Antisecretory Prostaglandins and Gastric Mucosal Erosions in the Rat
Antisecretory prostaglandins inhibit the formation of gastric ulcers and erosions induced by a variety of experimental techniques including pyloric-ligation, steroid administration or stress (Robert et al, 1968;Usardi et al, 1974). In the present paper, the relationship between inhibition of of gastric acid secretion and the prevention of gastric mucosal erosions, induced acutely by indomethacin or bile salts, has been investigated in the rat. In addition, since changes in gastric mucosal blood flow and in the resistance of the mucosa to acid back-diffusion may be possible mechanisms underlying such erosion formation, the effects of prostaglandins on these parameters have been studied.
KeywordsGastric Acid Secretion Mucosal Blood Flow Sodium Taurocholate Prostaglandin Analogue Gastric Erosion
Unable to display preview. Download preview PDF.
- LEE, Y. H., MOLLISON, K. W. & CHENG, W. D. (1971). The effects of antiulcer agents on indomethacin-induced gastric ulceration in the rat. Arch. Int. Pharmacodyn., 191, 370–377.Google Scholar
- MAIN, I. H. M. & WHITTLE, B. J. R. (1973a). Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat. Br. J. Pharmac, 49, 534–542.Google Scholar
- MAIN, I. H. M. & WHITTLE, B. J. R. (1973b). The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat, Br. J. Pharmac, 49, 428–436.Google Scholar
- MAIN, I. H. M. & WHITTLE, B. J. R. (1975a) Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs. Br. J. Pharmac, 53, 217–224.Google Scholar
- MAIN, I. H. M. & WHITTLE, B. J. R. (1975b). Potency and selectivity of methyl analogues of prostaglandin E2 on rat gastrointestinal function. Br. J. Pharmac, 54, 309–317.Google Scholar