Skip to main content

Biosynthesis of Prostaglandins

  • Chapter
Prostaglandins and Thromboxanes

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 13))

  • 83 Accesses

Abstract

The conversion of arachidonic acid into PGE2 by homogenates of sheep vesicular glands was demonstrated in 1964 by two groups (1,2). Analogous formation of PGE1 and PGE2 from al1-cis 8,11,14-eicosatri-enoic acid and al1-cis 5,8,11,14,17-eicosapentaenoic acid, was subsequently described (3,4). The parallel production of corresponding PGF compounds from the same precursors was demonstrated later.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. van Dorp., D.A., Beerthuis, R.K., Nugteren, D.H. and Vonkeman, H. Biochim. Biophys. Acta 90 (1964) 204.

    Article  CAS  Google Scholar 

  2. Bergström, S., Danielsson, H. and Samuelsson, B., Biochim. Bio-phys Acta 90 (1964) 207.

    Google Scholar 

  3. Bergström, S., Danielsson, H., Kienberg, D. and Samuelsson, B., J. Biol. Chem. 239 (1964) PC 4006.

    Google Scholar 

  4. van Dorp, D.A., Beerthuis, R.K., Nugteren, D.H. and Vonkeman, H., Nature, 203 (1964) 839.

    Article  Google Scholar 

  5. Änggärd, E. and Samuelsson, B., J. Biol. Chem. 240 (1965) 3518.

    PubMed  Google Scholar 

  6. Samuelsson, B., Granström, E., Gréen, K., Hamberg, M. and Hammarström, S., Ann. Rev. Biochem. 44 (1975) 669.

    Article  PubMed  CAS  Google Scholar 

  7. Samuelsson, B., J. Am. Chem. Soc. 87 (1965) 3011.

    Article  PubMed  CAS  Google Scholar 

  8. Hamberg, M. and Samuelsson, B., J. Am. Chem. Soc. 88 (1966) 2349.

    Article  CAS  Google Scholar 

  9. Nugteren, D.H., Beerthuis, R.K. and van Dorp, D.A., Rec. Trav. Chim. Pays-Bas, 85 (1966) 405.

    Article  CAS  Google Scholar 

  10. Hamberg, M. and Samuelsson, B., J. Biol. Chem. 242 (1967) 5336.

    PubMed  CAS  Google Scholar 

  11. Hamberg, M. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 70 (1973) 899.

    Article  PubMed  CAS  Google Scholar 

  12. Nugteren, D.H. and Hazelhof, E., Biochim, Biophys. Acta, 326 (1973) 448

    CAS  Google Scholar 

  13. Hamberg, M., Svensson, J., Wakabayashi, T. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 71 (1974) 345.

    Article  PubMed  CAS  Google Scholar 

  14. Samuelsson, B. and Hamberg, M., In: Prostaglandin Synthetase Inhibitors. Eds. H.J. Robinson and J.R. Vane, Raven Press, New York. 1974, p.107.

    Google Scholar 

  15. Lee, R.E. and Lands, W.E.M., Biochim. Biophys. Acta, 260 (1972) 203.

    PubMed  CAS  Google Scholar 

  16. Sih, C.J., Takeguchi, C. and Foss, P., J. Am. Chem. Soc. 92 (1970) 6670.

    Article  PubMed  CAS  Google Scholar 

  17. Pace-Asciak, C. and Nashat, M. Biochim. Biophys. Acta, 388 (1975) 243.

    PubMed  CAS  Google Scholar 

  18. Chan, J.A., Nagsawa, M., Takeguchi, C. and Sih, C.J., Biochemistry, 14 (1975) 2987.

    Article  PubMed  CAS  Google Scholar 

  19. Miyamoto, T., Yamamoto, S., and Hayaishi, O., Proc. Nat. Acad. Sci. USA, 71 (1974) 3645.

    Article  PubMed  CAS  Google Scholar 

  20. Rome, L.H. and Lands, W.E.M., Prostaglandins, 10 (1975) 813.

    PubMed  CAS  Google Scholar 

  21. Ferreira, S.H. and Vane, J.R., Ann. Rev. Pharmacol. 14 (1974) 57.

    Article  CAS  Google Scholar 

  22. Flower, R.J. and Vane, J.R., Biochem. Pharmacol. 23 (1974) 1439.

    Article  PubMed  CAS  Google Scholar 

  23. Malmsten, C, Hamberg, M., Svensson, J. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 72 (1975) 1446.

    Article  PubMed  CAS  Google Scholar 

  24. Vargaftig, B.B. and Zirinis, P., Nature (New Biol.) 244 (1973) 114.

    CAS  Google Scholar 

  25. Silver, M.J., Smith, J.B., Ingerman, C. and Kocsis, J.J., Prostaglandins, 4 (1973) 863.

    Article  PubMed  CAS  Google Scholar 

  26. Zucker, M.B. and Petersen, J., Proc. Soc. Exp. Biol. Med. 127 (1968) 547.

    PubMed  CAS  Google Scholar 

  27. Willis, A.L., Science, 183 (1974) 325.

    Article  PubMed  CAS  Google Scholar 

  28. Hamberg, M. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 71 (1974) 3400.

    Article  PubMed  CAS  Google Scholar 

  29. Hamberg, M., Svensson, J. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 71 (1974) 3824.

    Article  PubMed  CAS  Google Scholar 

  30. Hamberg, M., Svensson, J. and Samuelsson, B., Proc. Nat. Acad. Sci. USA, 72 (1975) 2994.

    Google Scholar 

  31. Piper, P.J. and Vane, J.R., Nature, 223 (1969) 29.

    Article  PubMed  CAS  Google Scholar 

  32. Vargaftig, B. and Dao, N., Pharmacology, 6 (1971) 99.

    Article  PubMed  CAS  Google Scholar 

  33. Vargaftig, B. and Zirinis, P., Nature (New Biol.), 244 (1973) 114.

    CAS  Google Scholar 

  34. Svensson, J., Hamberg, M. and Samuelsson, B., Acta Physiol. Scand. 94 (1975) 222.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Plenum Press, New York

About this chapter

Cite this chapter

Granström, E. (1977). Biosynthesis of Prostaglandins. In: Berti, F., Samuelsson, B., Velo, G.P. (eds) Prostaglandins and Thromboxanes. NATO Advanced Study Institutes Series, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2778-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2778-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2780-6

  • Online ISBN: 978-1-4684-2778-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics