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Prostaglandins and Vascular Wall

  • Ryszard J. Gryglewski
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)

Abstract

Prostaglandins (PGs) are potent vasoactive agents. Prostaglandins of the F series (PGFs) constrict mainly capacitance vessels, whereas prostaglandins of the E series (PGEs) dilate arterioles, metaarterioles, precapillaries and venules (Greenberg and Sparks, 1969) in most organs except for nasal mucosa (Nakano, 1973). There are also species differences in vascular reactivity to PGE. PGE2 constricts renal blood vessels of rats and potentiates vascular sensitivity to pressor hormones in renal (Malik and McGiff, 1975a; Mullane et al., 1976), mesenteric (Malik and McGiff. 1975b; Horrobin et al., 1974) and coronary (Horrobin et al., 1974) regions. Also isolated rat aorta, carotid and femoral arteries keep their tone owing to a continuous generation of PGEs and are relaxed by PG synthetase inhibitors (Rioux and Regoli, 1975). Therefore speaking about vasoditator properties of PGEs we have to exclude rates. In most other species, including man.

Keywords

Vascular Wall Prostaglandin Endoperoxide Perfuse Rabbit Bioassay Technique Meclofenamic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Ryszard J. Gryglewski
    • 1
  1. 1.Department of Pharmacology, CopernicusAcademy of Medicine in CracowCracowPoland

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