Prostaglandins and Mast Cell Histamine Release

  • B. J. R. Whittle
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


Prostaglandin E1 (PGE1) increases cyclic AMP levels in rat mast cells and inhibits the release of histamine by antigen (Kaliner and Austen, 1974). In the present study, the actions of prostaglandins and drugs affecting prostaglandin metabolism on histamine release following chemical or immunological challenge have been further investigated.


Mast Cell Histamine Release Calcium Ionophore Flufenamic Acid Inhibit Histamine Release 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • B. J. R. Whittle
    • 1
  1. 1.Department of Pharmacology, Institute of Basic Medical SciencesRoyal College of SurgeonsLondonUK

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