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Metabolism of Prostaglandins

  • Elisabeth Granström
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)

Abstract

The major initial steps in the degradation of the prostaglandins are the oxidation of the secondary alcohol group at C-15 and the reduction of the Δ13 double bond (for a recent review, see 1). The two enzymes that catalyze these reactions are 15-hydroxyprosta-noate dehydrogenase and Δl3 reductase. The metabolites formed by these reactions, the 15-keto and the 15-keto-13,14-dihydro compounds, have considerably lower biologic activities than the parent prostaglandins; thus, the dehydrogenation has been considered a key step in the biological inactivation of prostaglandins. To a certain extent, reduction of the formed keto group to a hydroxyl may also take place. The biological activity of the resulting compound, the 13,14-dihydro prostaglandin, may be considerable in certain systems.

Keywords

Perfusion Experiment Tricyclic Antidepres Human Seminal Plasma Dioic Acid Lower Biologic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Elisabeth Granström
    • 1
  1. 1.Dept. of ChemistryKarolinska InstitutetStockholm 60Sweden

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