The Role of Prostaglandins in Gastrointestinal Tone and Motility
Prostaglandin-like material occurs in the alimentary tract of all species studied and is released from the tissue in vitro (e.g. frog intestine (1), rat stomach (2,3), human stomach (4) and in other tissues examined subsequently). Prostaglandin E2 (PGE2) has been formally identified in the gastrointestinal tract of the shark (Triakis scyllia)(5). It might therefore be expected that PGs contribute to the activity of isolated muscles. However, the effect would depend on the PGs released and the muscle layer concerned. In general, longitudinal muscle of the gut is contracted by PGE and F compounds, but the circular muscle is usually inhibited by PGE compounds and contracted by PGF compounds (6,7).
KeywordsLongitudinal Muscle Circular Muscle Internal Anal Sphincter Krebs Solution Lower Oesophageal Sphincter
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