Abstract
The conversion of arachidonic acid into PGE2 by homogenates of sheep vesicular glands was demonstrated in 1964 by two groups (1,2). Analogous formation of PGE1 and PGE2 from al1-cis 8,11,14-eicosatri-enoic acid and al1-cis 5,8,11,14,17-eicosapentaenoic acid, was subsequently described (3,4). The parallel production of corresponding PGF compounds from the same precursors was demonstrated later.
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References
van Dorp., D.A., Beerthuis, R.K., Nugteren, D.H. and Vonkeman, H. Biochim. Biophys. Acta 90 (1964) 204.
Bergström, S., Danielsson, H. and Samuelsson, B., Biochim. Bio-phys Acta 90 (1964) 207.
Bergström, S., Danielsson, H., Kienberg, D. and Samuelsson, B., J. Biol. Chem. 239 (1964) PC 4006.
van Dorp, D.A., Beerthuis, R.K., Nugteren, D.H. and Vonkeman, H., Nature, 203 (1964) 839.
Änggärd, E. and Samuelsson, B., J. Biol. Chem. 240 (1965) 3518.
Samuelsson, B., Granström, E., Gréen, K., Hamberg, M. and Hammarström, S., Ann. Rev. Biochem. 44 (1975) 669.
Samuelsson, B., J. Am. Chem. Soc. 87 (1965) 3011.
Hamberg, M. and Samuelsson, B., J. Am. Chem. Soc. 88 (1966) 2349.
Nugteren, D.H., Beerthuis, R.K. and van Dorp, D.A., Rec. Trav. Chim. Pays-Bas, 85 (1966) 405.
Hamberg, M. and Samuelsson, B., J. Biol. Chem. 242 (1967) 5336.
Hamberg, M. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 70 (1973) 899.
Nugteren, D.H. and Hazelhof, E., Biochim, Biophys. Acta, 326 (1973) 448
Hamberg, M., Svensson, J., Wakabayashi, T. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 71 (1974) 345.
Samuelsson, B. and Hamberg, M., In: Prostaglandin Synthetase Inhibitors. Eds. H.J. Robinson and J.R. Vane, Raven Press, New York. 1974, p.107.
Lee, R.E. and Lands, W.E.M., Biochim. Biophys. Acta, 260 (1972) 203.
Sih, C.J., Takeguchi, C. and Foss, P., J. Am. Chem. Soc. 92 (1970) 6670.
Pace-Asciak, C. and Nashat, M. Biochim. Biophys. Acta, 388 (1975) 243.
Chan, J.A., Nagsawa, M., Takeguchi, C. and Sih, C.J., Biochemistry, 14 (1975) 2987.
Miyamoto, T., Yamamoto, S., and Hayaishi, O., Proc. Nat. Acad. Sci. USA, 71 (1974) 3645.
Rome, L.H. and Lands, W.E.M., Prostaglandins, 10 (1975) 813.
Ferreira, S.H. and Vane, J.R., Ann. Rev. Pharmacol. 14 (1974) 57.
Flower, R.J. and Vane, J.R., Biochem. Pharmacol. 23 (1974) 1439.
Malmsten, C, Hamberg, M., Svensson, J. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 72 (1975) 1446.
Vargaftig, B.B. and Zirinis, P., Nature (New Biol.) 244 (1973) 114.
Silver, M.J., Smith, J.B., Ingerman, C. and Kocsis, J.J., Prostaglandins, 4 (1973) 863.
Zucker, M.B. and Petersen, J., Proc. Soc. Exp. Biol. Med. 127 (1968) 547.
Willis, A.L., Science, 183 (1974) 325.
Hamberg, M. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 71 (1974) 3400.
Hamberg, M., Svensson, J. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 71 (1974) 3824.
Hamberg, M., Svensson, J. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 72 (1975) 2994.
Piper, P.J. and Vane, J.R., Nature, 223 (1969) 29.
Vargaftig, B. and Dao, N., Pharmacology, 6 (1971) 99.
Vargaftig, B. and Zirinis, P., Nature (New Biol.), 244 (1973) 114.
Svensson, J., Hamberg, M. and Samuelsson, B., Acta Physiol. Scand. 94 (1975) 222.
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Granström, E. (1977). Biosynthesis of Prostaglandins. In: Berti, F., Samuelsson, B., Velo, G.P. (eds) Prostaglandins and Thromboxanes. NATO Advanced Study Institutes Series, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2778-3_6
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