embedded. This overview will consider interconversions which result from significant alterations in molecular size and/or shape due to enzymatically or physico-chemically-induced changes in core and/or surface domains of a lipoprotein molecule. Analytic approaches to the investigation of interconversions include: preparative and analytic ultracentrifugation, electron microscopy, gel chromatography and electrophoresis, and chemical analysis.


Cholesteryl Ester LCAT Activity Flotation Rate DMPC Vesicle Interconversion Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Shen, B. W., Scanu, A. M. and Kezdy, F. J. Proc. Natl. Acad. Sci. (USA) 74: 837, 1977.CrossRefGoogle Scholar
  2. 2.
    Verdery, R. B. III and Nichols, A. V. Chem. Phys. Lipids 14: 123, 1975.PubMedCrossRefGoogle Scholar
  3. 3.
    Nichols, A. V., Strisower, E. J., Lindgren, F. T., Adamson, G. L. and Coggiola, E. L. Clin. Chim. Acta 20: 277, 1968.PubMedCrossRefGoogle Scholar
  4. 4.
    Eisenberg, S., Bilheimer, D. W., Levy, R. I. and Lindgren, F.T. Biochim. Biophys. Acta 326: 361, 1973.PubMedGoogle Scholar
  5. 5.
    Glomset, J. A., Norum, K. R., Nichols, A. V., King, W. C., Mitchell, C. D., Applegate, K. R., Gong, E. L. and Gjone, E. Scand. J. Clin. Lab. Invest. 35 Suppl. 142: 3, 1975.Google Scholar
  6. 6.
    Eisenberg, S. and Schurr, D. J. Lipid Res. 17: 578, 1976.PubMedGoogle Scholar
  7. 7.
    Schumaker, V. N. and Adams, G. H. J. Theor. Biol. 26: 89, 1970.CrossRefGoogle Scholar
  8. 8.
    Olivecrona, T., Bengtsson, G., Marklund, S., Lindahl, U. and Höök, M. Fed. Proc. 36: 60, 1977.PubMedGoogle Scholar
  9. 9.
    Eisenberg, S. and Levy, R. I. Advan. Lipid Res. 13: 1, 1975.Google Scholar
  10. 10.
    Kane, J. P., Sata, T., Hamilton, R. L. and Havel, R. J. J. Clin. Invest. 56: 1622, 1975.CrossRefGoogle Scholar
  11. 11.
    Mahley, R. W., Hamilton, R. L. and LeQuire, V. S. J. Lipid Res. 10: 433, 1969.PubMedGoogle Scholar
  12. 12.
    Hamilton, R. L. and Kayden, H. J. In: The Liver: Normal and Abnormal Functions, F. F. Becker, ed., Marcel Dekker, Inc., New York, Part A, 1974, p. 531.Google Scholar
  13. 13.
    Rubinstein, B. and Rubinstein, D. J. Lipid Res. 13: 317, 1972.PubMedGoogle Scholar
  14. 14.
    Forte, T., Nichols, A., Glomset, J. and Norum, K. Scand. J. Clin. Lab. Invest. 33 Suppl. 137: 121, 1974.Google Scholar
  15. 15.
    Hamilton, R. L., Williams, M. C., Havel, R. J. and Fielding, C. J. In: Atherosclerosis III, G. Schettler and A. Weizel, eds., Springer-Verlag, Berlin, abstr. 936, 1974.Google Scholar
  16. 16.
    Segrest, J. P. Chem. Phys. Lipids 18: 7, 1977.PubMedCrossRefGoogle Scholar
  17. 17.
    Hamilton, R. L., Williams, M. C., Fielding, C. J. and Havel, R. J. J. Clin. Invest. 58: 667, 1976.CrossRefGoogle Scholar
  18. 18.
    Fainaru, M., Havel, R. J. and Imaizumi, K. Biochim. Biophys. Acta 490: 144, 1977.PubMedGoogle Scholar
  19. 19.
    Mahley, R. W. and Holcombe, K. S. J. Lipid Res. 18: 314, 1977.PubMedGoogle Scholar
  20. 20.
    Norum, K. R., Glomset, J. A., Nichols, A. V., Forte, T., Albers, J. J., King, W. C., Mitchell, C. D., Applegate, K. R., Crony, E., Cabana, V. and Gjone, E. Scand. J. Clin. Lab. Invest. 35 Suppl. 142: 31, 1975.Google Scholar
  21. 21.
    Glomset, J. A., Norum, K. R. and King, W. J. Clin. Invest. 49: 1827, 1970.CrossRefGoogle Scholar
  22. 22.
    Torsvik, H. Clin. Genet. 3: 188, 1972.PubMedCrossRefGoogle Scholar
  23. 23.
    Utermann, G., Menzel, H. J. and Langer, K. H. FEBS Letters 45: 29, 1974.CrossRefGoogle Scholar
  24. 24.
    Anderson, D. W., Nichols, A. V. and Lindgren, F. T. Biochim. Biophys. Acta, in press.Google Scholar
  25. 25.
    Anderson, D. W., Nichols, A. V., Pan, S. S. and Lindgren, F. T. Atherosclerosis, accepted for publication.Google Scholar
  26. 26.
    Nichols, A. V., Gong, E., Blanche, P., Forte, T. M. and Anderson, D. W. Biochim. Biophys. Acta 446: 226, 1976.PubMedGoogle Scholar
  27. 27.
    Tall, A. R. and Small, D. M. Nature 265: 163, 1977.CrossRefGoogle Scholar
  28. 28.
    Nichols, A. V., Forte, T. M., Gong, E. L., Blanche, P. J., and Nordhausen, R., in preparation.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Alex V. Nichols
    • 1
  1. 1.Donner Laboratory, Lawrence Berkeley LaboratoryUniversity of CaliforniaBerkeleyUSA

Personalised recommendations