The Role of Prostaglandins and Cyclic Nucleotides in Inflammation

  • J. P. Giroud
  • G. P. Velo
  • D. A. Willoughby
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


One of the main problems surrounding the study of the PG’s in the inflammatory response has been the lack of suitable models. The inflammatory process is a highly dynamic state. There is a constant change in the volume of exudate, increased lymphatic drainage, arrival of different cell types, and even these different cell types change during the inflammatory process. Thus not only do we see tissue cell changes but the arrival of polymorphs which discharge lysosomal enzymes; usually this is followed by the arrival of mononuclear cells which transform into macrophages. These cells are actively phagocytic, they then transform further into “activated macrophages” with surface changes, plus increased numbers of lysosomes. Often these cells may proliferate or fuse into giant cells and even in this form may undergo proliferation.


Cyclic Nucleotide Pleural Cavity Purify Protein Derivative Calcium Pyrophosphate Pseudo Gout 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    AUSTEN K.F., LEWIS R.A., STECHSCHULTE D.J., WASSERMAN S.I., LEID R.W. and GOETZL E.J.—”Generation and release of chemical mediators of immediate hypersensitivity”. In Progr. in Immunol., 11, 2, 6l, 1973. Eds. L. Brent and J. Holborow, North Holland Publishing Co Ltd.Google Scholar
  2. 2.
    BRUNO J.J., TAYLOR L.A., DROLLER M.J.—“Effects of PGE2 on human platelet adenyl cyclase and aggregation”. Nature, 251, 721, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    CAPASSO F., DUNN C.J., YAMAMOTO S., WILLOUGHBY D.A. AND GIROUD J.P.— “Further studies of carrageenan-induced pleurisy in rats”. J. Path., 116, 117, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    CRUNKHORN PEARL AND WILLIS A.L.— “Cutaneous reactions to intradermal prostaglandins” Brit. J. Pharmacol., 41 (1), 49, 1971.Google Scholar
  5. 5.
    DEPORTER D.A., DIEPPE P. AND WILLOUGHBY D.A.—“Pyrophosphate-induced inflammation: an in vivo study of the interrelationship of intracellular cyclic AMP and cyclic GMP”. Agents and Actions, 6, 476, 1976.PubMedCrossRefGoogle Scholar
  6. 6.
    DI ROSA M.-In Future Trends in Inflammation. Eds. Velo G.P., Willoughby D.A. and Giroud J.P. Piccin Medical Books, Padua, p.153, 1974.Google Scholar
  7. 7.
    DI ROSA M., GIROUD J.P. and WILLOUGHBY D.A.— “Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine”. J. Path., 104, 15, 1971.PubMedCrossRefGoogle Scholar
  8. 8.
    DUNN C.J., WILLOUGHBY D.A., GIROUD J.P. and YAMAMOTO S.—”An appraisal of the interrelationship between prostaglandins and cyclic nucleotides in inflammation”. Biomedicine, 24, n° 4, 214, 1976.PubMedGoogle Scholar
  9. 9.
    FERREIRA S.H. and VANE J.R.—”Inhibition of prostaglandin biosynthesis and the mechanism of action of non-steroidal antiinflammatory agents”. In Future Trends in Inflammation. Eds. Velo G.P., Willoughby D.A. and Giroud J.P. Piccin Medical Books, Padua, p. 171, 1974.Google Scholar
  10. 10.
    FONTAGNE J. and GIROUD J.P.—”Pathopharmacologie expérimentale de la reaction inflammatoire aigue”. Revue des Sciences Médicales, 218, 7, 1976.Google Scholar
  11. 11.
    HIRSCHHORN R., GROSSMAN J. AND WEISSMANN G.— “Effect of cyclic 3′5′-adenosine monophosphate and theophylline on lymphocyte transformation”. Proc. Soc. Exp. Biol. Med., 133, 136l, 1970.Google Scholar
  12. 12.
    IGNARRO L.J.—”Regulation of lysosomal enzyme secretion: Role in inflammation”. Agents and Actions, 4, (4), 241, 1974.PubMedCrossRefGoogle Scholar
  13. 13.
    KALEY G. and WEINER R.—”Effect of PGE1 on leucocyte migration”. Nature New Biol., 234, 114, 1971.PubMedGoogle Scholar
  14. 14.
    KALINER M. and AUSTEN K.F.—”Cyclic AMP, ATP and reversed anaphylactic histamine release from rat mast cells”. J. Immunol., 112, (2), 664, 1974.PubMedGoogle Scholar
  15. 15.
    KALINER M. and AUSTEN K.F.—”Immunologic release of chemical mediators from human tissues”. Ann. Rev. Pharmacol., 15, 177, 1975.PubMedCrossRefGoogle Scholar
  16. 16.
    RYAN G.B. and SPECTOR W.G.-”Macrophages turnover in inflamed connective tissue”. Proc. Roy. Soc. 175, 269, 1970.CrossRefGoogle Scholar
  17. 17.
    SMITH J.W., STEINER A.L. and PARKER C.W. — “Human lymphocyte metabolism. Effects of cyclic and non-cyclic nucleotides on stimulation by phytohaemagglutinin”. J. Clin. Invest., 50, 442, 1971.PubMedCrossRefGoogle Scholar
  18. 18.
    STROM T.B., CARPENTER C.B., GAROVOY M.R., AUSTEN K.F., MERRILL J.P. and KALINER M.—”The modulating influence of cyclic nucleotides upon lymphocyte mediated cytotoxicity”. J. Exp. Med., 138, 38l, 1973.CrossRefGoogle Scholar
  19. 19.
    TAUBER A.I., KALINER M., STECHSCHULTE D.J. and AUSTEN K.F.—”Immunologic release of histamine and slow-reacting substance of anaphylaxis from human lung. V — Effects of prostaglandins on release of histamine”. J. Immunol., 111, 27, 1973.PubMedGoogle Scholar
  20. 20.
    VELO G.P. and ABDULLAHI S.E.—”General concepts of inflammation”. In Inflammatory Arthropathies. Eds. Huskisson E.C. and Velo G.P. Excerpta Medica, Amsterdam and Oxford, p. 3, 1976.Google Scholar
  21. 21.
    VELO G.P., DUNN C., GIROUD J.P., TIMSIT J. and WILLOUGHBY D.A.—”Distribution of prostaglandins in inflammatory exudate”. J. Path., 111, 149, 1973.PubMedCrossRefGoogle Scholar
  22. 22.
    VIGDAHL R.L., MARQUIS N.R. and TAVORMINA P.A.—”Platelet aggregation: Adenyl cyclase, PGE1 and calcium”. Biochem. Biophys., 37, 409, 1969.CrossRefGoogle Scholar
  23. 23.
    WILLOUGHBY D.A.—“Effects of prostaglandins PGF and PGE1 on vascular permeability”. J. Path., 96, 38l, 1968.CrossRefGoogle Scholar
  24. 24.
    WILLOUGHBY D.A. and DI ROSA M.—Proc. Symp. Internat. Inflammation Club. Immunopathology of Inflammation, Exc. Med. Intern. Congr., 229, p. 28, 1970.Google Scholar
  25. 25.
    WILLOUGHBY D.A., DUNN C.J., YAMAMOTO S., CAPASSO F., DEPORTER D.A. and GIROUD J.P.-“Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation”. Agents and Actions, 5, 35, 1975.PubMedCrossRefGoogle Scholar
  26. 26.
    YAMAMOTO S.—“Studies on mechanisms of immobilization of mononuclear cells in the delayed hypersensitivity (DH) reaction”. In Future Trends in Inflammation II. Eds. Giroud J.P., Willoughby D.A. and Velo G.P. Birkhäuser Verlag, Basel, p. 16, 1975.Google Scholar
  27. 27.
    YAMAMOTO S., DUNN C.J., CAPASSO F., DEPORTER D.A. and WILLOUGHBY D.A.—”Quantitative studies on cell-mediated immunity in the pleural cavity of guinea-pigs”. J. Path., 117, 65, 1975.PubMedCrossRefGoogle Scholar
  28. 28.
    YAMAMOTO S., DUNN C.J., DEPORTER D.A., CAPASSO F., WILLOUGHBY D.A. and HUSKISSON E.C.—“A model for the quantitative study of Arthus (immunologic) hypersensitivity in rats”. Agents and Actions, 5, 374, 1975.PubMedCrossRefGoogle Scholar
  29. 29.
    YAMAMOTO S., DUNN C.J. and WILLOUGHBY D.A.—”Studies on delayed hypersensitivity pleural exudates in guinea-pigs. I — Demonstration of substances in the cell-free exudate which cause inhibition of mononuclear cell migration in vitro”. Immunol., 30, 505, 1976.Google Scholar
  30. 30.
    YAMAMOTO S., DUNN C.J. and WILLOUGHBY D.A.—“Studies on delayed hypersensitivity pleural exudates in guinea-pigs. II — The interrelationship of monocytic and lymphocytic cells with respect to migration activity”. Immunol., 30, 513, 1976.Google Scholar
  31. 31.
    ZURIER R.B., WEISSMANN G., HOFFSTEIN S., KAMMERMAN S., HSIN HSIUNG THAI—”Mechanisms of lysosomal enzyme release from human leucocytes. II — Effects of cyclic AMP, cyclic GMP, autonomic agonists and agents which affect microtubule function”. J. Clin. Invest., 53, 297, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. P. Giroud
    • 1
  • G. P. Velo
    • 2
  • D. A. Willoughby
    • 3
  1. 1.Département de Pharmacologie - ERA 629C.N.R.S. Faculté de Médecine Cochin Port-RoyalParisFrance
  2. 2.Istituto di Farmacologia - Centro Ospedaliero Clinicizzato di Borgo RomaUniversità di PadovaVeronaItaly
  3. 3.Department of Experimental PathologySt Bartholomew’s Hospital Medical CollegeLondonEngland

Personalised recommendations