Influence of Anti-Inflammatory Steroids on Prostaglandin and Thromboxane Release from Tissues

  • R. D. Gryglewski
  • R. Korbut
  • A. Dembińska-Kieć
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


Natural glucocorticosteroids and synthetic antiinflammatory steroids (“steroids” for brevity) are widely used in the treatment of allergic and inflammatory conditions however the mechanism of their immunosuppressive and anti-inflammatory actions remains unknown. Steroids do not significantly affect antibody production in man but seem to prevent macrophages from responding to lymphokines that are elaborated by T lymphocytes (Claman, 1975). Steroids potentiate stimulatory effects of catecholamines and PGE1 on accumulation of cyclic-AMP in human leucocytes and lymphocytes (Parker et al. 1973; Mendelsohn et al., 1973), and if so, this might result in a decreased liberation of eosinophil chemo-tactic factor of anaphylaxis (ECF-A), slow reacting substance of anaphylaxis (SRS-A) and histamine from appropriate cells (Kaliner and Austen, 1975). Indeed, steroids depress the release of histamine from anaphylactic guinea pig lungs (Gryglewski et al., 1975) and from other tissues (Kurihara and Shibata, 1975). Early reports that steroids impair the formation of kinins has not been confirmed (Eisen et al., 1968).


Arachidonic Acid Perfuse Lung Prostaglandin Biosynthesis Prostaglandin Synthetase Prostaglandin Release 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. D. Gryglewski
    • 1
  • R. Korbut
    • 1
  • A. Dembińska-Kieć
    • 1
  1. 1.Department of Pharmacology, CopernicusAcademy of Medicine in CracowCracowPoland

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