Influence of Prostaglandins on Central Functions

  • R. Fumagalli
  • G. C. Folco
  • D. Longiave
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


Biologically active compounds have been described in brain and cerebrospinal fluid some twenty years ago. These substances behaved like unsaturated acidic lipids, displayed direct effects on a number of isolated tissue preparations and influenced the action of known agonists on some classical experimental model. In the early sixties some of these compounds were chemically characterized, their presence in the Central Nervous System (CNS) definitely assessed, and found to correspond to prostaglandins (PGs). The function of prostaglandins in CNS has, since then, become a stimulating goal. The recent discovery that brain cortex is able to form thromboxanes from endogenous precursors provides new impetus to research in this field and opens new perspectives to the understanding of the possible roles played by prostaglandins in the Central Nervous System. The aim of this chapter is to update (end of June 1976) current knowledge on prostaglandins as related to CNS, previously discussed and reported (1–3).


Purkinje Cell Cyclic Nucleotide Cerebral Vasospasm Free Arachidonic Acid Endogenous Precursor 


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. Fumagalli
    • 1
  • G. C. Folco
    • 1
  • D. Longiave
    • 1
  1. 1.Institute of Pharmacology and PharmacognosyUniversity of MilanoMilanoItaly

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