The Role of Prostaglandins in Gastrointestinal Tone and Motility

  • Alan Bennett
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


Prostaglandin-like material occurs in the alimentary tract of all species studied and is released from the tissue in vitro (e.g. frog intestine (1), rat stomach (2,3), human stomach (4) and in other tissues examined subsequently). Prostaglandin E2 (PGE2) has been formally identified in the gastrointestinal tract of the shark (Triakis scyllia)(5). It might therefore be expected that PGs contribute to the activity of isolated muscles. However, the effect would depend on the PGs released and the muscle layer concerned. In general, longitudinal muscle of the gut is contracted by PGE and F compounds, but the circular muscle is usually inhibited by PGE compounds and contracted by PGF compounds (6,7).


Longitudinal Muscle Circular Muscle Internal Anal Sphincter Krebs Solution Lower Oesophageal Sphincter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Vogt, W., Suzuki, T. and Babilli, S. (1966). Prostaglandins in SRS-C and in darmstoff preparation from frog intestinal dialysates. Mem. Soc. Endocrinol. 14, 137–142.Google Scholar
  2. 2.
    Bennett, A., Friedmann, C.A. and Vane, J.R. (1967). Release of prostaglandin E1 from the rat stomach. Nature (Lond) 216, 873–876.CrossRefGoogle Scholar
  3. 3.
    Coceani, F., Pace-Asciak, C., Volta, F. and Wolfe, L.S. (1967). Effect of nerve stimulation on prostaglandins formation and release from the rat stomach. Am. J. Physiol. 213, 1056–1064.PubMedGoogle Scholar
  4. 4.
    Bennett, A., Murray, J.G. and Wyllie, J.H. (1968). Occurrence of prostaglandin E2 in the human stomach, and a study of its effects on human isolated gastric muscle. Br. J. Pharmacol. Chemother. 32, 339–349.Google Scholar
  5. 5.
    Ogata, H. and Nomura, T. (1975). Isolation and identification of prostaglandin E2 from the gastrointestinal tract of shark triakis scyllia. Biochim. Biophys. Acta. 388, 84–91.PubMedGoogle Scholar
  6. 6.
    Bennett, A. and Fleshier, B. (1970). Prostaglandins and the gastrointestinal tract. Gastroenterology, 59, 790–800.PubMedGoogle Scholar
  7. 7.
    Bennett, A. (1976). Prostaglandins and the alimentary tract. In: Prostaglandins: physiological, pharmacological and pathological aspects. Ed. S.M.M. Karim, MTP Press Ltd., Lancaster, England, pp 247–276.Google Scholar
  8. 8.
    Posner, J. (1970). The release of prostaglandin E2 from the bovine iris. Br. J. Pharmacol. 40, 163P–164P.PubMedGoogle Scholar
  9. 9.
    Bennett, A. and Posner, J. (1971). Studies on prostaglandin antagonists. Br. J. Pharmacol. 42, 584–594.PubMedGoogle Scholar
  10. 10.
    Eckenfels, A. and Vane, J.R. (1972). Prostaglandins, oxygen tension and smooth muscle tone. Br. J. Pharmacol. 45, 451–462.PubMedGoogle Scholar
  11. 11.
    Ferreira, S.H., Herman, A. and Vane, J.R. (1972). Prostaglandin generation maintains the smooth muscle tone of the rabbit isolated jejunum. Br. J. Pharmacol. 44, 328P–329P.PubMedGoogle Scholar
  12. 12.
    Davison, P., Ramwell, P.W. and Willis, A.L. (1972). Inhibition of intestinal tone and prostaglandin synthesis by 5,8,11,14-tetraynoic acid. Br. J. Pharmacol. 46, 547P–548P.PubMedGoogle Scholar
  13. 13.
    Botting, J.H. and Salzmann, R. (1974). The effect of indomethacin on the release of prostaglandin E2 and acetylcholine from guinea-pig isolated ileum at rest and during field stimulation. Br. J. Pharmacol. 50, 119–124.PubMedGoogle Scholar
  14. 14.
    Ferreira, S.H., Herman, A.G. and Vane, J.R. (1976). Prostaglandin production by rabbit isolated jejunum and its relationship to the inherent tone of the preparation. Br. J. Pharmac. 56, 469–477.Google Scholar
  15. 15.
    Collier, H.O.J. (1974). Prostaglandin synthetase inhibitors and the gut. In: “Prostaglandin synthetase inhibitors”. H.J. Robinson and J.R. Vane, Raven Press, New York, p121–133.Google Scholar
  16. 16.
    Collier, H.O.J., McDonald-Gibson, W.J. and Saeed, S.A. (1975). Stimulation of prostaglandin biosynthesis by capsaicin, ethanol, and tyramine. Lancet, 1, 702.PubMedCrossRefGoogle Scholar
  17. 17.
    Bennett, A., Eley, K.G. and Stockley, H.L. (1975). The effects of prostaglandins on guinea-pig isolated intestine and their possible contribution to muscle activity and tone. Br. J. Pharmacol. 54, 197–204.PubMedGoogle Scholar
  18. 18.
    Stockley, H.L. and Bennett, A. (1976). Modulation of activity by prostaglandins in human gastrointestinal muscle. Proceedings of the Fifth International Symposium on gastrointestinal motility. Typoff-Press, Herentals, Belgium.Google Scholar
  19. 19.
    D’Mello, A., Burleigh, D.E. and Parks, A.G. (1975). A non-adrenergic inhibitory mechanism in the human internal anal sphincter probably involving the release of prostaglandins. Abstracts, Sixth International Congress of Pharmacology, Helsinki, p158.Google Scholar
  20. 20.
    Dilawari, J.B., Newman, A., Poleo, J. and Misiewicz, J.J. (1975). Response of the human cardiac sphincter to circulating prostaglandins F and E2 and to anti-inflammatory drugs. Gut, 16, 137–143.PubMedCrossRefGoogle Scholar
  21. 21.
    Willis, A.L., Davison, P. and Ramwell, P.W. (1974). Inhibition of intestinal tone, motility and prostaglandin biosynthesis by 5,8,11,14-eicosatetray-noic acid (TYA). Prostaglandins 5, 355–368.PubMedCrossRefGoogle Scholar
  22. 22.
    Newman, A., De Moraes-Filho, J.P.P., Philippakos, D. and Misiewicz, J.J. (1975). The effect of intravenous infusions of prostaglandins E2 and F on human gastric function. Gut, 16, 272–276.PubMedCrossRefGoogle Scholar
  23. 23.
    Cummings, J.H., Newman, A., Misiewicz, J.J., Milton-Thompson, G.J. and Billings, J.A. (1973). Effect of intravenous prostaglandin F on small intestinal function in man. Nature (Lond). 243, 169–171.CrossRefGoogle Scholar
  24. 24.
    Connell, A.M. (1962). The motility of the pelvic colon. Part II. Paradoxical motility in diarrhoea and constipation. Gut, 3, 342–348.PubMedCrossRefGoogle Scholar
  25. 25.
    Hedqvist, P. (1971). Prostaglandin E compounds and sympathetic neuromuscular transmission. Ann. N.Y. Acad. Sci. 180, 410–415.PubMedCrossRefGoogle Scholar
  26. 26.
    Hedqvist, P. (1976). Effects of prostaglandins on the autonomic neurotransmission. In: Prostaglandins: physiological, pharmacological and pathological aspects. Ed. S.M.M. Karim, MTP Press Ltd., Lancaster, England, pp 37–61.Google Scholar
  27. 27.
    Ehrenpreis, S., Greenberg, J. and Belman, S. (1973). Prostaglandins reverse inhibition of electrically-induced contractions of guinea pig ileum by morphine, indomethacin and acetylsalicylic acid. Nature (New Biol), 245, 280–282.CrossRefGoogle Scholar
  28. 28.
    Bennett, A., Eley, K.G. and Stockley, H.L. (1975). Modulation by prostaglandins of contractions in guinea-pig ileum. Prostaglandins, 9, 377–384.PubMedCrossRefGoogle Scholar
  29. 29.
    Chong, E.K.S. and Downing, O.A. (1974). Reversal by prostaglandin E2 of the inhibitory effect of indomethacin on contractions of guinea-pig ileum induced by angiotensin. J.Pharm. Pharmacol. 26, 729–730.PubMedCrossRefGoogle Scholar
  30. 30.
    Kadlec, O., Masek, K. and Seferna, I. (1974). A modulating role of prostaglandins in contractions of the guinea-pig ileum. Br. J. Pharmacol. 51, 565–570.PubMedGoogle Scholar
  31. 31.
    Bennett, A., Eley, K.G. and Stockley, H.L. (1976). Inhibition of peristalsis in guinea-pig ileum and colon by drugs which block prostaglandin synthesis. Br. J. Pharmac. 52, 335–340.Google Scholar
  32. 32.
    Burnstock, G., Cocks, T., Paddle, B. and Staszewska-Barczac, J. (1975). Evidence that prostaglandin is responsible for the ‘rebound contraction’ following stimulation of non-adrenergic non-cholinergic (‘purinergic’) inhibitory nerves. Eur. J. Pharmacol. 31, 360–362.PubMedCrossRefGoogle Scholar
  33. 33.
    Bennett, A., Eley, K.G. and Scholes, G.B. (1968). Effect of prostaglandins E1 and E2 on intestinal motility in the guinea-pig and rat. Br. J. Pharmacol. 34. 639–647.PubMedGoogle Scholar
  34. 34.
    Radmanović, B.Z. (1972). Effect of prostaglandin E1 on the peristaltic activity of the guinea-pig isolated ileum. Arch. Int. Pharmacodyn. Ther. 200, 396–404.PubMedGoogle Scholar
  35. 35.
    Takai, M., Matsuyama, S. and Yagasaki, O. (1974). Prostaglandin release during extension of the small intestine of the guinea pig.(In Japanese). Jap. J. Smooth Muscle Res. 10, 187–189.Google Scholar
  36. 36.
    Ishizawa, M. and Miyazaki, E. (1973). Effect of prostaglandin on the movement of isolated guinea pig intestine. (In Japanese). Jap. J. Smooth Muscle Res. 9, 235–237.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Alan Bennett
    • 1
  1. 1.Department of SurgeryKing’s College Hospital Medical SchoolLondonUK

Personalised recommendations