Inflammatory Pain and Fever

  • S. H. Ferreira
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


The existence of an ongoing inflammatory process is generally indicated by pain or fever and these symptoms are also the first to be relieved by nonsteroidal anti-inflammatory therapy. This is a brief review of the participation of prostaglandins in the genesis of these symptoms.


Visceral Pain Cerebral Ventricle Pain Receptor Prostaglandin Release Endogenous Pyrogen 
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  1. 1.
    Ferreira, S.H. and Vane, J.R., 1974, New aspects of the mode of action of non-steroid anti-inflammatory drugs, Ann. Rev. of Pharmacol. 14: 57.CrossRefGoogle Scholar
  2. 2.
    Feldberg, W., 1974, Fever, Prostaglandins and Anti-pyretics in Prostaglandin Synthetase inhibitors, H.J. Robinson and R. Vane, Raven Press, N.Y.Google Scholar
  3. 3.
    Beeson, P.B., 1948, Temperature elevating effect of a substance obtained from polymorphonuclear leucocytes, J. Clin. Invest. 27: 524.PubMedGoogle Scholar
  4. 4.
    Bennett, I.L. and Beeson, P.B., 1953, Studies in the pathogenesis of fever. II characterization of fever producing substances from polymorphonuclear leucocytes and from the fluid of sterile exudates, J. exp. Med. 98: 493.PubMedCrossRefGoogle Scholar
  5. 5.
    Milton, A.S. and Wendlant, S., 1968, The effect of 4-acetamidophenol in reducing fever produced by the intracerebral injection of 5-hydroxytryptamine and pyrogen in concions cat, Br. J. Pharmac. 34: 215.Google Scholar
  6. 6.
    Milton, A.S. and Wendlant, S., 1971, Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized rats and rabbits, J. Physiol. 218; 325.PubMedGoogle Scholar
  7. 7.
    Feldberg, W. and Saxena, P.N., 1971 a, Fever produced by prostaglandin E1, J. Physiol. 217: 547.PubMedGoogle Scholar
  8. 8.
    Feldberg, W. and Gupta, K.P., 1973, Pyrogen fever and prostaglandin activity in cerebrospinal fluid, J. Physiol. 228; 41.PubMedGoogle Scholar
  9. 9.
    Clark, W.C. and Moyer, S.G., 1972, The effect of acetaminophen and sodium salicylate on the release and activity of leukocytic pyrogen in the cat, J. Pharmac. exp. Ther. 181: 183.Google Scholar
  10. 10.
    Milton, A.S., 1973, Prostaglandin release in the central nervous system during endotoxin induced fever. In Advance in Biosciences, 9: ed. S. Bergström S. Bernard, Pergamon Press-Vieweg, Braunschweig, p. 495.Google Scholar
  11. 11.
    Cranston, W.I., Duff, G.W., Hellon, R.F. and Mitchell, D. Department of Pharmacology, Faculty of Medicine, 1976, Effect of a prostaglandin antagonist on the pyrixias caused by PGE2 and leucocyte pyrogen in rabbits, J. Physiol. (Lond.) in press.Google Scholar
  12. 12.
    Solomon, L.M., Juhlin, L. and Kirschenbaum, M.B., 1968, Prostaglandin on cutaneous vasculature, J. Invest. Derm. 51: 280.PubMedGoogle Scholar
  13. 13.
    Michaelsson, G., 1970, Effects of antihistamines, acetylsalicylic acid and prednisone on cutaneous reactions to kallikrein and prostaglandin E1. Acta derm, venereol. 30: 31.Google Scholar
  14. 14.
    Bergström, S., Duner, H., Euler, U.S., Pernow, B. and Sjovall, J., 1959, Observations on the effects of infusions of prostaglandin E in man, Acta Physiol. Scand. 45: 145.PubMedCrossRefGoogle Scholar
  15. 15.
    Collier, J.G., Karim, S.M.M., Robinson, B. and Somers, K., 1972, Action of prostaglandins A2, B1, E2 and F on superficial hand veins of man, Br. J. Pharmac. 44: 374.Google Scholar
  16. 16.
    Karim, S.M.M., 1971, Action of prostaglandin in the pregnant woman, Ann. N.Y. Acad. Sc. 180: 483.CrossRefGoogle Scholar
  17. 17.
    Vane, J.R., 1971, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, New Biol. 231: 232.Google Scholar
  18. 18.
    Ferreira, S.H., Moncada, S. and Vane, J.R., 1971, Indo-methacin and aspirin abolish prostaglandin release from the spleen, Nature, New Biol. 231: 237.CrossRefGoogle Scholar
  19. 19.
    Smith, J.B. and Willis, A.L., 1971, Aspirin selectively inhibits prostaglandin production in human platelets. Nature, New Biol. 231: 256.Google Scholar
  20. 20.
    Horton, E.W., 1963, Action of prostaglandin E1 on tissues which respond to bradykinin, Nature 200: 892.PubMedCrossRefGoogle Scholar
  21. 21.
    Cruunkhorn, P. and Willis, A.L., 1971, Cutaneous reactions to intradermal prostaglandins, Br. J. Pharmac. 41; 49.Google Scholar
  22. 22.
    Ferreira, S.H., 1972, Prostaglandins, aspirin-like drugs and analgesia, Nature, New Biol. 240; 200.CrossRefGoogle Scholar
  23. 23.
    Guzman, F., Braun, C. and Lim, R.K.S., 1962, Visceral pain and the pseud-affective response to intra--arterial injection of bradykinin and other algesic agents. Arch. Int. Pharm. 136: 353.Google Scholar
  24. 24.
    Guzman, F., Braun, C., Lim, R.K.S., Potter, G.D. and Rodgers, D.W., 1964, Narcotic and non-narcotic analgesics which block visceral pain evoked by intra--arterial injection of bradykinin and other algesic agents, Arch. Int. Pharmac. 149: 571.Google Scholar
  25. 25.
    Lim, R.K.S., Guzman, F., Rodgers, D.W., Goto, K., Braun, G., Dickerson, G.D. and Engle, R.J., 1964, Site of action of narcotic and non-narcotic analgesic determined by blocking bradykinin-evoked visceral pain. Arch. Int. Pharmacol. 152: 25.Google Scholar
  26. 26.
    Ferreira, S.H., Moncada, S. and Vane, J.R., 1973, Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs, Brit. J. Pharmacol. 49: 86.Google Scholar
  27. 27.
    Greaves, M.W. and MacDonald-Gibson, W., 1973, Itch: Role of prostaglandins, Br. Med. J. 3: 608.PubMedCrossRefGoogle Scholar
  28. 28.
    Moncada, S., Ferreira, S.H. and Vane, J.R., 1975, Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint, Eur. J. Pharmacol. 31: 250.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • S. H. Ferreira
    • 1
  1. 1.Department of PharmacologyFaculty of Medicine of Ribeirão PretoS. P.Brazil

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