Prostaglandins and Vascular Wall

  • Ryszard J. Gryglewski
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


Prostaglandins (PGs) are potent vasoactive agents. Prostaglandins of the F series (PGFs) constrict mainly capacitance vessels, whereas prostaglandins of the E series (PGEs) dilate arterioles, metaarterioles, precapillaries and venules (Greenberg and Sparks, 1969) in most organs except for nasal mucosa (Nakano, 1973). There are also species differences in vascular reactivity to PGE. PGE2 constricts renal blood vessels of rats and potentiates vascular sensitivity to pressor hormones in renal (Malik and McGiff, 1975a; Mullane et al., 1976), mesenteric (Malik and McGiff. 1975b; Horrobin et al., 1974) and coronary (Horrobin et al., 1974) regions. Also isolated rat aorta, carotid and femoral arteries keep their tone owing to a continuous generation of PGEs and are relaxed by PG synthetase inhibitors (Rioux and Regoli, 1975). Therefore speaking about vasoditator properties of PGEs we have to exclude rates. In most other species, including man.


Vascular Wall Prostaglandin Endoperoxide Perfuse Rabbit Bioassay Technique Meclofenamic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aiken, J.W., 1974, Effects of prostaglandin synthesis inhibitors on angiotensin tachyphylaxis on the isolated coeliac and mesenteric arteries of the rabbit. Pol. D. Pharmac, Pharmacol. 26: 217–227,Google Scholar
  2. Bunting, S., Moncada, S., and Vane, J.R., 1976, The effects of prostaglandin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations. Proc. Br. Pharmacol. Soc. 1–2 April, p. 48.Google Scholar
  3. Christ, E.G., and van Dorp, D.A., 1972, Comparative aspects of prostaglandin biosynthesis in animal tissues. Biochem. Biophys. Acta 270: 537–545.Google Scholar
  4. Ferreira, S.H., 1972, Prostaglandins, aspirin-like drugs and analgesia. Nature New Biology 240: 200–203.PubMedCrossRefGoogle Scholar
  5. Ferreira, S.H., and Vane, J.R., 1967, Prostaglandins: their disappearance from and release into circulation. Nature (London), 216: 868–873.CrossRefGoogle Scholar
  6. Gilmore, N., Vane, D.R., and Wyllie, J.H., 1968, Prostaglandins released by the spleen. Nature 218: 1135–1140.PubMedCrossRefGoogle Scholar
  7. Gimborne, M.A., Dr., and Alexander, R.W., 1975, Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium. Science 189: 219–220.CrossRefGoogle Scholar
  8. Greenberg, R., 1974, The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid on the response of the rabbit portal vein to electrical stimulation. Br. D. Pharmac. 52: 61–68.Google Scholar
  9. Greenberg, R.A., and Sparks, H.V., 1969, Prostaglandins and consecutive vascular segments of the canine hindlimb. Amer. J. Physiol. 216: 567–571.PubMedGoogle Scholar
  10. Grodzińska, L., Panczenko- B., and Gryglewski, R.J., 1976, Release of prostaglandin-like material from perfused mesenteric blood vessels of rabbits. J. Pharm. Pharmac. 28: 40–43.CrossRefGoogle Scholar
  11. Gryglewski, R.J., Grodzińska, L., Korbut, R., Ocetkiewicz, A., and Panczenko, B., 1975, Regulatory role of prostaglandins in the vascular system. Materia Med. Pol. 7: 314–321.Google Scholar
  12. Gryglewski, R.J., and Korbut, R., 1975, Prostaglandin feedback mechanism limits vasoconstrictor action of norepinephrine in perfused rabbit ear. Experientia 31: 89–90.PubMedCrossRefGoogle Scholar
  13. Gryglewski, R.J., and Korbut, R., 1976, Bioassay of histamine in the presence of prostaglandins. Br. J. Pharmac. 56: 39.Google Scholar
  14. Gryglewski, R.J., and Ocetkiewicz, A., 1974, A release of prostaglandins may be responsible for acute tolerance to norepinephrine infusions. Prostaglandins 8: 31–42.PubMedCrossRefGoogle Scholar
  15. Grygtewski, R.J., and Vane, J.R., 1970, The inactivation of noradrenaline and isoprenaline in dogs. Br. J. Pharmac. 39: 573–584.Google Scholar
  16. Hadházy, P., and Nador, T., 1976, Effects of indomethacin and PGE1 on the vasoconstrictor responses of the rabbit ear artery to nerve stimulation. Prostaglandins 11: 241–250.PubMedCrossRefGoogle Scholar
  17. Hamberg, M., Svensson, J., and Samuelsson, B., 1975, Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Nat. Acad. Sci. USA 72: 2994–2998.PubMedCrossRefGoogle Scholar
  18. Hedqvist, P., 1970, Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues. Acta physiol. scand. (suppl.), 345: 1–40.Google Scholar
  19. Hedqvist, P., 1972, Prostaglandin-induced inhibition of vascular tone and reactivity in the cat’s hindleg in vivo. Europ. J. Pharmacol. 17: 157–162.Google Scholar
  20. Hollander, W., Kramsch, D.M., Franzblau, C., Paddock, J., and Colombo, M.A., 1974, Supression of atheromatous fibrous plaque formation by antiproliferative and anti-inflammatory drugs, in: Hypertension XXII: Peptides, Lipids, Electrolytes and Hypertension, (J.C. Hunt, ed.), pp. 131–141,Google Scholar
  21. Hollander, W., Kramsch, D.M., Franzblau, C., Paddock, J., and Colombo, M.A., 1974, Supression of atheromatous fibrous plaque formation by antiproliferative and anti-inflammatory drugs, Circulation Res. 34: and 35 (Suppl. I).Google Scholar
  22. Horrobin, D.F., Manko, M.S., Karmali, R., Nassae, B.A., and Davis, P.A., 1974, Aspirin, indomethacin, catecholamine and prostaglandin interaction on rat arteriales and rabbit hearts. Nature (London) 250: 425–426.CrossRefGoogle Scholar
  23. Horton, E.W., 1969, Hypotheses on physiological roles of prostaglandins. Physiol. Rev. 49: 122–141.PubMedGoogle Scholar
  24. Korbut, R., Ocetkiewicz, A., and Gryglewski, R.J., 1975, Release of a prostaglandin E-like substance into mixed venous blood during endotoxin hypotension in cats. Pol. J. Pharmacol. 27: 439–443.Google Scholar
  25. Lewis, G.P., and Piper, P.J., 1975, Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids. Nature 254: 308–311.PubMedCrossRefGoogle Scholar
  26. Malik, K.U., McGiff, J.C., 1975a, Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney. Circ. Res. 36: 599–609.PubMedGoogle Scholar
  27. Malik, K.U., and McGiff, J.C., 1975b, Modulation by prostaglandin E1 of adrenergic transmission in isolated perfused rabbit and rat mesenteric arteries. Fed. Proc. 34: 763.Google Scholar
  28. Malik, K.U., and McGiff, J.C., 1976, Cardiovascular actions of prostaglandins, in: Recent Advances in Prostaglandin Research, Vol. 3, (S.M.M. Karim, ed.), MTP, Lancaster.Google Scholar
  29. McGiff, J.C., 1975, Prostaglandins as regulators of blood pressure. Hosp. Pract. 10: 101–112.Google Scholar
  30. Mullane, K.M., Armstrong, J.M., McGiff, J.C., 1976, Potentiation by prostaglandins of send vascular sensitivity to pressor hormones in normotensive and genetically hypertensive rats of the New Zealand strain, in: Advances in Prostaglandin and Thromboxane Research, Vol. 2, (B. Samuelsson and R. Paoletti eds.), p. 954, Raven Press, New York.Google Scholar
  31. Nakano, J., 1973, Cardiovascular action, in: The Prostaglandins, Vol. 1 (P.W. Ramwell, ed.), p. 239, Plenum Press, New York-London.Google Scholar
  32. Pace-Asciak, C., 1972, Prostaglandin synthetase activity in the rat stomach fundus. Activation by l-norepi-nephrine and related compounds. Biochim. Biophys. Acta 280: 161–171.PubMedGoogle Scholar
  33. Piper, P.J., and Vane, J.R., 1969, Release of additional factors in anaphylaxis and its antagonism by antiinflammatory drugs. Nature 233: 29–35.CrossRefGoogle Scholar
  34. Rioux, F., and Regoli, D., 1975, In vitro production of prostaglandins by isolated aorta strips of normotensive and hypertensive rats. Can. J. Physiol. Pharmacol. 53: 673–677.Google Scholar
  35. Staszewska-Barczak, J., and Vane, J.R., 1975, The role of prostaglandins in the local control of circulation. Clin. Exp. Pharmacol. Physiol. Suppl. 2, 71–78.PubMedGoogle Scholar
  36. Svensson, J., Hamberg, M., and Samuelsson, B., 1975, Prostaglandin endoperoxides IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lungs and human platelets. Acta physiol. scand. 94: 222–228.PubMedCrossRefGoogle Scholar
  37. Terragno, D.A., Crowshaw, K., Terragno, N.A., and McGiff, J.C., 1975, Prostaglandin synthesis by bovine mesenteric arteries and veins. Circulation Res. 36 and 37, suppl. I. 76–80.Google Scholar
  38. Tuvemo, T., and Wide, L., 1973, Prostaglandin release from the human umbilical artery in vitro. Prostaglandins 4: 689–694.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Ryszard J. Gryglewski
    • 1
  1. 1.Department of Pharmacology, CopernicusAcademy of Medicine in CracowCracowPoland

Personalised recommendations