The Role of Prostaglandins and Cyclic Nucleotides in Inflammation
One of the main problems surrounding the study of the PG’s in the inflammatory response has been the lack of suitable models. The inflammatory process is a highly dynamic state. There is a constant change in the volume of exudate, increased lymphatic drainage, arrival of different cell types, and even these different cell types change during the inflammatory process. Thus not only do we see tissue cell changes but the arrival of polymorphs which discharge lysosomal enzymes; usually this is followed by the arrival of mononuclear cells which transform into macrophages. These cells are actively phagocytic, they then transform further into “activated macrophages” with surface changes, plus increased numbers of lysosomes. Often these cells may proliferate or fuse into giant cells and even in this form may undergo proliferation.
KeywordsCyclic Nucleotide Pleural Cavity Purify Protein Derivative Calcium Pyrophosphate Pseudo Gout
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- 1.AUSTEN K.F., LEWIS R.A., STECHSCHULTE D.J., WASSERMAN S.I., LEID R.W. and GOETZL E.J.—”Generation and release of chemical mediators of immediate hypersensitivity”. In Progr. in Immunol., 11, 2, 6l, 1973. Eds. L. Brent and J. Holborow, North Holland Publishing Co Ltd.Google Scholar
- 4.CRUNKHORN PEARL AND WILLIS A.L.— “Cutaneous reactions to intradermal prostaglandins” Brit. J. Pharmacol., 41 (1), 49, 1971.Google Scholar
- 6.DI ROSA M.-In Future Trends in Inflammation. Eds. Velo G.P., Willoughby D.A. and Giroud J.P. Piccin Medical Books, Padua, p.153, 1974.Google Scholar
- 9.FERREIRA S.H. and VANE J.R.—”Inhibition of prostaglandin biosynthesis and the mechanism of action of non-steroidal antiinflammatory agents”. In Future Trends in Inflammation. Eds. Velo G.P., Willoughby D.A. and Giroud J.P. Piccin Medical Books, Padua, p. 171, 1974.Google Scholar
- 10.FONTAGNE J. and GIROUD J.P.—”Pathopharmacologie expérimentale de la reaction inflammatoire aigue”. Revue des Sciences Médicales, 218, 7, 1976.Google Scholar
- 11.HIRSCHHORN R., GROSSMAN J. AND WEISSMANN G.— “Effect of cyclic 3′5′-adenosine monophosphate and theophylline on lymphocyte transformation”. Proc. Soc. Exp. Biol. Med., 133, 136l, 1970.Google Scholar
- 20.VELO G.P. and ABDULLAHI S.E.—”General concepts of inflammation”. In Inflammatory Arthropathies. Eds. Huskisson E.C. and Velo G.P. Excerpta Medica, Amsterdam and Oxford, p. 3, 1976.Google Scholar
- 24.WILLOUGHBY D.A. and DI ROSA M.—Proc. Symp. Internat. Inflammation Club. Immunopathology of Inflammation, Exc. Med. Intern. Congr., 229, p. 28, 1970.Google Scholar
- 26.YAMAMOTO S.—“Studies on mechanisms of immobilization of mononuclear cells in the delayed hypersensitivity (DH) reaction”. In Future Trends in Inflammation II. Eds. Giroud J.P., Willoughby D.A. and Velo G.P. Birkhäuser Verlag, Basel, p. 16, 1975.Google Scholar
- 29.YAMAMOTO S., DUNN C.J. and WILLOUGHBY D.A.—”Studies on delayed hypersensitivity pleural exudates in guinea-pigs. I — Demonstration of substances in the cell-free exudate which cause inhibition of mononuclear cell migration in vitro”. Immunol., 30, 505, 1976.Google Scholar
- 30.YAMAMOTO S., DUNN C.J. and WILLOUGHBY D.A.—“Studies on delayed hypersensitivity pleural exudates in guinea-pigs. II — The interrelationship of monocytic and lymphocytic cells with respect to migration activity”. Immunol., 30, 513, 1976.Google Scholar
- 31.ZURIER R.B., WEISSMANN G., HOFFSTEIN S., KAMMERMAN S., HSIN HSIUNG THAI—”Mechanisms of lysosomal enzyme release from human leucocytes. II — Effects of cyclic AMP, cyclic GMP, autonomic agonists and agents which affect microtubule function”. J. Clin. Invest., 53, 297, 1974.PubMedCrossRefGoogle Scholar