Antisecretory Prostaglandins and Gastric Mucosal Erosions in the Rat

  • B. J. R. Whittle
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


Antisecretory prostaglandins inhibit the formation of gastric ulcers and erosions induced by a variety of experimental techniques including pyloric-ligation, steroid administration or stress (Robert et al, 1968;Usardi et al, 1974). In the present paper, the relationship between inhibition of of gastric acid secretion and the prevention of gastric mucosal erosions, induced acutely by indomethacin or bile salts, has been investigated in the rat. In addition, since changes in gastric mucosal blood flow and in the resistance of the mucosa to acid back-diffusion may be possible mechanisms underlying such erosion formation, the effects of prostaglandins on these parameters have been studied.


Gastric Acid Secretion Mucosal Blood Flow Sodium Taurocholate Prostaglandin Analogue Gastric Erosion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. CHVASTA, T. E. & COOKE, A. R. (1972). The effect of several ulcerogenic drugs on the canine gastric mucosal barrier. J. Lab. clin. Med., 79, 302–315.PubMedGoogle Scholar
  2. LEE, Y. H., MOLLISON, K. W. & CHENG, W. D. (1971). The effects of antiulcer agents on indomethacin-induced gastric ulceration in the rat. Arch. Int. Pharmacodyn., 191, 370–377.Google Scholar
  3. MAIN, I. H. M. & WHITTLE, B. J. R. (1973a). Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat. Br. J. Pharmac, 49, 534–542.Google Scholar
  4. MAIN, I. H. M. & WHITTLE, B. J. R. (1973b). The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat, Br. J. Pharmac, 49, 428–436.Google Scholar
  5. MAIN, I. H. M. & WHITTLE, B. J. R. (1975a) Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs. Br. J. Pharmac, 53, 217–224.Google Scholar
  6. MAIN, I. H. M. & WHITTLE, B. J. R. (1975b). Potency and selectivity of methyl analogues of prostaglandin E2 on rat gastrointestinal function. Br. J. Pharmac, 54, 309–317.Google Scholar
  7. MCCALL, E., WHITTLE, B. J. R. & YOULTEN, L. J. F. (1976). Effects of prostaglandin E2 methyl analogues on the antiinflammatory and gastric erosive activity of indomethacin. J. Pharm. Pharmac., 28, 588–389.CrossRefGoogle Scholar
  8. MONCADA, S., FERREIRA, S. H. & VANE, J. R. (1973). Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature, New Biol., 246, 217–219.CrossRefGoogle Scholar
  9. ROBERT, A. (1974). Effects of prostaglandins on the stomach and intestine. Prostaglandins, 6, 523–532.PubMedCrossRefGoogle Scholar
  10. ROBERT, A., NEZAMIS, J. F. & PHILLIPS, J. P. (1968). Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat. Gastroenterology, 55, 481–487.PubMedGoogle Scholar
  11. USARDI, M. M., FRANCESCHINI, J., MANDELLI, V., DATURI, S. & MIZZOTTI, B. (1974). ‘Prostaglandins VIII’: A proposed role for PGE2 in the genesis of stress-induced gastric ulcers. Prostaglandins, 8, 43–51.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • B. J. R. Whittle
    • 1
  1. 1.Department of Pharmacology, Institute of Basic Medical SciencesRoyal College of SurgeonsLondonUK

Personalised recommendations