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Prostaglandins as Modulators of Autonomic Neuroeffector Transmission

  • Per Hedqvist
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)

Abstract

The concept of chemical transmission at autonomic synapses, originally proposed by Elliot (1), and firstly verified by Loewi (2), evidently represents the basis for our present knowledge about how nerve impulses are conveyed to effector cells. For many years it was believed that the only factor determining the release of transmitter, and hence the ensuing effector response, was the number of nerve impulses travelling down the axon. However, research over the past decade has disclosed that the transmitter quantum released per nerve impulse is not fixed, but subject to facilitation and depression processes. Moreover, the nerve terminal membrane seems to possess receptors through which a number of different substances, naturally occurring in the body, may act to increase or decrease the amount of transmitter released in response to forthcoming nerve impulses.

Keywords

Nerve Stimulation Nerve Impulse Rabbit Heart Vagal Nerve Stimulation Adrenergic Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Per Hedqvist
    • 1
  1. 1.Department of PhysiologyKarolinska InstitutetStockholm 60Sweden

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