Prostaglandins and Non-Steroidal Anti-Inflammatory Drugs

  • S. H. Ferreira
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


The chemical aspects of the inhibition of the synthesis of prostaglandins by non-steroidal antiinflammatory agents have been amply discussed in other papers in this volume. We shall be mainly concerned with those aspects which are relevant to the discussion of the hypothesis which proposes the inhibition of prostaglandin synthesis as the mechanism of action of aspirin-like drugs (1).


Prostaglandin Synthesis Sodium Salicylate Prostaglandin Biosynthesis Disodium Cromoglycate Prostaglandin Synthetase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    VANE, J.R. (1971). Inhibition of prostaglandin stnthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231; 232.PubMedGoogle Scholar
  2. 2.
    WILLIS, A.L. (1969). Release of histamine, kinin and prostaglandin during carrageenin-induced inflammation in the rat. In: Prostaglandins, peptides and amines 31–38, ed. by P. Mantegazza and E.W. Horton. Academic Press, London, New York.Google Scholar
  3. 3.
    GREAVES, M.W., SøNDERGAARD, J. and MCDONALD-GIBSON, W. (1971). Recovery of prostaglandins in human cutaneous inflammation. Br. Med. J. 2: 258.PubMedCrossRefGoogle Scholar
  4. 4.
    FERREIRA, S.H. and VANE, J.R. (1974). Aspirin and prostaglandins. In: The Prostaglandins II, ed. P.W. Ramwell, pp. 1–39, New York, London, Plenum Press.CrossRefGoogle Scholar
  5. 5.
    SOLOMON, L.M., JUHLIN, L. and KIRSCHENBAUM, M.B. (1968). Prostaglandin on cutaneous vasculature. J. Inv. Derm. 51: 280.Google Scholar
  6. 6.
    CRUNKHORN, P. and WILLIS, A.L. (1971). Custaneous reactions to intradermal prostaglandins. Br. J. Pharm. 41: 49.Google Scholar
  7. 7.
    MONCADA, S., FERREIRA, S.H. and VANE, J.R. (1973). Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature 246: 217.PubMedCrossRefGoogle Scholar
  8. 8.
    THOMAS, G. and WEST, G.B. (1973). Prostaglandins as regulators of bradykinin responses. J. Pharm. Pharmac. 25: 747.CrossRefGoogle Scholar
  9. 9.
    FERREIRA, S.H. (1972). Prostaglandins, aspirin-like drugs and analgesia. Nature, New Biology 240: 200.CrossRefGoogle Scholar
  10. 10.
    MONCADA, S., FERREIRA, S.H. and VANE, J.R. (1975). Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint. Eur. J. Pharmac. 31: 250.CrossRefGoogle Scholar
  11. 11.
    FELDBERG, W. (1974). Fever, Prostaglandins and Antipyretics, in Prostaglandin Synthetase inhibitors. H.J. Robinson and R. Vane, Raven Press, New York.Google Scholar
  12. 12.
    FERREIRA, S.H., MONCADA, S. and VANE, J.R. (1971). Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature, New Biology 231: 237.CrossRefGoogle Scholar
  13. 13.
    SMITH, J.B. and WILLIS, A.L. (1971). Aspirin selectively inhibits prostaglandin production in human platelets. Nature, New Biology 231: 256.Google Scholar
  14. 14.
    FLOWER, R.J., CHEUNG, H.S. and CUSHMAN, D.W. (1973). Quantitiative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase system of bovine seminal vesicles. Prostaglandins 4: 325.PubMedCrossRefGoogle Scholar
  15. 15.
    HAM, E.A., CIRILLO, V.J., ZANETTI, M., SHEN, T.Y. and KUEHL, F.A. JR..(1972). Studies on the mode of action of non-steroidal anti-inflammatory agents. In: Prostaglandins in cellular biology, ed. Ramwell, P.W. and Pharris, B.B. 343, Plenum Press, New York.Google Scholar
  16. 16.
    TAKEGUCHI, C. and SIH, C.J. (1972). A rapid spectro-phometric assay for prostaglandin synthetase application to the study of non-steroidal anti--inflammatory agents. Prostaglandins 2: 169.PubMedCrossRefGoogle Scholar
  17. 17.
    FLOWER, R.J., GRYGLEWSKI, R, HERBACZYNSKA, C.K. and VANE, J.R. (1972). The effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature, New Biology 238: 107.Google Scholar
  18. 18.
    TOMLINSON, R.V., RINGOLD, H.J., QURESHI, M.C. and FORCHIELLI, E. (1972). Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs. Biochem. Biophys. Res. Comm. 46: 552.PubMedCrossRefGoogle Scholar
  19. 19.
    FLOWER, R.J. and VANE, J.R. (1972). Inhibition of prostaglandin synthetase in brain explains the anti--pyretic activity of paracetamol (4-acetamido-phenol). Nature 240: 410.PubMedCrossRefGoogle Scholar
  20. 20.
    WILLIS, A.L., DAVIDSON, P., RAMWELL, P.W., BROCKLEHURST, W.E. and SMITH, B. (1972). Release and actions of prostaglandins in inflammation and fever: inhibition by anti-inflammatory and anti-pyretic drugs. Prostaglandins and cellular Biology, ed. Ramwell, P.W. and Pharris, B.P., 227. Plenum Press, New York, London.Google Scholar
  21. 21.
    BHATTACHERJEE, P. and EAKINS, K.E. (1973). Inhibition of the PG synthetase system in ocular tissue by indomethacin. The Pharmacologist 15: 209.Google Scholar
  22. 22.
    HAMBERG, M. (1972). Inhibition of prostaglandin synthesis in man. Biochem. Biophys. Res. Commu. 49: 720.CrossRefGoogle Scholar
  23. 23.
    PIPER, P.J. and VANE, J.R. (1969). Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature 223: 20.CrossRefGoogle Scholar
  24. 24.
    VARGAFTIG, B.B. and DAO HAI, N. (1971). Release of vasoactive substances from guinea-pig lungs by slow reacting substance C and arachidonic acid. Pharmacology 6: 99.PubMedCrossRefGoogle Scholar
  25. 25.
    PALMER, M.A., PIPER, P.J. and VANE, J.R. (1973). Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br. J. Pharmac. 49: 226.Google Scholar
  26. 26.
    GRYGLEWSKI, R. and VANE, J.R. (1972). The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. Br. J. Pharmac. 45: 37.Google Scholar
  27. 27.
    HAMBERG, M. and SAMUELSSON, B. (1974). Prostaglandin endoperoxides VII. Movel transformations of arachidonic acid in guinea pig lungs. Biochem. Biophys. Res. Comm. 61: 942.PubMedCrossRefGoogle Scholar
  28. 28.
    HAMBERG, M., SVENSSON, J. and SAMUELSSON, B. (1975). Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Nat. Ac. Sci. U.S.A. 72: 2994.CrossRefGoogle Scholar
  29. 29.
    HIGGS, G.A., HARVEY, E.A., FERREIRA, S.H. and VANE, J.R. (1976). The Effects of Anti-Inflammatory Drugs on the Production of Prostaglandins In Vivo. Advances in Prostaglandin and Thromboxane Research, 1: ed. B. Samuelsson and R. Paoletti.Google Scholar
  30. 30.
    FLOWER, R.J. (1974). Drugs which inhibit prostaglandin biosynthesis. Pharm. Revs. 26: 33.Google Scholar
  31. 31.
    BLACKWELL, G.J. and PARSONS, M. (1975). Personal Communication.Google Scholar
  32. 32.
    LEE, R.E. (1974). The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins 5: 63.PubMedCrossRefGoogle Scholar
  33. I am grateful to FAPESP (75/0296) and to the Wellcome Foundation for research Grants.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • S. H. Ferreira
    • 1
  1. 1.Department of PharmacologyFaculty of Medicine of Ribeirão PretoSão PauloBrazil

Personalised recommendations