Abstract
The chemical aspects of the inhibition of the synthesis of prostaglandins by non-steroidal antiinflammatory agents have been amply discussed in other papers in this volume. We shall be mainly concerned with those aspects which are relevant to the discussion of the hypothesis which proposes the inhibition of prostaglandin synthesis as the mechanism of action of aspirin-like drugs (1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
VANE, J.R. (1971). Inhibition of prostaglandin stnthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231; 232.
WILLIS, A.L. (1969). Release of histamine, kinin and prostaglandin during carrageenin-induced inflammation in the rat. In: Prostaglandins, peptides and amines 31–38, ed. by P. Mantegazza and E.W. Horton. Academic Press, London, New York.
GREAVES, M.W., SøNDERGAARD, J. and MCDONALD-GIBSON, W. (1971). Recovery of prostaglandins in human cutaneous inflammation. Br. Med. J. 2: 258.
FERREIRA, S.H. and VANE, J.R. (1974). Aspirin and prostaglandins. In: The Prostaglandins II, ed. P.W. Ramwell, pp. 1–39, New York, London, Plenum Press.
SOLOMON, L.M., JUHLIN, L. and KIRSCHENBAUM, M.B. (1968). Prostaglandin on cutaneous vasculature. J. Inv. Derm. 51: 280.
CRUNKHORN, P. and WILLIS, A.L. (1971). Custaneous reactions to intradermal prostaglandins. Br. J. Pharm. 41: 49.
MONCADA, S., FERREIRA, S.H. and VANE, J.R. (1973). Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature 246: 217.
THOMAS, G. and WEST, G.B. (1973). Prostaglandins as regulators of bradykinin responses. J. Pharm. Pharmac. 25: 747.
FERREIRA, S.H. (1972). Prostaglandins, aspirin-like drugs and analgesia. Nature, New Biology 240: 200.
MONCADA, S., FERREIRA, S.H. and VANE, J.R. (1975). Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint. Eur. J. Pharmac. 31: 250.
FELDBERG, W. (1974). Fever, Prostaglandins and Antipyretics, in Prostaglandin Synthetase inhibitors. H.J. Robinson and R. Vane, Raven Press, New York.
FERREIRA, S.H., MONCADA, S. and VANE, J.R. (1971). Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature, New Biology 231: 237.
SMITH, J.B. and WILLIS, A.L. (1971). Aspirin selectively inhibits prostaglandin production in human platelets. Nature, New Biology 231: 256.
FLOWER, R.J., CHEUNG, H.S. and CUSHMAN, D.W. (1973). Quantitiative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase system of bovine seminal vesicles. Prostaglandins 4: 325.
HAM, E.A., CIRILLO, V.J., ZANETTI, M., SHEN, T.Y. and KUEHL, F.A. JR..(1972). Studies on the mode of action of non-steroidal anti-inflammatory agents. In: Prostaglandins in cellular biology, ed. Ramwell, P.W. and Pharris, B.B. 343, Plenum Press, New York.
TAKEGUCHI, C. and SIH, C.J. (1972). A rapid spectro-phometric assay for prostaglandin synthetase application to the study of non-steroidal anti--inflammatory agents. Prostaglandins 2: 169.
FLOWER, R.J., GRYGLEWSKI, R, HERBACZYNSKA, C.K. and VANE, J.R. (1972). The effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature, New Biology 238: 107.
TOMLINSON, R.V., RINGOLD, H.J., QURESHI, M.C. and FORCHIELLI, E. (1972). Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs. Biochem. Biophys. Res. Comm. 46: 552.
FLOWER, R.J. and VANE, J.R. (1972). Inhibition of prostaglandin synthetase in brain explains the anti--pyretic activity of paracetamol (4-acetamido-phenol). Nature 240: 410.
WILLIS, A.L., DAVIDSON, P., RAMWELL, P.W., BROCKLEHURST, W.E. and SMITH, B. (1972). Release and actions of prostaglandins in inflammation and fever: inhibition by anti-inflammatory and anti-pyretic drugs. Prostaglandins and cellular Biology, ed. Ramwell, P.W. and Pharris, B.P., 227. Plenum Press, New York, London.
BHATTACHERJEE, P. and EAKINS, K.E. (1973). Inhibition of the PG synthetase system in ocular tissue by indomethacin. The Pharmacologist 15: 209.
HAMBERG, M. (1972). Inhibition of prostaglandin synthesis in man. Biochem. Biophys. Res. Commu. 49: 720.
PIPER, P.J. and VANE, J.R. (1969). Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature 223: 20.
VARGAFTIG, B.B. and DAO HAI, N. (1971). Release of vasoactive substances from guinea-pig lungs by slow reacting substance C and arachidonic acid. Pharmacology 6: 99.
PALMER, M.A., PIPER, P.J. and VANE, J.R. (1973). Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br. J. Pharmac. 49: 226.
GRYGLEWSKI, R. and VANE, J.R. (1972). The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. Br. J. Pharmac. 45: 37.
HAMBERG, M. and SAMUELSSON, B. (1974). Prostaglandin endoperoxides VII. Movel transformations of arachidonic acid in guinea pig lungs. Biochem. Biophys. Res. Comm. 61: 942.
HAMBERG, M., SVENSSON, J. and SAMUELSSON, B. (1975). Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Nat. Ac. Sci. U.S.A. 72: 2994.
HIGGS, G.A., HARVEY, E.A., FERREIRA, S.H. and VANE, J.R. (1976). The Effects of Anti-Inflammatory Drugs on the Production of Prostaglandins In Vivo. Advances in Prostaglandin and Thromboxane Research, 1: ed. B. Samuelsson and R. Paoletti.
FLOWER, R.J. (1974). Drugs which inhibit prostaglandin biosynthesis. Pharm. Revs. 26: 33.
BLACKWELL, G.J. and PARSONS, M. (1975). Personal Communication.
LEE, R.E. (1974). The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins 5: 63.
I am grateful to FAPESP (75/0296) and to the Wellcome Foundation for research Grants.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Ferreira, S.H. (1977). Prostaglandins and Non-Steroidal Anti-Inflammatory Drugs. In: Berti, F., Samuelsson, B., Velo, G.P. (eds) Prostaglandins and Thromboxanes. NATO Advanced Study Institutes Series, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2778-3_24
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2778-3_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2780-6
Online ISBN: 978-1-4684-2778-3
eBook Packages: Springer Book Archive