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The Role of Prostaglandins and Cyclic Nucleotides in Inflammation

  • J. P. Giroud
  • G. P. Velo
  • D. A. Willoughby
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)

Abstract

One of the main problems surrounding the study of the PG’s in the inflammatory response has been the lack of suitable models. The inflammatory process is a highly dynamic state. There is a constant change in the volume of exudate, increased lymphatic drainage, arrival of different cell types, and even these different cell types change during the inflammatory process. Thus not only do we see tissue cell changes but the arrival of polymorphs which discharge lysosomal enzymes; usually this is followed by the arrival of mononuclear cells which transform into macrophages. These cells are actively phagocytic, they then transform further into “activated macrophages” with surface changes, plus increased numbers of lysosomes. Often these cells may proliferate or fuse into giant cells and even in this form may undergo proliferation.

Keywords

Cyclic Nucleotide Pleural Cavity Purify Protein Derivative Calcium Pyrophosphate Pseudo Gout 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. P. Giroud
    • 1
  • G. P. Velo
    • 2
  • D. A. Willoughby
    • 3
  1. 1.Département de Pharmacologie - ERA 629C.N.R.S. Faculté de Médecine Cochin Port-RoyalParisFrance
  2. 2.Istituto di Farmacologia - Centro Ospedaliero Clinicizzato di Borgo RomaUniversità di PadovaVeronaItaly
  3. 3.Department of Experimental PathologySt Bartholomew’s Hospital Medical CollegeLondonEngland

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